Hub : Genes

RMI1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0650	0.0240	2.3e-04	0.056	0.041	0.046	0.045	0.058	1.9e-07	8.7e-06	2.4e-06	3.4e-06	1.4e-07
2	GTEx	Adipose Subcutaneous	0.1130	0.0420	8.8e-04	0.034	NA	0.024	NA	0.039	8.7e-04	NA	4.4e-03	NA	3.8e-04
3	GTEx	Muscle Skeletal	0.0768	0.0344	8.3e-03	-0.001	NA	0.003	NA	-0.002	4.7e-01	NA	1.6e-01	NA	5.6e-01
4	GTEx	Testis	0.1190	0.0470	3.9e-03	0.108	NA	0.136	NA	0.108	1.7e-05	NA	1.3e-06	NA	1.7e-05
5	METSIM	Adipose	0.0428	0.0167	1.6e-03	0.025	0.008	0.011	0.007	0.012	1.0e-04	2.1e-02	7.8e-03	2.6e-02	4.9e-03
6	YFS	Blood	0.0683	0.0144	0.0e+00	0.087	0.080	0.088	0.089	0.088	4.9e-27	6.3e-25	2.3e-27	1.6e-27	2.6e-27
7	TCGA	Breast Invasive Carcinoma	0.0179	0.0131	1.3e-03	0.016	0.013	0.007	NA	0.008	2.1e-04	8.8e-04	1.0e-02	NA	5.8e-03
8	TCGA	Cervical Squamous Cell Carcinoma	0.0500	0.0330	9.4e-03	0.038	0.004	0.001	NA	0.005	5.6e-03	1.8e-01	2.7e-01	NA	1.8e-01
9	TCGA	Colon Adenocarcinoma	0.4000	0.1490	1.1e-04	0.030	0.046	0.045	NA	0.061	7.8e-03	1.1e-03	1.4e-03	NA	2.0e-04
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0267	0.0168	6.9e-04	0.029	0.031	0.036	NA	0.038	2.7e-04	1.7e-04	5.3e-05	NA	4.1e-05
11	TCGA	Brain Lower Grade Glioma	0.0318	0.0212	9.4e-04	0.027	0.013	0.001	NA	0.012	4.6e-04	1.2e-02	2.1e-01	NA	1.3e-02
12	TCGA	Prostate Adenocarcinoma	0.0787	0.0453	7.5e-05	0.047	0.055	0.054	NA	0.043	1.1e-05	1.8e-06	2.2e-06	NA	2.7e-05
13	TCGA	Stomach Adenocarcinoma	0.0510	0.0360	8.7e-04	0.056	0.029	0.064	NA	0.014	7.0e-05	3.5e-03	2.2e-05	NA	3.0e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	3.3	5.2	7.6	-2.0	-2.7	-1.0	-2.7	-2.4	1.6	-2.5	-2.4	-2.7	-2.7	-2.3	-1.8	-2.0
Bipolar Disorder or Schizophrenia	1.9	4.5	6.6	-2.5	-1.5	-1.4	-2.4	-2.2	2.2	-2.5	-1.9	-1.4	-2.6	-2.5	-1.2	-2.6
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	-1.0	0.9	0.0	0.0	0.8	0.4	-0.4	0.3	1.0	-0.5	-0.7	-0.4	1.0
Depression (Nagel 2018)	0.7	1.0	3.0	0.2	1.7	0.2	1.1	1.2	-0.2	0.7	1.2	1.7	0.6	0.5	0.1	1.4
Intelligence (Savage-Jansen 2018)	3.2	9.7	17.2	3.8	2.2	0.8	3.6	3.0	-3.6	3.8	3.0	2.0	4.1	3.8	1.9	3.2
Neuroticism (Nagel 2018)	1.3	3.1	7.0	-2.6	-0.2	-0.5	-1.9	-1.1	2.2	-2.0	-1.5	-0.1	-2.4	-2.3	-2.3	-1.2
Schizophrenia (2018)	0.6	1.2	2.7	-1.6	0.2	-1.0	-0.9	-0.8	1.5	-1.2	-0.5	0.4	-1.1	-1.4	-0.1	-1.6
Schizophrenia vs Biploar Disorder	1.6	2.1	4.8	-0.1	2.1	0.5	1.4	1.9	0.5	0.8	2.0	2.2	1.1	0.4	1.7	1.9
Worry (Nagel 2018)	4.7	9.9	17.4	-3.6	-1.4	-1.6	-3.6	-3.0	3.4	-3.3	-3.4	-1.3	-4.0	-3.3	-4.2	-3.2
Alzheimer’s Disease (in mother)	0.4	0.4	2.0	0.0	0.5	-1.1	0.6	0.6	-0.4	0.1	1.0	0.5	0.3	0.0	1.4	0.4
Alzheimer’s Disease (in father)	1.0	1.1	1.9	-1.1	-0.6	-0.7	-1.3	-0.9	0.9	-1.1	-0.9	-0.5	-1.2	-1.2	-1.3	-1.4
Alzheimer’s Disease (including proxy)	0.2	0.3	1.1	-0.3	0.5	-1.1	0.4	0.4	-0.7	0.2	0.6	0.5	-0.0	0.1	0.5	-0.1
Crohns Disease (2017)	3.1	6.8	11.2	-2.1	-2.6	-0.9	-3.1	-3.1	1.8	-2.7	-3.3	-2.6	-2.5	-2.2	-3.0	-3.1
Irritable Bowel Disease (IBD)	1.7	3.9	6.2	-1.7	-1.7	-1.8	-2.2	-2.1	1.6	-2.1	-2.5	-1.7	-2.0	-1.8	-2.1	-2.3
Ulcerative Colitis (UC)	0.1	0.2	1.6	-0.4	-0.2	-1.3	-0.3	-0.0	0.4	-0.5	-0.5	-0.2	-0.5	-0.5	-0.2	-0.2
Major Depression (MDD)	0.3	0.3	0.9	0.6	-0.6	0.8	0.5	0.5	-0.7	0.3	0.3	-0.6	0.6	0.4	0.5	1.0
Reaction Time	12.1	23.0	33.3	-5.4	-4.6	-1.8	-5.5	-4.5	5.0	-5.8	-4.6	-4.6	-5.7	-5.6	-2.5	-4.9
Verbal and Numeric Reasoning (VNR)	2.5	6.1	13.1	3.5	0.8	0.6	2.6	1.6	-3.6	3.2	1.7	0.7	3.3	3.5	1.0	2.4
Breast Cancer	0.6	1.4	2.5	1.0	1.0	0.2	1.2	1.6	-0.7	1.3	1.5	0.9	1.6	1.3	1.4	1.2
Ovarian Cancer	1.3	1.8	3.7	-1.2	-1.2	-0.7	-1.7	-1.9	0.9	-1.4	-1.5	-1.1	-1.4	-1.2	-1.2	-1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	2.9	4.3	7.2	-2.7	-1.9	-1.8	-2.2	-1.7	1.6	-2.3	-2.1	-2.0	-2.5	-2.2	-1.2	-2.0
Bipolar Disorder (2011)	2.9	2.8	4.1	-1.7	-1.8	0.3	-1.9	-1.7	1.3	-1.9	-1.7	-1.8	-2.0	-1.9	-1.4	-1.4
Body Mass Index (BMI) (2010)	0.9	1.2	1.7	1.1	1.2	-0.6	1.2	1.3	-0.8	1.2	1.1	1.1	1.2	1.2	0.8	1.3
Coronary Artery Disease (CAD)	0.1	0.2	0.4	0.6	0.3	0.6	0.2	0.5	-0.5	0.5	0.2	0.1	0.5	0.6	-0.1	0.2
Crohns Disease (2012)	1.6	2.6	3.8	-1.4	-1.6	-0.3	-1.9	-1.7	1.5	-1.7	-1.9	-1.7	-1.6	-1.5	-1.7	-1.7
Mean Putamen Volume	0.6	0.7	2.3	-0.4	-1.5	-0.4	-0.9	-0.6	0.2	-0.8	-0.9	-1.5	-0.6	-0.6	0.3	-1.0
Fasting Glucose	0.3	0.3	1.3	-0.3	0.5	0.8	-0.0	1.1	0.9	-0.3	0.5	0.2	-0.2	-0.3	0.5	0.4
HbA1C	3.0	3.3	6.2	0.9	2.4	-0.7	2.0	2.0	-0.8	1.7	2.5	2.4	1.6	1.4	1.7	2.2
HDL Cholesterol	2.4	3.9	15.1	-3.2	0.3	0.1	-1.3	0.3	3.9	-2.5	0.0	0.4	-2.3	-3.1	0.9	-1.3
LDL Cholesterol	0.9	1.4	5.2	-0.9	-1.1	-2.3	-1.0	-1.4	0.7	-1.1	-1.2	-0.8	-1.1	-1.1	-0.3	-1.6
