[Hub]/) : Traits : Heel T-Score : ← →

chr1:118,878,656-120,517,959

Best TWAS P=2.49e-27 · Best GWAS P=1.6e-38 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	RP11-418J17.1	0.32	0.40	lasso	7	0.39	4.9e-34	4.9	-5.2	1.7e-07	-0.60	1.00	0.00	FALSE
2	GTEx	Artery Coronary	RP11-418J17.1	0.38	0.31	lasso	7	0.30	7.8e-11	6.5	-6.4	1.2e-10	-0.68	1.00	0.00	FALSE
3	GTEx	Brain Caudate basal ganglia	WARS2	0.38	0.14	lasso	5	0.26	5.7e-08	6.5	-5.5	4.3e-08	-0.60	0.57	0.21	FALSE
4	GTEx	Brain Caudate basal ganglia	RP11-418J17.1	0.25	0.26	lasso	8	0.25	7.1e-08	4.9	-6.0	2.0e-09	-0.61	0.77	0.04	FALSE
5	GTEx	Brain Cerebellar Hemisphere	WARS2	0.51	0.32	enet	34	0.44	1.6e-12	1.4	-5.4	6.3e-08	-0.60	0.94	0.02	FALSE
6	GTEx	Brain Cerebellar Hemisphere	RP11-418J17.1	0.48	0.38	enet	31	0.39	3.5e-11	4.9	-5.9	4.0e-09	-0.62	0.93	0.05	FALSE
7	GTEx	Brain Cerebellum	RP11-418J17.1	0.45	0.34	enet	18	0.46	1.9e-15	5.0	-7.4	1.7e-13	-0.70	1.00	0.00	TRUE
8	GTEx	Brain Cortex	WARS2	0.40	0.16	enet	31	0.34	3.6e-10	1.4	-5.4	8.4e-08	-0.61	0.36	0.50	FALSE
9	GTEx	Brain Cortex	RP11-418J17.1	0.18	0.21	lasso	8	0.13	2.2e-04	4.9	-5.4	6.6e-08	-0.62	0.27	0.34	FALSE
10	GTEx	Brain Hippocampus	WARS2	0.23	0.06	lasso	4	0.11	1.8e-03	8.3	5.6	1.8e-08	-0.11	0.07	0.12	FALSE
11	GTEx	Brain Hippocampus	RP11-418J17.1	0.33	0.18	lasso	8	0.08	8.0e-03	5.0	-5.3	1.2e-07	-0.58	0.12	0.06	FALSE
12	GTEx	Brain Hypothalamus	WARS2	0.28	0.15	enet	13	0.25	1.1e-06	6.5	-6.7	2.8e-11	-0.66	0.26	0.30	FALSE
13	GTEx	Brain Hypothalamus	RP11-418J17.1	0.40	0.31	lasso	8	0.34	8.4e-09	4.9	-6.2	7.9e-10	-0.60	0.64	0.04	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	RP11-418J17.1	0.25	0.07	lasso	4	0.12	3.6e-04	6.5	-7.2	7.1e-13	-0.69	0.36	0.14	FALSE
15	GTEx	Brain Putamen basal ganglia	WARS2	0.44	0.23	lasso	4	0.35	3.3e-09	6.6	-5.4	8.3e-08	-0.61	0.31	0.32	FALSE
16	GTEx	Brain Putamen basal ganglia	RP11-418J17.1	0.49	0.26	lasso	10	0.37	1.3e-09	5.0	-6.5	6.1e-11	-0.61	0.62	0.25	TRUE
17	GTEx	Breast Mammary Tissue	RP11-418J17.1	0.42	0.38	lasso	6	0.38	1.1e-20	4.9	-5.2	1.8e-07	-0.57	1.00	0.00	FALSE
18	GTEx	Breast Mammary Tissue (Male)	WARS2	0.34	0.16	lasso	2	0.22	8.3e-06	6.6	-5.2	1.7e-07	-0.61	0.20	0.10	FALSE
19	GTEx	Breast Mammary Tissue (Male)	RP11-418J17.1	0.31	0.24	lasso	4	0.20	1.7e-05	5.0	-5.9	4.4e-09	-0.62	0.32	0.47	FALSE
20	GTEx	Breast Mammary Tissue (Female)	WARS2	0.37	0.23	lasso	6	0.20	1.1e-06	6.6	-6.9	4.1e-12	-0.68	0.28	0.21	FALSE
21	GTEx	Breast Mammary Tissue (Female)	RP11-418J17.1	0.27	0.28	lasso	9	0.24	6.7e-08	5.0	-5.8	6.6e-09	-0.56	0.92	0.01	FALSE
22	GTEx	Cells EBV-transformed lymphocytes	WARS2	0.34	0.36	lasso	9	0.39	1.2e-13	6.6	-7.3	2.3e-13	-0.72	0.28	0.71	FALSE
