[Hub]/) : Traits : Heel T-Score :

chr6:82,912,153-84,606,555

Best TWAS P=1.14e-27 · Best GWAS P=5.76e-29 conditioned to 0.00382

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous DOPEY1 0.29 0.27 lasso 6 0.28 4.2e-23 6.1 -7.3 2.7e-13 -0.62 1.00 0.00 FALSE
2 GTEx Adipose Visceral Omentum DOPEY1 0.20 0.18 enet 11 0.20 1.1e-10 6.1 -6.2 7.7e-10 -0.50 0.98 0.01 FALSE
3 GTEx Artery Aorta DOPEY1 0.36 0.20 enet 34 0.25 5.4e-14 6.1 -6.4 1.4e-10 -0.56 0.98 0.02 FALSE
4 GTEx Artery Tibial DOPEY1 0.33 0.28 lasso 7 0.30 2.0e-23 6.1 -7.9 2.1e-15 -0.66 1.00 0.00 FALSE
5 GTEx Brain Caudate basal ganglia UBE3D 0.29 0.28 lasso 2 0.26 5.9e-08 6.6 6.6 3.8e-11 0.55 0.80 0.02 FALSE
6 GTEx Brain Cerebellar Hemisphere RWDD2A 0.26 -0.01 lasso 6 -0.01 9.2e-01 9.3 -7.1 1.4e-12 -0.62 0.05 0.07 FALSE
7 GTEx Brain Putamen basal ganglia UBE3D 0.40 0.21 lasso 5 0.21 9.5e-06 6.6 6.5 7.3e-11 0.53 0.25 0.10 FALSE
8 GTEx Breast Mammary Tissue DOPEY1 0.32 0.18 enet 29 0.16 1.2e-08 6.1 -5.8 7.3e-09 -0.50 1.00 0.00 FALSE
9 GTEx Breast Mammary Tissue (Female) DOPEY1 0.31 0.14 lasso 5 0.07 4.5e-03 6.1 -6.3 3.4e-10 -0.52 0.10 0.13 FALSE
10 GTEx Cells Transformed fibroblasts DOPEY1 0.17 0.14 enet 16 0.17 1.8e-12 6.1 -7.4 1.6e-13 -0.60 1.00 0.00 FALSE
11 GTEx Colon Sigmoid DOPEY1 0.19 0.21 lasso 6 0.21 5.6e-08 6.6 -6.7 1.9e-11 -0.58 0.83 0.14 FALSE
12 GTEx Colon Transverse DOPEY1 0.14 0.13 enet 7 0.12 2.3e-06 6.1 -6.7 1.6e-11 -0.55 0.59 0.04 FALSE
13 GTEx Esophagus Gastroesophageal Junction DOPEY1 0.19 0.11 lasso 5 0.08 6.0e-04 6.1 -6.5 8.3e-11 -0.54 0.29 0.08 FALSE
14 GTEx Esophagus Muscularis DOPEY1 0.25 0.15 enet 10 0.14 1.4e-08 6.1 -6.2 5.3e-10 -0.53 1.00 0.00 FALSE
15 GTEx Lung DOPEY1 0.11 0.13 lasso 3 0.12 2.9e-09 6.1 -6.1 1.1e-09 -0.50 1.00 0.00 FALSE
16 GTEx Lung UBE3D 0.07 0.01 enet 16 0.02 9.8e-03 11.1 5.9 2.8e-09 0.66 0.01 0.94 FALSE
17 GTEx Muscle Skeletal DOPEY1 0.13 0.11 lasso 5 0.10 4.2e-10 6.1 -7.2 5.8e-13 -0.59 1.00 0.00 FALSE
18 GTEx Nerve Tibial DOPEY1 0.23 0.28 lasso 3 0.28 3.7e-20 6.1 -7.1 1.5e-12 -0.59 1.00 0.00 FALSE
19 GTEx Skin Sun Exposed Lower leg DOPEY1 0.16 0.17 lasso 5 0.16 4.0e-13 6.6 -7.6 2.3e-14 -0.67 1.00 0.00 FALSE
