Hub : Genes

C9orf66

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Head and Neck Squamous Cell Carcinoma	0.1011	0.0451	5.1e-06	0.047	0.053	0.052	NA	0.049	4.6e-06	1.4e-06	1.5e-06	NA	3.1e-06
2	TCGA	Kidney Renal Clear Cell Carcinoma	0.0453	0.0256	5.7e-05	0.036	0.033	0.042	NA	0.044	5.3e-05	1.1e-04	1.5e-05	NA	1.0e-05
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.0900	0.0550	2.1e-03	0.024	0.020	0.021	NA	0.020	8.4e-03	1.6e-02	1.3e-02	NA	1.6e-02
4	TCGA	Prostate Adenocarcinoma	0.0526	0.0273	1.4e-03	0.047	0.025	0.040	NA	0.039	1.1e-05	1.1e-03	4.4e-05	NA	5.7e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.3	0.4	1.2	-0.7	0.0	-1.1	-0.1
Bipolar Disorder or Schizophrenia	0.8	2.0	4.8	-1.2	-2.2	1.1	-0.7
Depressed Affect (Nagel 2018)	0.2	0.3	0.7	-0.8	-0.7	0.4	-0.2
Depression (Nagel 2018)	0.1	0.1	0.4	-0.1	-0.6	0.3	0.1
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.5	0.5	-0.7	0.0	0.5
Neuroticism (Nagel 2018)	0.4	0.9	2.4	0.0	-1.6	0.5	1.0
Schizophrenia (2018)	1.2	2.5	5.1	-0.9	-2.3	1.9	-0.8
Schizophrenia vs Biploar Disorder	0.8	1.0	2.4	-0.8	-0.4	1.5	-0.9
Worry (Nagel 2018)	0.3	0.7	1.6	0.1	-1.3	-0.3	1.1
Alzheimer’s Disease (in mother)	1.0	1.2	3.5	-1.0	0.1	-1.9	-0.5
Alzheimer’s Disease (in father)	1.5	1.6	2.8	1.7	-0.8	1.0	1.4
Alzheimer’s Disease (including proxy)	0.1	0.2	0.3	-0.6	-0.2	-0.6	-0.2
Crohns Disease (2017)	1.7	3.8	8.9	-0.9	3.0	-2.3	-0.4
Irritable Bowel Disease (IBD)	0.9	2.1	5.3	-0.9	2.3	-1.4	-0.6
Ulcerative Colitis (UC)	0.1	0.2	0.4	-0.3	0.4	0.6	-0.3
Major Depression (MDD)	1.6	1.9	4.9	-1.0	0.5	2.2	-1.2
Reaction Time	0.5	1.0	1.7	0.7	-1.3	1.0	1.0
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.3	-0.5	-0.3	-0.6	-0.3
Breast Cancer	0.2	0.6	0.8	-0.6	0.9	0.7	-0.9
Ovarian Cancer	2.0	2.6	5.7	-2.4	0.3	0.3	-2.1
Prostate Cancer	0.4	0.6	0.8	-0.9	0.8	-0.1	-0.9
Age at First Birth	0.2	0.3	0.7	0.5	0.8	0.1	0.5
Bipolar Disorder (2011)	0.2	0.2	0.5	-0.3	-0.7	-0.0	0.2
Body Mass Index (BMI) (2010)	0.1	0.2	0.4	0.4	0.2	0.7	-0.2
Coronary Artery Disease (CAD)	2.4	2.9	5.9	-2.4	1.3	-1.3	-1.6
Crohns Disease (2012)	1.7	2.7	5.6	-0.3	2.4	-2.3	0.1
Mean Putamen Volume	0.3	0.3	0.9	-0.5	-0.4	0.2	-1.0
Fasting Glucose	0.6	0.8	1.6	1.1	-0.3	-0.3	1.2
HbA1C	1.6	1.7	4.2	0.5	-2.1	-0.0	1.5
HDL Cholesterol	0.8	1.3	2.2	0.6	-1.3	0.9	1.5
LDL Cholesterol	0.5	0.7	1.7	0.4	-1.0	1.3	0.3
Lupus	0.5	0.7	2.6	-0.3	-1.6	-0.0	-0.2
Neuroticism (2016)	1.8	2.6	4.4	1.4	-2.1	0.8	1.9
Primary Biliary Cirrhosis	0.7	1.0	1.9	-1.4	0.4	-0.0	-1.4
Rheumatoid Arthritis	0.8	1.1	2.0	-1.4	-0.9	-0.3	-1.2
Schizophrenia (2014)	1.6	3.6	8.4	-0.1	-2.9	2.5	-0.2
Triglycerides	0.3	0.5	1.4	1.2	0.5	-0.1	0.6
