Hub : Genes

PAPSS2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.1980 0.0480 4.5e-10 0.173 NA 0.128 NA 0.152 4.3e-14 NA 1.3e-10 NA 2.0e-12
2 GTEx Adipose Visceral Omentum 0.1430 0.0470 1.4e-04 0.153 NA 0.121 NA 0.151 2.3e-08 NA 7.4e-07 NA 3.1e-08
3 GTEx Artery Aorta 0.1220 0.0530 9.9e-03 -0.004 NA -0.005 NA -0.003 5.8e-01 NA 7.6e-01 NA 5.1e-01
4 GTEx Breast Mammary Tissue 0.1090 0.0470 7.9e-03 0.001 NA 0.011 NA 0.006 3.0e-01 NA 8.9e-02 NA 1.6e-01
5 GTEx Breast Mammary Tissue (Female) 0.0946 0.0569 5.9e-02 -0.010 NA -0.010 NA 0.010 9.7e-01 NA 9.5e-01 NA 1.6e-01
6 GTEx Heart Atrial Appendage 0.1970 0.0670 5.9e-04 0.046 NA 0.085 NA 0.092 3.8e-03 NA 1.2e-04 NA 6.5e-05
7 GTEx Heart Left Ventricle 0.1063 0.0439 2.0e-03 0.119 NA 0.085 NA 0.099 7.3e-07 NA 2.8e-05 NA 5.9e-06
8 GTEx Lung 0.1318 0.0482 6.2e-04 0.007 NA 0.012 NA 0.011 9.1e-02 NA 4.1e-02 NA 4.2e-02
9 GTEx Muscle Skeletal 0.2358 0.0472 8.1e-14 0.200 NA 0.203 NA 0.205 2.4e-19 NA 1.3e-19 NA 8.3e-20
10 GTEx Nerve Tibial 0.1165 0.0428 4.2e-03 0.003 NA 0.044 NA 0.021 2.0e-01 NA 4.5e-04 NA 1.1e-02
11 GTEx Skin Sun Exposed Lower leg 0.1020 0.0310 1.3e-05 0.114 NA 0.069 NA 0.099 1.1e-09 NA 2.2e-06 NA 1.5e-08
12 GTEx Thyroid 0.1100 0.0330 3.6e-06 0.011 NA 0.063 NA 0.050 4.8e-02 NA 1.4e-05 NA 1.1e-04
13 METSIM Adipose 0.1090 0.0309 1.8e-07 0.033 0.056 0.068 0.060 0.081 9.7e-06 9.3e-09 1.9e-10 2.2e-09 3.8e-12
14 YFS Blood 0.0833 0.0180 0.0e+00 0.022 0.069 0.070 0.068 0.067 9.4e-08 1.4e-21 6.4e-22 2.1e-21 4.1e-21
15 TCGA Cervical Squamous Cell Carcinoma 0.2020 0.0880 9.3e-03 0.021 0.012 0.028 NA 0.022 3.1e-02 8.1e-02 1.6e-02 NA 3.0e-02
16 TCGA Kidney Renal Papillary Cell Carcinoma 0.1150 0.0570 2.1e-03 0.008 0.022 0.013 NA 0.011 1.1e-01 1.9e-02 5.6e-02 NA 7.1e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
Bipolar Disorder (2018) 0.5 0.7 2.8 0.4 0.4 -0.2 0.3 0.8 0.6 0.3 1.5 0.5 1.3 0.9 0.0 1.7 0.4 0.6 -1.2
Bipolar Disorder or Schizophrenia 0.8 2.0 5.6 1.6 1.5 -1.4 0.9 1.4 1.0 1.4 1.9 1.4 1.1 1.1 1.3 2.4 1.4 -0.3 -1.3
Depressed Affect (Nagel 2018) 0.4 0.9 2.0 -1.2 -1.0 -0.3 -0.9 -1.2 -0.4 -1.1 0.2 -0.8 1.1 -0.8 -0.8 -1.3 -1.4 -1.0 0.7
Depression (Nagel 2018) 0.5 0.8 2.4 -1.2 -1.1 0.6 0.4 0.1 -0.4 -1.3 -1.6 -1.1 1.2 0.2 -0.7 -0.1 -0.5 -0.6 1.0
Intelligence (Savage-Jansen 2018) 1.5 4.6 13.2 -3.2 -3.2 1.0 -0.5 0.5 -2.9 -3.6 -1.1 -3.5 -0.2 -0.3 -1.8 -0.2 0.1 2.0 3.0
Neuroticism (Nagel 2018) 0.4 0.9 2.0 -1.1 -0.9 -0.4 -1.2 -0.8 -0.7 -0.9 0.2 -0.7 1.1 -0.8 -1.4 -0.9 -1.4 -0.7 1.0
Schizophrenia (2018) 0.8 1.6 3.0 1.7 1.6 -1.7 0.9 1.2 0.8 1.6 1.3 1.4 0.4 0.7 1.6 1.7 1.4 -0.8 -0.6
Schizophrenia vs Biploar Disorder 0.3 0.5 2.0 -0.6 -0.8 -0.2 -0.5 -0.4 -0.4 -0.3 -0.2 -0.9 -1.4 -0.7 -0.0 -1.1 0.1 0.8 0.7
Worry (Nagel 2018) 0.1 0.3 1.3 -0.3 -0.2 -0.7 -1.1 0.2 -0.4 -0.0 0.8 -0.1 0.8 -0.2 -0.4 0.1 -0.2 -0.7 0.4
Alzheimer’s Disease (in mother) 1.4 1.6 10.2 -1.0 -1.1 1.5 -1.5 -0.1 -1.0 -0.9 -0.1 -1.1 0.9 -1.6 -0.6 -3.2 -0.8 0.8 -0.3
Alzheimer’s Disease (in father) 0.9 0.9 2.7 0.9 0.9 -1.6 1.5 -0.1 -0.3 1.0 -1.3 0.7 -0.8 -0.1 0.7 1.4 -0.1 1.4 -0.3
Alzheimer’s Disease (including proxy) 0.8 1.1 4.7 -0.6 -0.6 -0.1 -1.0 -0.8 -1.2 -0.3 -0.8 -0.7 0.0 -1.7 -1.0 -2.2 -0.6 1.7 -1.1
Crohns Disease (2017) 0.3 0.6 1.3 0.7 0.9 0.3 1.1 0.2 1.0 0.7 1.0 0.7 1.1 0.2 0.0 0.6 1.0 -0.6 0.6
Irritable Bowel Disease (IBD) 0.2 0.5 2.1 0.0 0.2 0.5 1.5 0.4 0.5 0.2 0.2 -0.0 1.0 0.7 -0.5 0.9 0.4 0.1 1.4
Ulcerative Colitis (UC) 0.2 0.5 2.1 -0.2 -0.2 -0.2 1.3 0.5 -0.2 -0.1 -0.8 -0.3 0.2 0.8 -0.3 1.1 -0.3 0.5 1.4
Major Depression (MDD) 1.6 1.9 5.7 1.6 1.5 1.6 0.9 -0.4 2.2 1.7 1.9 1.6 -0.4 -0.3 0.8 0.8 0.7 -0.4 -2.4
Reaction Time 0.4 0.8 2.9 -0.8 -0.5 0.9 -1.7 -0.9 -0.1 -0.9 1.5 -0.6 0.1 -0.4 -1.3 -1.1 -0.4 -0.5 0.2
Verbal and Numeric Reasoning (VNR) 2.1 5.0 14.1 -3.4 -3.4 1.1 -1.1 0.1 -2.8 -3.8 -0.9 -3.7 -0.3 -0.5 -2.3 -0.8 -0.2 1.5 3.2
