Hub : Genes

RASGRF2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1280 0.0390 1.6e-05 0.045 0.047 0.043 0.055 0.036 2.9e-06 2.0e-06 5.6e-06 3.1e-07 2.8e-05
2 GTEx Adipose Subcutaneous 0.1030 0.0440 8.9e-03 0.069 NA 0.041 NA 0.054 2.7e-06 NA 2.6e-04 NA 2.9e-05
3 GTEx Colon Transverse 0.2270 0.0800 6.6e-03 -0.005 NA 0.000 NA -0.005 6.5e-01 NA 3.3e-01 NA 6.4e-01
4 GTEx Liver 0.2970 0.1060 3.8e-03 0.049 NA 0.036 NA 0.088 1.7e-02 NA 3.6e-02 NA 2.0e-03
5 GTEx Thyroid 0.2630 0.0770 1.7e-04 0.033 NA 0.110 NA 0.091 1.4e-03 NA 9.7e-09 NA 1.9e-07
6 METSIM Adipose 0.2436 0.0416 2.9e-15 0.161 0.126 0.149 0.164 0.160 2.0e-23 2.5e-18 1.3e-21 8.5e-24 3.6e-23
7 TCGA Breast Invasive Carcinoma 0.0317 0.0149 4.8e-03 0.027 0.012 0.021 NA 0.024 2.9e-06 1.1e-03 2.5e-05 NA 8.6e-06
8 TCGA Pheochromocytoma and Paraganglioma 0.2410 0.0850 1.7e-03 0.019 0.041 0.062 NA 0.051 5.8e-02 9.7e-03 1.9e-03 NA 4.4e-03
9 TCGA Thyroid Carcinoma 0.1160 0.0380 6.2e-05 0.070 0.067 0.061 NA 0.057 2.4e-07 4.3e-07 1.4e-06 NA 2.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bipolar Disorder (2018) 0.6 0.9 2.5 1.0 -0.3 -1.2 0.2 -1.6 -0.5 -0.4 1.5 -0.8
Bipolar Disorder or Schizophrenia 0.2 0.6 1.6 1.3 -0.6 -0.8 0.1 0.3 -1.0 0.8 0.2 0.8
Depressed Affect (Nagel 2018) 0.7 1.4 2.9 -1.5 -0.7 -0.8 -1.0 -0.1 -1.6 -1.7 -1.6 -0.8
Depression (Nagel 2018) 0.5 0.8 3.3 -0.3 -1.0 0.8 -0.8 0.7 -1.8 -0.5 -0.8 0.5
Intelligence (Savage-Jansen 2018) 0.5 1.5 3.6 -1.4 -1.9 0.7 -0.2 -0.9 -1.6 -1.2 -1.3 -0.9
Neuroticism (Nagel 2018) 1.3 3.1 10.0 -0.8 -0.2 -0.7 -2.0 -1.2 -0.9 -3.2 -2.5 -2.2
Schizophrenia (2018) 0.5 1.1 3.1 0.9 -0.5 -0.1 0.1 1.6 -0.9 1.3 -0.8 1.8
Schizophrenia vs Biploar Disorder 0.5 0.7 2.6 -0.8 -0.2 0.5 -0.2 1.6 -0.2 0.7 0.0 1.3
Worry (Nagel 2018) 1.7 3.6 11.2 1.0 -0.4 -1.0 -1.8 -1.6 -1.1 -3.4 -2.2 -2.6
Alzheimer’s Disease (in mother) 1.2 1.4 4.5 -2.1 -0.6 1.5 -1.4 0.9 0.6 -0.5 -1.4 -0.2
Alzheimer’s Disease (in father) 0.4 0.5 1.7 1.3 -0.2 0.0 -0.5 -0.8 -0.7 -0.8 0.3 0.2
Alzheimer’s Disease (including proxy) 0.5 0.8 2.4 -0.5 -0.2 0.7 -1.6 -0.7 0.3 -1.1 -1.1 -0.7
Crohns Disease (2017) 0.1 0.3 1.5 0.5 0.3 -1.2 -0.5 0.4 0.0 -0.7 -0.3 0.2
Irritable Bowel Disease (IBD) 0.3 0.7 2.4 -0.9 0.4 -0.4 -1.6 1.1 0.1 -0.9 0.3 -0.7
Ulcerative Colitis (UC) 0.7 1.2 3.2 -1.8 0.0 0.9 -1.6 1.1 -0.1 -0.9 0.3 -1.6
Major Depression (MDD) 0.5 0.6 1.9 -1.0 -0.5 0.3 1.0 1.4 -1.0 0.4 -0.0 0.3
Reaction Time 0.7 1.4 2.9 1.4 -0.6 -1.7 -0.8 -1.1 -0.5 -1.0 -1.2 -1.5
Verbal and Numeric Reasoning (VNR) 0.5 1.1 3.2 -0.8 -0.9 0.1 0.3 -1.5 -0.5 -1.6 0.3 -1.8
Breast Cancer 0.6 1.4 3.6 -0.5 1.5 1.9 0.2 -0.9 1.2 -1.4 -1.1 -1.1
Ovarian Cancer 0.3 0.4 1.0 0.8 0.6 1.0 0.3 0.3 -0.0 0.4 0.6 0.7
Prostate Cancer 0.6 0.9 2.5 0.4 1.1 -0.7 -1.6 1.2 1.0 0.5 0.3 0.8
Age at First Birth 0.4 0.5 1.5 1.2 -0.7 0.6 -0.3 -0.2 -0.4 0.2 1.2 -0.9
Bipolar Disorder (2011) 0.4 0.4 1.4 -0.7 0.7 -0.1 0.3 -1.2 0.3 0.1 -1.1 0.2
Body Mass Index (BMI) (2010) 0.3 0.5 1.7 1.3 -0.5 -1.3 0.1 0.0 -0.6 -0.4 0.3 -0.4
Coronary Artery Disease (CAD) 0.4 0.5 2.3 -0.8 -0.3 -0.7 0.3 -0.6 -0.7 -0.2 1.5 0.4
Crohns Disease (2012) 1.3 2.0 4.8 1.0 2.1 -2.2 0.2 1.4 2.0 0.6 0.3 1.3
Mean Putamen Volume 0.6 0.7 3.0 -0.9 -0.2 1.2 0.5 -0.2 -0.3 -0.4 -1.7 -0.6
Fasting Glucose 0.3 0.4 1.2 -1.1 0.0 0.8 -0.1 -0.2 -0.0 -0.7 0.6 -0.8
HbA1C 0.3 0.4 0.9 -0.2 0.9 -0.7 -0.2 -0.4 0.9 -0.5 -0.8 0.3
HDL Cholesterol 0.7 1.2 5.7 0.1 -0.2 -0.1 -2.4 0.2 -0.1 -2.2 -0.6 -0.1
LDL Cholesterol 0.2 0.3 0.9 -0.0 0.8 -1.0 -0.4 -0.7 0.1 -0.6 0.1 -0.4
Lupus 0.7 1.1 2.6 -0.4 -0.0 -0.9 -1.4 0.5 -0.5 -1.6 1.0 -1.6
Neuroticism (2016) 0.9 1.2 3.4 -1.1 -1.6 0.5 -1.8 0.3 -1.8 0.1 -0.5 -0.2
Primary Biliary Cirrhosis 0.4 0.6 2.1 -0.2 -0.0 -1.5 -1.2 0.2 0.2 -1.0 -0.1 -0.8