Type 2 Diabetes (T2D) (2012)	3.1	3.6	7.8	-2.1	0.6	1.3	-2.8
Ulcerative Colitis	0.6	0.9	1.4	-1.0	-0.1	1.2	-1.2
Blood Eosinophil Count	0.6	4.7	9.5	-3.1	0.2	-1.7	-2.5
Blood Platelet Count	0.9	10.8	32.3	0.2	-5.7	3.3	-0.2
Blood Red Count	0.8	8.0	18.3	-2.4	4.3	-1.5	-2.4
Blood White Count	0.3	2.5	7.9	-0.0	2.8	-1.5	-0.1
Heel T-Score	1.5	11.9	29.4	0.7	-4.2	5.4	-0.2
BMI	0.1	0.5	0.9	-0.1	-0.9	1.0	-0.4
Height	0.1	1.0	2.2	-0.1	-1.5	1.2	-0.6
Waist Hip Ratio (WHR)	0.2	0.8	1.9	-0.6	1.4	-0.9	-0.5
Systolic Blood Pressure	2.2	11.2	23.5	-2.6	4.8	-3.1	-2.2
Smoking Status	0.2	0.5	1.0	1.0	0.3	0.4	1.0
Allergy or Eczema	0.5	1.3	2.1	1.2	-0.6	-1.4	1.0
Cardiovascular Disease	1.1	3.6	8.5	-1.2	2.9	-1.7	-1.3
Hypothyroidism (self reported)	0.3	0.6	1.7	-0.2	-0.4	1.3	-0.7
Respiratory disease	0.2	0.5	1.4	0.3	0.7	-1.2	0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.1	-0.1	-0.4	1.1	-0.4
Lung FEV1/FVC ratio	0.1	0.8	2.9	-0.3	0.2	-1.7	-0.1
Lung FVC	0.1	0.5	1.4	0.6	0.2	-0.0	1.2
Neuroticism	0.3	0.7	1.9	-0.3	-1.4	0.9	0.3
Chronotype (morning person)	0.3	0.8	2.1	-0.9	-0.4	-1.5	-0.5
Hair Pigment	1.5	41.9	96.4	-4.8	9.8	-5.5	-4.2
Tanning	0.1	1.8	3.6	-0.7	1.9	-1.7	-0.2
Hand grip strength (left)	0.2	0.4	1.3	0.1	-0.1	-1.1	0.6
Number of treatments/medications taken	0.9	1.7	4.2	-1.1	2.0	-0.5	-1.1
Average weekly spirits intake	0.0	0.0	0.1	-0.2	0.1	0.3	-0.2
Sensitivity / hurt feelings	0.9	1.5	2.5	1.1	-1.5	0.4	1.6
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.4	0.3	-0.4	0.7	0.3
Hearing difficulty/problems: Yes	1.6	2.4	3.6	-1.8	1.6	-0.1	-1.9
Relative age of first facial hair	0.1	0.3	0.4	-0.4	0.6	-0.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	-0.2	0.8	0.7	-0.4
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.4	-0.3	-0.2	0.2	-0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	-0.1	-0.5	-0.1	0.0
Systolic blood pressure, automated reading	0.9	2.5	5.8	-1.0	2.4	-1.7	-0.6
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.2	-0.4	-0.8	1.1	-0.9
Angina	1.2	1.5	3.9	-0.5	2.0	-1.1	-0.9
Medication for hormone replacement therapy	0.2	0.2	0.6	0.8	-0.0	-0.3	0.2
Vitamin and mineral supplements	0.1	0.2	0.4	0.1	0.4	0.3	-0.6
Supplements: Zinc	1.3	1.5	3.8	0.2	-1.9	1.4	-0.1
Medication: Co-codamol	0.4	0.4	1.2	-0.5	-1.1	0.4	-0.2
Medication: Metformin	0.1	0.2	0.4	-0.1	-0.6	0.4	-0.4
Diabetes (father)	0.7	0.9	2.2	-0.6	-0.8	1.5	-0.6
Diabetes (mother)	0.1	0.1	0.2	-0.4	-0.3	0.1	-0.2
Severe depression (siblings)	0.4	0.4	1.1	0.6	0.4	-0.3	1.1
Pack years adult smoking proportion	0.6	0.9	1.7	1.1	0.8	0.1	1.3
Impedance of leg (right)	0.1	0.3	0.8	-0.8	-0.9	-0.2	-0.0
Leg fat-free mass (left)	0.1	0.3	0.9	-0.1	-0.1	0.9	-0.7