Lupus	0.4	0.7	2.9	0.2	1.6	0.7	0.7	0.2	0.2	0.6	1.0	1.7	0.7	0.4	0.2	0.1
Neuroticism (2016)	0.2	0.3	1.0	-1.0	-0.2	0.7	-0.5	-0.1	0.8	-0.8	0.1	-0.3	-0.6	-0.9	0.3	-0.2
Primary Biliary Cirrhosis	3.4	4.8	11.8	1.6	1.5	0.0	2.7	2.8	-1.0	1.8	3.1	1.5	2.3	1.5	3.4	2.7
Rheumatoid Arthritis	1.0	1.4	3.2	-1.8	-0.9	-1.2	-1.1	-0.3	1.6	-1.6	-0.4	-1.0	-1.3	-1.8	0.3	-0.6
Schizophrenia (2014)	1.0	2.2	4.9	-2.2	-0.5	-0.7	-1.6	-1.0	2.1	-1.9	-0.8	-0.5	-1.8	-2.1	-0.3	-1.6
Triglycerides	2.1	3.4	6.2	2.4	0.9	0.9	2.1	1.2	-2.5	2.3	1.6	0.6	2.3	2.4	1.3	2.0
Type 2 Diabetes (T2D) (2012)	0.7	0.9	2.1	0.6	1.4	0.3	0.9	1.1	-0.1	1.0	0.7	1.5	1.0	1.0	0.4	0.9
Ulcerative Colitis	0.1	0.2	1.3	0.6	-0.1	-1.1	0.3	0.3	-0.4	0.3	-0.2	-0.1	0.1	0.3	-0.3	0.5
Blood Eosinophil Count	3.1	23.8	61.9	-7.6	-1.6	-2.3	-5.1	-2.1	7.9	-6.1	-2.6	-1.6	-6.1	-7.1	-1.7	-3.8
Blood Platelet Count	2.0	23.7	39.1	-6.2	-3.8	-2.2	-5.5	-3.5	6.0	-6.2	-4.2	-3.8	-6.2	-6.2	-2.8	-3.9
Blood Red Count	0.6	5.5	10.4	1.5	2.8	-1.4	2.7	2.9	-0.7	2.2	3.2	2.8	2.4	1.7	2.7	2.1
Blood White Count	8.5	63.1	110.2	10.5	6.0	1.3	8.7	5.9	-10.4	10.0	6.1	5.9	9.9	10.5	3.4	7.9
Heel T-Score	1.8	14.6	38.8	5.8	0.8	2.4	3.6	1.3	-6.2	4.7	1.8	0.9	4.8	5.4	1.1	4.0
BMI	0.1	0.8	1.7	1.1	-1.1	0.8	0.5	0.3	-1.3	0.5	0.1	-1.1	0.8	0.8	0.9	1.1
Height	5.2	101.0	163.8	-12.7	-7.5	-4.2	-11.2	-7.7	12.8	-12.3	-8.5	-7.4	-12.3	-12.7	-4.9	-10.7
Waist Hip Ratio (WHR)	0.4	1.6	9.6	0.5	-0.7	-3.1	-0.7	-1.3	-1.0	0.0	-1.4	-0.6	-0.3	0.3	-1.7	-1.2
Systolic Blood Pressure	0.8	4.0	8.1	-0.3	-2.4	0.7	-2.2	-2.8	-0.3	-1.2	-2.8	-2.4	-1.2	-0.6	-2.9	-2.8
Smoking Status	0.9	2.1	9.4	0.8	-2.2	3.1	-0.5	-1.4	-1.5	-0.1	-1.5	-2.2	0.0	0.4	-1.1	0.2
Allergy or Eczema	1.5	4.0	7.8	1.4	2.8	0.4	2.3	2.4	-0.5	1.8	2.5	2.8	1.9	1.5	1.9	2.2
Cardiovascular Disease	0.8	2.5	5.4	-0.8	-1.6	-0.6	-2.0	-2.2	0.3	-1.2	-2.3	-1.6	-1.6	-0.9	-2.1	-1.8
Hypothyroidism (self reported)	1.2	2.8	5.2	-1.0	-1.8	1.4	-1.8	-2.3	0.4	-1.4	-2.2	-1.7	-1.6	-1.0	-1.9	-2.1
Respiratory disease	0.2	0.3	1.3	-0.6	0.3	1.1	-0.6	-0.5	0.3	-0.4	-0.4	0.3	-0.5	-0.3	-0.3	-1.2
Type 2 Diabetes (T2D) (2018)	2.6	4.8	8.8	1.7	2.0	0.5	2.7	2.7	-1.5	2.0	2.9	1.9	2.1	1.6	3.0	2.5
Lung FEV1/FVC ratio	2.0	10.2	19.4	-2.5	-4.3	-1.9	-3.5	-3.2	2.0	-3.4	-3.7	-4.4	-3.2	-3.0	-2.1	-3.2
Lung FVC	5.4	27.7	52.0	3.2	7.1	1.5	6.0	6.3	-2.1	4.9	6.8	7.2	4.9	3.9	4.8	5.8
Neuroticism	1.8	4.4	8.9	-2.6	-0.7	-1.2	-2.3	-2.0	2.2	-2.2	-2.2	-0.6	-2.7	-2.3	-3.0	-1.6
Chronotype (morning person)	9.8	22.7	35.9	-5.7	-3.5	-2.5	-5.5	-4.5	5.0	-5.5	-4.5	-3.5	-6.0	-5.6	-3.7	-5.0
Hair Pigment	0.0	0.6	1.6	-1.2	-0.4	0.1	-0.5	0.1	1.1	-1.1	-0.2	-0.3	-1.0	-1.2	-0.2	-0.7
Tanning	0.1	0.9	2.4	-1.0	1.2	0.2	-0.8	-0.4	1.2	-0.6	-0.7	1.3	-1.0	-0.8	-1.6	-0.9
Hand grip strength (left)	1.7	4.5	8.2	2.9	1.5	0.1	2.4	1.6	-2.7	2.6	1.7	1.5	2.8	2.8	1.3	1.8
Number of treatments/medications taken	0.8	1.4	6.4	-0.6	-0.4	0.3	-1.4	-1.7	0.7	-0.9	-1.8	-0.4	-1.0	-0.8	-2.5	-0.6
Average weekly spirits intake	1.7	2.2	4.6	-0.8	-1.4	1.5	-1.7	-2.0	0.7	-1.1	-2.1	-1.3	-1.3	-0.9	-2.2	-1.2
Sensitivity / hurt feelings	5.9	10.0	18.1	-4.3	-1.5	-1.7	-3.5	-2.6	3.8	-3.9	-2.7	-1.4	-4.1	-4.1	-2.3	-3.1
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.6	-0.2	1.8	-0.7	0.8	1.0	0.1	0.5	1.2	1.9	0.4	0.2	0.4	0.5
Hearing difficulty/problems: Yes	0.8	1.3	3.0	0.8	1.0	-0.8	1.4	1.2	-0.6	1.0	1.5	1.0	1.3	0.8	1.1	1.7
Relative age of first facial hair	0.9	1.8	6.4	-1.5	-0.4	-2.5	-1.3	-0.8	1.5	-1.3	-1.1	-0.3	-1.5	-1.4	-1.1	-1.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.8	-0.5	0.3	-0.5	-0.4	-0.8	0.5	-0.2	-0.3	0.3	-0.3	-0.2	-0.6	-0.9
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.9	-0.1	0.9	-0.3	-0.1	0.1	0.2	0.2	-0.0	0.9	-0.2	0.1	-1.0	0.2
Ever had hysterectomy (womb removed)	0.8	0.9	2.4	0.4	1.5	1.1	0.8	1.0	-0.3	0.9	0.9	1.5	0.7	0.5	0.0	1.4
Systolic blood pressure, automated reading	0.5	1.4	2.8	0.9	-1.4	1.7	-0.7	-1.5	-1.2	-0.1	-1.5	-1.4	-0.0	0.4	-1.5	-1.0
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.7	-1.2	-0.5	-0.8	-0.7	0.1	1.2	-1.0	0.0	-0.6	-0.9	-1.3	0.5	-0.5
Angina	0.1	0.2	0.9	-0.2	0.9	-0.1	-0.1	-0.2	0.3	-0.1	-0.0	0.9	-0.3	-0.2	-0.0	0.1
Medication for hormone replacement therapy	0.5	0.5	1.9	-1.0	0.7	0.6	-0.7	-0.1	1.4	-0.3	-0.3	0.8	-0.8	-0.6	-0.9	-0.4
Vitamin and mineral supplements	2.8	3.8	6.1	1.5	2.4	-0.3	2.2	2.2	-0.9	2.1	2.5	2.4	1.7	1.7	1.7	2.3
Supplements: Zinc	0.2	0.2	2.3	-0.4	0.1	-1.5	-0.1	0.3	0.6	-0.1	0.2	0.1	-0.2	-0.3	0.2	0.2
Medication: Co-codamol	0.7	0.9	4.2	-1.4	0.9	-2.0	-0.1	0.1	1.0	-0.6	0.3	1.0	-0.7	-0.8	0.1	-0.7
Medication: Metformin	1.3	1.9	3.6	0.6	1.5	-1.2	1.6	1.8	-0.3	1.1	1.8	1.5	1.1	0.7	1.5	1.9
