[Hub]/) : Traits : Heel T-Score : ← →

chr9:108,998-1,162,143

Best TWAS P=2.67e-15 · Best GWAS P=4.06e-12 conditioned to 0.385

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	DOCK8	0.06	0.03	lasso	4	0.04	5.3e-06	6.1	5.7	1.0e-08	0.83	0.03	0.96	FALSE
2	GTEx	Adipose Subcutaneous	CBWD1	0.37	0.22	enet	17	0.23	5.2e-19	6.5	6.2	5.5e-10	0.80	0.04	0.96	FALSE
3	GTEx	Adipose Visceral Omentum	CBWD1	0.26	0.06	enet	30	0.14	1.7e-07	5.7	5.2	1.8e-07	0.63	0.32	0.68	FALSE
4	GTEx	Artery Aorta	CBWD1	0.26	0.09	enet	20	0.16	3.1e-09	5.7	5.6	1.9e-08	0.71	0.26	0.74	FALSE
5	GTEx	Artery Tibial	CBWD1	0.33	0.21	enet	10	0.22	3.0e-17	5.1	6.3	2.3e-10	0.76	0.85	0.15	FALSE
6	GTEx	Brain Caudate basal ganglia	CBWD1	0.23	0.11	lasso	3	0.02	7.5e-02	6.0	6.9	5.9e-12	0.76	0.06	0.80	FALSE
7	GTEx	Brain Cortex	DOCK8	0.22	0.05	lasso	5	0.04	3.2e-02	6.2	6.5	1.1e-10	0.74	0.07	0.60	FALSE
8	GTEx	Brain Cortex	CBWD1	0.37	0.20	lasso	3	0.25	1.4e-07	6.5	6.5	7.6e-11	0.89	0.04	0.95	FALSE
9	GTEx	Brain Frontal Cortex BA9	CBWD1	0.24	0.17	enet	16	0.17	3.0e-05	6.5	5.9	3.5e-09	0.83	0.03	0.84	FALSE
10	GTEx	Brain Hippocampus	CBWD1	0.23	0.04	enet	21	0.01	1.5e-01	5.1	6.0	2.4e-09	0.66	0.07	0.62	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	CBWD1	0.34	0.18	lasso	4	0.19	7.5e-06	6.5	6.9	6.4e-12	0.93	0.01	0.99	FALSE
12	GTEx	Breast Mammary Tissue	CBWD1	0.23	0.06	lasso	4	0.09	2.1e-05	6.5	7.0	2.0e-12	0.83	0.05	0.94	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	CBWD1	0.29	0.17	lasso	5	0.17	3.5e-06	6.5	6.6	3.4e-11	0.85	0.03	0.96	FALSE
14	GTEx	Cells Transformed fibroblasts	CBWD1	0.61	0.29	enet	18	0.45	4.1e-37	6.5	6.5	7.3e-11	0.79	0.04	0.96	FALSE
15	GTEx	Colon Sigmoid	CBWD1	0.23	0.06	enet	11	0.09	5.9e-04	6.5	7.9	2.7e-15	0.81	0.06	0.89	TRUE
16	GTEx	Colon Transverse	CBWD1	0.44	0.32	enet	22	0.28	1.3e-13	5.7	6.3	2.3e-10	0.76	0.40	0.60	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	CBWD1	0.15	0.11	enet	9	0.09	4.4e-04	5.7	6.3	2.6e-10	0.70	0.24	0.57	FALSE
18	GTEx	Esophagus Mucosa	DOCK8	0.08	0.04	lasso	6	0.04	1.2e-03	6.4	6.6	4.5e-11	0.75	0.03	0.94	FALSE
19	GTEx	Esophagus Mucosa	CBWD1	0.43	0.41	enet	23	0.49	6.4e-37	5.7	6.3	2.6e-10	0.73	0.80	0.20	FALSE
20	GTEx	Heart Atrial Appendage	CBWD1	0.48	0.20	lasso	9	0.26	4.5e-12	5.7	5.8	7.1e-09	0.63	0.57	0.43	FALSE
21	GTEx	Liver	CBWD1	0.30	0.00	lasso	4	0.04	3.4e-02	5.7	5.3	9.2e-08	0.67	0.03	0.77	FALSE
22	GTEx	Lung	CBWD1	0.24	0.15	lasso	5	0.18	1.0e-13	5.1	6.1	1.3e-09	0.66	0.81	0.19	FALSE
23	GTEx	Muscle Skeletal	CBWD1	0.31	0.17	enet	8	0.23	1.7e-22	5.2	5.5	4.5e-08	0.55	0.91	0.09	FALSE
24	GTEx	Nerve Tibial	CBWD1	0.35	0.24	lasso	7	0.23	1.7e-16	6.5	6.8	9.7e-12	0.87	0.03	0.97	FALSE
25	GTEx	Pancreas	DOCK8	0.39	0.24	lasso	7	0.26	1.5e-11	-5.5	-5.2	2.0e-07	-0.59	0.88	0.11	FALSE
26	GTEx	Pancreas	CBWD1	0.20	0.03	enet	20	0.06	2.0e-03	6.0	6.7	2.3e-11	0.70	0.14	0.66	FALSE
27	GTEx	Pituitary	CBWD1	0.47	0.16	enet	8	0.18	2.8e-05	5.8	6.2	6.1e-10	0.82	0.08	0.89	FALSE