Trunk fat percentage	0.0	0.1	0.2	-0.3	0.3	0.4	-0.4
Hand grip strength (right)	0.2	0.5	1.6	-0.4	0.5	-1.3	0.3
Townsend deprivation index at recruitment	0.6	0.9	1.9	1.4	0.1	0.5	1.2
Current tobacco smoking	0.4	0.7	1.0	1.0	1.0	0.2	0.9
Average weekly fortified wine intake	1.7	2.0	3.5	-1.1	1.9	0.5	-1.8
Maternal smoking around birth	0.4	0.5	1.2	-0.8	0.6	0.2	-1.1
Fed-up feelings	0.1	0.1	0.2	-0.2	-0.2	-0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	1.3	1.0	0.5	0.0	1.1
Relative age voice broke	1.5	2.3	4.9	-1.6	1.3	0.4	-2.2
Taking other prescription medications	0.1	0.2	0.5	-0.3	0.7	0.0	-0.1
Age when periods started (menarche)	0.2	0.4	1.2	-1.1	-0.1	0.3	-0.5
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	3.2	-1.1	0.5	1.1	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.5	4.2	-0.3	-2.0	1.3	-0.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.9	0.2	0.3	1.0	-0.2
Qualifications: CSEs or equivalent	1.9	2.5	6.2	-0.9	1.8	-2.5	-0.4
Serious illness, injury or assault to yourself	1.4	1.7	2.5	-1.5	1.4	0.4	-1.6
High blood pressure	0.9	2.6	6.8	-0.8	2.6	-1.6	-0.7
Hayfever, allergic rhinitis or eczema	0.3	0.7	2.7	0.4	0.2	-1.7	0.1
Multivitamins +/- minerals	0.1	0.2	0.4	0.0	-0.6	0.3	0.4
Stomach or abdominal pain in last month	0.1	0.1	0.2	0.2	-0.2	0.5	0.1
Supplements: Glucosamine	0.4	0.5	0.9	-0.9	-0.9	0.5	-0.3
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.2	-0.5	1.1	-0.7	-0.3
Medication: Atenolol	0.1	0.1	0.3	0.3	-0.3	-0.5	-0.0
Medication: Levothyroxine sodium	0.2	0.3	1.3	0.0	1.1	-0.2	-0.0
Sitting height	0.1	0.7	1.5	-1.2	0.0	0.2	-1.2
Chronic bronchitis/emphysema (father)	2.5	2.9	4.3	1.7	-2.1	1.2	1.8
High blood pressure (mother)	1.3	1.9	3.5	1.3	0.4	-1.5	1.9
Body mass index (BMI)	0.1	0.3	0.5	-0.3	0.2	0.6	-0.7
Impedance of leg (left)	0.1	0.5	0.9	-1.0	-0.7	-0.7	-0.1
Leg predicted mass (left)	0.1	0.3	1.0	0.0	-0.2	1.0	-0.6
Trunk fat mass	0.1	0.2	0.6	-0.3	-0.1	0.8	-0.5
Waist circumference	0.1	0.4	0.8	-0.0	0.9	0.6	-0.7
Number of incorrect matches in round	0.9	1.5	3.2	1.6	-0.2	1.8	0.6
Past tobacco smoking	0.2	0.3	0.7	-0.8	0.1	-0.5	-0.6
Alcohol usually taken with meals	0.4	0.6	1.0	0.9	-1.0	-0.0	0.8
Nervous feelings	1.8	3.3	8.4	0.9	-2.9	0.9	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.6	-0.8	0.2	0.3	-0.2
Hearing difficulty/problems with background noise	0.0	0.0	0.1	0.1	-0.4	0.2	0.1
Hair/balding pattern: Pattern 2	0.3	0.4	0.9	0.6	0.9	0.0	0.4
Had menopause	1.5	1.9	3.8	1.9	0.0	-0.4	1.9
Had other major operations	1.0	1.2	3.1	-0.9	0.9	-1.8	0.0
Forced vital capacity (FVC)	0.1	0.4	1.3	0.7	0.0	-0.0	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.7	3.9	8.3	-0.2	-2.9	2.7	-0.2