Diabetes (father)	0.9	1.1	5.0	-1.5	0.2	-2.2	-0.4	-0.3	1.3	-1.1	0.3	0.1	-1.0	-1.4	0.7	-0.9
Diabetes (mother)	1.5	1.9	3.2	1.6	0.8	-0.7	1.7	1.3	-1.8	1.5	1.5	0.8	1.5	1.5	1.5	1.1
Severe depression (siblings)	1.9	2.1	5.2	-2.0	-0.7	-1.0	-1.6	-0.5	2.3	-1.7	-1.1	-0.6	-1.8	-1.8	-0.7	-1.5
Pack years adult smoking proportion	1.5	2.2	3.4	1.7	1.6	1.2	1.5	1.4	-1.3	1.8	1.0	1.6	1.7	1.8	0.3	1.8
Impedance of leg (right)	1.5	7.1	12.8	-1.0	-2.9	-2.7	-2.8	-3.5	0.3	-1.9	-3.5	-2.8	-2.4	-1.4	-3.6	-3.3
Leg fat-free mass (left)	0.2	1.2	3.2	-1.7	-0.6	0.6	-1.1	-0.3	1.8	-1.4	-0.6	-0.6	-1.3	-1.6	0.3	-0.8
Trunk fat percentage	4.0	15.9	21.7	-3.6	-4.6	-2.0	-4.6	-3.8	3.1	-4.5	-4.7	-4.6	-4.5	-4.1	-3.0	-3.8
Hand grip strength (right)	1.1	3.0	5.8	2.4	1.1	0.5	1.9	1.2	-2.3	2.2	1.3	1.1	2.4	2.4	0.8	1.5
Townsend deprivation index at recruitment	1.5	2.1	3.9	1.7	1.2	1.8	1.4	0.8	-2.0	1.8	1.0	1.2	1.6	1.8	-0.1	1.3
Current tobacco smoking	1.2	2.0	5.9	1.3	1.0	2.4	1.4	1.2	-1.2	1.3	1.1	1.1	1.5	1.4	0.6	1.9
Average weekly fortified wine intake	3.0	3.6	5.1	-2.2	-1.8	-1.3	-2.2	-1.8	2.0	-2.3	-1.9	-1.8	-2.1	-2.1	-0.8	-1.7
Maternal smoking around birth	0.4	0.6	1.1	-0.2	-1.0	0.9	-0.7	-0.6	0.1	-0.6	-1.0	-1.0	-0.9	-0.6	-1.1	-0.1
Fed-up feelings	0.7	1.3	2.3	1.1	1.3	0.8	1.3	1.1	-1.4	1.2	0.8	1.4	1.2	1.2	0.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	3.8	5.1	7.3	2.2	2.3	1.0	2.7	2.2	-2.1	2.3	2.5	2.3	2.5	2.2	1.8	2.6
Relative age voice broke	0.3	0.5	4.1	-0.3	0.7	-2.0	-0.1	-0.2	0.2	0.0	-0.1	0.7	-0.3	-0.2	-0.9	-0.2
Taking other prescription medications	1.9	3.0	5.7	-2.4	-0.8	-1.0	-1.9	-1.1	2.4	-2.1	-1.4	-0.8	-2.2	-2.2	-0.8	-1.7
Age when periods started (menarche)	2.7	6.4	14.5	-3.3	-0.3	-3.8	-2.4	-1.5	3.6	-2.6	-1.5	-0.3	-3.2	-3.1	-1.8	-2.2
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.4	-0.1	1.5	1.3	0.5	1.0	0.4	0.5	1.1	1.6	0.2	0.1	0.5	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	3.3	1.4	0.2	-0.6	0.8	0.4	-1.8	1.1	0.2	0.2	0.9	1.3	0.1	1.0
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.5	-1.6	-0.5	-1.0	-1.2	-0.7	1.5	-1.2	-0.7	-0.4	-1.3	-1.4	-1.2	0.3
Qualifications: CSEs or equivalent	0.4	0.6	2.4	-0.6	0.4	1.6	-0.1	0.5	1.5	-0.6	0.4	0.4	-0.5	-0.8	0.7	0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.5	-0.6	0.0	0.7	-0.3	-0.0	0.6	-0.3	-0.0	0.0	-0.3	-0.3	-0.1	-0.1
High blood pressure	2.4	6.7	15.8	-0.7	-2.5	-0.6	-3.0	-4.0	0.0	-1.8	-4.0	-2.4	-2.0	-1.0	-3.9	-3.3
Hayfever, allergic rhinitis or eczema	1.5	3.3	8.4	0.9	2.9	0.3	2.0	2.0	-0.2	1.6	2.3	2.9	1.6	1.2	1.6	1.4
Multivitamins +/- minerals	0.8	1.1	2.3	-0.6	-1.5	0.1	-1.1	-1.1	0.3	-1.1	-1.3	-1.5	-0.8	-0.8	-0.8	-1.2
Stomach or abdominal pain in last month	0.8	1.0	4.6	0.2	-0.3	0.8	-0.8	-1.5	-0.4	-0.3	-1.4	-0.3	-0.4	0.1	-2.1	-1.3
Supplements: Glucosamine	0.8	1.0	1.8	-1.1	-1.1	1.0	-1.1	-0.7	1.3	-1.3	-0.8	-1.0	-1.1	-1.3	-0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.6	0.5	0.3	0.6	0.3	-0.1	-0.8	0.4	0.2	0.2	0.2	0.5	0.0	0.2
Medication: Atenolol	3.0	3.7	8.5	-1.6	-1.6	-0.7	-2.3	-2.4	1.1	-1.7	-2.5	-1.5	-2.1	-1.5	-2.9	-1.9
Medication: Levothyroxine sodium	3.6	6.0	13.0	-1.0	-3.0	0.5	-2.8	-3.3	0.3	-1.9	-3.6	-2.9	-2.2	-1.2	-3.4	-2.5
Sitting height	1.2	8.4	15.5	-3.9	-2.5	-0.0	-3.0	-1.7	3.9	-3.6	-2.0	-2.5	-3.4	-3.8	-0.1	-3.2
Chronic bronchitis/emphysema (father)	0.6	0.7	1.9	1.1	0.5	1.2	0.3	-0.9	-1.4	0.8	-0.2	0.6	0.6	1.0	-1.3	-0.0
High blood pressure (mother)	0.3	0.4	1.0	-0.8	0.5	-0.4	-0.4	-0.5	1.0	-0.4	-0.1	0.5	-0.8	-0.6	-0.5	-1.0
Body mass index (BMI)	0.6	2.8	5.3	2.3	0.7	1.0	1.6	1.3	-2.2	1.9	1.0	0.7	2.0	2.1	0.9	2.3
Impedance of leg (left)	1.6	7.6	12.2	-1.7	-2.9	-2.7	-3.0	-3.3	1.1	-2.5	-3.4	-2.9	-2.8	-2.1	-3.1	-3.5
Leg predicted mass (left)	0.2	1.2	3.1	-1.7	-0.6	0.7	-1.1	-0.3	1.8	-1.4	-0.5	-0.6	-1.3	-1.5	0.3	-0.8
Trunk fat mass	2.9	12.6	17.3	-3.4	-3.9	-1.6	-4.2	-3.3	3.0	-4.0	-4.1	-3.9	-4.1	-3.7	-2.6	-3.4
Waist circumference	0.2	0.7	2.1	-0.1	-1.1	-0.8	-1.0	-1.0	0.0	-0.6	-1.4	-1.0	-0.6	-0.3	-1.2	-0.6
Number of incorrect matches in round	1.2	2.0	5.7	-2.4	0.0	0.7	-1.5	-0.8	2.3	-1.6	-0.7	0.1	-1.7	-1.8	-1.1	-1.0
Past tobacco smoking	0.7	1.3	3.8	-0.7	1.9	-1.1	0.6	1.5	1.2	0.1	1.5	1.9	0.2	-0.3	0.9	0.5
Alcohol usually taken with meals	7.8	12.5	23.1	-4.8	-2.9	-2.8	-3.7	-1.9	4.7	-4.6	-2.2	-2.9	-4.2	-4.8	-0.1	-3.2
Nervous feelings	0.7	1.3	3.5	-1.5	0.1	-0.0	-1.2	-1.0	1.5	-1.1	-1.1	0.2	-1.6	-1.2	-1.9	-0.8
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	3.3	-0.1	1.8	0.0	0.6	0.5	-0.2	0.5	0.9	1.8	0.3	0.3	-0.1	0.5
Hearing difficulty/problems with background noise	1.5	2.4	5.8	1.0	2.3	0.6	1.8	1.4	-0.9	1.6	1.7	2.4	1.5	1.4	0.4	1.7
