[Hub]/) : Traits : Heel T-Score : ← →

chr1:149,672,809-152,424,848

Best TWAS P=6.24e-17 · Best GWAS P=1.73e-19 conditioned to 0

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CTSS	0.04	0.01	bslmm	313	0.02	5.5e-04	-5.959	6.6	3.9e-11	-0.28	0.08	0.84	FALSE
2	GTEx	Adipose Subcutaneous	SEMA6C	0.12	0.11	lasso	2	0.11	1.8e-09	-5.515	-5.5	3.4e-08	0.28	0.65	0.35	FALSE
3	GTEx	Adipose Subcutaneous	SV2A	0.08	0.00	lasso	5	0.02	5.2e-03	2.622	7.2	4.1e-13	-0.58	0.03	0.53	FALSE
4	GTEx	Adipose Subcutaneous	RP11-196G18.22	0.13	0.02	enet	16	0.06	6.4e-06	0.871	6.7	2.3e-11	-0.52	0.01	0.88	TRUE
5	GTEx	Adipose Subcutaneous	RP11-196G18.24	0.18	0.06	lasso	3	0.10	2.7e-08	-7.512	6.2	4.4e-10	-0.61	0.04	0.92	FALSE
6	GTEx	Artery Aorta	HIST2H2BF	0.07	0.00	lasso	5	0.00	2.0e-01	-7.059	-7.0	2.0e-12	0.92	0.01	0.90	FALSE
7	GTEx	Artery Tibial	SV2A	0.08	0.07	enet	7	0.07	2.5e-06	-6.242	7.4	1.0e-13	-0.87	0.12	0.87	FALSE
8	GTEx	Artery Tibial	HIST2H2AA3	0.22	0.02	enet	20	0.12	1.8e-09	6.327	7.7	1.3e-14	-0.47	0.34	0.55	FALSE
9	GTEx	Artery Tibial	RP11-196G18.22	0.25	0.05	lasso	5	0.07	1.8e-06	5.717	8.4	6.2e-17	-0.46	0.44	0.32	TRUE
10	GTEx	Artery Tibial	RP11-196G18.24	0.31	0.08	enet	26	0.10	6.1e-08	6.327	7.5	6.3e-14	-0.34	0.67	0.14	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	CTSS	0.28	0.22	lasso	8	0.30	3.0e-10	4.615	5.3	1.3e-07	-0.14	0.96	0.04	FALSE
12	GTEx	Cells Transformed fibroblasts	SV2A	0.23	0.23	lasso	6	0.25	1.7e-18	-6.814	7.1	1.3e-12	-0.89	0.98	0.02	FALSE
13	GTEx	Colon Transverse	SV2A	0.09	0.00	lasso	9	0.00	2.2e-01	-9.029	6.2	5.0e-10	-0.78	0.01	0.82	FALSE
14	GTEx	Colon Transverse	CTSS	0.10	0.15	lasso	4	0.16	2.7e-08	-6.325	7.1	1.3e-12	-0.37	0.02	0.97	FALSE
15	GTEx	Esophagus Muscularis	SV2A	0.15	0.18	enet	16	0.18	6.4e-11	-6.814	7.5	6.3e-14	-0.91	0.11	0.89	FALSE
16	GTEx	Esophagus Muscularis	CTSS	0.05	0.04	enet	12	0.06	1.2e-04	4.615	6.1	9.2e-10	-0.18	0.05	0.93	FALSE
17	GTEx	Esophagus Muscularis	BOLA1	0.07	0.00	lasso	4	0.00	2.5e-01	-5.915	5.3	9.2e-08	-0.56	0.03	0.11	FALSE
18	GTEx	Esophagus Muscularis	HIST2H2AA3	0.18	0.02	lasso	4	0.03	5.4e-03	-9.029	7.0	2.9e-12	-0.81	0.00	0.94	FALSE
19	GTEx	Esophagus Muscularis	RP11-196G18.22	0.18	0.02	enet	9	0.01	1.2e-01	-3.872	6.7	2.0e-11	-0.66	0.02	0.72	FALSE
20	GTEx	Esophagus Muscularis	RP11-196G18.24	0.15	0.00	enet	17	0.00	7.3e-01	-3.872	5.9	3.1e-09	-0.69	0.01	0.69	FALSE