Breast Cancer 0.5 1.3 4.6 -0.8 -0.5 0.3 -1.3 -1.5 0.6 -0.1 1.1 -0.6 1.8 -1.2 -0.5 -2.1 -0.3 2.1 0.1
Ovarian Cancer 0.2 0.3 2.1 0.1 -0.1 1.4 -0.8 0.7 0.6 0.1 -0.2 -0.2 0.7 -0.1 0.1 0.2 0.2 -0.1 0.2
Prostate Cancer 1.0 1.4 4.9 0.4 0.4 -0.5 -1.0 -0.6 0.3 0.6 -2.0 0.7 -2.0 -1.1 -1.1 0.3 -0.6 -2.2 -1.8
Age at First Birth 1.7 2.5 11.0 1.4 1.4 -0.6 3.3 2.5 0.1 1.2 0.7 1.2 0.9 1.4 2.0 1.7 1.2 -0.9 1.8
Bipolar Disorder (2011) 0.6 0.5 1.6 1.2 1.1 0.0 0.1 0.8 -0.3 0.0 0.2 1.3 -0.1 0.7 0.8 1.2 -0.5 0.1 -0.9
Body Mass Index (BMI) (2010) 1.4 2.0 6.1 1.4 1.7 -0.6 1.0 -0.7 1.7 1.8 1.9 1.8 0.8 0.1 0.7 1.5 1.2 0.9 -2.5
Coronary Artery Disease (CAD) 1.0 1.2 3.7 0.6 0.6 -0.4 1.2 1.5 0.2 0.0 1.9 0.4 1.9 1.4 0.7 0.8 1.7 0.3 1.3
Crohns Disease (2012) 0.4 0.7 4.3 0.5 0.5 -0.1 0.8 0.5 0.6 0.6 2.1 0.4 1.6 0.8 0.4 0.2 0.8 0.4 0.6
Mean Putamen Volume 0.6 0.7 1.6 0.8 1.1 -0.1 1.0 -0.1 1.1 0.6 1.1 1.0 1.2 0.6 0.9 0.6 0.5 -0.6 -0.6
Fasting Glucose 1.2 1.5 4.1 -1.4 -1.6 0.6 1.6 -0.1 -0.6 -1.9 0.6 -1.7 0.9 -1.1 0.3 -0.6 -0.7 2.0 1.3
HbA1C 0.8 0.8 3.0 -1.1 -1.2 1.6 0.4 0.3 0.2 -1.3 0.4 -1.1 0.3 -0.9 -0.6 -1.7 -0.2 -0.5 0.4
HDL Cholesterol 0.3 0.5 2.7 -0.6 -0.4 1.3 -0.6 -0.4 -0.1 -0.4 0.1 -0.5 -0.9 0.3 -0.6 -0.7 0.3 1.6 0.7
LDL Cholesterol 0.6 1.0 5.3 0.2 0.3 1.2 0.5 0.1 1.2 0.1 2.3 0.2 2.2 0.6 0.2 0.2 0.5 0.3 1.5
Lupus 0.2 0.3 1.0 -0.4 -0.3 1.0 -0.6 0.6 -0.6 -0.8 0.0 -0.4 0.7 0.6 -0.8 -0.4 0.5 -0.1 0.4
Neuroticism (2016) 0.8 1.1 5.8 -1.1 -0.8 0.7 -1.6 -1.1 -1.3 -0.6 -0.7 -0.7 -0.2 -1.3 -2.4 -0.7 -0.9 -0.1 0.2
Primary Biliary Cirrhosis 0.8 1.2 3.6 1.1 1.3 -0.5 0.8 -0.4 1.3 1.4 1.9 1.1 1.2 0.2 0.5 1.2 -0.2 1.7 -0.5
Rheumatoid Arthritis 0.7 0.9 6.6 0.4 0.3 -0.4 0.6 0.9 0.5 0.4 2.6 0.4 0.3 1.4 1.2 1.2 0.5 -0.2 -1.0
Schizophrenia (2014) 1.0 2.2 6.7 2.1 2.0 -1.8 0.1 0.9 1.0 2.1 1.6 1.7 0.7 0.3 1.0 2.6 1.1 -0.2 -1.3
Triglycerides 0.9 1.5 4.3 1.1 1.2 -2.1 1.1 -0.0 0.7 1.1 1.3 1.1 1.6 0.9 1.5 1.6 0.8 1.5 -0.7
Type 2 Diabetes (T2D) (2012) 0.5 0.5 1.8 1.0 1.3 -0.7 -0.0 0.1 -0.2 1.2 0.1 1.2 0.8 0.6 -0.1 0.8 0.6 0.3 0.1
Ulcerative Colitis 0.3 0.5 1.9 -0.6 -0.6 0.9 0.5 -0.1 -0.7 -0.5 -0.9 -0.6 0.4 -0.0 -1.0 0.4 -1.4 -0.3 1.1
Blood Eosinophil Count 0.4 2.8 11.5 0.6 0.3 0.5 -1.6 3.4 0.6 -0.4 0.4 0.2 2.5 2.4 1.1 -0.2 3.2 -2.0 1.5
Blood Platelet Count 0.3 3.5 10.0 -0.8 -0.8 0.6 -1.7 -3.2 0.4 -0.1 -1.9 -0.4 -1.8 -2.8 -2.2 0.1 -3.1 -1.3 -3.1
Blood Red Count 0.1 1.2 6.7 -0.5 -0.8 0.4 -1.7 0.8 1.0 -0.7 -0.1 -0.7 1.1 -0.3 -0.5 -2.6 1.9 -0.5 -0.1
Blood White Count 0.3 2.5 11.0 0.3 0.3 0.5 0.6 2.4 1.1 -0.1 2.3 0.3 3.3 2.6 1.1 -0.3 2.9 -0.3 -0.1
Heel T-Score 3.0 23.6 60.2 7.3 7.1 -1.2 0.4 -1.1 4.7 7.8 -1.8 7.8 -1.4 -1.0 1.9 4.5 -0.6 -6.8 -7.1
BMI 0.3 1.9 4.2 1.4 1.3 -2.0 1.0 -1.4 1.9 1.6 0.6 1.5 -0.7 -1.2 0.7 0.5 -0.7 -1.7 -2.1
Height 0.8 14.7 36.7 -4.7 -5.0 3.2 -6.1 -1.2 -3.9 -4.7 -0.9 -4.7 -2.6 -2.2 -2.8 -5.3 -3.8 1.7 3.9
Waist Hip Ratio (WHR) 0.1 0.6 3.9 0.3 0.3 0.4 0.7 0.5 2.0 -0.1 -0.0 0.4 1.0 -0.1 -0.3 -0.2 -0.2 -1.8 0.3
Systolic Blood Pressure 0.9 4.3 8.0 2.7 2.4 -0.9 2.6 1.9 2.8 2.2 1.6 2.4 2.6 2.3 2.0 1.1 2.5 -0.5 -0.7
Smoking Status 0.3 0.6 1.7 -0.4 -0.5 0.4 -1.2 0.2 0.0 -0.6 -1.3 -0.5 0.4 -0.1 -1.2 -1.1 1.2 -1.0 0.3
Allergy or Eczema 0.2 0.5 2.7 -0.1 -0.0 -0.7 0.2 0.9 -0.2 -0.1 1.2 -0.4 0.6 0.1 -0.5 0.4 1.6 0.8 1.0
Cardiovascular Disease 0.3 1.1 2.2 0.9 0.9 -1.4 -0.1 0.3 1.4 0.7 1.5 0.9 1.4 1.0 0.8 -0.7 1.4 0.7 -1.4
Hypothyroidism (self reported) 0.8 1.9 6.3 1.5 1.4 -1.5 0.7 0.7 1.2 1.5 1.5 1.5 0.1 1.4 2.5 0.8 0.9 1.2 -1.9
Respiratory disease 0.9 2.0 5.7 1.2 1.0 1.0 0.6 2.3 1.4 0.9 2.2 1.0 2.4 1.7 1.5 0.6 1.5 -0.4 -0.5
Type 2 Diabetes (T2D) (2018) 0.8 1.4 5.8 1.5 1.2 1.3 0.6 1.4 1.8 1.1 -0.4 1.4 -0.6 0.2 0.3 0.9 0.1 -2.4 -1.0
Lung FEV1/FVC ratio 0.5 2.7 10.8 1.8 1.8 -1.6 3.3 -1.0 2.1 1.9 -0.1 1.9 -0.4 -1.2 1.1 0.9 -0.2 -2.2 -1.3
Lung FVC 0.1 0.5 2.1 0.3 0.3 -0.3 -0.1 -1.0 -0.5 0.8 -0.4 0.3 -1.5 -1.0 0.4 0.7 -1.2 0.7 -0.7