Hair/balding pattern: Pattern 2	0.3	0.4	1.6	-0.6	0.2	-0.2	-0.5	-0.6	0.7	-0.3	-0.6	0.2	-0.6	-0.4	-1.3	-0.6
Had menopause	0.5	0.6	1.5	-1.2	-0.4	-0.6	-0.8	-0.3	1.2	-1.0	-0.3	-0.3	-1.0	-1.2	0.0	-0.3
Had other major operations	0.3	0.4	1.2	-0.1	-1.0	-0.7	-0.7	-0.7	0.1	-0.5	-0.6	-1.1	-0.3	-0.4	-0.6	-0.2
Forced vital capacity (FVC)	0.3	1.2	2.9	-1.0	1.6	0.5	0.4	1.4	1.5	-0.2	1.3	1.7	-0.2	-0.6	1.5	-0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	4.9	1.9	-0.0	0.1	1.2	0.7	-2.2	1.4	0.5	-0.1	1.4	1.6	0.5	1.8
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.4	0.6	-0.3	0.5	0.4	-0.3	0.5	0.6	0.6	0.4	0.4	0.2	0.6
Qualifications: None of the above	4.0	8.5	13.4	-2.4	-3.1	0.4	-3.3	-3.7	1.6	-3.0	-3.6	-3.1	-3.2	-2.7	-3.4	-2.6
Financial difficulties in last 2 years	5.3	7.2	11.9	3.3	2.3	0.8	2.9	2.0	-3.2	3.3	2.1	2.3	3.1	3.4	0.5	3.5
Mouth/teeth dental problems	0.2	0.3	0.7	0.7	0.2	0.1	0.3	0.3	-0.8	0.8	0.1	0.1	0.7	0.8	-0.2	0.5
Heart attack	0.5	0.6	1.0	1.0	0.7	0.4	0.8	0.7	-1.0	0.9	0.4	0.7	0.9	1.0	0.2	0.9
Allergy	0.8	1.9	7.8	0.2	-2.8	-0.0	-1.1	-1.4	-0.7	-0.8	-1.7	-2.8	-0.6	-0.3	-0.8	-0.6
Pain all over the body in last month	2.4	2.5	5.0	-0.7	-2.2	0.3	-1.9	-1.8	0.9	-1.5	-2.2	-2.2	-1.6	-1.1	-1.3	-1.6
Diabetes (self-reported)	3.9	6.0	13.1	1.1	2.7	-0.3	2.8	3.6	-0.5	1.7	3.5	2.6	2.1	1.1	3.6	2.8
Hayfever/allergic rhinitis (self-reported)	1.9	2.5	4.4	-1.9	-0.9	-0.4	-1.7	-1.2	2.1	-1.8	-1.7	-0.9	-1.8	-1.8	-1.7	-1.4
Medication: Ramipril	0.1	0.1	0.5	0.1	0.1	-0.4	-0.3	-0.3	-0.5	0.0	-0.6	0.1	-0.1	0.2	-0.7	-0.2
Medication: Simvastatin	0.1	0.2	1.4	0.1	0.2	1.2	-0.0	-0.4	-0.3	0.2	-0.2	0.2	-0.0	0.2	-0.7	-0.0
Fluid intelligence score	2.2	4.7	8.5	2.9	0.3	1.6	2.3	2.1	-2.7	2.4	1.8	0.1	2.9	2.6	1.8	2.2
Illnesses of siblings	4.5	6.3	9.9	2.0	2.8	-0.6	3.0	3.1	-1.6	2.6	3.1	2.8	2.8	2.3	2.0	2.7
Neuroticism score	1.0	2.1	5.4	-1.9	-0.3	-0.8	-1.5	-1.4	1.2	-1.5	-1.5	-0.1	-1.9	-1.6	-2.3	-1.2
Weight	0.4	2.0	3.2	-1.5	-1.5	-0.3	-1.8	-1.1	1.5	-1.7	-1.6	-1.4	-1.7	-1.6	-0.8	-1.3
Impedance of arm (right)	14.4	66.9	87.5	-8.0	-8.3	-5.0	-9.4	-7.8	7.3	-9.1	-8.6	-8.3	-9.3	-8.7	-5.8	-9.3
Arm fat percentage (right)	1.3	5.1	10.7	-1.3	-3.2	-1.4	-2.6	-2.1	1.1	-2.3	-2.9	-3.3	-2.2	-1.9	-1.7	-2.0
Trunk fat-free mass	0.1	0.5	1.1	-0.3	1.0	0.9	0.4	0.8	0.5	0.3	0.8	1.1	0.3	0.1	0.8	0.3
Hip circumference	0.2	0.9	2.3	-0.6	-1.2	0.2	-1.2	-0.9	0.4	-0.9	-1.5	-1.2	-0.9	-0.6	-1.1	-0.8
Time employed in main current job	0.6	0.7	1.3	-0.7	-1.1	0.5	-1.0	-0.7	0.8	-1.0	-0.7	-1.1	-0.8	-0.9	-0.2	-1.0
Alcohol intake versus 10 years previously	0.1	0.1	0.4	-0.5	0.3	-0.2	0.0	0.2	0.7	-0.3	0.3	0.2	-0.2	-0.4	0.4	0.6
Father’s age at death	3.8	5.1	10.8	0.8	3.0	-0.8	2.6	3.1	-0.2	1.7	3.3	3.0	1.8	1.1	2.8	1.9
Worrier / anxious feelings	4.0	7.5	12.2	-3.0	-2.1	-1.2	-3.1	-2.5	2.4	-3.1	-3.1	-2.1	-3.5	-2.9	-2.7	-3.1
Frequency of tiredness / lethargy in last 2 weeks	6.2	10.1	18.6	2.7	4.3	0.6	3.6	3.0	-2.5	3.6	3.4	4.3	3.3	3.2	1.2	3.3
Falls in the last year	1.4	1.9	3.8	-1.1	-1.3	-0.0	-1.7	-1.8	0.7	-1.3	-1.9	-1.3	-1.5	-1.1	-1.7	-1.5
Hair/balding pattern: Pattern 3	0.2	0.2	1.4	0.3	0.3	-1.2	0.3	0.0	-0.8	0.4	0.1	0.4	0.4	0.5	-0.2	0.1
Number of live births	0.1	0.1	0.7	-0.2	-0.3	-0.5	-0.1	0.3	0.6	-0.2	0.2	-0.3	-0.1	-0.3	0.8	-0.0
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	4.5	-1.8	0.7	-0.4	-0.4	0.7	2.1	-1.1	0.6	0.8	-0.9	-1.4	1.1	-1.2
Pulse rate	0.4	0.7	2.5	0.5	-0.8	0.4	-0.7	-1.5	-0.4	-0.1	-1.1	-0.8	-0.2	0.2	-1.6	-0.7
Happiness	1.7	2.1	3.9	1.3	1.9	-0.2	1.6	1.5	-1.1	1.7	1.4	2.0	1.5	1.5	0.4	1.4
Noisy workplace	0.9	1.1	3.4	1.0	0.9	-0.4	1.1	1.1	-0.9	1.1	0.9	0.9	1.1	1.0	0.9	1.8
Qualifications: A levels/AS levels or equivalent	3.6	8.0	12.6	3.1	1.9	-1.1	3.3	3.2	-2.5	3.1	3.0	1.8	3.5	3.1	3.2	2.7
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	7.2	0.2	2.6	-0.8	1.8	2.5	0.1	1.4	2.2	2.7	1.3	0.9	1.8	1.4
Mouth/teeth dental problems: Dentures	1.4	2.4	5.9	-1.0	-1.7	0.1	-1.7	-2.4	0.7	-1.5	-2.0	-1.7	-1.6	-1.3	-1.6	-1.6
Asthma	0.6	1.1	5.0	-0.3	2.2	-0.0	0.7	1.2	0.5	0.5	1.2	2.2	0.4	0.2	0.7	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.6	0.6	-0.8	-0.6	-0.4	-0.8	-1.0	-0.0	-1.3	-0.7	0.1	0.4	-1.2	-0.4
Medication: Cholesterol lowering	0.1	0.2	0.6	0.0	-0.3	0.8	-0.4	-0.7	-0.1	-0.0	-0.5	-0.2	-0.2	0.1	-0.7	-0.3
Depression (self-reported)	0.2	0.3	0.8	-0.5	0.8	0.5	-0.2	-0.3	0.9	-0.1	0.1	0.9	-0.5	-0.4	-0.5	-0.1
Medication: Lansoprazole	0.9	1.0	2.8	-0.3	1.2	-0.4	0.9	1.3	0.5	0.4	1.5	1.1	0.5	0.1	1.7	1.4
Prospective memory result	1.3	1.6	3.9	-2.0	-0.0	0.4	-1.2	-0.8	1.8	-1.5	-0.8	0.0	-1.8	-1.7	-1.0	-1.2