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	-0.0	0.2	-0.4	0.1
Qualifications: None of the above	0.2	0.4	0.8	0.9	0.0	0.7	0.6
Financial difficulties in last 2 years	0.6	0.8	1.9	-0.4	1.4	-1.0	-0.1
Mouth/teeth dental problems	0.1	0.1	0.4	0.0	-0.1	-0.6	0.2
Heart attack	0.3	0.4	0.7	-0.5	0.9	-0.5	-0.5
Allergy	0.4	0.9	3.3	-0.5	-0.2	1.8	-0.4
Pain all over the body in last month	0.1	0.1	0.4	-0.0	-0.1	0.3	-0.7
Diabetes (self-reported)	0.1	0.2	0.4	-0.1	-0.6	0.6	-0.3
Hayfever/allergic rhinitis (self-reported)	3.0	4.0	10.1	-1.4	1.8	-3.2	-0.7
Medication: Ramipril	0.4	0.5	1.1	0.8	1.1	0.5	0.1
Medication: Simvastatin	1.0	1.4	3.2	-1.0	1.2	0.0	-1.8
Fluid intelligence score	0.6	1.3	4.2	-0.9	-2.0	-0.3	-0.3
Illnesses of siblings	0.3	0.5	0.8	-0.4	0.9	0.6	-0.8
Neuroticism score	0.3	0.6	1.7	0.1	-1.3	0.3	0.8
Weight	0.1	0.7	1.9	-0.3	-0.4	1.4	-0.8
Impedance of arm (right)	0.1	0.6	1.5	0.8	0.1	-0.4	1.2
Arm fat percentage (right)	0.1	0.2	0.4	0.6	0.2	0.6	0.1
Trunk fat-free mass	0.3	1.7	4.1	-0.0	-1.4	2.0	-0.7
Hip circumference	0.1	0.4	1.5	-0.1	0.3	1.2	-0.5
Time employed in main current job	1.5	1.7	3.0	-1.1	1.7	0.9	-1.4
Alcohol intake versus 10 years previously	0.5	0.7	1.7	0.6	-1.3	0.7	0.6
Father’s age at death	1.2	1.6	3.2	-1.7	0.4	0.2	-1.8
Worrier / anxious feelings	0.3	0.6	1.4	0.6	-0.5	-0.6	1.2
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	3.2	0.7	-0.8	1.8	0.2
Falls in the last year	0.7	1.0	2.7	-0.9	1.6	0.0	-0.7
Hair/balding pattern: Pattern 3	0.4	0.6	1.7	0.5	-1.3	0.5	-0.3
Number of live births	4.5	6.4	9.0	-2.6	3.0	-1.5	-2.7
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.1	0.4	-0.2	-0.6	1.0
Pulse rate	0.1	0.2	0.2	-0.4	0.3	0.4	-0.4
Happiness	0.3	0.4	1.1	0.3	-0.5	1.1	0.1
Noisy workplace	0.8	1.0	2.0	-1.1	0.9	0.3	-1.4
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.2	-0.1	0.5	0.2	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.5	0.5	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.7	0.4	-0.6	0.4
Asthma	0.3	0.6	1.4	-0.5	0.5	-1.2	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	2.3	1.5	-0.4	1.3	1.3
Medication: Cholesterol lowering	0.3	0.4	0.9	-0.6	0.6	0.0	-1.0
Depression (self-reported)	1.6	1.9	2.9	1.5	1.0	1.7	1.2
Medication: Lansoprazole	0.4	0.4	1.2	-0.4	-1.1	0.5	-0.5
Prospective memory result	1.4	1.7	5.1	-0.9	2.3	-0.2	-0.9
Lung cancer (father)	0.4	0.5	1.0	0.6	-1.0	0.7	0.1
Illnesses of mother	0.2	0.3	0.9	0.1	0.9	-0.4	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.5	1.3	0.7	-0.5	0.2	1.1
Pulse wave Arterial Stiffness index	1.1	1.2	2.1	-1.0	1.4	-0.9	-0.9
Impedance of arm (left)	0.1	0.4	0.7	0.5	0.7	-0.5	0.8