Neuroticism 0.3 0.8 2.0 -0.8 -0.6 -1.0 -1.0 -1.1 -1.1 -0.5 -0.5 -0.5 0.8 -0.8 -1.2 -1.1 -1.4 0.1 0.5
Chronotype (morning person) 0.5 1.3 10.1 -0.6 -0.6 -1.9 -0.5 -0.3 -0.9 -0.3 -0.4 -0.7 -0.7 0.0 1.2 -0.8 1.0 3.2 -0.3
Hair Pigment 0.1 2.0 5.3 2.0 1.8 -1.0 1.0 0.7 1.9 1.9 2.3 1.8 1.0 -0.9 1.5 1.0 0.3 -0.7 -1.1
Tanning 0.0 0.4 1.2 -0.0 0.2 0.4 -1.1 -1.0 -0.3 0.5 -0.1 0.1 1.0 -0.1 -1.0 -0.3 -0.6 0.7 -0.4
Hand grip strength (left) 0.4 1.0 3.7 -0.8 -0.9 1.8 -0.9 -1.1 -0.5 -0.9 0.7 -0.7 -0.9 -0.2 0.6 -0.8 -1.4 1.9 -0.8
Number of treatments/medications taken 1.3 2.4 7.3 1.9 1.8 -1.8 1.0 2.1 0.1 1.5 -0.6 1.7 -0.3 1.7 1.9 1.7 2.7 -0.3 -0.9
Average weekly spirits intake 0.7 0.8 2.4 1.0 1.0 -1.1 1.4 0.4 1.0 0.9 0.9 1.0 -0.0 0.3 0.2 1.4 -0.3 -1.5 0.3
Sensitivity / hurt feelings 1.2 2.1 4.9 -2.0 -1.7 -0.5 -1.3 -0.7 -2.2 -1.8 -1.0 -2.0 1.2 -0.4 -2.2 -1.2 -0.8 1.7 0.5
Frequency of depressed mood in last 2 weeks 0.7 1.0 2.3 -1.4 -1.1 -1.0 -0.3 -1.3 -1.1 -1.1 -0.7 -1.0 -0.9 -0.6 -1.0 -0.3 -1.5 0.3 0.9
Hearing difficulty/problems: Yes 0.8 1.1 9.1 -0.4 -0.1 -0.8 -0.9 -1.6 -1.4 -0.1 -3.0 -0.1 -0.8 -0.7 -0.7 -0.5 -0.3 0.7 -0.7
Relative age of first facial hair 0.4 0.8 6.8 0.2 0.4 -1.1 0.4 -0.1 -0.1 0.3 -0.4 0.2 1.5 0.0 -0.2 0.3 -0.6 -0.9 2.6
Other serious medical condition/disability diagnosed by doctor 2.4 3.1 5.6 2.4 2.3 -1.6 1.6 1.9 2.3 2.1 1.9 2.1 1.2 1.8 1.6 1.2 2.0 -0.4 -0.6
Ever used hormone-replacement therapy (HRT) 0.3 0.4 1.6 0.6 0.7 -1.3 0.5 -0.6 0.9 0.9 0.9 0.8 -0.1 -0.3 0.2 0.0 0.6 0.0 -0.1
Ever had hysterectomy (womb removed) 0.6 0.7 2.3 -1.0 -1.0 -0.7 -0.2 -0.9 -0.2 -1.1 1.4 -0.8 -1.0 -0.7 0.2 -0.5 -0.6 -1.5 -0.0
Systolic blood pressure, automated reading 1.4 4.0 9.5 2.6 2.4 -2.5 2.4 0.9 3.1 2.4 1.6 2.6 1.0 0.9 2.1 1.7 1.5 -1.4 -0.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 2.7 0.4 0.4 1.6 -0.2 -0.6 0.4 0.4 -1.0 0.5 -0.6 -0.3 -0.3 -0.6 0.1 -0.9 0.1
Angina 0.2 0.3 0.6 0.7 0.6 0.8 -0.4 0.6 0.3 0.5 0.1 0.7 0.5 0.5 0.3 0.0 0.7 -0.5 -0.6
Medication for hormone replacement therapy 1.7 2.0 5.8 -0.9 -0.8 1.9 -2.4 -1.4 0.0 -0.7 -1.2 -0.9 -0.6 -1.8 -2.4 -2.4 -0.5 0.1 -0.7
Vitamin and mineral supplements 0.6 0.8 4.5 0.8 1.0 0.4 -0.1 -0.9 0.8 0.9 -0.7 1.1 1.0 -0.7 0.3 0.2 -0.7 -2.1 -0.9
Supplements: Zinc 1.3 1.5 3.9 -1.9 -2.0 0.0 -1.2 -0.3 -1.6 -2.0 -0.8 -1.8 -1.0 -0.2 -1.0 -1.1 0.1 0.5 0.8
Medication: Co-codamol 1.1 1.3 4.0 1.4 1.3 0.6 -0.4 1.1 1.0 1.1 -0.6 1.4 -0.9 0.4 0.5 -0.8 2.0 -1.0 -1.9
Medication: Metformin 1.0 1.4 5.9 1.4 1.1 0.1 1.2 1.8 1.8 1.0 -0.3 1.2 -1.0 0.2 1.2 0.8 0.3 -2.4 -0.2
Diabetes (father) 0.7 0.9 3.6 1.0 0.8 -1.1 0.9 -0.4 0.9 1.1 0.5 0.9 -0.2 0.0 1.7 0.5 -0.9 0.7 -1.9
Diabetes (mother) 0.8 1.0 3.3 -0.1 -0.1 1.8 -1.6 -1.0 1.3 -0.1 0.8 0.1 0.7 -1.1 -1.2 -0.8 -1.6 -0.6 0.2
Severe depression (siblings) 2.2 2.5 9.2 1.1 1.1 1.9 1.3 1.6 2.2 0.6 1.8 1.0 3.0 1.9 0.9 0.8 2.0 -0.4 1.2
Pack years adult smoking proportion 0.2 0.4 1.0 0.4 0.6 -0.3 -0.8 -0.7 -0.0 0.6 0.6 0.5 0.6 -0.8 -0.7 0.6 0.5 0.1 -1.0
Impedance of leg (right) 0.2 0.7 3.4 -0.8 -0.6 1.3 0.7 -1.0 -0.0 -0.5 0.2 -0.5 1.0 0.0 -0.7 -1.4 -1.8 0.7 0.0
Leg fat-free mass (left) 0.1 0.5 3.1 -0.3 -0.6 -0.1 -1.8 0.5 -0.2 -0.7 -0.1 -0.4 -1.1 -0.3 -0.3 -0.6 0.1 -1.5 0.5
Trunk fat percentage 0.2 0.9 5.0 0.6 0.5 -1.0 1.9 -0.3 1.2 0.5 0.2 0.6 -0.1 -0.4 0.4 0.4 -0.8 -2.2 1.0
Hand grip strength (right) 0.5 1.4 4.4 -0.6 -0.8 2.0 -1.0 -1.2 0.1 -0.6 0.9 -0.6 -0.3 -0.7 1.0 -2.1 -1.8 2.1 -0.7
Townsend deprivation index at recruitment 0.3 0.4 1.8 0.1 0.1 -0.6 -0.9 1.3 -0.8 -0.2 -0.9 -0.2 0.8 0.5 -0.6 0.2 0.8 -0.7 0.2
Current tobacco smoking 0.4 0.6 2.7 -0.2 0.1 0.1 -1.0 -0.3 0.2 -0.0 -0.3 -0.2 1.3 -0.6 -1.4 -1.1 1.6 -0.0 -0.1
Average weekly fortified wine intake 0.8 1.0 2.4 1.5 1.5 -0.6 1.5 -0.2 0.7 1.4 0.3 1.4 -0.0 0.9 1.0 1.3 -0.3 0.1 0.3
Maternal smoking around birth 0.5 0.7 4.4 -0.5 -0.5 0.9 -1.1 -0.8 -1.2 -0.6 -2.1 -0.4 -0.4 -0.8 -0.5 0.3 -1.2 -0.0 -0.1