21	GTEx	Heart Atrial Appendage	SV2A	0.17	0.06	enet	9	0.05	1.9e-03	-7.081	7.2	6.6e-13	-0.88	0.07	0.90	FALSE
22	GTEx	Heart Atrial Appendage	MRPS21	0.16	0.08	lasso	11	0.11	9.3e-06	3.109	-5.4	6.0e-08	0.40	0.79	0.07	FALSE
23	GTEx	Heart Left Ventricle	MTMR11	0.11	0.05	lasso	3	0.05	9.3e-04	-5.915	-7.0	2.4e-12	0.74	0.15	0.34	FALSE
24	GTEx	Lung	SV2A	0.08	0.03	enet	7	0.03	1.8e-03	-7.001	7.0	2.3e-12	-0.85	0.04	0.93	FALSE
25	GTEx	Muscle Skeletal	CTSS	0.04	0.01	enet	13	0.03	1.4e-03	4.088	6.2	4.1e-10	-0.17	0.38	0.26	FALSE
26	GTEx	Nerve Tibial	SV2A	0.08	0.03	lasso	4	0.04	5.2e-04	-6.814	7.7	1.5e-14	-0.93	0.01	0.96	FALSE
27	GTEx	Ovary	SEMA6C	0.29	0.13	enet	11	0.14	2.6e-04	-5.959	-5.8	5.7e-09	0.26	0.13	0.32	FALSE
28	GTEx	Pituitary	OAZ3	0.29	0.10	enet	9	0.12	6.1e-04	5.092	5.3	1.2e-07	-0.03	0.01	0.95	TRUE
29	GTEx	Prostate	GOLPH3L	0.47	0.01	lasso	7	0.00	3.2e-01	-5.959	-5.4	5.3e-08	0.22	0.05	0.11	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ANXA9	0.11	0.12	lasso	2	0.13	2.0e-07	-6.621	6.8	1.3e-11	-0.16	0.00	0.99	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	SEMA6C	0.13	0.10	lasso	4	0.07	7.4e-05	-5.331	-5.2	1.9e-07	0.30	0.40	0.54	FALSE
32	GTEx	Skin Sun Exposed Lower leg	MTMR11	0.03	0.01	lasso	5	0.00	1.2e-01	-5.915	-7.0	2.6e-12	0.79	0.02	0.56	FALSE
33	GTEx	Skin Sun Exposed Lower leg	ANXA9	0.12	0.04	lasso	3	0.08	3.8e-07	-6.342	6.5	6.2e-11	-0.17	0.00	1.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	SEMA6C	0.10	0.07	lasso	5	0.04	2.6e-04	-5.331	-5.4	5.9e-08	0.31	0.67	0.28	FALSE
35	GTEx	Skin Sun Exposed Lower leg	SV2A	0.07	0.00	enet	15	0.02	6.0e-03	-7.081	5.7	1.5e-08	-0.62	0.04	0.47	TRUE
36	GTEx	Skin Sun Exposed Lower leg	CTSS	0.19	0.02	lasso	8	0.08	1.9e-07	0.083	5.3	9.7e-08	-0.10	0.07	0.93	TRUE
37	GTEx	Testis	ANXA9	0.30	0.19	enet	22	0.15	2.7e-07	-6.342	5.8	7.7e-09	-0.19	0.00	1.00	FALSE
38	GTEx	Thyroid	MTMR11	0.09	0.05	enet	9	0.06	1.5e-05	-5.985	-5.9	4.1e-09	0.66	0.21	0.53	FALSE
39	GTEx	Thyroid	ANXA9	0.10	0.06	lasso	3	0.05	2.0e-04	-5.620	5.7	1.3e-08	-0.07	0.19	0.25	FALSE
40	GTEx	Thyroid	SEMA6C	0.21	0.13	lasso	5	0.14	3.5e-11	-5.959	-5.6	2.1e-08	0.28	0.22	0.78	FALSE
41	GTEx	Thyroid	CTSS	0.15	0.12	enet	30	0.18	2.4e-13	4.038	5.7	1.0e-08	-0.19	1.00	0.00	FALSE
42	GTEx	Uterus	RP11-316M1.12	0.28	0.18	lasso	3	0.19	1.0e-04	4.038	-5.1	2.8e-07	0.14	0.55	0.10	FALSE
43	METSIM	Adipose	SV2A	0.02	0.03	enet	5	0.02	2.3e-04	-6.814	6.9	3.9e-12	-0.91	0.05	0.84	FALSE
44	NTR	Blood	MTMR11	0.03	0.02	enet	11	0.02	1.3e-07	-6.814	-5.2	2.6e-07	0.76	0.26	0.74	FALSE
