Best TWAS P=1.14e-27 · Best GWAS P=5.76e-29 conditioned to 0.00382
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | DOPEY1 | 0.29 | 0.27 | lasso | 6 | 0.28 | 4.2e-23 | 6.1 | -7.3 | 2.7e-13 | -0.62 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | DOPEY1 | 0.20 | 0.18 | enet | 11 | 0.20 | 1.1e-10 | 6.1 | -6.2 | 7.7e-10 | -0.50 | 0.98 | 0.01 | FALSE |
| 3 | GTEx | Artery Aorta | DOPEY1 | 0.36 | 0.20 | enet | 34 | 0.25 | 5.4e-14 | 6.1 | -6.4 | 1.4e-10 | -0.56 | 0.98 | 0.02 | FALSE |
| 4 | GTEx | Artery Tibial | DOPEY1 | 0.33 | 0.28 | lasso | 7 | 0.30 | 2.0e-23 | 6.1 | -7.9 | 2.1e-15 | -0.66 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Brain Caudate basal ganglia | UBE3D | 0.29 | 0.28 | lasso | 2 | 0.26 | 5.9e-08 | 6.6 | 6.6 | 3.8e-11 | 0.55 | 0.80 | 0.02 | FALSE |
| 6 | GTEx | Brain Cerebellar Hemisphere | RWDD2A | 0.26 | -0.01 | lasso | 6 | -0.01 | 9.2e-01 | 9.3 | -7.1 | 1.4e-12 | -0.62 | 0.05 | 0.07 | FALSE |
| 7 | GTEx | Brain Putamen basal ganglia | UBE3D | 0.40 | 0.21 | lasso | 5 | 0.21 | 9.5e-06 | 6.6 | 6.5 | 7.3e-11 | 0.53 | 0.25 | 0.10 | FALSE |
| 8 | GTEx | Breast Mammary Tissue | DOPEY1 | 0.32 | 0.18 | enet | 29 | 0.16 | 1.2e-08 | 6.1 | -5.8 | 7.3e-09 | -0.50 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | DOPEY1 | 0.31 | 0.14 | lasso | 5 | 0.07 | 4.5e-03 | 6.1 | -6.3 | 3.4e-10 | -0.52 | 0.10 | 0.13 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | DOPEY1 | 0.17 | 0.14 | enet | 16 | 0.17 | 1.8e-12 | 6.1 | -7.4 | 1.6e-13 | -0.60 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Colon Sigmoid | DOPEY1 | 0.19 | 0.21 | lasso | 6 | 0.21 | 5.6e-08 | 6.6 | -6.7 | 1.9e-11 | -0.58 | 0.83 | 0.14 | FALSE |
| 12 | GTEx | Colon Transverse | DOPEY1 | 0.14 | 0.13 | enet | 7 | 0.12 | 2.3e-06 | 6.1 | -6.7 | 1.6e-11 | -0.55 | 0.59 | 0.04 | FALSE |
| 13 | GTEx | Esophagus Gastroesophageal Junction | DOPEY1 | 0.19 | 0.11 | lasso | 5 | 0.08 | 6.0e-04 | 6.1 | -6.5 | 8.3e-11 | -0.54 | 0.29 | 0.08 | FALSE |
| 14 | GTEx | Esophagus Muscularis | DOPEY1 | 0.25 | 0.15 | enet | 10 | 0.14 | 1.4e-08 | 6.1 | -6.2 | 5.3e-10 | -0.53 | 1.00 | 0.00 | FALSE |
| 15 | GTEx | Lung | DOPEY1 | 0.11 | 0.13 | lasso | 3 | 0.12 | 2.9e-09 | 6.1 | -6.1 | 1.1e-09 | -0.50 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Lung | UBE3D | 0.07 | 0.01 | enet | 16 | 0.02 | 9.8e-03 | 11.1 | 5.9 | 2.8e-09 | 0.66 | 0.01 | 0.94 | FALSE |
| 17 | GTEx | Muscle Skeletal | DOPEY1 | 0.13 | 0.11 | lasso | 5 | 0.10 | 4.2e-10 | 6.1 | -7.2 | 5.8e-13 | -0.59 | 1.00 | 0.00 | FALSE |
| 18 | GTEx | Nerve Tibial | DOPEY1 | 0.23 | 0.28 | lasso | 3 | 0.28 | 3.7e-20 | 6.1 | -7.1 | 1.5e-12 | -0.59 | 1.00 | 0.00 | FALSE |
| 19 | GTEx | Skin Sun Exposed Lower leg | DOPEY1 | 0.16 | 0.17 | lasso | 5 | 0.16 | 4.0e-13 | 6.6 | -7.6 | 2.3e-14 | -0.67 | 1.00 | 0.00 | FALSE |