Fed-up feelings 0.3 0.6 3.7 -0.5 -0.3 0.2 -0.2 -1.0 -0.9 -0.5 -1.9 -0.3 0.1 -0.8 -0.8 0.0 -1.1 -1.0 -0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.6 1.2 1.3 -0.6 1.3 1.0 1.0 1.0 -0.5 1.3 2.1 1.5 0.8 2.1 0.7 -1.7 -0.2
Relative age voice broke 0.7 1.1 4.4 -1.5 -1.2 -0.5 0.2 -1.0 -1.1 -1.4 -0.6 -1.4 0.7 -0.5 -0.6 -0.8 -0.5 0.6 2.1
Taking other prescription medications 2.4 3.7 12.1 1.4 1.3 -0.6 2.3 3.5 1.0 0.8 1.0 0.9 2.4 2.7 1.8 2.2 3.5 0.6 0.9
Age when periods started (menarche) 1.2 2.8 8.6 -0.7 -0.8 0.0 -2.9 -2.2 -1.9 -0.1 -1.5 -0.5 -1.8 -2.9 -1.8 0.0 -2.8 -0.4 -0.8
Bilateral oophorectomy (both ovaries removed) 1.7 2.0 4.8 -1.9 -1.8 1.1 -1.1 -2.2 -0.4 -1.7 0.2 -1.5 -1.2 -2.0 -1.6 -1.0 -1.8 -0.3 0.4
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.3 8.7 2.6 2.6 0.1 0.6 -0.7 2.0 2.8 -1.0 3.0 0.0 0.4 1.0 2.4 -0.8 -1.9 -2.3
Tinnitus: Yes, but not now, but have in the past 1.0 1.0 5.1 1.1 1.0 -1.4 2.2 0.5 0.9 0.7 -0.4 1.0 0.7 0.6 1.1 -0.2 1.5 -0.1 -0.1
Qualifications: CSEs or equivalent 1.8 2.4 7.3 1.0 0.9 -0.8 1.0 2.2 1.9 0.4 1.3 0.9 1.9 2.4 1.7 1.6 1.1 -2.7 0.6
Serious illness, injury or assault to yourself 0.2 0.2 0.9 0.0 0.0 -0.1 0.5 0.9 0.5 -0.2 0.2 -0.2 0.7 0.7 -0.1 -0.0 0.9 -0.0 -0.1
High blood pressure 0.9 2.6 7.7 1.6 1.6 -1.1 1.1 1.3 2.3 1.3 2.0 1.5 1.6 2.0 1.7 0.8 2.8 0.2 -1.2
Hayfever, allergic rhinitis or eczema 0.2 0.5 2.1 0.5 0.4 -0.5 0.7 1.0 0.7 0.3 1.1 0.2 0.9 -0.0 -0.3 -0.3 1.5 0.3 0.5
Multivitamins +/- minerals 0.5 0.6 3.1 0.8 0.5 -0.9 0.6 0.9 0.3 0.7 0.7 0.6 -1.8 0.1 0.6 0.3 0.5 0.9 -0.8
Stomach or abdominal pain in last month 1.3 1.6 3.8 -2.0 -1.8 -1.8 0.0 0.6 -1.9 -1.9 -0.9 -2.0 0.5 0.6 -0.9 -0.1 0.3 1.0 0.9
Supplements: Glucosamine 0.3 0.3 1.1 -0.5 -0.5 -0.3 0.8 -0.5 -0.8 -0.2 0.3 -0.5 -1.0 -0.7 0.3 0.4 -0.5 0.8 0.5
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 2.2 -1.1 -1.1 1.5 -0.3 -0.2 -1.2 -1.1 -0.7 -1.2 -0.7 -0.8 -1.2 -0.8 -0.5 0.9 -0.0
Medication: Atenolol 0.9 1.1 2.3 1.5 1.4 -1.3 -0.1 0.2 0.2 1.5 -1.0 1.3 -1.2 -0.2 0.5 1.1 1.1 -0.4 -1.5
Medication: Levothyroxine sodium 2.0 3.3 9.0 1.5 1.5 -1.3 2.1 1.3 1.8 1.3 2.0 1.5 2.3 2.3 3.0 1.5 1.4 1.9 -1.4
Sitting height 0.5 3.6 18.1 -1.6 -1.7 2.3 -4.3 -1.6 -1.2 -1.7 0.2 -1.6 -1.7 -1.3 -1.3 -3.1 -0.9 1.6 -0.2
Chronic bronchitis/emphysema (father) 0.7 0.8 3.4 1.2 1.0 1.8 -0.2 0.8 0.8 0.7 -0.6 0.9 0.7 0.7 0.7 0.5 1.2 0.0 -0.4
High blood pressure (mother) 1.0 1.5 4.8 0.5 0.5 0.8 1.0 2.2 1.5 0.3 1.7 0.5 1.6 2.0 0.7 0.8 1.6 -0.7 -0.3
Body mass index (BMI) 0.5 2.0 7.7 1.7 1.4 -1.9 1.4 0.2 1.9 1.4 0.3 1.6 -0.8 -0.4 1.3 1.3 0.1 -2.8 -1.1
Impedance of leg (left) 0.2 1.0 3.5 -0.9 -0.8 1.2 0.3 -1.2 0.1 -0.6 1.0 -0.7 1.5 -0.2 -0.7 -1.6 -1.9 1.2 -0.2
Leg predicted mass (left) 0.1 0.5 3.0 -0.3 -0.5 -0.1 -1.7 0.5 -0.2 -0.6 -0.0 -0.3 -1.0 -0.2 -0.2 -0.6 0.2 -1.5 0.5
Trunk fat mass 0.1 0.6 5.2 0.4 0.2 -0.8 0.8 -0.3 0.9 0.2 0.4 0.4 -0.6 -0.6 0.2 -0.1 -0.8 -2.3 0.7
Waist circumference 0.4 1.3 8.2 1.2 1.0 -1.4 0.7 0.5 1.9 0.9 0.0 1.2 -0.6 -0.5 0.5 0.6 -0.1 -2.9 -0.4
Number of incorrect matches in round 0.2 0.3 1.4 0.2 0.3 0.3 -0.0 -0.5 -0.6 0.5 -0.5 0.3 -0.9 -0.4 -0.0 0.3 1.2 0.5 -1.0
Past tobacco smoking 0.7 1.3 6.6 -0.5 -0.3 -0.1 -0.6 -2.2 -0.8 0.1 0.3 -0.4 -0.9 -1.7 -0.1 -0.2 -1.1 2.6 -1.8
Alcohol usually taken with meals 0.4 0.6 2.5 0.6 0.4 0.1 0.9 0.8 0.7 0.4 0.6 0.4 -0.7 1.6 1.1 -0.1 1.3 1.1 -0.0
Nervous feelings 0.8 1.4 4.2 -1.0 -0.7 -0.9 -2.0 -1.5 -1.4 -0.5 -1.8 -0.6 -0.8 -1.6 -1.6 -0.4 -1.2 -0.9 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.5 0.2 0.4 -0.7 -0.3 -0.3 0.2 0.3 -0.1 0.5 0.7 -0.2 0.1 0.4 -0.3 -0.3 0.4
Hearing difficulty/problems with background noise 0.8 1.3 5.6 0.8 1.1 -1.0 -0.3 -0.9 -0.4 1.0 -2.4 1.4 -1.0 1.0 0.2 1.0 0.9 0.2 -2.4
Hair/balding pattern: Pattern 2 0.9 1.2 4.4 0.8 0.9 0.2 -1.3 -1.8 0.7 1.3 -0.8 0.9 -0.3 -2.1 0.2 -0.7 -0.8 0.4 -1.9
Had menopause 0.5 0.6 1.8 -0.7 -0.7 -1.0 0.5 -1.1 -1.0 -0.4 -0.9 -0.8 -0.7 -0.6 -0.7 0.6 0.3 1.4 0.1