Rheumatoid Arthritis 0.8 1.2 4.7 -0.9 0.4 2.2 -1.4 1.4 0.2 -0.5 0.2 -0.5
Schizophrenia (2014) 0.7 1.6 5.2 0.4 -1.1 -1.1 -1.1 2.3 -0.9 1.2 -0.2 1.7
Triglycerides 0.5 0.9 1.8 -1.3 1.1 1.3 0.5 1.1 1.0 0.7 -0.7 0.2
Type 2 Diabetes (T2D) (2012) 1.9 2.2 7.5 -1.9 0.1 -1.4 -1.8 -1.1 0.8 -1.4 -0.2 -2.7
Ulcerative Colitis 0.7 1.0 4.0 -2.0 0.5 0.0 -1.1 1.1 1.0 -0.2 0.5 -1.0
Blood Eosinophil Count 0.1 0.6 2.6 0.2 0.1 1.4 0.3 -0.9 0.2 0.1 -1.6 -0.5
Blood Platelet Count 0.1 0.6 2.2 -0.8 0.6 -0.2 -0.1 -0.8 0.9 1.5 1.0 -0.3
Blood Red Count 0.1 0.9 4.4 -0.2 -0.9 -1.1 -0.5 2.1 -0.2 0.7 -0.8 0.3
Blood White Count 0.1 0.7 1.3 0.1 -1.1 -1.2 0.4 -0.4 -1.1 -0.9 -1.0 -0.7
Heel T-Score 5.4 42.9 174.2 4.3 -1.3 -1.4 5.7 7.3 -0.5 13.2 4.5 9.1
BMI 0.5 2.9 11.2 1.4 -2.3 -3.4 -0.2 -1.0 -2.4 -0.7 0.6 0.1
Height 0.3 6.0 25.5 -0.8 -0.4 -0.3 0.2 4.2 -0.3 2.6 5.1 1.7
Waist Hip Ratio (WHR) 0.4 1.8 3.3 -1.8 0.7 1.5 -0.5 1.6 1.2 1.5 1.3 1.3
Systolic Blood Pressure 0.3 1.6 4.8 0.3 -2.2 0.5 -0.3 -0.6 -2.0 -1.0 0.5 -1.8
Smoking Status 1.4 3.4 7.3 1.5 1.1 -1.9 1.4 -1.2 1.1 2.7 -2.1 2.7
Allergy or Eczema 0.2 0.5 2.2 0.0 -0.1 0.1 -0.5 -1.0 1.5 -0.1 -0.4 -0.8
Cardiovascular Disease 0.3 1.0 3.9 -0.3 -0.9 -2.0 -1.3 -0.9 -0.7 0.0 -0.8 -0.3
Hypothyroidism (self reported) 0.5 1.2 2.4 0.8 -1.6 1.4 -1.4 -0.4 -1.6 -1.0 -0.6 -0.7
Respiratory disease 0.1 0.2 0.6 0.6 -0.2 -0.3 -0.8 0.2 0.2 0.3 -0.4 0.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.9 -0.8 0.3 -0.4 -1.5 -0.8 0.1 -1.7 -1.4 -1.1
Lung FEV1/FVC ratio 0.2 0.9 4.6 0.2 -1.0 -1.4 0.1 -0.3 -0.7 0.1 2.1 -0.2
Lung FVC 1.2 6.3 14.4 -1.9 3.1 1.6 -2.2 -2.9 2.3 -3.8 -1.9 -2.2
Neuroticism 0.9 2.1 7.9 0.7 -1.9 -1.1 -1.2 -0.2 -2.8 -1.6 -1.0 -0.6
Chronotype (morning person) 0.7 1.7 3.5 -1.5 -1.8 1.2 0.4 -0.6 -1.9 -1.7 0.6 -1.1
Hair Pigment 0.1 2.7 7.1 -0.4 2.6 -2.1 -2.3 0.0 2.7 0.1 0.5 -0.5
Tanning 0.1 1.7 3.7 1.9 0.8 0.2 0.4 1.3 1.8 1.9 -1.3 1.0
Hand grip strength (left) 0.5 1.3 4.8 1.3 1.7 -0.6 -0.6 -0.8 2.2 -0.1 0.5 -1.1
Number of treatments/medications taken 0.8 1.4 4.0 0.5 -0.8 -1.7 -1.2 -2.0 -1.1 -1.0 -0.9 -0.8
Average weekly spirits intake 0.4 0.5 2.2 0.2 0.8 0.1 0.1 0.2 0.3 0.2 -1.2 1.5
Sensitivity / hurt feelings 0.7 1.3 3.2 1.1 -1.8 -0.7 -1.2 -0.8 -1.1 -1.4 -0.5 -1.1
Frequency of depressed mood in last 2 weeks 1.3 1.9 5.1 0.5 -1.6 0.3 -1.6 -0.9 -2.3 -1.6 -1.5 -0.7
Hearing difficulty/problems: Yes 0.7 1.1 2.6 -1.3 -1.5 0.6 -0.3 -0.9 -0.8 -1.1 -1.6 -0.6
Relative age of first facial hair 0.8 1.6 6.7 2.0 1.1 -2.6 -0.1 -0.7 0.8 -0.3 -1.0 0.3
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.8 -0.3 -0.5 -1.4 -0.8 -1.1 -0.2 -0.2 -0.2 0.9
Ever used hormone-replacement therapy (HRT) 0.8 1.0 3.0 0.4 0.6 -1.7 1.6 -0.0 0.1 1.1 -0.5 1.1
Ever had hysterectomy (womb removed) 2.3 2.7 7.2 -0.4 -2.7 -1.4 -1.7 -0.5 -2.2 -1.9 -1.3 -1.1
Systolic blood pressure, automated reading 0.2 0.5 1.2 0.8 -1.1 -1.1 0.5 -0.7 -0.8 0.1 0.0 -0.5
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.4 -0.9 0.1 1.2 0.2 0.5 0.3 0.7 0.9 -0.3
Angina 1.8 2.4 8.6 -1.1 -2.3 1.6 0.9 -1.2 -2.9 -1.0 0.6 -0.5
Medication for hormone replacement therapy 0.9 1.0 2.4 1.1 0.2 -0.1 1.4 -1.6 -0.9 -1.3 0.3 -0.7
Vitamin and mineral supplements 0.5 0.7 4.5 -2.1 0.1 0.9 0.0 0.8 0.4 -0.4 0.2 0.6
Supplements: Zinc 1.1 1.2 6.0 2.4 0.5 -1.5 -0.5 -1.0 0.3 -0.3 0.6 -0.7
Medication: Co-codamol 0.3 0.4 1.4 -0.4 -0.1 0.2 -0.2 -1.2 -0.3 -0.9 0.4 -0.7
Medication: Metformin 2.3 3.2 8.0 -1.6 -0.7 -0.1 -2.8 -1.4 -0.2 -2.8 -1.1 -2.6
Diabetes (father) 0.2 0.3 1.1 0.7 -1.1 -0.6 0.2 0.1 -0.3 -0.4 0.3 0.1
Diabetes (mother) 0.8 1.0 2.2 -1.1 -0.8 0.6 0.4 -1.3 -1.2 -0.8 0.7 -1.5
Severe depression (siblings) 0.4 0.5 1.4 -0.1 0.7 -0.6 0.0 -0.7 0.5 -1.2 -1.1 -0.4