28	GTEx	Skin Not Sun Exposed Suprapubic	CBWD1	0.49	0.23	enet	16	0.41	6.2e-24	5.1	6.6	3.5e-11	0.79	0.34	0.66	FALSE
29	GTEx	Skin Sun Exposed Lower leg	CBWD1	0.43	0.21	enet	21	0.37	1.3e-31	5.1	6.2	6.0e-10	0.77	0.38	0.62	FALSE
30	GTEx	Small Intestine Terminal Ileum	CBWD1	0.30	0.19	lasso	2	0.22	1.2e-05	6.0	5.9	3.0e-09	0.66	0.11	0.57	FALSE
31	GTEx	Spleen	CBWD1	0.24	-0.01	lasso	6	0.00	3.1e-01	5.7	7.2	5.2e-13	0.51	0.11	0.19	FALSE
32	GTEx	Thyroid	DOCK8	0.18	0.14	lasso	8	0.16	1.9e-12	2.1	5.2	2.3e-07	0.60	0.79	0.21	FALSE
33	GTEx	Thyroid	CBWD1	0.38	0.24	lasso	4	0.32	1.8e-25	6.5	6.5	8.8e-11	0.80	0.06	0.94	FALSE
34	GTEx	Vagina	CBWD1	0.52	0.21	enet	28	0.32	3.6e-08	5.1	5.7	9.3e-09	0.68	0.12	0.84	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	CBWD1	0.31	0.27	lasso	7	0.26	9.2e-34	4.0	5.2	2.3e-07	0.68	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	CBWD1	0.14	0.06	blup	30	0.08	2.4e-03	6.0	6.2	7.8e-10	0.65	0.02	0.42	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBWD1	0.11	0.11	lasso	3	0.13	2.1e-14	4.0	5.1	2.9e-07	0.61	0.66	0.34	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CBWD1	0.06	0.02	enet	17	0.05	2.2e-06	5.1	5.9	3.8e-09	0.72	0.02	0.97	FALSE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CBWD1	0.26	0.04	blup	30	0.09	1.2e-05	6.1	6.6	3.8e-11	0.69	0.01	0.85	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	CBWD1	0.15	0.11	lasso	3	0.11	1.4e-12	4.0	5.3	9.0e-08	0.67	0.80	0.20	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	DOCK8	0.12	0.10	enet	13	0.12	3.9e-13	5.2	6.2	5.7e-10	0.80	0.71	0.29	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CBWD1	0.07	0.08	enet	4	0.09	1.8e-10	4.0	5.5	4.0e-08	0.72	0.88	0.12	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	DOCK8	0.05	0.01	blup	283	0.03	8.7e-05	-2.9	6.1	1.2e-09	0.64	0.34	0.38	FALSE
44	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C9orf66	0.09	0.02	enet	7	0.02	1.3e-02	5.8	5.4	6.0e-08	0.78	0.01	0.81	FALSE
45	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CBWD1	0.11	0.09	enet	5	0.10	5.6e-07	6.0	6.0	2.3e-09	0.68	0.13	0.87	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CBWD1	0.10	0.10	blup	30	0.11	1.9e-05	5.7	5.3	8.6e-08	0.55	0.14	0.54	FALSE
47	The Cancer Genome Atlas	Rectum Adenocarcinoma	CBWD1	0.40	0.14	blup	30	0.26	9.9e-07	4.0	5.9	4.6e-09	0.62	0.04	0.78	FALSE
48	The Cancer Genome Atlas	Soft Tissue Sarcoma	CBWD1	0.06	0.02	blup	30	0.03	8.8e-03	5.7	6.4	1.2e-10	0.80	0.02	0.52	FALSE
49	The Cancer Genome Atlas	Stomach Adenocarcinoma	CBWD1	0.26	0.17	blup	30	0.22	1.5e-15	6.0	5.3	1.4e-07	0.51	0.17	0.83	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	CBWD1	0.20	0.16	blup	30	0.21	4.1e-20	5.1	5.7	1.3e-08	0.61	0.60	0.40	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	DOCK8	0.10	0.05	lasso	3	0.05	2.6e-05	6.0	5.6	2.7e-08	0.59	0.20	0.72	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	CBWD1	0.15	0.13	lasso	2	0.10	8.8e-04	6.5	6.5	1.1e-10	0.85	0.00	0.84	FALSE