Best TWAS P=1.02e-17 · Best GWAS P=9.58e-15 conditioned to 0.0265
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TSPAN14 | 0.15 | 0.13 | enet | 17 | 0.15 | 3.2e-18 | -4.7 | 5.2 | 1.8e-07 | 0.00 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | ZCCHC24 | 0.12 | 0.01 | lasso | 6 | 0.03 | 3.4e-03 | -7.4 | -8.5 | 2.7e-17 | 0.80 | 0.01 | 0.97 | TRUE |
| 3 | GTEx | Brain Frontal Cortex BA9 | FAM213A | 0.29 | 0.13 | lasso | 4 | 0.10 | 1.0e-03 | -7.2 | -7.7 | 1.9e-14 | 0.00 | 0.01 | 0.95 | TRUE |
| 4 | GTEx | Brain Frontal Cortex BA9 | RP11-137H2.6 | 0.20 | 0.11 | lasso | 5 | 0.08 | 4.8e-03 | -6.4 | -6.0 | 1.7e-09 | 0.00 | 0.04 | 0.91 | FALSE |
| 5 | GTEx | Esophagus Mucosa | MBL1P | 0.10 | 0.00 | enet | 16 | 0.02 | 1.5e-02 | 3.0 | -5.7 | 1.6e-08 | 0.03 | 0.20 | 0.31 | FALSE |
| 6 | GTEx | Lung | TSPAN14 | 0.07 | 0.02 | lasso | 5 | 0.03 | 1.2e-03 | -4.0 | -6.2 | 4.3e-10 | -0.01 | 0.05 | 0.92 | FALSE |
| 7 | GTEx | Muscle Skeletal | RP11-119F19.2 | 0.12 | 0.03 | lasso | 7 | 0.06 | 2.3e-06 | 3.4 | 5.3 | 1.0e-07 | 0.00 | 0.92 | 0.01 | FALSE |
| 8 | GTEx | Nerve Tibial | RP11-506M13.3 | 0.08 | 0.04 | lasso | 3 | 0.05 | 3.3e-04 | -3.0 | 5.1 | 2.7e-07 | 0.02 | 0.39 | 0.05 | FALSE |
| 9 | GTEx | Pituitary | MBL1P | 0.49 | 0.05 | enet | 36 | 0.12 | 8.4e-04 | -3.0 | -5.4 | 7.1e-08 | -0.01 | 0.21 | 0.10 | FALSE |
| 10 | GTEx | Prostate | MBL1P | 0.24 | 0.02 | lasso | 5 | 0.01 | 2.1e-01 | -2.7 | -6.0 | 2.2e-09 | 0.01 | 0.04 | 0.35 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | ZCCHC24 | 0.09 | 0.00 | enet | 18 | 0.00 | 2.3e-01 | -3.0 | -8.6 | 1.0e-17 | 0.39 | 0.02 | 0.64 | TRUE |
| 12 | GTEx | Testis | FAM213A | 0.14 | 0.08 | lasso | 4 | 0.02 | 2.7e-02 | 5.8 | -6.2 | 6.5e-10 | 0.01 | 0.05 | 0.86 | FALSE |
| 13 | GTEx | Thyroid | FAM213A | 0.11 | 0.05 | lasso | 8 | 0.06 | 1.4e-05 | -6.9 | -6.7 | 1.6e-11 | 0.00 | 0.01 | 0.98 | FALSE |
| 14 | GTEx | Whole Blood | TSPAN14 | 0.08 | 0.08 | enet | 12 | 0.07 | 7.6e-07 | 5.2 | -5.4 | 8.2e-08 | 0.03 | 0.71 | 0.27 | FALSE |
| 15 | METSIM | Adipose | RP11-137H2.6 | 0.11 | 0.11 | lasso | 9 | 0.11 | 1.1e-16 | 5.7 | 5.8 | 5.4e-09 | -0.01 | 0.93 | 0.07 | FALSE |
| 16 | METSIM | Adipose | TSPAN14 | 0.06 | 0.01 | blup | 570 | 0.02 | 2.5e-04 | -7.0 | -5.6 | 1.7e-08 | -0.04 | 0.02 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ZCCHC24 | 0.06 | 0.00 | blup | 89 | 0.01 | 6.2e-02 | -2.3 | -8.2 | 2.1e-16 | 0.48 | 0.01 | 0.18 | FALSE |
| 18 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C10orf58 | 0.02 | 0.03 | enet | 2 | 0.02 | 1.1e-05 | 5.8 | -6.1 | 1.0e-09 | 0.01 | 0.75 | 0.20 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C10orf58 | 0.03 | 0.01 | blup | 65 | 0.01 | 2.9e-02 | -4.4 | -6.2 | 4.0e-10 | -0.03 | 0.02 | 0.61 | FALSE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C10orf58 | 0.04 | 0.01 | blup | 65 | 0.02 | 6.9e-03 | -3.5 | -6.1 | 1.1e-09 | -0.01 | 0.04 | 0.59 | FALSE |
| 21 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ZCCHC24 | 0.07 | 0.05 | enet | 9 | 0.04 | 6.7e-05 | -7.2 | -7.9 | 3.2e-15 | 0.84 | 0.02 | 0.97 | FALSE |
| 22 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DYDC2 | 0.11 | 0.02 | enet | 4 | 0.06 | 1.3e-03 | -4.5 | 6.3 | 2.1e-10 | -0.03 | 0.02 | 0.48 | FALSE |
| 23 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TSPAN14 | 0.17 | 0.02 | blup | 84 | 0.04 | 1.9e-03 | 6.0 | 5.6 | 2.4e-08 | 0.04 | 0.04 | 0.37 | FALSE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | C10orf58 | 0.07 | 0.00 | blup | 65 | 0.03 | 3.8e-04 | -6.0 | -5.5 | 4.7e-08 | 0.01 | 0.08 | 0.45 | FALSE |