Pack years adult smoking proportion 0.8 1.2 2.6 -0.4 1.3 -1.6 0.9 0.8 1.2 1.6 -0.6 1.1
Impedance of leg (right) 0.3 1.3 4.1 -0.6 1.0 2.0 -0.6 -0.3 1.4 -0.7 -1.3 -1.4
Leg fat-free mass (left) 0.4 1.9 6.4 -0.1 -1.5 -1.6 -0.3 1.0 -1.9 0.2 2.5 0.9
Trunk fat percentage 0.4 1.6 6.2 -0.8 -1.3 -2.5 -0.3 -1.4 -1.7 -0.3 -0.7 -0.2
Hand grip strength (right) 0.3 0.8 4.8 0.3 1.3 -0.1 -0.4 -0.3 2.2 0.0 0.5 -0.3
Townsend deprivation index at recruitment 0.7 1.0 2.2 1.4 -1.4 0.5 0.8 -0.7 -1.5 -0.2 -0.5 0.9
Current tobacco smoking 1.6 2.5 7.7 2.8 1.3 -1.6 1.8 -0.6 0.9 1.6 -1.2 1.6
Average weekly fortified wine intake 0.5 0.6 1.1 0.4 0.6 -1.0 -0.1 -0.9 1.0 1.1 -1.0 -0.2
Maternal smoking around birth 4.2 6.1 16.6 1.6 -1.0 -1.1 3.2 2.2 -1.2 4.0 0.8 4.1
Fed-up feelings 0.5 0.9 3.1 -0.6 -1.1 0.0 -0.2 -0.0 -1.6 -1.8 -0.8 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.8 2.2 -1.1 -1.2 0.9 0.2 0.4 -1.5 -0.3 -0.7 0.9
Relative age voice broke 1.1 1.6 4.1 0.6 1.3 -2.0 -0.7 -1.9 1.0 -1.0 -0.7 -1.2
Taking other prescription medications 1.0 1.6 3.7 -0.4 -0.8 0.5 -1.5 -1.9 -0.9 -1.9 -1.2 -1.3
Age when periods started (menarche) 0.4 1.0 2.3 -0.2 0.8 0.9 1.0 0.6 0.4 1.5 -1.0 1.5
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.7 -0.5 -1.7 -0.2 1.6 0.7 -1.9 0.6 -0.0 1.6
Heel bone mineral density (BMD) T-score, automated (left) 4.9 11.1 48.9 1.6 0.5 -0.6 3.1 3.9 0.4 7.0 1.1 4.6
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.4 -0.4 0.9 0.7 -0.1 -0.7 1.1 -0.6 0.0 -1.2
Qualifications: CSEs or equivalent 0.7 0.9 2.7 0.2 0.8 0.8 -1.2 -0.0 0.7 -1.6 -0.3 -1.4
Serious illness, injury or assault to yourself 0.9 1.1 4.5 -0.5 0.7 2.1 1.6 -1.3 -0.5 0.1 0.2 0.4
High blood pressure 0.4 1.0 3.7 0.8 -1.8 -1.9 -0.4 -0.2 -1.1 0.3 0.2 0.2
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.4 0.5 0.3 0.9 -0.1 -1.1 1.6 -0.6 0.0 -0.9
Multivitamins +/- minerals 0.8 1.0 3.6 1.9 -0.3 0.3 1.2 -0.5 -1.1 1.3 -0.1 0.7
Stomach or abdominal pain in last month 1.4 1.8 5.8 0.4 -1.6 -0.5 1.2 0.7 -0.4 1.8 1.5 2.4
Supplements: Glucosamine 1.0 1.3 5.5 0.1 0.9 -2.3 -0.3 0.2 1.2 1.8 0.1 0.9
Diverticular disease/diverticulitis (self-reported) 0.9 1.0 3.7 -0.2 -0.7 0.1 1.9 0.5 -1.1 1.5 -0.0 1.2
Medication: Atenolol 1.1 1.4 4.5 0.3 -1.6 -0.4 -1.7 -0.6 -2.1 -1.3 -0.7 -0.3
Medication: Levothyroxine sodium 1.3 2.1 7.7 2.0 -2.5 0.4 -0.5 -0.0 -2.8 -0.5 -0.7 -0.2
Sitting height 0.2 1.4 3.4 -1.4 0.7 -0.1 1.6 1.1 0.5 1.9 1.5 0.6
Chronic bronchitis/emphysema (father) 1.3 1.5 5.9 -0.4 0.0 -1.0 0.7 -2.4 -0.7 -1.3 -1.4 -1.4
High blood pressure (mother) 0.9 1.3 4.8 0.0 -2.2 -0.3 0.3 -1.5 -1.8 -0.7 -0.6 -0.8
Body mass index (BMI) 0.4 1.9 5.3 -0.6 -2.1 -2.1 0.1 -1.2 -2.3 -0.4 0.3 0.2
Impedance of leg (left) 0.4 1.9 5.2 -0.8 1.2 2.3 -0.8 -0.4 1.6 -0.5 -1.9 -1.5
Leg predicted mass (left) 0.4 1.9 6.5 -0.0 -1.5 -1.7 -0.3 1.0 -1.9 0.2 2.5 0.8
Trunk fat mass 0.4 1.6 5.5 -0.9 -1.8 -2.4 -0.4 -0.6 -2.1 -0.1 0.1 0.1
Waist circumference 0.5 1.7 4.0 -1.8 -1.7 -2.0 -1.1 -0.6 -1.6 -0.6 0.7 -0.1
Number of incorrect matches in round 1.1 1.8 6.3 -0.1 1.6 0.1 -2.5 -0.4 1.5 -1.1 -1.4 -1.1
Past tobacco smoking 0.4 0.8 1.9 -0.5 0.1 1.1 -0.5 1.4 -0.2 -1.0 0.9 -1.1
Alcohol usually taken with meals 0.8 1.3 3.2 0.9 -0.9 -0.5 1.7 0.7 -0.0 1.8 1.8 -0.7
Nervous feelings 3.0 5.6 15.4 -0.2 -1.5 -0.4 -2.2 -2.0 -2.1 -3.9 -2.9 -3.3
Frequency of tenseness / restlessness in last 2 weeks 1.8 2.8 9.2 -0.5 -3.0 -0.2 -1.9 -0.0 -2.9 -1.2 -1.4 0.1
Hearing difficulty/problems with background noise 0.3 0.5 2.4 -1.1 -1.5 0.3 -0.3 -0.4 -0.8 -0.2 -0.1 0.4
Hair/balding pattern: Pattern 2 0.4 0.5 1.5 -0.5 -0.4 -0.8 -0.5 -0.1 -0.3 -0.2 -1.1 -1.2
Had menopause 0.6 0.8 2.3 -0.1 1.5 -1.0 0.1 -0.4 1.3 0.7 -0.8 -0.7