45	YFS	Blood	CTSS	0.17	0.11	enet	42	0.17	4.2e-52	4.413	6.3	2.1e-10	-0.15	1.00	0.00	FALSE
46	YFS	Blood	FCGR1A	0.12	0.11	lasso	4	0.11	2.4e-33	-6.242	-6.2	4.2e-10	0.80	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	CTSS	0.02	0.01	enet	4	0.01	2.8e-03	4.264	6.2	4.3e-10	-0.08	0.02	0.90	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	SV2A	0.03	0.02	enet	3	0.02	8.0e-06	-7.104	8.2	1.6e-16	-0.80	0.00	0.99	FALSE
49	The Cancer Genome Atlas	Colon Adenocarcinoma	ENSA	0.10	0.04	lasso	3	0.04	3.1e-03	-4.649	5.5	3.3e-08	-0.21	0.00	0.77	FALSE
50	The Cancer Genome Atlas	Esophageal Carcinoma	HORMAD1	0.31	0.36	enet	32	0.35	7.8e-12	4.272	5.2	2.3e-07	-0.01	0.98	0.02	FALSE
51	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CTSS	0.05	0.03	blup	49	0.04	1.6e-05	4.321	5.2	2.4e-07	-0.06	0.32	0.64	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SV2A	0.03	0.02	lasso	1	0.01	2.8e-02	-6.566	6.6	5.2e-11	-0.86	0.01	0.74	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CTSS	0.04	0.01	enet	4	0.03	4.7e-04	4.615	6.6	3.1e-11	-0.14	0.01	0.96	TRUE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	HIST2H3D	0.03	0.04	lasso	1	0.03	1.3e-04	-7.104	7.1	1.2e-12	-0.83	0.00	0.98	TRUE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SV2A	0.05	0.02	blup	9	0.03	2.5e-04	-5.915	7.4	1.8e-13	-0.78	0.00	0.90	FALSE
56	The Cancer Genome Atlas	Brain Lower Grade Glioma	CTSS	0.29	0.08	lasso	3	0.08	1.5e-09	-6.621	6.9	4.6e-12	-0.16	0.00	1.00	TRUE
57	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	GOLPH3L	0.02	0.02	blup	49	0.01	1.6e-02	4.079	-5.2	1.5e-07	0.02	0.09	0.12	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CTSS	0.16	0.08	enet	8	0.07	1.6e-05	-6.621	6.4	1.4e-10	-0.10	0.00	0.99	TRUE
59	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SV2A	0.13	0.08	lasso	2	0.07	8.4e-04	-7.104	7.1	1.2e-12	-0.83	0.00	0.95	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	GOLPH3L	0.03	0.01	blup	49	0.01	2.2e-02	4.265	-6.0	2.3e-09	0.05	0.02	0.75	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	SV2A	0.11	0.10	blup	9	0.11	3.8e-11	-7.104	7.9	2.6e-15	-0.84	0.00	1.00	FALSE
62	The Cancer Genome Atlas	Skin Cutaneous Melanoma	FCGR1A	0.10	0.03	lasso	4	0.04	3.9e-02	-5.915	7.0	2.2e-12	-0.82	0.01	0.34	FALSE
63	The Cancer Genome Atlas	Thyroid Carcinoma	ANXA9	0.10	0.05	lasso	4	0.04	4.1e-05	-6.585	6.6	4.3e-11	-0.21	0.00	1.00	FALSE