Best TWAS P=4.29e-09 · Best GWAS P=1.04e-09 conditioned to 0.000176
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | BCKDHB | 0.11 | 0.09 | bslmm | 563 | 0.09 | 1.1e-10 | 4.9 | 5.8 | 8.6e-09 | -0.02 | 0.65 | 0.35 | FALSE |
| 2 | GTEx | Artery Coronary | BCKDHB | 0.29 | 0.05 | lasso | 27 | 0.11 | 1.7e-04 | 4.9 | 5.4 | 5.4e-08 | 0.29 | 0.29 | 0.32 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | BCKDHB | 0.15 | 0.11 | enet | 34 | 0.07 | 3.1e-03 | 4.2 | 5.9 | 4.3e-09 | 0.48 | 0.16 | 0.59 | TRUE |
| 4 | GTEx | Cells Transformed fibroblasts | RP11-250B2.6 | 0.11 | 0.01 | lasso | 7 | 0.00 | 1.4e-01 | -4.2 | -5.7 | 1.3e-08 | -0.11 | 0.20 | 0.48 | FALSE |
| 5 | GTEx | Pancreas | BCKDHB | 0.14 | 0.08 | enet | 6 | 0.05 | 3.8e-03 | 5.6 | 5.5 | 3.1e-08 | 0.08 | 0.15 | 0.69 | FALSE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | BCKDHB | 0.18 | 0.13 | lasso | 6 | 0.14 | 2.9e-17 | 4.9 | 5.1 | 3.0e-07 | 0.04 | 0.64 | 0.36 | FALSE |