Arm fat mass (right)	0.1	0.3	1.0	0.1	-0.3	1.0	-0.4
Trunk predicted mass	0.3	1.8	4.2	-0.1	-1.4	2.1	-0.8
Standing height	0.2	1.7	3.5	-0.0	-1.9	1.7	-0.2
Length of working week for main job	0.1	0.1	0.3	-0.2	0.5	-0.1	-0.5
Exposure to tobacco smoke at home	2.0	2.3	5.6	0.9	-2.4	0.8	1.4
Breastfed as a baby	1.1	1.4	3.2	-1.0	1.8	-0.9	-0.8
Tense / ‘highly strung’	0.1	0.1	0.2	-0.5	-0.2	-0.3	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.0	0.9	-1.1	1.4	0.9
Hair/balding pattern: Pattern 4	2.5	6.1	13.5	1.6	-3.7	2.4	1.6
Birth weight of first child	1.1	2.1	5.9	0.9	-1.2	2.4	0.5
Peak expiratory flow (PEF)	0.8	1.9	3.0	1.2	-1.7	-0.1	1.7
Pulse wave reflection index	2.3	2.8	6.4	-1.2	1.6	-2.5	-0.9
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.8	-0.4	0.5	1.0
Loud music exposure frequency	3.5	3.8	6.3	-2.3	1.9	-0.1	-2.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.6	-0.1	-0.1	0.8	-0.1
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	0.5	0.2	0.7	0.2	0.1
Blood clot in the leg (DVT)	0.8	1.0	2.3	0.5	-1.2	0.1	1.5
Medication: Paracetamol	0.9	1.5	2.6	1.3	1.4	0.2	1.6
Headache pain in last month	0.7	1.3	4.2	-0.1	0.3	-2.1	0.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.4	0.8	0.4	-0.8	0.2	0.9
Glaucoma (self-reported)	1.3	1.5	3.1	1.0	-1.8	0.1	1.3
Gout (self-reported)	0.1	0.2	0.5	0.4	0.1	0.7	0.3
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.2	0.0	1.1	0.8	-0.4
Medication: Amlodipine	0.2	0.3	0.7	-0.7	-0.0	0.3	-0.8
Medication: Ventolin 100micrograms inhaler	1.5	1.9	4.9	0.1	1.6	-2.2	0.2
Birth weight	0.1	0.2	0.7	0.2	-0.8	0.5	0.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.4	0.9	-1.5	0.9	0.8
High blood pressure (siblings)	0.5	0.7	1.3	0.4	-1.2	-0.6	0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	1.9	1.2	-0.5	0.9	1.4
Body fat percentage	0.0	0.2	0.2	-0.3	0.3	0.4	-0.5
Leg fat percentage (right)	0.1	0.2	0.4	-0.6	0.1	0.2	-0.6
Arm fat-free mass (right)	0.2	1.2	2.3	-1.1	-0.5	0.9	-1.5
Exposure to tobacco smoke outside home	2.6	3.5	7.8	-2.8	0.9	-0.0	-2.3
Comparative body size at age 10	0.6	1.6	2.5	1.6	-1.5	0.1	1.3
Number of full brothers	1.0	1.2	2.7	-1.1	-1.7	-0.3	-0.9
Worry too long after embarrassment	1.2	2.0	6.8	0.3	-2.6	0.9	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	5.4	0.9	-1.9	2.3	0.6
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	-0.1	0.0	-0.6	-0.2
Number of children fathered	2.2	2.5	5.6	1.8	-1.2	0.1	2.4
Reason for reducing amount of alcohol drunk: Health precaution	3.2	3.7	6.7	-2.6	-0.7	-1.0	-2.6
Age at first live birth	0.2	0.3	0.5	0.7	-0.6	0.5	0.3
Pulse wave peak to peak time	1.2	1.4	2.4	1.0	-1.6	1.2	0.9