Lung cancer (father)	4.6	5.3	14.8	-1.6	-1.6	0.0	-2.7	-3.4	1.2	-1.8	-3.0	-1.5	-2.2	-1.6	-3.9	-2.8
Illnesses of mother	1.2	1.4	2.6	1.5	0.4	1.4	1.3	1.2	-1.3	1.3	0.7	0.3	1.6	1.5	0.7	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	8.0	-2.3	0.5	-0.6	-0.7	0.8	2.8	-1.5	0.6	0.5	-1.3	-1.9	1.5	-1.3
Pulse wave Arterial Stiffness index	4.4	5.1	8.7	2.9	1.9	0.1	2.6	1.8	-2.5	2.7	1.7	1.9	2.9	2.8	0.8	2.7
Impedance of arm (left)	11.9	55.1	77.1	-7.9	-7.0	-4.7	-8.3	-6.6	7.3	-8.6	-7.3	-7.0	-8.8	-8.4	-4.6	-8.4
Arm fat mass (right)	0.5	2.0	4.0	-0.8	-2.0	-0.7	-1.7	-1.3	0.7	-1.4	-2.0	-2.0	-1.4	-1.2	-1.1	-1.1
Trunk predicted mass	0.1	0.4	1.0	-0.3	1.0	1.0	0.4	0.8	0.5	0.3	0.8	1.0	0.3	0.1	0.8	0.3
Standing height	4.8	47.4	72.1	-8.5	-5.3	-2.9	-7.8	-5.5	8.2	-8.2	-6.1	-5.2	-8.4	-8.3	-3.7	-8.0
Length of working week for main job	3.2	3.5	5.2	2.1	1.8	0.6	1.9	1.8	-1.8	2.2	1.8	1.7	2.3	2.2	1.2	2.2
Exposure to tobacco smoke at home	2.0	2.2	5.1	0.9	1.5	1.4	1.6	1.8	-0.6	1.3	1.8	1.5	1.5	1.1	1.4	2.3
Breastfed as a baby	1.5	1.9	5.4	0.3	1.3	2.3	1.4	1.9	-0.2	0.8	1.8	1.2	1.1	0.5	1.9	1.0
Tense / ‘highly strung’	1.5	2.4	7.4	-2.5	0.8	-0.5	-1.3	-0.5	2.7	-1.6	-0.6	0.9	-1.9	-2.1	-1.5	-0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.4	2.1	5.9	-1.4	0.1	-0.4	-1.7	-1.6	1.3	-1.2	-1.7	0.2	-1.7	-1.2	-2.4	-1.9
Hair/balding pattern: Pattern 4	3.8	9.3	15.4	-3.9	-2.1	-2.0	-3.3	-2.5	3.5	-3.7	-2.6	-2.0	-3.8	-3.8	-1.5	-3.3
Birth weight of first child	0.7	1.2	3.4	-1.5	-0.4	0.6	-1.1	-0.6	1.8	-1.3	-0.8	-0.4	-1.6	-1.4	-0.7	-0.7
Peak expiratory flow (PEF)	2.5	5.9	10.0	-2.7	-2.2	-1.3	-2.8	-2.0	2.6	-2.8	-2.4	-2.1	-2.6	-2.7	-1.5	-3.2
Pulse wave reflection index	9.7	12.0	16.8	3.4	3.6	0.1	4.1	3.5	-3.2	3.8	3.7	3.5	4.0	3.6	2.6	3.8
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.3	0.3	-0.7	0.5	0.6	-0.6	0.3	0.4	0.3	0.4	0.3	0.5	0.5
Loud music exposure frequency	0.6	0.7	1.9	0.4	1.4	-0.8	0.8	0.9	-0.4	0.8	0.9	1.4	0.5	0.6	0.2	0.8
Qualifications: O levels/GCSEs or equivalent	6.4	10.2	14.9	2.9	3.4	0.0	3.9	3.6	-2.5	3.6	3.7	3.3	3.8	3.3	3.0	2.6
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.9	-1.2	0.6	-1.1	0.2	0.9	1.3	-0.7	0.9	0.5	-0.6	-1.0	1.7	-0.4
Blood clot in the leg (DVT)	0.5	0.6	1.7	-1.3	-0.0	-0.0	-0.9	-0.3	1.2	-0.8	-0.5	0.0	-1.1	-1.1	-1.1	-0.1
Medication: Paracetamol	0.6	1.0	3.8	-0.2	-1.1	0.9	-1.1	-1.3	-0.1	-0.6	-1.4	-1.2	-0.4	-0.4	-1.9	-0.1
Headache pain in last month	0.3	0.5	1.0	0.6	1.0	0.5	0.6	0.2	-0.9	0.9	0.3	1.0	0.4	0.9	-0.7	0.3
Medication for cholesterol, blood pressure or diabetes	1.4	2.2	4.5	0.9	1.8	0.7	1.7	2.1	-0.4	1.3	1.9	1.8	1.3	1.1	1.9	1.6
Glaucoma (self-reported)	1.4	1.7	5.0	-0.9	-0.7	1.1	-1.5	-1.7	0.9	-1.0	-1.8	-0.7	-1.3	-0.8	-2.2	-1.3
Gout (self-reported)	0.8	1.1	3.4	1.3	-0.8	1.6	-0.0	-1.0	-1.8	0.5	-0.6	-0.8	0.7	1.0	-0.5	-1.3
Hypothyroidism/myxoedema (self-reported)	2.6	5.2	11.7	-1.2	-2.0	1.2	-2.5	-3.1	0.7	-1.8	-3.2	-1.9	-2.2	-1.2	-3.4	-2.9
Medication: Amlodipine	1.1	1.5	6.7	-0.4	-0.4	0.0	-1.4	-1.6	0.1	-0.7	-1.9	-0.3	-0.9	-0.4	-2.6	-1.6
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.1	1.2	0.5	0.7	0.8	0.7	-1.4	1.0	0.5	0.4	1.1	1.2	0.4	0.5
Birth weight	2.1	4.6	7.1	-2.0	-2.2	-1.2	-2.4	-2.4	1.7	-2.3	-2.3	-2.2	-2.4	-2.1	-1.6	-2.7
Chronic bronchitis/emphysema (mother)	3.9	4.6	8.0	-2.5	-1.3	-0.4	-2.5	-1.9	2.6	-2.5	-2.2	-1.2	-2.8	-2.6	-1.9	-2.1
High blood pressure (siblings)	3.7	5.3	8.8	-1.8	-2.2	1.1	-2.8	-2.7	1.8	-2.3	-3.0	-2.2	-2.7	-2.1	-2.4	-2.2
Forced vital capacity (FVC), Best measure	0.4	1.6	4.8	-1.5	1.2	0.4	0.1	1.5	2.2	-0.7	1.3	1.2	-0.5	-1.1	2.0	-0.4
Body fat percentage	2.1	8.4	13.4	-2.2	-3.6	-1.6	-3.4	-2.9	1.8	-3.1	-3.6	-3.7	-3.1	-2.7	-2.5	-2.5
Leg fat percentage (right)	0.3	1.1	4.2	1.7	-0.9	-0.8	0.1	-0.5	-2.1	0.8	-0.9	-0.9	0.6	1.3	-1.1	0.7
Arm fat-free mass (right)	0.6	3.3	4.7	1.2	2.1	1.6	2.0	2.0	-1.0	1.8	2.2	2.1	1.8	1.5	2.0	1.9
Exposure to tobacco smoke outside home	1.5	2.0	5.0	-0.3	2.2	0.6	1.2	1.9	0.9	0.5	2.0	2.2	0.6	0.0	2.0	1.4
Comparative body size at age 10	2.7	7.4	11.6	-2.8	-3.4	1.1	-3.1	-2.3	2.8	-3.4	-2.6	-3.4	-2.9	-3.2	-1.0	-2.0
Number of full brothers	0.9	1.2	4.1	1.5	-0.6	-0.5	-0.2	-1.4	-2.0	0.7	-1.1	-0.5	0.6	1.2	-1.7	-0.6
Worry too long after embarrassment	2.0	3.4	5.8	-1.6	-1.8	-0.6	-2.1	-2.2	0.7	-1.8	-2.4	-1.7	-2.1	-1.6	-2.3	-2.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.4	1.8	5.8	-2.3	0.1	0.1	-1.2	-0.5	2.4	-1.6	-0.5	0.2	-1.7	-2.0	-0.7	-0.6
Wheeze or whistling in the chest in last year	0.9	1.6	2.8	-1.4	-0.3	1.0	-1.7	-1.4	1.4	-1.4	-1.4	-0.3	-1.3	-1.2	-1.5	-1.1
Number of children fathered	3.5	3.9	6.2	-1.6	-2.5	-1.4	-2.3	-2.2	1.2	-2.2	-2.2	-2.5	-2.0	-1.9	-1.1	-1.8