Had other major operations 0.2 0.3 0.8 0.7 0.0 0.5 -0.3 -0.2 0.6 0.9 0.6 0.3
Forced vital capacity (FVC) 0.3 1.3 4.8 -1.3 1.5 2.2 -0.3 0.8 1.2 -0.3 0.5 0.5
Heel bone mineral density (BMD) T-score, automated (right) 5.5 12.6 50.3 2.8 -1.0 -1.1 3.0 4.1 -0.7 7.1 1.8 4.9
Ever unenthusiastic/disinterested for a whole week 1.7 2.1 8.4 -2.9 0.7 2.0 -1.5 -0.1 0.5 -1.2 -0.5 -1.4
Qualifications: None of the above 1.0 2.2 5.3 -1.9 -0.8 0.3 -1.0 -1.3 -0.5 -2.3 -1.8 -1.8
Financial difficulties in last 2 years 1.1 1.5 4.6 0.5 -1.4 -0.3 0.3 0.6 -1.2 2.1 0.3 2.1
Mouth/teeth dental problems 0.8 1.2 5.0 2.2 -0.4 0.1 -0.9 0.2 0.5 1.0 1.9 0.1
Heart attack 0.4 0.5 1.3 -0.8 -0.3 0.6 1.1 0.2 -0.5 -0.1 1.1 0.5
Allergy 0.3 0.7 2.1 -0.3 -0.6 -1.4 0.7 1.2 -1.2 0.5 -0.1 0.6
Pain all over the body in last month 0.9 0.9 3.8 -0.9 -1.4 -1.0 0.3 0.2 -1.9 0.3 -0.6 -0.7
Diabetes (self-reported) 1.2 1.8 4.4 -1.5 1.1 -0.7 -2.1 -1.3 1.0 -1.6 -0.4 -1.6
Hayfever/allergic rhinitis (self-reported) 1.0 1.3 5.8 -1.1 -0.3 1.2 -1.1 -0.9 -0.3 -1.0 0.2 -2.4
Medication: Ramipril 0.7 0.9 2.1 -0.4 -1.4 -0.4 -0.9 1.2 -1.1 0.0 -0.9 1.2
Medication: Simvastatin 1.3 1.9 5.5 -0.9 0.5 -0.0 -1.6 -1.8 -0.0 -2.4 -1.0 -1.8
Fluid intelligence score 0.2 0.5 1.4 0.0 -0.1 -1.2 0.5 0.5 0.2 -1.2 0.9 -0.3
Illnesses of siblings 0.5 0.7 2.1 -0.5 1.2 -0.8 -0.6 1.1 0.6 1.5 0.1 -0.2
Neuroticism score 1.7 3.5 13.1 0.5 -2.7 -0.1 -0.5 -1.3 -3.6 -2.4 -1.5 -0.9
Weight 0.4 2.1 6.1 -1.0 -2.3 -2.0 0.0 0.3 -2.5 0.1 1.6 0.4
Impedance of arm (right) 0.2 1.0 5.4 0.5 2.3 0.7 -0.3 -0.2 1.5 -0.1 -0.8 -0.2
Arm fat percentage (right) 0.4 1.7 6.1 -0.4 -1.5 -2.5 -0.2 -1.5 -2.0 -0.3 -0.1 0.2
Trunk fat-free mass 0.4 2.4 7.9 -0.5 -2.0 -0.3 -0.1 2.2 -2.0 0.5 2.8 0.9
Hip circumference 0.6 2.6 6.0 -1.1 -2.3 -2.3 -0.5 -1.4 -2.5 -1.4 1.0 -0.9
Time employed in main current job 0.2 0.2 1.0 -0.1 -1.0 -0.2 0.2 0.4 -0.5 -0.6 0.1 0.5
Alcohol intake versus 10 years previously 1.1 1.6 3.8 -1.0 -2.0 1.8 -1.3 1.2 -1.4 -1.0 0.5 0.0
Father’s age at death 0.9 1.2 2.4 -1.5 1.4 0.7 0.7 0.4 1.4 0.0 1.0 -1.6
Worrier / anxious feelings 1.8 3.4 8.3 0.3 -2.2 0.3 -0.6 -2.6 -2.9 -2.3 -1.7 -1.5
Frequency of tiredness / lethargy in last 2 weeks 1.2 1.9 6.0 -2.4 -1.6 1.9 -1.0 0.5 -1.3 -0.7 -0.6 1.2
Falls in the last year 0.9 1.2 2.7 -1.0 -1.3 0.4 1.6 -0.5 -1.6 0.7 1.0 1.0
Hair/balding pattern: Pattern 3 0.4 0.7 2.6 0.3 0.2 0.7 1.2 0.8 -0.0 0.8 0.3 1.6
Number of live births 0.8 1.1 3.2 -1.3 -0.7 0.6 -1.8 -0.5 -0.9 -0.9 -1.0 -1.3
Forced expiratory volume in 1-second (FEV1) 0.2 0.6 1.5 -0.9 0.5 1.2 -0.9 0.8 0.5 -0.5 0.9 0.3
Pulse rate 1.0 1.6 4.4 -0.9 -1.2 2.1 -0.6 -1.7 -0.7 -1.2 1.1 -1.2
Happiness 0.8 1.0 6.2 0.4 -0.5 2.5 0.8 1.1 -0.8 0.0 0.2 0.1
Noisy workplace 0.6 0.8 2.2 0.4 -0.6 0.4 0.0 -1.5 -0.7 -1.2 -1.3 -0.6
Qualifications: A levels/AS levels or equivalent 0.3 0.6 1.6 1.3 1.2 -0.2 0.4 0.0 0.8 1.1 0.0 0.0
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 6.3 2.5 0.5 -1.4 1.8 -0.4 0.6 0.8 -0.4 0.5
Mouth/teeth dental problems: Dentures 0.3 0.6 1.8 -1.3 -0.6 0.4 -0.3 -0.8 -0.8 0.2 -1.2 0.1
Asthma 0.3 0.5 1.1 -0.2 0.9 1.0 -0.9 -0.7 1.0 -0.3 0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.1 3.7 0.5 -0.7 0.1 1.2 0.1 -0.6 1.5 1.0 1.9
Medication: Cholesterol lowering 0.4 0.6 1.3 -0.8 -0.6 -0.7 -0.0 -1.2 -0.7 -0.5 1.1 -0.5
Depression (self-reported) 1.7 2.1 4.9 -0.5 -1.7 1.0 -1.6 -1.1 -2.2 -1.8 0.3 -1.6
Medication: Lansoprazole 0.3 0.3 1.1 -0.5 -0.3 -0.8 -1.0 -0.8 -0.1 -0.7 -0.2 0.2
Prospective memory result 0.7 0.8 1.9 -0.5 0.7 -0.7 -1.1 -1.2 0.7 -1.4 0.2 -1.2
Lung cancer (father) 0.5 0.6 1.7 -1.3 -1.2 -0.3 -0.5 -0.7 -0.7 -0.8 -0.8 -0.2