Health satisfaction	0.1	0.1	0.5	-0.0	0.7	0.2	0.0
Shortness of breath walking on level ground	0.1	0.2	0.2	-0.0	0.4	0.5	-0.5
Qualifications: College or University degree	0.1	0.4	1.2	-0.1	-1.1	0.5	-0.3
Eye problems/disorders: None of the above	0.9	1.1	2.0	1.0	0.7	1.4	0.9
Mouth/teeth dental problems: Loose teeth	1.3	1.5	2.6	1.6	-1.4	0.0	1.2
Emphysema/chronic bronchitis	0.9	1.1	2.5	1.3	0.0	0.1	1.6
Medication for pain relief, constipation, heartburn	1.0	1.7	2.7	-1.3	-1.6	-0.9	-1.2
Neck or shoulder pain in last month	1.8	2.6	7.2	0.8	-2.7	1.4	0.7
Medication: Blood pressure	0.1	0.2	0.5	-0.2	0.7	0.1	-0.7
Angina (self-reported)	1.3	1.8	4.8	-0.5	2.2	-1.1	-0.9
Migraine (self-reported)	0.7	0.9	2.4	0.4	0.5	-1.6	0.9
Medication: Ibuprofen	0.4	0.4	0.6	0.7	0.3	0.7	0.8
Medication: Allopurinol	0.2	0.3	0.6	-0.2	-0.7	0.8	-0.1
Medication: Omeprazole	0.7	0.8	1.4	1.2	0.1	1.1	0.8
Medication: Seretide 50 evohaler	0.0	0.0	0.1	0.0	-0.2	-0.4	-0.1
Mean time to correctly identify matches	0.6	1.2	3.0	1.1	-0.7	1.7	0.6
Heart disease (mother)	0.9	1.1	2.6	0.1	-1.6	1.4	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.4	-0.3	0.3	-1.6	-0.1
Whole body fat mass	0.1	0.2	0.6	-0.2	0.0	0.8	-0.5
Leg fat mass (right)	0.1	0.3	0.6	-0.6	0.1	0.5	-0.8
Arm predicted mass (right)	0.3	1.8	3.2	-1.3	-0.8	1.2	-1.8
Pulse rate, automated reading	0.6	2.0	6.8	0.2	-1.0	2.6	-0.0
Alcohol intake frequency.	0.8	1.9	4.0	0.2	1.5	-2.0	1.0
Comparative height size at age 10	0.2	1.1	2.7	0.7	-1.6	1.1	0.4
Number of full sisters	1.1	1.3	2.5	-0.6	1.6	-1.5	-0.3
Suffer from ‘nerves’	0.9	1.4	3.8	1.2	-0.5	-0.5	2.0
Overall health rating	0.5	1.1	3.5	0.7	-0.6	1.9	0.5
Chest pain or discomfort	0.2	0.3	0.7	0.9	-0.0	-0.5	0.6
Had major operations	0.1	0.1	0.2	0.2	0.1	0.5	-0.3
Age at last live birth	0.0	0.1	0.2	0.4	0.2	-0.1	-0.1
Family relationship satisfaction	0.6	0.7	1.3	1.1	-0.5	0.3	1.1
Leg pain on walking	1.3	1.7	3.2	-1.1	-1.0	1.8	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.9	1.9	-1.4	0.0	-0.8	-0.9
Commuting to job workplace: Car/motor vehicle	1.3	1.5	2.7	-0.7	1.6	-1.6	-0.5
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	4.9	0.8	-2.2	1.3	0.6
Medication: Aspirin	2.9	3.8	8.8	-1.4	3.0	-1.8	-1.2
Supplements: Vitamin C	0.9	1.0	2.5	1.2	-0.2	0.1	1.6
Knee pain experienced in last month	0.3	0.4	1.4	0.2	-1.2	0.4	0.5
Hypertension (Self-reported)	0.8	2.1	5.7	-0.8	2.4	-1.3	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.6	0.8	-0.4	0.5	0.5
Illnesses of father: Heart disease	0.4	0.5	0.6	-0.7	0.5	-0.8	-0.8
Illnesses of siblings: Diabetes	1.7	2.0	4.6	-2.1	0.3	-0.8	-1.7
