Best TWAS P=4.7e-10 · Best GWAS P=3.21e-10 conditioned to 0.0761
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | -5.7 | 5.8 | 5.5e-09 | -0.91 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Esophagus Mucosa | GKAP1 | 0.09 | 0.06 | lasso | 2 | 0.02 | 2.9e-02 | -5.3 | 5.6 | 2.7e-08 | -0.59 | 0.23 | 0.59 | FALSE |
| 3 | YFS | Blood | RMI1 | 0.07 | 0.09 | bslmm | 528 | 0.09 | 1.5e-27 | -5.5 | -6.2 | 4.7e-10 | 0.87 | 0.05 | 0.95 | TRUE |
| 4 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | -5.9 | 5.4 | 6.8e-08 | -0.88 | 0.01 | 0.94 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | GKAP1 | 0.05 | 0.06 | lasso | 3 | 0.06 | 1.2e-06 | -5.3 | 5.3 | 1.1e-07 | -0.62 | 0.04 | 0.96 | FALSE |