Best TWAS P=8.28e-15 · Best GWAS P=1.08e-17 conditioned to 7.57e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | PAPSS2 | 0.20 | 0.17 | lasso | 6 | 0.15 | 1.9e-12 | -7.9 | 7.3 | 2.8e-13 | 0.04 | 0.18 | 0.82 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PAPSS2 | 0.14 | 0.15 | lasso | 4 | 0.15 | 3.1e-08 | -7.9 | 7.1 | 1.2e-12 | 0.01 | 0.12 | 0.87 | FALSE |
| 3 | GTEx | Heart Left Ventricle | PAPSS2 | 0.11 | 0.12 | lasso | 3 | 0.10 | 5.9e-06 | -8.0 | 7.8 | 8.3e-15 | 0.02 | 0.06 | 0.91 | TRUE |
| 4 | GTEx | Muscle Skeletal | PAPSS2 | 0.24 | 0.20 | lasso | 5 | 0.20 | 8.3e-20 | -7.9 | 7.8 | 8.8e-15 | 0.03 | 0.08 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | PAPSS2 | 0.20 | 0.02 | enet | 18 | 0.03 | 1.6e-02 | 8.6 | -6.8 | 8.6e-12 | -0.61 | 0.00 | 0.68 | TRUE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PAPSS2 | 0.11 | 0.01 | blup | 98 | 0.02 | 1.9e-02 | -4.9 | -7.1 | 1.3e-12 | 0.06 | 0.03 | 0.09 | FALSE |