Smoking status: Previous	0.4	0.5	0.8	0.9	-0.4	0.7	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	0.9	1.9	-0.8	0.6	1.0	-1.4
Whole body fat-free mass	0.2	0.9	2.3	-0.1	-0.9	1.5	-0.8
Leg fat-free mass (right)	0.0	0.2	0.6	0.0	-0.1	0.8	-0.6
Arm fat percentage (left)	0.0	0.1	0.3	0.2	0.6	0.2	-0.2
Average weekly red wine intake	0.1	0.1	0.3	-0.3	0.6	-0.3	-0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.4	0.2	0.2	0.6	-0.2
Mood swings	0.1	0.2	0.6	-0.4	-0.4	0.8	-0.1
Loneliness, isolation	1.2	1.7	3.2	-1.3	1.8	-0.1	-1.3
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.3	0.7	0.3	-0.1
Ever had bowel cancer screening	0.9	1.1	2.2	-1.0	0.8	0.8	-1.5
Diabetes diagnosed by doctor	0.2	0.2	0.7	-0.1	-0.2	0.8	-0.5
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.7	2.1	0.6	0.4	1.5	-0.2
Friendships satisfaction	0.4	0.5	1.1	0.8	0.0	0.0	1.1
Qualifications: nursing, teaching	0.2	0.4	0.7	-0.8	-0.3	-0.7	-0.4
Commuting to job workplace: Walk	0.3	0.3	1.1	0.1	-1.0	0.3	0.4
Eye problems/disorders: Cataract	0.3	0.3	1.1	-0.3	-0.3	-1.0	-0.1
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	6.0	-0.3	-1.6	2.4	0.0
Medication for cholesterol	1.6	2.4	6.4	0.5	-2.5	1.6	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.4	-1.2	-0.0	0.8	-1.1
Back pain experienced in last month	0.7	1.0	1.4	1.2	-0.9	0.9	1.0
Mineral and other dietary supplements	0.6	0.7	1.7	1.3	1.0	0.0	0.6
Breast cancer (self-reported)	0.0	0.0	0.1	-0.3	0.2	-0.0	-0.0
Asthma (self-reported)	0.5	1.0	1.9	-0.7	0.9	-1.4	-0.9
Osteoporosis (self-reported)	0.6	0.8	1.9	0.3	-0.2	-1.4	1.1
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.4	0.2	0.7	-0.6
Medication: Aspirin	2.5	3.2	7.4	-1.2	2.7	-1.8	-0.9
Medication: Gliclazide	0.3	0.3	0.7	0.3	-0.8	0.6	-0.1
Illnesses of father: None of the above (group 1)	0.3	0.3	0.6	0.1	0.8	-0.7	-0.4
Smoking status: Current	0.4	0.6	1.0	1.0	0.8	0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.7	-0.5	0.9	0.5
Whole body water mass	0.2	1.0	2.5	-0.1	-0.9	1.6	-0.8
Leg predicted mass (right)	0.1	0.3	0.7	-0.1	-0.0	0.8	-0.7
Arm fat mass (left)	0.1	0.2	0.7	-0.0	0.1	0.8	-0.5
Number of self-reported non-cancer illnesses	0.1	0.2	0.3	-0.2	0.6	0.4	-0.3
Average weekly champagne plus white wine intake	0.6	0.8	1.1	0.7	1.0	-0.9	0.9
Miserableness	0.1	0.2	0.3	-0.5	0.4	-0.3	-0.3
Guilty feelings	0.6	0.9	3.5	-0.3	-1.9	0.3	0.2
Wears glasses or contact lenses	1.3	1.5	2.7	1.5	0.9	0.5	1.6
Ever taken oral contraceptive pill	1.3	1.4	4.2	0.7	-2.0	0.8	0.5
Hearing aid user	0.3	0.4	0.8	-0.6	0.6	0.1	-0.9
Mother’s age at death	1.8	2.3	2.9	1.3	-1.7	1.6	1.4
Financial situation satisfaction	1.7	2.1	4.2	-1.9	-0.8	-0.0	-2.1
Tinnitus: Yes, now most or all of the time	1.0	1.2	2.0	-1.3	0.1	-1.4	-1.1