20 GTEx Spleen DOPEY1 0.21 0.12 lasso 4 0.12 7.1e-04 10.7 -10.9 1.1e-27 -0.92 0.05 0.80 TRUE
21 GTEx Testis DOPEY1 0.19 0.00 lasso 9 0.03 2.4e-02 9.2 -9.3 1.9e-20 -0.82 0.11 0.40 FALSE
22 METSIM Adipose DOPEY1 0.08 0.08 lasso 10 0.07 2.4e-10 6.1 -7.4 1.4e-13 -0.62 0.98 0.02 FALSE
23 ROSMAP Brain Pre-frontal Cortex DOPEY1 0.11 0.08 enet 45 0.09 2.9e-11 9.0 -7.2 6.5e-13 -0.60 1.00 0.00 FALSE
24 YFS Blood DOPEY1 0.18 0.21 lasso 9 0.21 1.4e-67 6.1 -7.1 1.7e-12 -0.60 1.00 0.00 FALSE
25 YFS Blood RWDD2A 0.02 0.01 bslmm 347 0.00 8.2e-03 9.3 -8.4 3.1e-17 -0.69 0.44 0.51 FALSE
26 The Cancer Genome Atlas Breast Invasive Carcinoma DOPEY1 0.05 0.06 lasso 2 0.06 2.6e-12 6.1 -6.5 6.1e-11 -0.54 1.00 0.00 FALSE
27 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOPEY1 0.08 0.08 blup 47 0.09 2.3e-10 6.1 -8.8 1.9e-18 -0.75 0.48 0.52 FALSE
28 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DOPEY1 0.06 0.08 lasso 2 0.04 3.9e-03 7.3 -7.9 2.5e-15 -0.69 0.02 0.76 FALSE
29 The Cancer Genome Atlas Lung Adenocarcinoma DOPEY1 0.03 0.02 lasso 2 0.02 2.1e-03 6.1 -6.4 1.4e-10 -0.54 0.08 0.12 FALSE
30 The Cancer Genome Atlas Lung Squamous Cell Carcinoma DOPEY1 0.07 0.05 lasso 3 0.04 8.7e-06 6.1 -6.1 1.1e-09 -0.50 0.65 0.04 FALSE
31 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma DOPEY1 0.08 0.05 blup 47 0.04 1.4e-03 6.0 -5.2 2.0e-07 -0.45 0.13 0.09 FALSE
32 The Cancer Genome Atlas Pancreatic Adenocarcinoma DOPEY1 0.17 0.16 lasso 3 0.14 1.6e-06 6.1 -6.1 1.1e-09 -0.50 0.64 0.19 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma DOPEY1 0.07 0.11 blup 47 0.11 1.7e-11 9.2 -9.3 1.4e-20 -0.81 0.98 0.02 FALSE
34 The Cancer Genome Atlas Prostate Adenocarcinoma PGM3 0.03 0.02 enet 6 0.03 7.4e-04 9.7 -8.0 1.7e-15 -0.70 0.01 0.85 FALSE
35 The Cancer Genome Atlas Soft Tissue Sarcoma DOPEY1 0.04 0.02 blup 47 0.02 1.4e-02 9.7 -9.4 3.8e-21 -0.83 0.06 0.26 FALSE
36 The Cancer Genome Atlas Soft Tissue Sarcoma UBE2CBP 0.09 0.00 blup 85 0.03 6.4e-03 -3.0 8.7 3.9e-18 0.80 0.01 0.83 FALSE
37 The Cancer Genome Atlas Stomach Adenocarcinoma DOPEY1 0.11 0.06 lasso 3 0.06 4.1e-05 6.1 -6.3 3.4e-10 -0.50 0.60 0.09 FALSE