Illnesses of mother 0.9 1.1 3.7 0.9 1.9 1.5 0.1 0.5 1.7 0.4 -0.2 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 4.2 -0.9 0.8 2.0 -2.0 0.4 0.6 -1.1 0.8 -0.1
Pulse wave Arterial Stiffness index 1.1 1.3 3.6 -1.3 1.7 1.3 -0.9 -1.0 1.9 -0.4 0.2 0.3
Impedance of arm (left) 0.3 1.2 5.5 0.5 2.3 0.4 0.2 -0.1 1.6 0.4 -1.4 -0.3
Arm fat mass (right) 0.5 1.9 6.5 -0.8 -2.0 -2.5 -0.3 -0.7 -2.2 -0.2 0.7 0.3
Trunk predicted mass 0.4 2.4 7.7 -0.4 -2.0 -0.3 -0.1 2.2 -1.9 0.5 2.8 0.8
Standing height 0.2 2.1 9.3 -0.7 -0.7 -0.2 -0.5 3.0 -0.7 1.1 2.5 0.7
Length of working week for main job 0.8 0.9 2.2 1.0 -1.5 -1.1 -1.1 -0.4 -1.0 0.4 0.2 -1.0
Exposure to tobacco smoke at home 0.7 0.7 3.1 0.1 0.6 0.3 0.4 0.4 0.6 0.0 -1.8 1.5
Breastfed as a baby 1.1 1.4 4.1 -1.2 0.4 0.9 0.2 1.6 1.0 1.6 2.0 0.5
Tense / ‘highly strung’ 0.6 1.0 4.3 0.0 -0.1 -0.6 -1.3 0.1 -1.4 0.3 -2.1 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.3 4.0 -0.4 -1.8 0.5 -1.0 -0.7 -2.0 -1.6 -0.6 -0.1
Hair/balding pattern: Pattern 4 0.2 0.5 1.1 -0.2 0.3 -0.1 -0.6 -1.1 0.1 -0.4 -1.1 -1.1
Birth weight of first child 0.4 0.7 2.5 0.8 -1.1 0.1 0.4 -0.3 -1.6 -0.8 -0.3 -0.9
Peak expiratory flow (PEF) 0.4 0.8 4.2 0.2 0.3 -0.8 0.8 0.7 0.8 0.7 2.1 0.2
Pulse wave reflection index 1.8 2.3 6.7 -0.4 2.6 0.9 -1.2 -1.5 2.1 -1.1 -1.8 -0.5
Ever highly irritable/argumentative for 2 days 0.8 0.9 3.5 0.2 -1.9 -0.3 0.9 0.5 -1.7 0.2 -0.7 0.5
Loud music exposure frequency 1.7 1.9 5.7 -0.0 -2.1 -1.2 1.6 -0.1 -2.4 0.8 1.3 0.3
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 1.4 1.2 0.2 -0.3 0.1 0.7 0.5 1.0 0.5 0.6
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 3.0 -0.9 -0.1 -0.1 0.6 0.8 -0.6 -1.7 -0.3 -0.7
Blood clot in the leg (DVT) 0.4 0.5 1.8 -1.3 -0.4 0.4 -0.7 -0.1 -0.9 -1.1 0.0 0.1
Medication: Paracetamol 0.9 1.5 4.3 -0.5 -1.6 1.4 0.7 1.2 -2.1 0.1 1.5 0.3
Headache pain in last month 1.5 2.6 6.1 -0.7 -1.2 1.6 1.1 2.1 -1.4 1.6 1.6 2.5
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.6 1.0 0.3 0.8 1.3 0.2 0.6 1.2 -0.6 0.7
Glaucoma (self-reported) 0.8 1.0 2.9 0.7 -1.0 -0.1 0.5 -1.7 -0.3 -1.3 0.8 -1.4
Gout (self-reported) 0.4 0.6 1.3 -0.3 -0.9 0.7 -0.7 0.1 -1.1 -0.6 -1.0 -0.9
Hypothyroidism/myxoedema (self-reported) 1.0 1.9 6.5 1.4 -2.5 1.0 -1.0 -0.2 -2.5 -0.2 -0.2 0.1
Medication: Amlodipine 0.3 0.4 1.4 -0.7 -0.3 -0.7 -0.3 0.8 -0.1 0.8 -0.2 1.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.7 0.4 -0.4 0.3 -0.1 0.3 -1.3 0.2 -1.1 0.8
Birth weight 0.4 0.8 4.0 0.4 -0.9 0.6 -0.4 0.6 -0.8 -0.8 2.0 0.1
Chronic bronchitis/emphysema (mother) 2.7 3.2 11.7 1.3 -0.8 -1.5 1.0 1.6 -0.4 3.4 -0.8 2.9
High blood pressure (siblings) 0.3 0.5 1.6 0.9 -0.5 -0.3 0.1 -1.0 0.0 -1.3 -0.6 0.1
Forced vital capacity (FVC), Best measure 0.5 1.8 8.8 -1.3 1.4 3.0 -1.4 0.7 1.0 -0.5 0.3 0.3
Body fat percentage 0.4 1.7 5.3 -1.1 -1.6 -2.3 -0.4 -1.5 -1.8 -0.4 -0.6 -0.3
Leg fat percentage (right) 0.5 1.8 4.6 -1.5 -2.1 -1.4 -0.6 -1.7 -1.8 -0.8 -0.3 -0.5
Arm fat-free mass (right) 0.5 2.5 6.7 -0.5 -2.4 -1.1 -0.1 1.9 -2.1 0.5 2.6 0.5
Exposure to tobacco smoke outside home 0.5 0.7 2.0 0.2 0.3 0.8 0.0 -1.4 1.2 -0.4 -1.1 -0.5
Comparative body size at age 10 0.1 0.3 1.2 0.3 0.0 -1.1 0.7 0.7 -0.6 0.3 0.4 0.2
Number of full brothers 0.5 0.6 3.4 0.0 0.3 1.9 1.1 -0.5 -0.4 -0.5 0.7 0.1
Worry too long after embarrassment 2.2 3.7 9.0 -0.6 -1.6 0.3 -3.0 -1.9 -1.6 -2.7 -2.2 -1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 4.0 0.2 -1.5 -0.0 -0.5 0.5 -2.0 -0.5 -0.5 1.1
Wheeze or whistling in the chest in last year 0.6 1.2 3.2 -1.3 -1.8 -0.1 1.1 -1.3 -1.3 0.1 -0.8 -0.4
Number of children fathered 1.5 1.7 7.0 -0.9 1.1 -0.3 0.4 2.0 1.3 0.3 0.2 2.6
Reason for reducing amount of alcohol drunk: Health precaution 1.6 1.9 9.1 0.7 -0.3 -1.4 -0.8 -3.0 -0.1 -1.3 -1.4 -1.0