Had other major operations 0.4 0.5 2.7 0.7 0.8 -0.6 0.4 0.3 0.1 0.9 0.9 0.8 0.8 0.6 0.3 1.6 0.9 -0.2 -0.2
Forced vital capacity (FVC) 0.6 2.3 5.7 -1.7 -1.6 2.0 -2.4 -1.2 -1.7 -1.5 -0.2 -1.6 -1.0 -1.1 -1.2 -1.2 -1.7 1.6 1.0
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 5.8 2.0 1.9 0.7 0.7 -0.7 2.2 2.2 -0.4 2.4 -0.5 0.3 1.1 1.8 -1.1 -1.7 -1.9
Ever unenthusiastic/disinterested for a whole week 1.8 2.2 6.7 2.1 2.1 -1.1 1.2 0.7 0.4 2.0 0.5 2.2 -0.1 0.9 1.4 2.6 1.1 -0.9 -1.1
Qualifications: None of the above 0.9 1.9 5.9 1.1 0.9 -0.7 -2.3 -1.2 1.1 1.4 -1.1 1.1 -1.2 -2.4 -0.2 -1.3 -0.9 -1.0 -2.1
Financial difficulties in last 2 years 0.9 1.3 3.3 -1.2 -1.4 -1.8 -0.7 -1.1 -1.2 -1.1 -1.0 -1.2 -0.7 -1.5 -0.5 -0.6 -1.8 0.2 -0.2
Mouth/teeth dental problems 0.5 0.8 2.4 -0.5 -0.5 1.2 1.6 0.1 -0.4 -0.7 1.1 -0.4 0.1 0.6 1.0 1.3 -1.0 -0.6 1.2
Heart attack 0.5 0.7 2.6 0.8 0.9 -1.0 0.5 0.3 0.8 0.8 0.5 0.8 0.4 0.8 0.4 1.1 1.6 0.5 -0.9
Allergy 0.4 1.0 4.1 -0.6 -0.5 -0.0 -0.9 -1.5 -1.5 -0.3 -1.8 -0.4 -2.0 -1.1 -0.1 -0.2 -1.4 0.1 -0.1
Pain all over the body in last month 0.5 0.5 2.4 0.6 0.6 -0.0 0.1 0.7 1.0 0.7 0.7 0.6 1.6 0.2 -0.4 -0.2 0.5 -0.9 1.2
Diabetes (self-reported) 1.2 1.9 5.8 1.7 1.3 1.2 1.1 1.4 2.4 1.2 -0.1 1.6 -0.7 0.4 0.9 0.6 0.4 -2.0 -2.0
Hayfever/allergic rhinitis (self-reported) 0.3 0.4 2.5 0.1 0.1 -1.6 -0.3 -0.0 0.1 0.2 1.1 -0.1 1.2 -0.1 -0.4 -0.2 0.3 0.1 0.9
Medication: Ramipril 0.7 0.9 2.5 0.8 0.8 -1.1 -1.1 0.4 1.2 0.9 1.6 0.8 0.7 0.5 0.8 -0.9 0.7 0.7 -1.5
Medication: Simvastatin 1.6 2.4 6.9 2.5 2.5 -0.8 0.3 0.9 1.9 2.6 0.8 2.4 0.3 0.5 1.8 0.5 1.0 -1.0 -1.1
Fluid intelligence score 2.0 4.1 9.1 -3.0 -2.9 0.2 -2.2 -1.2 -2.5 -3.0 -0.5 -3.0 -1.1 -1.1 -2.4 -0.6 -1.2 2.2 1.7
Illnesses of siblings 1.1 1.6 4.4 1.8 1.8 -1.1 0.4 0.7 1.3 2.0 -0.2 1.9 1.2 -0.1 0.6 1.1 0.2 -2.1 -0.5
Neuroticism score 0.3 0.6 2.5 -1.0 -0.7 -0.8 -0.6 -0.6 -1.6 -0.8 -0.8 -0.8 0.6 -0.3 -0.8 -0.7 -0.2 0.4 0.6
Weight 0.1 0.6 4.3 0.2 -0.1 -0.8 -0.8 -0.1 0.8 -0.1 0.4 0.2 -1.3 -0.8 0.2 -0.4 -0.6 -2.1 -0.0
Impedance of arm (right) 0.3 1.5 8.5 -1.3 -1.1 0.8 1.2 0.6 -1.4 -1.2 -0.5 -1.3 1.4 0.9 -1.2 -0.6 -0.4 0.7 2.9
Arm fat percentage (right) 0.4 1.4 5.9 1.2 1.0 -1.6 2.3 0.0 1.3 1.0 0.4 1.1 -0.2 -0.3 0.9 1.1 -0.4 -2.4 0.3
Trunk fat-free mass 0.3 1.6 12.3 -0.8 -1.1 0.7 -3.5 -0.5 -0.3 -1.0 0.4 -0.8 -1.3 -1.0 -0.4 -1.9 -1.0 -0.5 -0.6
Hip circumference 0.1 0.2 1.3 0.3 0.0 -0.7 -0.3 -0.1 0.4 0.1 0.4 0.2 -0.6 -0.6 0.2 -0.5 -0.7 -1.1 0.1
Time employed in main current job 1.4 1.6 4.9 -1.6 -1.4 0.3 -0.5 0.4 -1.9 -1.6 -1.4 -1.7 0.2 0.2 -2.1 -0.4 -0.2 0.1 2.2
Alcohol intake versus 10 years previously 0.4 0.6 4.8 -0.3 -0.5 0.6 -0.6 -0.1 -0.4 -0.4 -2.2 -0.5 -0.5 -1.0 -0.8 0.8 0.4 -0.5 -0.5
Father’s age at death 0.6 0.7 4.2 -0.9 -0.9 -0.4 0.9 -0.7 -1.1 -0.7 -1.0 -0.8 -2.1 -0.2 -0.1 -0.7 -0.5 0.5 0.6
Worrier / anxious feelings 0.5 1.0 4.7 0.3 0.6 -1.4 -0.0 -0.2 -0.6 0.6 -0.3 0.4 1.4 1.0 0.2 0.7 2.2 1.8 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.6 -0.5 -0.1 -0.2 -1.5 -0.5 -0.9 -0.3 -0.4 -0.3 0.8 0.1 -1.6 -0.8 0.7 0.5 -0.2
Falls in the last year 0.3 0.4 2.2 0.2 0.4 -1.2 0.5 -0.7 0.4 0.5 -0.9 0.3 0.5 0.0 -0.6 0.7 0.1 1.5 -0.3
Hair/balding pattern: Pattern 3 0.4 0.6 4.8 0.1 -0.0 -2.2 -0.4 -0.3 -0.6 0.3 -0.1 0.3 -1.1 0.1 -0.4 0.6 -0.9 0.4 -1.3
Number of live births 0.4 0.5 5.7 -0.5 -0.4 0.4 -0.4 -0.6 -0.2 -0.1 0.2 -0.5 0.6 -0.7 -0.3 -0.5 0.0 2.4 -0.3
Forced expiratory volume in 1-second (FEV1) 0.5 1.8 3.6 -1.3 -1.3 1.6 -1.9 -1.7 -1.1 -1.0 -0.5 -1.3 -1.5 -1.8 -1.0 -1.1 -1.7 1.4 -0.1
Pulse rate 0.6 0.9 4.0 -0.8 -0.9 -1.1 0.0 0.1 -2.0 -0.8 -1.7 -0.7 -0.9 -0.8 -0.5 0.3 -0.4 -1.5 -0.5
Happiness 1.1 1.4 3.8 0.3 0.5 -1.7 0.4 1.4 -1.5 0.4 -0.7 0.3 -0.0 2.0 0.5 1.7 1.0 1.2 1.9
Noisy workplace 1.6 2.0 9.5 1.1 1.0 -1.5 1.7 1.7 1.0 0.6 -0.1 1.1 1.4 1.3 1.6 0.3 1.7 -3.1 0.1