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.3	-0.4	0.9	-1.5	0.3	0.6	0.7	0.1	0.8	0.9	0.1	-0.3	1.3	0.0
Age at first live birth	0.2	0.4	1.2	-0.4	-1.0	-0.8	-0.2	0.1	0.3	-0.5	-0.2	-1.1	-0.0	-0.3	0.8	-0.7
Pulse wave peak to peak time	6.2	7.3	11.9	-3.5	-2.3	-0.2	-3.1	-2.2	2.9	-3.2	-2.2	-2.3	-3.4	-3.3	-1.0	-3.3
Health satisfaction	0.8	1.0	3.8	-0.6	1.9	-0.0	0.6	1.0	1.0	0.2	1.2	1.9	0.1	-0.3	0.4	0.8
Shortness of breath walking on level ground	0.2	0.3	1.2	-0.5	0.7	-1.1	-0.1	0.1	0.6	-0.1	0.1	0.7	-0.4	-0.4	-0.3	0.5
Qualifications: College or University degree	1.6	5.2	12.6	1.4	2.1	-1.3	2.6	3.1	-0.8	2.1	3.1	2.2	2.5	1.8	3.6	1.3
Eye problems/disorders: None of the above	1.9	2.1	3.5	1.5	1.0	-0.5	1.7	1.8	-1.4	1.4	1.6	0.9	1.6	1.5	1.6	1.9
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.5	0.3	0.0	0.8	0.4	-0.8	0.5	0.7	0.3	0.5	0.4	0.7	0.6
Emphysema/chronic bronchitis	0.9	1.0	4.3	-0.9	-0.2	-2.1	-0.9	-0.9	0.7	-0.8	-0.6	-0.1	-1.1	-0.8	0.1	-1.7
Medication for pain relief, constipation, heartburn	0.7	1.1	4.4	0.4	0.8	-0.4	1.3	1.3	-0.1	0.8	1.8	0.8	0.8	0.5	2.1	0.7
Neck or shoulder pain in last month	1.4	2.0	4.4	1.7	0.8	0.9	1.6	1.3	-2.1	1.6	1.1	0.7	1.9	1.9	1.0	1.0
Medication: Blood pressure	1.8	3.2	6.3	-0.8	-2.2	-1.4	-2.0	-2.5	0.2	-1.4	-2.5	-2.1	-1.3	-1.1	-2.3	-2.0
Angina (self-reported)	0.1	0.2	0.7	-0.3	0.8	-0.1	-0.2	-0.2	0.4	-0.2	-0.0	0.9	-0.4	-0.3	0.0	0.1
Migraine (self-reported)	2.3	2.8	6.3	1.6	2.5	-0.5	1.8	1.5	-0.8	1.9	1.7	2.5	1.8	1.7	0.4	1.6
Medication: Ibuprofen	0.3	0.3	1.3	0.8	-0.0	-0.5	-0.0	-0.3	-1.0	0.4	-0.8	0.0	0.4	0.7	-1.1	-0.1
Medication: Allopurinol	0.7	0.9	4.0	1.4	-0.9	0.5	0.2	-0.6	-2.0	0.8	-0.3	-1.0	1.0	1.2	-0.3	-0.7
Medication: Omeprazole	0.9	1.1	2.0	-1.0	-0.7	-0.5	-1.2	-1.2	0.7	-1.1	-1.2	-0.7	-1.2	-1.1	-1.4	-1.1
Medication: Seretide 50 evohaler	0.4	0.5	1.7	0.6	-0.5	0.7	-0.4	-0.8	-1.3	0.3	-0.8	-0.5	0.2	0.6	-1.2	-0.1
Mean time to correctly identify matches	16.7	31.9	46.6	-6.4	-5.1	-1.9	-6.5	-5.5	5.7	-6.8	-5.6	-5.1	-6.8	-6.7	-3.7	-5.6
Heart disease (mother)	0.8	0.9	2.9	0.3	-1.1	-1.3	-0.7	-1.4	-0.9	-0.1	-1.2	-1.0	-0.4	0.1	-1.7	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.9	-1.4	-0.1	0.3	-1.0	-1.3	1.4	-1.1	-0.7	-0.1	-1.1	-1.3	-1.0	-1.1
Whole body fat mass	1.4	5.8	9.2	-2.1	-3.0	-1.1	-2.9	-2.2	1.7	-2.7	-2.9	-3.0	-2.7	-2.4	-1.7	-2.0
Leg fat mass (right)	0.2	0.7	2.0	0.4	-1.3	-0.6	-0.8	-1.0	-0.6	-0.3	-1.4	-1.3	-0.4	0.1	-1.1	-0.2
Arm predicted mass (right)	0.6	3.3	4.6	1.2	2.1	1.6	2.0	2.1	-1.0	1.8	2.1	2.1	1.8	1.6	2.0	1.9
Pulse rate, automated reading	1.3	4.1	5.6	-1.7	-2.0	-1.5	-2.2	-2.4	1.6	-2.3	-2.0	-2.0	-2.3	-2.1	-1.6	-2.3
Alcohol intake frequency.	0.2	0.5	1.9	-1.0	0.8	-1.0	0.1	0.0	1.4	-0.5	0.6	0.8	-0.5	-0.8	0.1	-0.3
Comparative height size at age 10	4.4	24.4	34.6	-5.1	-4.9	0.5	-5.9	-4.7	4.8	-5.6	-5.3	-4.9	-5.6	-5.3	-3.7	-5.6
Number of full sisters	2.2	2.7	5.7	2.2	1.1	0.5	1.6	1.0	-2.4	2.1	0.9	1.1	2.0	2.2	-0.3	1.9
Suffer from ‘nerves’	4.1	6.4	10.0	-3.2	-1.6	-0.3	-2.9	-2.2	3.0	-3.0	-2.5	-1.6	-3.1	-2.9	-2.4	-2.6
Overall health rating	0.3	0.6	2.3	0.2	1.5	1.0	0.4	0.1	-0.1	0.6	0.6	1.5	0.5	0.5	-0.8	0.5
Chest pain or discomfort	0.6	0.8	2.3	1.4	-0.3	1.3	0.5	-0.1	-1.5	0.9	-0.3	-0.4	0.9	1.3	-0.5	0.8
Had major operations	2.4	2.9	4.5	-2.0	-1.2	-1.4	-2.0	-1.4	1.7	-2.1	-1.6	-1.3	-2.1	-2.1	-1.0	-1.5
Age at last live birth	0.5	0.8	1.6	0.9	0.4	-0.0	1.1	1.2	-0.8	1.0	0.9	0.3	1.3	1.0	1.2	0.3
Family relationship satisfaction	2.4	2.9	5.2	1.5	2.3	0.5	2.0	1.7	-1.6	2.1	1.6	2.2	1.8	1.9	0.2	1.3
Leg pain on walking	2.0	2.5	6.5	1.5	1.0	0.9	1.8	1.8	-1.2	1.6	1.6	0.9	2.0	1.5	1.3	2.5
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	4.6	1.9	1.3	0.9	1.4	1.2	-1.6	1.8	1.0	1.2	1.8	1.8	-0.3	2.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.7	-0.2	-0.6	-1.4	-0.8	-1.1	-0.0	-0.4	-1.0	-0.7	-0.6	-0.1	-1.7	-0.9
Illness, injury, bereavement, stress in last 2 years	2.8	3.4	5.3	-1.6	-2.3	-0.5	-2.0	-1.8	1.4	-2.2	-2.0	-2.3	-2.0	-2.0	-1.0	-2.0
Medication: Aspirin	0.2	0.2	0.6	0.1	-0.3	0.8	-0.6	-0.8	-0.2	-0.1	-0.7	-0.3	-0.3	-0.0	-0.5	-0.4
Supplements: Vitamin C	9.8	11.6	16.2	-3.7	-3.0	-0.9	-4.0	-3.3	3.0	-3.9	-3.8	-2.9	-3.8	-3.6	-3.1	-4.0
Knee pain experienced in last month	0.1	0.1	0.3	-0.4	0.3	-0.4	0.1	0.4	0.1	-0.2	0.2	0.3	0.0	-0.3	0.1	0.6
Hypertension (Self-reported)	2.3	6.5	16.2	-0.7	-2.3	-0.7	-3.0	-3.8	0.0	-1.7	-3.9	-2.3	-1.9	-1.0	-4.0	-3.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.0	0.5	-0.3	0.1	0.3	0.2	0.1	0.2	0.5	0.1	0.1	-0.1	0.2
Illnesses of father: Heart disease	3.6	5.0	10.8	-1.3	-2.7	-0.1	-2.7	-2.7	0.7	-2.1	-3.3	-2.7	-2.1	-1.5	-2.9	-1.8