Commuting to job workplace: Public transport	0.7	0.9	1.6	0.9	-0.8	1.3	0.7
Eye problems/disorders: Glaucoma	1.2	1.4	3.0	1.1	-1.7	0.0	1.3
Medication: Blood pressure	1.4	2.7	6.0	-0.8	2.5	-2.0	-0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.7	-0.8	-0.6	-0.0	-0.7
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.8	-0.6	-0.5	-0.4
High cholesterol (Self-reported)	0.2	0.4	0.8	-0.5	0.4	-0.6	-0.9
Medication: Bendroflumethiazide	0.8	1.3	1.5	-1.1	1.2	-1.2	-1.0
Medication: Paracetamol	0.4	0.6	0.8	0.6	0.9	0.7	0.8
Medication: Lisinopril	1.6	2.0	4.2	-1.1	2.0	-1.4	-0.8
Medication: Atorvastatin	0.1	0.1	0.2	-0.2	-0.1	0.5	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.1	-0.0	1.0	0.8	-0.3
Alcohol drinker status: Never	0.7	0.8	1.3	-1.1	1.0	-0.9	-0.6
Ever smoked	0.1	0.1	0.3	0.5	0.2	0.3	0.3
Basal metabolic rate	0.2	0.9	2.4	-0.2	-0.8	1.6	-0.8
Leg fat percentage (left)	0.0	0.2	0.3	-0.6	0.1	-0.1	-0.6
Arm fat-free mass (left)	0.3	1.4	2.5	-0.6	-1.1	1.6	-1.3
Number of operations (self-reported)	0.3	0.4	0.9	0.3	-1.0	-0.2	0.7
Average weekly beer plus cider intake	0.2	0.2	0.5	0.4	0.7	0.4	0.2
Irritability	0.5	0.9	2.7	-0.7	1.6	-0.4	-0.4
Risk taking	0.6	0.9	2.4	-1.1	0.1	0.0	-1.6
Ever had prostate specific antigen (PSA) test	0.0	0.1	0.1	-0.1	-0.3	0.3	0.1
Fractured/broken bones in last 5 years	2.4	3.1	10.8	-0.5	3.3	-1.1	0.0
Age started oral contraceptive pill	0.2	0.2	0.4	-0.6	0.3	-0.4	-0.6
Diastolic blood pressure, automated reading	0.3	1.0	1.8	-1.2	1.4	-0.6	-0.5
Ever depressed for a whole week	0.4	0.5	1.1	-0.5	-0.0	1.1	-0.9
Unable to work because of sickness or disability	2.0	2.6	3.9	-1.6	2.0	0.5	-1.9
Commuting to job workplace: Cycle	0.8	1.0	3.0	0.6	-1.7	-0.3	0.7
Myopia	2.0	2.9	5.0	1.9	-1.7	0.4	2.2
Vascular/heart problems diagnosed by doctor	1.0	2.8	6.5	1.1	-2.5	1.6	1.1
Cholesterol lowering medication	0.5	0.7	2.1	-0.5	1.5	-0.3	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.8	1.1	0.2	1.3	0.6
Pain experienced in last month	0.6	1.0	3.2	-0.0	0.7	1.8	-0.5
Supplements: Calcium	1.5	1.6	2.0	-1.4	1.4	-1.4	-0.9
Basal cell carcinoma (self-reported)	1.5	1.8	3.2	0.9	-1.5	1.8	1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.5	-0.4	0.7	-0.5	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	2.7	0.6	-1.3	0.3	1.7
Heart disease (siblings)	0.2	0.2	0.8	0.3	0.1	-0.9	0.4
Alcohol drinker status: Previous	1.9	2.2	4.7	0.4	2.2	-1.6	1.1
Pack years of smoking	0.6	0.8	1.4	1.1	0.8	0.5	1.2
Impedance of whole body	0.0	0.2	0.6	-0.2	-0.1	-0.8	0.5
Leg fat mass (left)	0.1	0.2	0.4	-0.5	0.1	0.5	-0.7
Arm predicted mass (left)	0.3	1.4	2.4	-0.7	-0.7	1.6	-1.4