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.9 -1.5 -1.4 0.9 -1.1 -0.3 -1.9 -1.3 0.2 -1.4 0.5 -0.6 -2.0 -0.9 -0.1 1.3 0.5
Serious illness, injury or assault of a close relative in last 2 years 1.6 1.9 4.8 -2.0 -2.1 0.9 -0.6 0.6 -0.8 -2.1 -0.2 -2.2 1.0 -0.5 -1.5 -1.3 -0.8 -1.3 1.5
Mouth/teeth dental problems: Dentures 1.5 2.5 7.7 0.9 0.8 -1.1 -2.6 -1.6 1.6 1.5 -1.8 0.8 -0.4 -2.6 -1.4 -1.8 -0.1 0.2 -2.8
Asthma 1.4 2.7 4.5 2.1 2.1 0.2 1.2 1.4 2.0 1.9 1.8 2.0 2.0 1.9 1.4 1.6 1.9 0.1 -0.9
Medication: Ibuprofen (e.g. Nurofen) 1.5 1.9 6.0 -0.7 -0.8 -0.8 -0.6 -1.0 -1.8 -0.9 -1.9 -0.5 -2.2 -1.5 -0.7 -0.2 -2.2 -2.4 0.9
Medication: Cholesterol lowering 0.8 1.3 3.2 1.4 1.4 0.3 1.2 1.0 1.8 1.2 0.4 1.3 1.0 1.3 1.7 -0.8 1.2 -0.4 0.1
Depression (self-reported) 1.4 1.7 5.0 1.4 1.5 -2.2 0.9 0.8 -0.2 1.4 -0.6 1.4 -0.8 1.2 1.3 1.9 2.2 0.0 -0.5
Medication: Lansoprazole 1.1 1.3 5.2 1.2 1.0 0.7 0.6 2.3 1.1 0.7 0.5 0.8 0.9 1.6 0.9 1.0 1.9 -0.5 0.3
Prospective memory result 0.7 0.9 2.5 1.3 1.4 -0.4 -0.1 -0.7 1.3 1.4 0.6 1.6 -0.7 0.0 0.5 0.7 0.0 -0.9 -1.1
Lung cancer (father) 0.7 0.8 2.7 -0.2 -0.0 -0.1 -1.2 -1.6 -1.4 0.1 -1.4 -0.3 -0.5 -1.4 -1.4 -0.6 -0.4 0.7 -0.1
Illnesses of mother 0.7 0.8 4.5 -0.5 -0.4 -1.8 0.4 -0.6 -1.4 -0.3 -2.1 -0.5 -1.0 -0.6 0.3 0.0 -0.2 0.7 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 1.9 4.2 -1.2 -1.3 1.1 -1.6 -1.9 -0.9 -0.7 -1.1 -1.2 -1.5 -1.9 -0.8 -1.3 -2.0 1.6 -0.1
Pulse wave Arterial Stiffness index 0.6 0.7 2.1 -1.3 -1.2 -0.0 -0.2 -0.8 -0.8 -1.3 -0.1 -1.2 0.1 -0.0 -0.1 -0.2 -0.1 1.5 0.7
Impedance of arm (left) 0.3 1.3 8.5 -1.0 -0.7 0.7 1.7 0.6 -1.3 -0.8 -0.6 -0.9 1.1 1.1 -0.8 -0.1 -0.1 0.8 2.9
Arm fat mass (right) 0.3 1.1 6.5 1.1 0.8 -1.2 1.3 0.2 1.5 0.8 0.6 1.0 -0.4 -0.2 1.0 0.6 -0.1 -2.5 0.1
Trunk predicted mass 0.3 1.6 12.7 -0.9 -1.2 0.8 -3.6 -0.5 -0.4 -1.1 0.3 -0.8 -1.3 -1.1 -0.4 -1.9 -1.0 -0.5 -0.5
Standing height 0.7 6.6 24.2 -3.1 -3.2 2.5 -4.9 -0.9 -2.1 -3.2 0.2 -3.0 -1.1 -1.1 -2.4 -3.9 -1.6 0.8 2.1
Length of working week for main job 0.7 0.8 2.0 0.8 1.0 0.4 1.0 0.1 0.7 0.6 1.1 0.8 1.1 0.9 0.2 1.2 1.4 1.1 -0.1
Exposure to tobacco smoke at home 0.6 0.6 1.5 -1.1 -1.0 -0.7 -0.4 0.6 -1.2 -1.2 0.1 -1.2 0.6 0.8 0.3 -0.5 0.6 0.7 0.6
Breastfed as a baby 0.8 1.0 4.8 -0.0 -0.0 2.2 0.8 0.7 1.1 -0.2 -0.3 0.0 1.5 0.3 -0.4 -1.1 -0.0 -1.6 1.4
Tense / ‘highly strung’ 0.3 0.5 1.3 -0.0 0.3 -0.9 -0.6 -0.9 -0.7 0.6 0.7 0.3 -0.0 -0.7 -0.4 -0.1 1.1 1.1 -1.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 5.4 0.2 0.1 -0.5 0.7 1.7 0.0 -0.1 0.1 0.1 0.6 1.2 0.6 -0.6 2.3 -0.8 -0.2
Hair/balding pattern: Pattern 4 0.3 0.7 4.6 0.5 0.7 2.1 0.3 0.4 0.5 0.1 -0.1 0.3 1.3 0.6 -0.4 0.7 1.2 -1.1 0.8
Birth weight of first child 0.5 1.0 5.2 -0.7 -0.7 -2.3 0.9 1.1 -0.9 -0.5 0.5 -0.8 0.5 0.2 0.4 -0.5 0.2 1.3 1.7
Peak expiratory flow (PEF) 0.5 1.1 3.3 0.0 0.0 1.1 -1.7 -1.6 -0.1 0.2 0.0 -0.0 -1.5 -1.6 -0.2 -1.2 -0.3 1.1 -1.8
Pulse wave reflection index 0.7 0.8 5.8 -1.0 -1.0 -0.1 -0.9 -1.2 -0.3 -0.9 -0.5 -1.1 -0.5 -0.2 -0.1 0.2 0.1 2.4 -0.4
Ever highly irritable/argumentative for 2 days 1.5 1.8 3.5 1.5 1.7 -0.9 1.2 1.7 0.9 1.6 0.8 1.5 1.5 1.9 1.2 1.6 1.5 -0.2 0.6
Loud music exposure frequency 1.2 1.3 6.0 1.5 1.6 -1.2 0.4 -0.0 0.5 1.7 -0.6 1.5 0.5 -0.4 0.3 1.3 -0.2 -2.4 0.4
Qualifications: O levels/GCSEs or equivalent 1.7 2.7 6.8 -2.2 -1.9 2.0 -0.9 -0.4 -2.1 -2.1 -1.4 -2.0 0.6 -0.7 -2.6 -2.0 -0.1 0.7 1.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 2.2 -0.2 0.1 0.6 -0.7 -0.2 0.0 -0.3 -0.4 -0.1 0.4 0.9 -0.2 -0.2 0.5 1.5 0.0
Blood clot in the leg (DVT) 1.0 1.3 6.9 -1.5 -1.8 0.4 -0.8 0.4 0.1 -1.6 -1.0 -1.5 0.0 -0.3 -0.8 -0.1 -0.9 -2.6 -0.1
Medication: Paracetamol 0.9 1.4 3.9 1.8 1.7 -1.1 -1.1 0.1 -0.1 2.0 -0.5 1.8 -0.9 -0.4 -0.0 1.2 0.3 -0.7 -1.9
Headache pain in last month 2.1 3.6 11.3 1.9 1.9 -2.6 1.5 2.9 0.7 1.6 0.5 1.5 0.9 2.8 1.8 1.8 3.4 0.4 -1.4