Illnesses of siblings: Diabetes	0.3	0.4	1.2	0.8	0.2	0.5	0.2	-0.5	-1.0	0.8	-0.2	0.2	0.5	0.9	-1.1	-0.1
Smoking status: Previous	1.1	1.6	5.4	0.1	-2.3	0.2	-1.0	-1.8	-0.7	-0.7	-1.7	-2.3	-0.6	-0.2	-0.9	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	3.3	6.8	14.5	-3.6	-2.1	-1.8	-2.6	-1.1	3.8	-3.2	-1.6	-2.1	-2.8	-3.4	0.0	-2.8
Whole body fat-free mass	0.1	0.4	0.9	-0.8	0.6	0.9	0.0	0.6	0.9	-0.2	0.5	0.6	-0.2	-0.5	0.9	0.1
Leg fat-free mass (right)	0.3	1.4	4.8	-2.0	-0.4	0.7	-1.0	0.1	2.2	-1.5	-0.2	-0.4	-1.3	-1.8	0.9	-0.7
Arm fat percentage (left)	0.8	3.4	7.0	-1.2	-2.6	-1.3	-2.1	-1.6	0.9	-1.9	-2.3	-2.6	-1.9	-1.6	-1.2	-1.5
Average weekly red wine intake	0.3	0.4	2.0	-0.2	-1.4	-0.3	-0.6	-0.1	-0.0	-0.4	-0.7	-1.4	-0.2	-0.2	0.3	-0.4
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.5	-0.5	0.6	1.2	-0.4	-0.2	0.5	-0.4	-0.1	0.6	-0.6	-0.5	-0.4	-0.7
Mood swings	0.7	1.2	2.2	-1.4	-0.7	-0.5	-1.2	-1.1	0.6	-1.5	-1.0	-0.6	-1.5	-1.4	-0.7	-1.2
Loneliness, isolation	2.3	3.1	7.7	0.8	2.8	1.0	1.7	1.8	-0.5	1.9	1.9	2.8	1.5	1.5	-0.3	2.3
Long-standing illness, disability or infirmity	0.3	0.4	1.8	-0.2	1.3	-0.9	0.3	0.6	0.4	0.0	0.5	1.3	0.1	-0.1	0.2	0.0
Ever had bowel cancer screening	1.9	2.2	5.3	-1.3	-1.4	0.4	-1.6	-1.8	0.6	-1.6	-1.6	-1.4	-1.7	-1.4	-1.0	-2.3
Diabetes diagnosed by doctor	2.8	4.7	9.8	1.0	2.4	-0.3	2.6	3.0	-0.4	1.6	3.1	2.3	1.7	1.0	3.0	2.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	1.6	0.0	0.0	1.3	0.3	0.7	-0.2	0.1	0.4	0.0	0.3	0.1	0.7	0.2
Friendships satisfaction	1.9	2.4	8.2	0.3	2.9	0.7	1.6	1.8	0.2	1.1	2.0	2.9	0.8	0.6	0.7	1.0
Qualifications: nursing, teaching	6.6	10.2	15.1	3.7	2.2	0.5	3.7	3.3	-3.5	3.6	3.2	2.1	3.9	3.6	3.0	3.4
Commuting to job workplace: Walk	0.2	0.3	1.4	-0.6	-0.2	-1.2	-0.2	-0.3	0.5	-0.5	0.0	-0.2	-0.3	-0.6	0.6	-0.3
Eye problems/disorders: Cataract	0.8	1.0	2.6	-1.4	0.1	0.7	-1.0	-1.1	1.6	-1.0	-0.5	0.2	-1.0	-1.2	-0.9	-0.8
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	4.4	-1.7	0.7	-2.0	-0.6	-0.3	2.1	-1.3	-0.0	0.7	-1.3	-1.5	-0.3	-0.6
Medication for cholesterol	0.3	0.4	1.0	0.7	-0.7	-0.3	0.6	0.5	-0.8	0.3	0.4	-0.7	0.7	0.4	1.0	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	2.2	-0.8	-0.1	1.5	-0.6	-0.2	1.1	-0.4	-0.5	-0.1	-0.6	-0.5	-1.4	0.4
Back pain experienced in last month	1.0	1.4	3.8	0.7	1.9	1.6	1.1	0.9	-0.6	1.1	1.0	2.0	1.0	1.1	-0.0	0.9
Mineral and other dietary supplements	1.8	2.5	4.8	1.4	2.2	0.2	1.8	1.7	-1.2	1.9	1.7	2.2	1.4	1.7	1.1	0.8
Breast cancer (self-reported)	0.8	1.0	1.5	-0.9	-0.9	0.9	-1.2	-1.0	1.0	-1.1	-1.1	-0.8	-1.0	-1.0	-0.8	-1.0
Asthma (self-reported)	0.5	1.1	4.1	-0.3	2.0	0.4	0.7	1.4	0.6	0.4	1.3	2.0	0.3	0.1	1.0	0.2
Osteoporosis (self-reported)	0.1	0.1	0.4	0.2	0.4	0.6	-0.0	-0.2	-0.0	0.1	-0.1	0.4	0.0	0.0	-0.7	-0.6
Osteoarthritis (self-reported)	0.7	0.9	3.2	0.9	0.9	1.8	0.8	1.0	-0.6	0.8	0.5	0.9	1.0	0.8	-0.3	1.3
Medication: Aspirin	0.1	0.2	0.7	0.3	0.2	0.8	-0.4	-0.5	-0.3	0.3	-0.6	0.3	-0.1	0.4	-0.8	0.1
Medication: Gliclazide	1.0	1.1	4.2	-0.9	-1.1	-2.1	-0.7	-0.1	1.1	-1.2	-0.3	-1.2	-1.0	-1.3	0.9	-0.6
Illnesses of father: None of the above (group 1)	5.2	6.5	13.4	1.4	2.7	0.3	2.9	3.7	-0.7	2.3	3.4	2.6	2.6	1.8	3.4	2.7
Smoking status: Current	0.9	1.5	4.7	0.9	1.0	2.2	1.2	1.2	-0.7	1.0	1.2	1.1	1.2	0.9	0.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.0	4.3	10.4	-0.3	3.0	-0.6	2.0	3.2	1.0	0.8	3.1	2.9	0.9	0.1	3.0	1.7
Whole body water mass	0.1	0.3	0.8	-0.7	0.6	0.9	0.1	0.6	0.8	-0.2	0.6	0.6	-0.1	-0.4	0.9	0.1
Leg predicted mass (right)	0.3	1.4	4.6	-1.9	-0.4	0.7	-1.0	0.1	2.1	-1.5	-0.2	-0.4	-1.3	-1.7	0.9	-0.7
Arm fat mass (left)	0.5	1.9	3.8	-1.0	-1.9	-0.5	-1.7	-1.2	0.9	-1.5	-1.8	-1.9	-1.4	-1.3	-0.9	-1.1
Number of self-reported non-cancer illnesses	2.8	4.9	8.9	-2.9	-0.8	-0.7	-2.6	-1.7	3.0	-2.7	-2.0	-0.8	-2.7	-2.8	-1.6	-2.4
Average weekly champagne plus white wine intake	0.2	0.3	0.9	-1.0	-0.2	-0.1	-0.3	0.5	0.8	-0.6	0.3	-0.3	-0.4	-0.7	0.8	-0.1
Miserableness	0.1	0.2	0.4	-0.4	0.5	-0.3	0.3	0.6	-0.1	-0.2	0.4	0.5	-0.2	-0.3	0.6	0.3
Guilty feelings	0.4	0.6	2.3	-0.9	-0.0	1.1	-0.7	-0.9	0.3	-0.6	-0.6	-0.0	-0.9	-0.7	-1.5	-0.5
Wears glasses or contact lenses	2.0	2.3	5.2	-0.8	-1.9	-0.9	-1.6	-2.3	0.1	-1.1	-1.8	-1.8	-1.3	-1.0	-1.7	-1.8
Ever taken oral contraceptive pill	1.2	1.3	4.9	2.0	-0.4	0.6	0.7	-0.1	-2.2	1.3	-0.3	-0.4	1.4	1.8	-0.3	-0.2
Hearing aid user	0.3	0.3	1.2	0.9	-0.3	-0.4	0.5	0.0	-0.5	0.5	0.3	-0.3	0.7	0.6	0.7	1.1
Mother’s age at death	0.2	0.3	1.3	-0.3	-0.4	-0.9	0.1	0.1	0.5	-0.5	0.5	-0.5	-0.0	-0.6	1.1	0.0
Financial situation satisfaction	3.1	3.8	7.2	1.4	2.7	0.1	2.1	2.1	-1.2	2.0	2.1	2.7	2.0	1.9	0.6	2.5