Age at first live birth 0.8 1.4 5.3 1.2 2.3 -0.3 -0.2 -0.4 2.3 0.7 -0.1 -0.3
Pulse wave peak to peak time 1.1 1.3 3.8 1.1 -1.7 -1.1 0.8 1.3 -2.0 0.5 0.1 -0.2
Health satisfaction 0.9 1.2 2.9 -1.2 1.3 1.7 -0.6 -0.7 1.4 -1.0 0.7 -0.4
Shortness of breath walking on level ground 0.9 1.0 4.5 -0.1 -0.4 -0.2 0.4 -1.4 0.1 -1.4 -2.1 -0.7
Qualifications: College or University degree 0.5 1.6 7.9 -0.1 0.7 1.5 -1.0 1.2 0.8 0.7 2.8 -0.7
Eye problems/disorders: None of the above 1.1 1.3 4.6 -2.1 1.8 0.2 -0.8 0.0 1.3 -0.2 -1.1 -0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.3 1.3 -0.1 0.0 -1.2 0.5 0.4 -0.3 -0.3 -0.7 0.4
Emphysema/chronic bronchitis 1.4 1.6 4.3 0.9 -1.7 1.9 -0.3 0.5 -2.1 -0.5 0.9 1.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.6 -0.4 0.7 0.8 -1.1 -0.6 1.1 0.1 -1.3 -0.9
Neck or shoulder pain in last month 0.3 0.5 2.7 -1.6 -0.6 0.5 -0.4 -0.8 0.2 -0.2 -0.1 -0.1
Medication: Blood pressure 0.5 0.8 3.4 -0.0 -1.5 -0.9 -0.7 0.2 -1.9 -0.5 0.4 -0.3
Angina (self-reported) 1.9 2.5 8.8 -1.1 -2.4 1.6 0.8 -1.1 -3.0 -0.9 0.8 -0.5
Migraine (self-reported) 0.7 0.9 2.8 -0.3 1.0 -1.1 0.5 1.7 -0.2 1.1 0.0 1.3
Medication: Ibuprofen 0.3 0.4 2.5 0.2 -0.4 -0.1 0.3 0.1 -0.3 0.7 0.2 1.6
Medication: Allopurinol 0.3 0.4 0.8 0.7 -0.6 0.8 -0.2 -0.3 -0.9 -0.8 -0.0 -0.6
Medication: Omeprazole 0.6 0.7 2.0 -0.0 0.6 -1.1 1.0 -1.4 0.4 -0.5 0.2 -1.1
Medication: Seretide 50 evohaler 1.0 1.1 4.0 2.0 -0.4 -0.3 0.5 -1.9 -0.4 -1.0 -0.7 -0.6
Mean time to correctly identify matches 1.0 1.8 4.4 0.9 -0.8 -2.0 -0.6 -1.4 -0.7 -1.0 -2.1 -1.6
Heart disease (mother) 0.8 1.0 4.0 -0.9 -1.5 -0.4 0.4 -2.0 -1.0 0.1 0.9 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 2.0 0.6 -1.0 0.5 1.0 1.1 -0.7 1.4 -0.2 0.9
Whole body fat mass 0.4 1.8 6.7 -1.1 -1.9 -2.6 -0.3 -0.6 -2.0 -0.2 0.3 0.1
Leg fat mass (right) 0.4 1.5 4.2 -1.4 -2.0 -1.6 -0.8 -0.5 -1.9 -0.6 0.5 0.0
Arm predicted mass (right) 0.5 2.4 6.3 -0.5 -2.5 -1.0 -0.1 1.8 -2.2 0.5 2.3 0.4
Pulse rate, automated reading 0.4 1.3 5.6 -1.4 -1.1 2.4 -0.6 0.2 -0.9 -0.5 1.1 -0.1
Alcohol intake frequency. 1.7 3.9 10.6 -3.2 -1.2 2.2 -2.8 0.9 -1.6 -2.4 -0.8 -0.8
Comparative height size at age 10 0.4 2.4 7.0 -2.0 0.2 -1.0 0.2 2.5 0.6 1.7 2.6 0.0
Number of full sisters 0.3 0.3 0.9 0.9 -0.2 0.2 0.6 0.5 0.7 0.5 0.6 -0.2
Suffer from ‘nerves’ 2.1 3.3 9.9 -0.1 -2.1 0.7 -1.7 -1.7 -1.9 -3.1 -0.7 -2.2
Overall health rating 0.4 0.9 5.4 -2.3 -0.7 0.9 -0.6 -0.6 -0.5 0.2 -0.1 0.6
Chest pain or discomfort 2.1 3.1 9.1 -3.0 -1.0 2.9 -1.5 -1.3 -0.6 -1.6 -0.4 -1.6
Had major operations 0.9 1.1 3.0 1.4 0.7 -0.9 -1.3 0.7 0.1 0.3 1.7 1.0
Age at last live birth 0.4 0.6 1.8 0.8 0.2 0.9 0.1 -1.3 0.2 0.3 0.1 -1.3
Family relationship satisfaction 0.8 1.0 6.2 0.3 0.1 2.5 0.3 1.1 -0.2 -0.4 0.9 0.2
Leg pain on walking 1.1 1.4 4.7 -1.3 -0.6 -0.3 -0.3 -2.2 -0.5 -2.0 -0.3 -1.1
Qualifications: NVQ or HND or HNC or equivalent 1.5 1.8 4.7 1.6 -1.6 -1.2 2.2 -0.4 -1.6 1.5 0.2 0.6
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.4 0.7 0.0 0.2 -0.6 1.2 -0.2 1.2 0.3 1.6
Illness, injury, bereavement, stress in last 2 years 1.6 2.0 6.5 -1.3 0.6 0.9 -2.5 0.1 1.1 -1.9 -0.2 -1.8
Medication: Aspirin 0.9 1.1 6.4 0.1 -0.7 -2.5 -0.6 -0.5 -1.0 -1.1 -0.7 -0.1
Supplements: Vitamin C 0.8 0.9 4.7 0.4 -0.1 -0.7 -0.3 -0.8 0.5 -0.3 -1.3 -2.2
Knee pain experienced in last month 0.2 0.3 1.0 -0.5 -0.7 0.7 -0.4 0.3 -0.4 -0.4 -0.2 1.0
Hypertension (Self-reported) 0.4 1.0 4.0 0.3 -1.7 -2.0 -0.5 -0.7 -1.1 0.3 0.3 -0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 1.4 1.2 -0.1 -0.7 0.0 -0.3 -0.4 -0.5 0.1 0.1
Illnesses of father: Heart disease 0.3 0.4 1.4 -0.5 -0.7 0.5 0.1 0.7 -0.4 -0.4 1.2 -0.0