23	GTEx	Cells EBV-transformed lymphocytes	RP11-418J17.1	0.19	0.15	lasso	6	0.10	2.9e-04	6.5	-6.3	2.2e-10	-0.68	0.49	0.26	FALSE
24	GTEx	Colon Transverse	WARS2	0.20	0.25	lasso	4	0.26	1.8e-12	6.6	-6.3	3.0e-10	-0.67	0.90	0.10	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	WARS2	0.36	0.12	enet	9	0.29	5.0e-11	1.4	-7.2	8.4e-13	-0.68	0.14	0.86	TRUE
26	GTEx	Esophagus Mucosa	RP11-418J17.1	0.42	0.38	lasso	6	0.38	5.4e-27	4.9	-5.5	2.8e-08	-0.60	1.00	0.00	TRUE
27	GTEx	Heart Left Ventricle	WARS2	0.14	0.15	enet	3	0.10	3.9e-06	6.6	-5.3	1.3e-07	-0.60	0.96	0.01	FALSE
28	GTEx	Lung	WARS2	0.45	0.36	lasso	3	0.48	1.2e-41	6.6	-5.3	1.2e-07	-0.59	1.00	0.00	FALSE
29	GTEx	Lung	RP11-418J17.1	0.38	0.39	lasso	13	0.40	6.1e-33	4.9	-6.0	2.7e-09	-0.65	1.00	0.00	FALSE
30	GTEx	Nerve Tibial	WARS2	0.49	0.43	lasso	8	0.49	9.6e-39	6.6	-7.0	2.2e-12	-0.67	1.00	0.00	FALSE
31	GTEx	Ovary	WARS2	0.27	0.11	lasso	3	0.18	3.2e-05	6.6	-6.7	2.1e-11	-0.67	0.12	0.32	FALSE
32	GTEx	Pancreas	WARS2	0.33	0.14	lasso	8	0.28	3.8e-12	6.6	-6.7	2.0e-11	-0.63	0.87	0.13	TRUE
33	GTEx	Pituitary	RP11-418J17.1	0.33	0.22	enet	15	0.22	3.6e-06	6.5	-5.5	2.9e-08	-0.63	0.72	0.02	FALSE
34	GTEx	Prostate	WARS2	0.36	0.29	lasso	5	0.19	1.6e-05	6.6	-5.2	2.6e-07	-0.65	0.65	0.12	FALSE
35	GTEx	Small Intestine Terminal Ileum	RP11-418J17.1	0.46	0.09	enet	12	0.00	3.9e-01	6.6	-5.4	7.4e-08	-0.60	0.15	0.24	TRUE
36	GTEx	Spleen	RP11-418J17.1	0.45	0.36	lasso	15	0.38	1.3e-10	5.0	-5.8	6.3e-09	-0.64	0.87	0.12	FALSE
37	GTEx	Testis	WARS2	0.25	0.17	lasso	3	0.17	4.3e-08	8.5	10.8	2.5e-27	0.64	0.49	0.46	TRUE
38	GTEx	Vagina	RP11-418J17.1	0.24	0.10	lasso	9	0.13	8.5e-04	6.5	-6.0	2.4e-09	-0.61	0.31	0.11	FALSE
39	ROSMAP	Brain Pre-frontal Cortex	RP11-418J17.1	0.19	0.23	lasso	10	0.23	4.4e-29	4.9	-6.2	5.9e-10	-0.66	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WARS2	0.10	0.08	lasso	5	0.12	2.0e-10	6.6	-5.3	9.1e-08	-0.63	0.95	0.05	FALSE
41	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	WARS2	0.13	0.14	lasso	6	0.12	1.9e-06	6.5	-6.1	8.7e-10	-0.67	0.27	0.72	FALSE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	WARS2	0.31	0.34	enet	15	0.38	1.5e-23	6.5	-6.7	2.6e-11	-0.66	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	WARS2	0.40	0.38	enet	20	0.50	2.4e-65	1.4	-5.7	9.5e-09	-0.60	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WARS2	0.12	0.04	blup	73	0.06	5.6e-04	6.5	-5.6	1.7e-08	-0.60	0.13	0.62	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WARS2	0.13	0.12	lasso	3	0.14	4.8e-16	6.5	-5.3	1.3e-07	-0.62	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Skin Cutaneous Melanoma	WARS2	0.30	0.12	blup	73	0.29	2.3e-08	1.4	-5.6	1.8e-08	-0.59	0.10	0.83	FALSE