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.4	-1.2	-1.9	-0.0	-1.1	-0.5	1.5	-1.5	-0.9	-1.9	-1.1	-1.5	0.4	-0.2
Commuting to job workplace: Public transport	0.7	0.8	2.4	-0.7	1.3	1.5	0.3	0.5	1.2	-0.1	1.0	1.3	-0.1	-0.5	1.0	-0.2
Eye problems/disorders: Glaucoma	1.0	1.1	5.0	0.1	-0.5	2.2	-0.9	-1.2	-0.2	-0.2	-1.5	-0.5	-0.5	0.1	-2.0	-0.8
Medication: Blood pressure	1.3	2.4	6.8	-1.0	-0.6	-0.7	-2.0	-2.2	0.7	-1.3	-2.2	-0.6	-1.6	-1.0	-2.6	-1.9
Pain type(s) experienced in last month: Hip pain	0.0	0.0	0.2	0.1	-0.0	0.1	0.1	0.5	-0.2	0.1	-0.0	-0.1	0.3	0.1	0.1	0.4
Supplements: Fish oil (including cod liver oil)	2.5	3.2	4.6	-1.7	-2.1	0.1	-2.2	-1.9	1.6	-2.1	-1.9	-2.1	-1.8	-2.1	-1.6	-1.3
High cholesterol (Self-reported)	0.1	0.2	0.7	-0.8	0.5	0.7	-0.0	0.3	0.6	-0.2	0.4	0.5	-0.4	-0.5	-0.2	0.5
Medication: Bendroflumethiazide	0.7	1.0	3.4	-0.5	-0.8	-0.2	-1.3	-1.3	0.6	-0.7	-1.4	-0.8	-0.9	-0.7	-1.8	-0.7
Medication: Paracetamol	0.4	0.6	3.5	0.3	-0.5	1.0	-0.5	-1.1	-0.5	-0.2	-1.0	-0.5	-0.0	0.0	-1.9	0.1
Medication: Lisinopril	1.0	1.3	4.0	-0.5	-1.2	0.6	-1.2	-1.9	0.6	-1.0	-1.2	-1.2	-1.0	-0.8	-0.6	-2.0
Medication: Atorvastatin	0.2	0.2	0.6	-0.7	0.1	-0.3	-0.5	-0.2	0.8	-0.5	-0.1	0.1	-0.6	-0.5	0.1	-0.6
Illnesses of father: High blood pressure	1.3	1.6	2.7	-1.1	-1.3	-1.2	-1.5	-1.6	0.9	-1.2	-1.5	-1.3	-1.5	-1.2	-1.2	-0.8
Alcohol drinker status: Never	1.1	1.3	3.3	0.1	1.8	-0.7	1.2	1.3	-0.1	0.9	1.8	1.8	0.7	0.5	1.0	1.1
Ever smoked	0.4	0.8	2.3	1.0	-1.3	1.2	0.1	-0.7	-1.5	0.4	-0.7	-1.3	0.5	0.7	-0.4	0.0
Basal metabolic rate	0.1	0.4	1.3	-1.0	0.0	0.6	-0.5	0.2	1.1	-0.7	-0.1	0.1	-0.6	-0.8	0.5	-0.3
Leg fat percentage (left)	0.1	0.5	1.7	1.0	-0.8	-0.7	-0.0	-0.3	-1.3	0.4	-0.7	-0.8	0.4	0.7	-0.7	0.7
Arm fat-free mass (left)	0.3	1.3	2.7	0.7	1.3	1.6	1.1	1.3	-0.5	1.1	1.1	1.3	1.1	1.0	1.1	1.2
Number of operations (self-reported)	0.6	0.9	3.3	-1.1	-0.3	-1.8	-0.9	-0.6	1.1	-1.1	-0.7	-0.4	-1.2	-1.2	-0.7	-0.4
Average weekly beer plus cider intake	1.0	1.5	6.9	1.7	-1.1	2.6	0.4	-0.2	-1.8	0.9	-0.2	-1.2	1.0	1.3	0.1	0.2
Irritability	0.5	0.9	4.0	-0.4	1.9	-0.5	0.8	1.0	0.1	0.4	1.0	2.0	0.5	0.2	0.6	0.7
Risk taking	1.7	2.4	5.2	-2.3	-1.4	0.5	-1.6	-0.5	2.2	-2.0	-0.9	-1.3	-2.1	-2.2	-0.1	-0.6
Ever had prostate specific antigen (PSA) test	3.0	3.5	7.5	-2.7	-0.0	-2.7	-1.8	-1.0	2.7	-2.1	-0.9	0.0	-2.4	-2.5	-0.8	-1.3
Fractured/broken bones in last 5 years	0.6	0.8	2.8	-1.5	0.5	0.4	-0.6	-0.0	1.7	-1.0	0.2	0.5	-0.9	-1.2	0.6	-0.8
Age started oral contraceptive pill	4.2	5.3	8.6	-1.9	-2.6	-2.6	-2.5	-2.5	1.2	-2.3	-2.4	-2.5	-2.3	-2.1	-1.4	-2.9
Diastolic blood pressure, automated reading	0.4	1.2	3.1	1.5	-0.8	1.8	-0.1	-1.0	-1.8	0.5	-1.0	-0.8	0.6	1.0	-1.3	-0.7
Ever depressed for a whole week	1.0	1.3	3.5	-0.0	1.9	-0.9	1.1	1.5	0.2	0.9	1.4	1.8	0.7	0.5	0.3	1.2
Unable to work because of sickness or disability	1.3	1.7	5.2	0.7	2.2	0.9	1.4	1.2	-0.5	1.4	1.6	2.3	1.1	1.0	-0.0	0.8
Commuting to job workplace: Cycle	0.5	0.6	1.4	0.3	0.5	0.7	1.0	1.2	-0.5	0.5	1.1	0.4	0.7	0.5	1.2	1.0
Myopia	0.4	0.5	1.5	1.0	-0.7	0.7	0.5	0.3	-1.2	0.8	0.3	-0.7	0.9	0.9	0.2	0.6
Vascular/heart problems diagnosed by doctor	2.5	6.7	15.8	0.8	2.5	0.4	3.1	4.0	-0.0	1.9	3.9	2.5	2.1	1.2	3.6	3.2
Cholesterol lowering medication	0.6	0.9	2.2	-0.6	1.2	1.1	0.7	1.2	0.6	0.1	1.4	1.1	0.1	-0.3	1.5	0.8
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	1.1	-0.6	-0.5	-0.4	-0.9	-0.9	0.3	-0.7	-0.9	-0.5	-1.0	-0.7	-1.0	-1.0
Pain experienced in last month	0.2	0.3	2.5	0.6	-0.6	-1.6	0.1	0.0	-0.3	0.4	0.0	-0.6	0.3	0.3	0.1	0.4
Supplements: Calcium	0.1	0.1	0.5	-0.1	0.6	-0.6	0.2	0.0	0.2	0.1	0.3	0.7	0.1	0.0	0.1	-0.5
Basal cell carcinoma (self-reported)	2.2	2.6	4.1	-1.5	-1.7	0.6	-2.0	-1.6	1.6	-1.6	-1.7	-1.7	-1.7	-1.6	-1.9	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.1	1.0	0.4	0.2	0.6	0.4	-1.0	0.8	0.1	0.4	0.8	1.0	-0.0	0.7
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	-1.3	0.1	-0.3	-0.9	-0.3	1.1	-0.7	-0.5	0.1	-1.1	-1.0	-1.1	-0.2
Heart disease (siblings)	3.8	4.7	10.3	-0.5	-2.8	0.7	-2.1	-3.2	-0.6	-1.4	-2.9	-2.8	-1.8	-1.0	-3.2	-2.0
Alcohol drinker status: Previous	0.4	0.5	1.3	-0.3	-1.0	-1.1	-0.6	-0.6	0.5	-0.6	-0.7	-1.0	-0.5	-0.5	-0.4	-0.9
Pack years of smoking	1.3	1.8	2.9	1.7	1.4	0.9	1.4	1.1	-1.3	1.6	0.9	1.5	1.6	1.7	0.2	1.6
Impedance of whole body	6.9	35.0	47.9	-5.6	-5.9	-3.9	-6.7	-5.8	5.0	-6.5	-6.3	-5.9	-6.8	-6.2	-4.4	-6.9
Leg fat mass (left)	0.2	0.6	1.7	-0.0	-1.3	-0.6	-0.9	-0.9	-0.2	-0.6	-1.3	-1.3	-0.5	-0.3	-0.9	-0.3
Arm predicted mass (left)	0.2	1.0	2.0	0.6	1.2	1.4	1.0	1.1	-0.4	0.9	1.0	1.2	1.0	0.8	0.8	1.0