Illnesses of siblings: Diabetes 1.7 2.1 4.8 -2.2 -1.7 2.0 0.6 -0.9 -1.3 -1.6 0.7 -0.9
Smoking status: Previous 0.3 0.4 1.7 -0.1 -0.4 -1.3 0.2 -0.8 0.1 0.8 -0.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.4 -0.0 -1.5 0.9 0.1 1.0 -1.2 0.4 1.1 0.8
Whole body fat-free mass 0.4 2.3 7.7 -0.4 -1.9 -1.0 -0.1 1.9 -2.0 0.5 2.8 0.9
Leg fat-free mass (right) 0.3 1.6 5.2 -0.2 -1.4 -1.6 -0.2 1.0 -1.7 0.3 2.3 0.8
Arm fat percentage (left) 0.4 1.6 6.5 -0.2 -1.5 -2.6 0.0 -1.4 -1.9 -0.2 -0.3 0.2
Average weekly red wine intake 1.6 2.3 10.4 -0.5 0.5 -0.1 3.2 0.2 0.9 2.1 2.0 0.9
Handedness (chirality/laterality): Left-handed 0.4 0.4 1.3 0.4 1.1 0.1 0.8 0.5 1.1 0.1 0.2 0.7
Mood swings 1.4 2.4 7.7 -0.9 -2.2 0.3 -1.4 -1.2 -2.8 -1.5 -1.3 -0.9
Loneliness, isolation 0.9 1.3 2.8 0.1 -1.4 -0.7 -1.3 -0.7 -1.5 -1.7 -1.2 -1.0
Long-standing illness, disability or infirmity 1.1 1.7 5.1 0.4 -1.8 0.1 -0.6 0.7 -1.8 0.7 1.3 2.3
Ever had bowel cancer screening 1.9 2.2 4.9 0.5 -0.5 -1.8 1.5 2.2 -1.3 1.5 0.1 2.1
Diabetes diagnosed by doctor 1.3 2.1 5.1 -2.0 0.4 0.2 -2.3 -1.4 0.3 -1.9 -0.2 -2.1
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 2.1 0.2 -0.0 -0.1 1.1 -0.2 -0.8 0.9 1.4 0.1
Friendships satisfaction 1.0 1.3 6.3 0.6 1.1 2.5 0.3 1.1 0.6 0.3 0.1 1.3
Qualifications: nursing, teaching 1.0 1.5 5.5 1.0 -0.1 0.5 -0.8 1.5 0.5 2.4 -0.6 1.7
Commuting to job workplace: Walk 0.8 0.9 2.5 0.4 -0.4 -0.6 0.5 -1.5 -0.6 -1.6 -0.8 -1.1
Eye problems/disorders: Cataract 0.6 0.7 1.7 1.1 -1.2 -1.3 0.1 -0.7 -0.7 0.3 0.6 0.5
Mouth/teeth dental problems: Mouth ulcers 0.4 0.7 1.8 -0.5 -1.3 0.8 1.2 0.3 -1.2 -0.5 0.6 -0.5
Medication for cholesterol 1.2 1.9 5.7 -0.2 0.5 0.8 0.1 2.4 1.1 1.9 1.8 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.5 1.8 0.4 0.0 -0.2 -0.7 0.3 0.2 -0.3 1.4 1.2
Back pain experienced in last month 0.6 0.9 2.8 0.9 -1.2 -1.7 0.5 -0.3 -0.7 0.1 -0.9 1.1
Mineral and other dietary supplements 1.0 1.3 4.4 -2.0 -1.0 2.1 0.4 0.7 -0.9 -0.0 -0.1 1.0
Breast cancer (self-reported) 1.0 1.2 2.5 1.6 0.5 -1.2 -1.0 0.4 1.6 1.3 0.2 1.1
Asthma (self-reported) 0.1 0.2 0.9 -0.1 0.5 0.4 -1.0 -0.4 0.7 -0.1 0.1 -0.0
Osteoporosis (self-reported) 0.9 1.2 3.8 0.4 -1.0 -1.3 -0.9 -0.5 -1.9 -1.5 -0.5 0.3
Osteoarthritis (self-reported) 0.3 0.4 2.0 -1.4 -0.5 0.3 0.4 0.0 -0.6 -0.4 -0.1 0.3
Medication: Aspirin 0.9 1.2 5.5 -0.3 -0.4 -2.3 -0.8 -1.0 -0.6 -1.3 -0.7 -0.5
Medication: Gliclazide 1.2 1.3 3.7 -1.8 1.2 -1.9 -0.7 -0.6 1.1 -0.4 -0.3 -1.0
Illnesses of father: None of the above (group 1) 0.8 1.0 2.9 1.0 0.9 0.8 0.0 1.0 0.7 1.7 -1.0 1.0
Smoking status: Current 1.2 1.9 6.4 2.5 1.0 -1.2 1.3 -0.9 0.9 1.2 -1.1 1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.7 1.4 3.9 -0.6 1.3 1.9 -1.3 0.8 2.0 -0.8 0.7 0.1
Whole body water mass 0.4 2.4 7.3 -0.3 -2.0 -1.1 -0.2 1.8 -2.0 0.5 2.7 0.9
Leg predicted mass (right) 0.3 1.6 4.9 -0.1 -1.4 -1.7 -0.2 1.1 -1.7 0.4 2.2 0.9
Arm fat mass (left) 0.4 1.6 6.5 -0.6 -1.7 -2.5 -0.2 -0.5 -2.0 0.1 0.5 0.4
Number of self-reported non-cancer illnesses 0.4 0.7 1.9 -0.4 -0.8 -1.4 -0.3 -0.3 -0.9 0.7 0.5 1.4
Average weekly champagne plus white wine intake 0.4 0.6 3.1 0.4 -0.0 -1.3 0.4 -0.4 0.2 1.7 -0.0 -0.1
Miserableness 1.5 2.6 6.5 -1.9 -1.6 1.1 -1.3 -0.1 -2.4 -1.2 -2.5 0.2
Guilty feelings 1.0 1.5 6.3 -0.3 -2.1 0.8 0.1 -0.6 -2.5 -1.0 -0.4 0.4
Wears glasses or contact lenses 1.5 1.7 5.7 0.8 -2.0 -1.5 0.1 -1.5 -2.4 0.1 0.2 -0.1
Ever taken oral contraceptive pill 2.0 2.2 6.4 0.2 1.1 0.5 2.5 0.7 0.5 2.1 2.1 1.6
Hearing aid user 1.3 1.5 4.2 1.4 -0.5 -1.7 1.4 0.2 0.1 2.1 0.2 1.4
Mother’s age at death 0.2 0.3 0.7 -0.8 -0.3 0.3 0.6 0.8 0.0 0.2 0.6 -0.8
Financial situation satisfaction 0.7 0.8 4.7 0.1 0.2 2.2 0.8 -0.3 0.5 0.5 1.2 0.3