Medication for cholesterol, blood pressure or diabetes 0.6 1.0 3.1 -0.7 -0.6 -0.4 -0.7 -1.2 -1.5 -0.6 -1.1 -0.6 -1.1 -0.8 -1.8 1.4 -1.0 0.4 -0.2
Glaucoma (self-reported) 0.5 0.5 3.4 -0.3 -0.2 -1.8 -1.0 -0.6 -0.5 0.0 0.4 0.1 0.8 0.3 0.3 -0.1 0.5 1.4 -0.4
Gout (self-reported) 1.8 2.4 8.6 1.3 1.4 1.8 1.5 1.3 2.1 0.9 1.6 1.4 2.9 2.0 1.4 1.9 0.4 -0.5 0.4
Hypothyroidism/myxoedema (self-reported) 2.3 4.6 11.8 2.3 2.2 -2.3 2.6 1.5 1.6 2.1 1.9 2.1 1.0 2.5 3.4 2.4 2.0 1.4 -1.6
Medication: Amlodipine 0.3 0.5 1.8 0.9 0.8 -0.8 0.1 -0.1 0.4 0.9 0.1 1.0 -0.2 -0.1 0.6 0.7 0.4 -1.0 -1.3
Medication: Ventolin 100micrograms inhaler 2.3 2.9 6.9 1.5 1.5 1.2 2.2 1.8 2.2 1.0 2.1 1.3 2.6 2.1 1.9 1.2 2.0 -0.2 0.3
Birth weight 0.8 1.7 5.1 -1.6 -1.6 0.3 -2.1 0.1 -2.3 -1.6 -0.8 -1.5 -0.6 -0.5 -0.5 -1.2 -1.2 0.8 1.6
Chronic bronchitis/emphysema (mother) 0.8 0.9 4.5 0.4 0.4 0.5 0.0 0.6 1.3 -0.1 2.1 0.4 1.4 0.8 0.5 1.1 0.1 -1.7 0.5
High blood pressure (siblings) 0.8 1.1 3.4 -1.5 -1.6 0.9 -0.1 -0.2 -0.8 -1.8 -0.2 -1.5 -1.0 0.7 -0.2 -1.0 -0.7 1.2 1.0
Forced vital capacity (FVC), Best measure 0.5 1.8 3.8 -1.4 -1.4 1.6 -1.7 -1.2 -1.4 -1.0 -0.5 -1.4 -0.8 -1.2 -0.8 -1.3 -1.9 1.9 1.0
Body fat percentage 0.3 1.1 5.5 0.8 0.6 -1.1 2.1 -0.5 1.5 0.7 0.4 0.8 -0.3 -0.6 0.5 0.6 -0.9 -2.3 0.3
Leg fat percentage (right) 0.3 1.0 5.5 0.7 0.5 -1.0 1.5 -1.0 1.2 0.6 0.1 0.7 -0.7 -1.0 0.3 0.4 -1.0 -2.3 -1.1
Arm fat-free mass (right) 0.2 1.1 7.8 -0.4 -0.7 0.4 -2.8 -0.7 0.3 -0.7 0.5 -0.4 -1.3 -1.3 -0.1 -1.6 -0.8 -0.8 -1.0
Exposure to tobacco smoke outside home 0.8 1.0 3.7 -0.7 -0.6 0.6 -1.6 -0.7 -0.9 -0.7 -1.9 -0.6 -0.0 -1.2 -1.3 -1.2 0.0 -1.5 0.0
Comparative body size at age 10 0.5 1.4 9.0 0.4 0.1 0.9 -0.3 -0.4 0.5 0.2 -1.7 0.5 -1.5 -1.5 -0.6 0.9 -1.4 -3.0 -0.5
Number of full brothers 0.4 0.5 3.1 -0.1 -0.3 -1.1 0.0 1.2 -0.5 -0.5 0.1 -0.3 -0.3 -0.6 -0.1 -1.8 0.2 -1.0 0.3
Worry too long after embarrassment 1.3 2.1 4.6 -2.1 -1.8 0.8 -1.3 -2.1 -1.3 -2.0 -0.6 -1.8 -0.1 -1.2 -1.6 -1.9 -1.2 1.1 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 3.6 0.1 0.3 -1.6 0.8 1.1 -0.4 0.1 0.8 0.3 0.7 1.4 0.1 0.8 1.9 0.1 0.8
Wheeze or whistling in the chest in last year 0.4 0.6 3.6 0.6 0.6 0.1 -0.2 0.3 0.9 0.7 1.5 0.6 1.9 0.1 -0.8 0.1 0.6 -0.5 -0.7
Number of children fathered 0.6 0.6 3.7 -0.7 -0.8 1.0 -0.5 -0.3 0.5 -0.6 0.1 -0.6 -0.1 -0.2 0.5 -1.9 -1.3 0.8 0.6
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 5.5 -1.2 -0.9 1.8 -0.4 -1.3 -0.6 -1.1 1.4 -1.0 0.2 -0.1 -1.5 -0.2 0.6 2.3 1.1
Age at first live birth 1.9 3.4 8.5 -2.5 -2.3 0.1 -1.3 -1.2 -2.9 -2.1 -1.4 -2.5 -1.4 -1.2 -1.8 -1.2 -1.5 2.5 1.5
Pulse wave peak to peak time 0.5 0.6 2.0 1.3 1.2 0.2 -0.0 0.8 0.8 1.3 0.1 1.2 -0.2 0.0 0.0 0.2 0.0 -1.4 -0.6
Health satisfaction 4.0 5.2 15.3 2.3 2.5 -3.9 2.3 2.4 0.3 2.0 0.8 2.2 1.7 3.4 2.4 2.4 3.1 0.2 -0.5
Shortness of breath walking on level ground 1.4 1.6 10.0 1.4 1.2 -3.2 1.3 1.0 0.8 1.3 0.6 1.2 0.7 0.4 1.4 0.9 0.8 -1.2 0.3
Qualifications: College or University degree 0.6 2.0 6.7 -2.0 -2.2 0.6 0.4 0.5 -2.6 -2.3 -1.4 -2.2 -0.9 0.0 -0.1 -0.9 0.0 0.7 1.4
Eye problems/disorders: None of the above 0.2 0.2 1.1 -0.1 -0.1 -0.9 0.6 0.2 -0.0 -0.3 -0.1 -0.3 -0.3 0.5 0.2 0.3 0.8 0.4 -1.0
Mouth/teeth dental problems: Loose teeth 1.6 1.9 4.7 2.0 1.9 -1.4 -0.4 0.3 1.1 2.0 0.9 2.2 -1.2 -0.1 1.0 0.1 1.1 -2.1 -1.4
Emphysema/chronic bronchitis 1.9 2.2 5.7 2.0 2.2 0.2 -0.0 1.0 1.8 1.8 1.0 2.4 1.9 1.7 0.7 1.2 1.2 -0.6 -1.4
Medication for pain relief, constipation, heartburn 0.3 0.5 1.9 -0.7 -0.8 0.8 0.9 -0.2 -0.1 -0.7 0.4 -0.8 0.5 0.9 0.6 -0.3 0.2 1.4 0.7
Neck or shoulder pain in last month 0.8 1.1 4.2 0.5 0.3 -0.2 0.8 1.5 -0.4 0.1 -1.8 0.3 -0.9 1.2 0.9 2.0 0.0 -2.0 0.2
Medication: Blood pressure 0.7 1.2 3.9 0.3 0.1 0.7 0.6 2.0 1.0 -0.1 0.7 0.2 1.9 1.3 1.1 -1.1 1.9 -1.1 0.2
Angina (self-reported) 0.3 0.5 1.1 1.0 1.0 0.6 -0.4 0.6 0.5 0.8 -0.3 1.0 0.5 0.6 0.3 0.3 1.0 -0.3 -0.8
Migraine (self-reported) 0.4 0.5 3.0 -0.3 -0.2 1.7 -1.4 -0.2 -0.6 -0.2 0.2 -0.3 0.6 0.1 -0.2 -0.6 0.0 0.9 0.8