| 20 | GTEx | Spleen | DOPEY1 | 0.21 | 0.12 | lasso | 4 | 0.12 | 7.1e-04 | 10.7 | -10.9 | 1.1e-27 | -0.92 | 0.05 | 0.80 | TRUE |
| 21 | GTEx | Testis | DOPEY1 | 0.19 | 0.00 | lasso | 9 | 0.03 | 2.4e-02 | 9.2 | -9.3 | 1.9e-20 | -0.82 | 0.11 | 0.40 | FALSE |
| 22 | METSIM | Adipose | DOPEY1 | 0.08 | 0.08 | lasso | 10 | 0.07 | 2.4e-10 | 6.1 | -7.4 | 1.4e-13 | -0.62 | 0.98 | 0.02 | FALSE |
| 23 | ROSMAP | Brain Pre-frontal Cortex | DOPEY1 | 0.11 | 0.08 | enet | 45 | 0.09 | 2.9e-11 | 9.0 | -7.2 | 6.5e-13 | -0.60 | 1.00 | 0.00 | FALSE |
| 24 | YFS | Blood | DOPEY1 | 0.18 | 0.21 | lasso | 9 | 0.21 | 1.4e-67 | 6.1 | -7.1 | 1.7e-12 | -0.60 | 1.00 | 0.00 | FALSE |
| 25 | YFS | Blood | RWDD2A | 0.02 | 0.01 | bslmm | 347 | 0.00 | 8.2e-03 | 9.3 | -8.4 | 3.1e-17 | -0.69 | 0.44 | 0.51 | FALSE |
| 26 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOPEY1 | 0.05 | 0.06 | lasso | 2 | 0.06 | 2.6e-12 | 6.1 | -6.5 | 6.1e-11 | -0.54 | 1.00 | 0.00 | FALSE |
| 27 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DOPEY1 | 0.08 | 0.08 | blup | 47 | 0.09 | 2.3e-10 | 6.1 | -8.8 | 1.9e-18 | -0.75 | 0.48 | 0.52 | FALSE |
| 28 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DOPEY1 | 0.06 | 0.08 | lasso | 2 | 0.04 | 3.9e-03 | 7.3 | -7.9 | 2.5e-15 | -0.69 | 0.02 | 0.76 | FALSE |
| 29 | The Cancer Genome Atlas | Lung Adenocarcinoma | DOPEY1 | 0.03 | 0.02 | lasso | 2 | 0.02 | 2.1e-03 | 6.1 | -6.4 | 1.4e-10 | -0.54 | 0.08 | 0.12 | FALSE |
| 30 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DOPEY1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 8.7e-06 | 6.1 | -6.1 | 1.1e-09 | -0.50 | 0.65 | 0.04 | FALSE |
| 31 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DOPEY1 | 0.08 | 0.05 | blup | 47 | 0.04 | 1.4e-03 | 6.0 | -5.2 | 2.0e-07 | -0.45 | 0.13 | 0.09 | FALSE |
| 32 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DOPEY1 | 0.17 | 0.16 | lasso | 3 | 0.14 | 1.6e-06 | 6.1 | -6.1 | 1.1e-09 | -0.50 | 0.64 | 0.19 | FALSE |
| 33 | The Cancer Genome Atlas | Prostate Adenocarcinoma | DOPEY1 | 0.07 | 0.11 | blup | 47 | 0.11 | 1.7e-11 | 9.2 | -9.3 | 1.4e-20 | -0.81 | 0.98 | 0.02 | FALSE |
| 34 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PGM3 | 0.03 | 0.02 | enet | 6 | 0.03 | 7.4e-04 | 9.7 | -8.0 | 1.7e-15 | -0.70 | 0.01 | 0.85 | FALSE |
| 35 | The Cancer Genome Atlas | Soft Tissue Sarcoma | DOPEY1 | 0.04 | 0.02 | blup | 47 | 0.02 | 1.4e-02 | 9.7 | -9.4 | 3.8e-21 | -0.83 | 0.06 | 0.26 | FALSE |
| 36 | The Cancer Genome Atlas | Soft Tissue Sarcoma | UBE2CBP | 0.09 | 0.00 | blup | 85 | 0.03 | 6.4e-03 | -3.0 | 8.7 | 3.9e-18 | 0.80 | 0.01 | 0.83 | FALSE |
| 37 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DOPEY1 | 0.11 | 0.06 | lasso | 3 | 0.06 | 4.1e-05 | 6.1 | -6.3 | 3.4e-10 | -0.50 | 0.60 | 0.09 | FALSE |