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.3 -0.3 -0.5 0.1 -1.0 -0.0 0.5 -0.2 -1.1 -0.7
Commuting to job workplace: Public transport 0.7 0.9 3.6 0.3 1.6 0.0 1.0 -0.7 1.9 0.4 -0.1 -0.0
Eye problems/disorders: Glaucoma 1.2 1.4 6.4 0.2 -0.7 0.6 -0.3 -1.4 -0.1 -2.5 0.5 -1.8
Medication: Blood pressure 1.3 2.5 5.4 0.0 -1.9 -1.0 -1.2 -2.3 -1.4 -1.6 -1.7 -1.9
Pain type(s) experienced in last month: Hip pain 1.2 1.5 6.7 0.2 -2.6 -2.0 -0.4 -0.2 -1.3 -0.2 -0.4 -0.7
Supplements: Fish oil (including cod liver oil) 1.6 2.2 6.1 2.5 1.8 -2.0 0.6 -0.1 1.8 0.4 1.3 -0.6
High cholesterol (Self-reported) 0.4 0.7 2.4 -0.7 0.2 -1.5 -0.7 -1.3 0.3 -0.1 -0.6 -0.9
Medication: Bendroflumethiazide 1.3 2.0 8.8 -0.1 -2.6 -0.2 -0.6 0.2 -3.0 -0.8 -0.4 1.0
Medication: Paracetamol 0.9 1.4 5.5 -0.5 -2.4 0.1 -0.1 0.1 -2.4 -0.5 0.8 -0.5
Medication: Lisinopril 0.5 0.6 1.6 -0.7 -0.3 0.3 1.2 -0.3 -1.3 -0.4 0.5 1.1
Medication: Atorvastatin 0.1 0.2 1.0 -0.2 -0.2 0.0 -0.3 -0.3 0.3 -1.0 0.1 -0.5
Illnesses of father: High blood pressure 0.1 0.1 0.5 -0.4 0.4 0.3 -0.0 0.2 0.1 -0.4 0.7 0.4
Alcohol drinker status: Never 1.9 2.2 6.2 -1.2 -1.2 0.6 -0.8 -1.6 -2.2 -2.5 -0.7 -1.5
Ever smoked 0.9 1.7 3.6 1.2 0.8 -0.7 1.5 -1.9 0.5 1.2 -1.6 1.6
Basal metabolic rate 0.4 2.2 6.5 -0.4 -2.1 -1.3 -0.2 1.4 -2.2 0.3 2.5 0.7
Leg fat percentage (left) 0.5 1.7 4.4 -1.8 -2.1 -1.3 -0.7 -1.4 -1.7 -0.4 -0.8 -0.3
Arm fat-free mass (left) 0.5 2.5 6.7 -0.7 -2.5 -0.9 -0.3 1.8 -2.1 0.4 2.6 0.6
Number of operations (self-reported) 1.2 1.7 3.5 1.6 -1.9 -0.8 -0.4 0.9 -1.7 1.5 0.4 1.6
Average weekly beer plus cider intake 0.4 0.5 1.5 0.7 0.6 1.1 1.0 -1.2 0.1 -0.0 -0.3 0.2
Irritability 0.9 1.6 6.7 -0.3 0.8 -1.4 -0.4 -2.1 0.1 -0.3 -2.6 -0.3
Risk taking 1.1 1.6 6.7 1.3 0.2 -1.0 1.5 -0.1 -0.3 2.6 1.5 0.9
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.0 0.3 0.7 0.1 -0.5 0.8 0.6 0.4 0.7 1.4
Fractured/broken bones in last 5 years 1.6 2.1 7.1 -1.0 0.9 0.6 0.5 -2.0 0.2 -2.7 -0.2 -2.2
Age started oral contraceptive pill 0.3 0.3 1.6 -0.4 -0.4 -0.1 -0.1 0.9 -0.5 -0.0 -0.3 -1.2
Diastolic blood pressure, automated reading 0.1 0.3 1.0 0.5 -0.5 -1.0 0.7 -0.6 -0.4 -0.0 -0.5 -0.2
Ever depressed for a whole week 1.7 2.1 5.6 -2.2 0.2 2.1 -1.3 -1.0 -0.3 -2.4 -0.6 -1.2
Unable to work because of sickness or disability 2.8 3.7 8.8 -3.0 -2.6 2.5 -1.8 -0.9 -2.0 -1.6 0.7 -0.2
Commuting to job workplace: Cycle 0.6 0.7 1.6 -0.6 -0.1 1.0 -1.2 1.3 -0.8 0.2 -0.1 -1.2
Myopia 0.4 0.6 2.3 0.6 0.5 0.3 1.2 -0.7 -0.1 0.5 1.5 0.7
Vascular/heart problems diagnosed by doctor 0.3 0.7 2.6 -0.3 1.6 1.4 -0.0 0.4 1.3 0.0 0.2 -0.3
Cholesterol lowering medication 1.1 1.6 5.9 -1.0 0.5 -0.0 -1.0 -1.5 0.2 -1.6 -2.4 -1.2
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 1.6 0.1 0.7 -1.1 1.3 -1.0 0.4 0.0 0.5 -0.7
Pain experienced in last month 0.6 1.0 3.3 1.0 1.0 1.0 -0.1 -0.2 0.9 -1.1 0.4 -1.8
Supplements: Calcium 1.2 1.3 3.8 1.2 -0.8 -0.8 0.5 -0.6 -1.9 -1.4 -0.8 -1.4
Basal cell carcinoma (self-reported) 0.3 0.3 1.2 0.6 -0.1 0.3 1.1 0.8 -0.0 0.6 -0.5 0.4
Heart attack/myocardial infarction (self-reported) 0.3 0.4 1.4 -0.7 -0.2 0.3 1.1 0.3 -0.5 -0.2 1.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.7 -1.3 -0.5 0.4 -1.0 -0.4 -1.1 -1.2 0.2 -0.2
Heart disease (siblings) 0.4 0.5 2.1 -0.4 0.8 -0.2 1.4 -0.7 0.5 0.4 0.6 0.0
Alcohol drinker status: Previous 0.8 0.9 2.5 -1.6 -0.3 1.2 -0.6 0.7 0.1 0.7 -1.6 0.5
Pack years of smoking 0.9 1.3 3.4 -0.5 1.2 -1.8 0.7 1.0 1.3 1.6 -0.6 1.1
Impedance of whole body 0.3 1.4 4.1 0.1 2.0 1.1 -0.2 -0.2 1.9 0.0 -1.9 -0.8
Leg fat mass (left) 0.4 1.5 4.4 -1.4 -2.1 -1.7 -0.8 -0.5 -1.9 -0.3 0.3 0.1
Arm predicted mass (left) 0.5 2.3 6.2 -0.7 -2.5 -1.4 -0.2 1.5 -2.1 0.3 2.3 0.3