Medication: Ibuprofen 1.3 1.6 6.8 -0.0 -0.1 -0.9 -0.9 -1.5 -0.8 0.0 -1.9 0.2 -2.6 -1.6 -0.2 0.3 -1.9 -1.8 -0.8
Medication: Allopurinol 2.5 3.4 7.8 2.1 2.0 0.2 2.3 1.9 2.6 1.5 1.0 1.9 2.8 2.1 2.1 1.8 1.1 -0.7 1.1
Medication: Omeprazole 0.2 0.2 1.7 -0.3 -0.1 0.2 -0.5 -0.3 0.3 -0.3 0.2 -0.2 0.4 -0.5 -1.3 0.1 0.4 0.2 0.4
Medication: Seretide 50 evohaler 3.0 3.4 6.5 2.1 2.3 -0.4 2.6 1.6 1.9 1.6 1.7 2.4 1.8 2.5 1.7 1.9 1.9 -1.5 -0.2
Mean time to correctly identify matches 0.2 0.4 2.4 0.0 0.3 0.0 -1.0 -1.0 0.3 0.1 1.6 0.1 0.3 -0.8 -0.5 -0.5 -0.1 -0.6 -0.3
Heart disease (mother) 0.8 1.0 2.7 1.0 0.9 -1.3 0.7 0.1 0.6 1.1 0.4 1.1 -0.6 0.7 0.6 1.6 1.0 -1.4 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.8 3.0 0.1 -0.1 1.1 -0.2 -1.2 0.5 0.2 -0.2 0.1 -1.6 -1.3 -0.4 -0.2 -1.7 -1.1 -0.6
Whole body fat mass 0.2 0.8 6.0 0.8 0.5 -0.8 1.0 -0.2 1.5 0.5 0.6 0.7 -0.5 -0.5 0.6 0.1 -0.7 -2.4 0.1
Leg fat mass (right) 0.3 1.1 7.8 1.0 0.7 -0.8 0.8 -0.3 1.6 0.7 0.5 1.0 -0.7 -0.6 0.8 0.1 -0.6 -2.8 -0.9
Arm predicted mass (right) 0.2 1.2 8.0 -0.3 -0.6 0.1 -2.8 -0.8 0.4 -0.5 0.7 -0.2 -1.3 -1.3 0.1 -1.6 -0.9 -0.6 -1.3
Pulse rate, automated reading 0.3 1.0 3.1 0.4 0.4 -0.7 1.4 0.9 -0.3 0.2 0.2 0.3 1.6 1.2 1.3 1.0 1.8 -0.2 -1.1
Alcohol intake frequency. 0.2 0.4 1.9 0.2 0.0 0.2 -0.6 0.0 1.4 0.3 0.1 0.2 1.0 -1.0 -0.8 0.1 -0.2 -0.7 -0.9
Comparative height size at age 10 0.4 2.3 6.1 -1.5 -1.7 2.1 -2.2 -0.4 -0.0 -1.6 0.2 -1.3 -0.2 -1.6 -1.5 -2.5 -2.1 -1.4 1.0
Number of full sisters 2.2 2.7 8.2 -1.8 -1.9 1.9 -2.9 0.1 -1.3 -2.1 -2.5 -1.9 -0.8 -0.7 -2.7 -0.1 -0.5 -0.6 0.1
Suffer from ‘nerves’ 0.2 0.2 1.3 -0.6 -0.3 -0.1 -1.1 -0.1 -0.7 -0.5 0.1 -0.3 0.5 0.3 -0.4 -0.2 0.1 0.1 0.9
Overall health rating 3.2 6.9 18.1 2.7 2.8 -2.4 2.7 3.7 2.1 1.9 -0.4 2.4 3.4 3.6 2.5 1.7 4.3 -1.3 1.3
Chest pain or discomfort 0.7 1.0 7.8 0.6 0.6 -0.2 -1.8 -0.7 0.4 0.9 1.0 0.8 1.1 -0.3 -0.2 0.1 0.4 0.1 -2.8
Had major operations 0.9 1.0 3.8 0.7 0.7 -0.7 0.7 1.0 1.2 0.7 0.4 0.8 1.6 1.5 2.0 -0.1 1.3 0.1 0.8
Age at last live birth 1.5 2.2 5.9 -1.4 -1.3 0.2 -1.8 -0.5 -2.4 -1.1 -2.2 -1.5 -1.6 -1.2 -1.5 -1.6 -0.0 2.1 0.3
Family relationship satisfaction 1.6 2.0 6.7 1.1 1.4 -0.7 2.4 1.2 0.2 1.0 0.2 1.3 0.8 2.6 0.7 2.3 1.7 0.8 1.1
Leg pain on walking 2.7 3.4 9.4 2.1 2.1 -3.1 1.1 0.4 2.2 2.1 0.7 2.1 1.9 1.1 1.7 1.5 2.2 -0.7 -2.1
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.9 2.5 1.0 1.1 -1.5 1.2 -0.2 0.8 1.0 -0.4 1.0 -0.6 -0.1 0.5 1.4 -0.7 -1.6 -0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.5 2.1 -0.4 -0.3 -0.5 1.2 0.0 0.5 -0.6 0.5 -0.4 0.3 1.2 1.3 0.3 -0.5 0.1 1.5
Illness, injury, bereavement, stress in last 2 years 1.8 2.2 4.9 2.1 2.1 -0.6 1.1 1.0 1.5 1.9 1.4 2.2 0.8 1.6 1.6 1.0 1.7 0.3 -1.1
Medication: Aspirin 1.0 1.4 4.0 0.8 0.8 -0.0 0.6 1.5 1.4 0.4 2.0 0.7 1.5 1.9 1.1 0.2 1.9 -0.1 -0.3
Supplements: Vitamin C 0.5 0.6 2.6 -0.8 -0.7 -0.2 0.1 0.1 -0.3 -0.9 1.1 -0.9 0.9 1.0 -0.0 0.3 0.5 1.2 1.6
Knee pain experienced in last month 1.0 1.6 4.5 1.6 1.5 -2.1 1.1 0.1 0.8 1.5 -0.2 1.4 -0.4 0.1 1.3 1.5 1.5 -0.6 -1.9
Hypertension (Self-reported) 1.1 3.2 7.3 2.0 2.0 -1.5 1.2 1.2 2.7 1.8 1.9 2.0 1.5 1.8 1.9 1.1 2.7 -0.3 -1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.2 0.7 0.7 0.2 0.6 1.1 0.7 0.5 0.8 0.7 0.9 1.2 1.1 1.0 1.5 0.3 0.4
Illnesses of father: Heart disease 0.5 0.7 4.7 -0.4 -0.1 -0.9 0.4 -0.4 0.5 -0.6 1.3 -0.1 2.2 0.8 -0.6 0.4 0.1 0.4 1.0
Illnesses of siblings: Diabetes 0.5 0.6 2.4 0.4 0.4 1.6 -1.4 -0.7 1.0 0.5 0.1 0.5 0.1 -0.3 -0.0 -0.2 -0.7 0.2 -1.3
Smoking status: Previous 0.9 1.3 5.2 0.7 0.4 0.7 1.0 2.0 1.2 0.1 -0.1 0.6 0.8 1.7 0.5 0.8 0.3 -2.3 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 7.2 -1.0 -1.1 2.7 -2.3 1.3 -1.2 -1.2 -0.6 -1.0 0.6 0.8 -1.2 -1.9 -0.3 0.1 0.5
Whole body fat-free mass 0.2 1.0 8.4 -0.5 -0.8 0.3 -2.9 -0.0 -0.2 -0.8 0.4 -0.5 -1.2 -0.7 -0.2 -1.4 -0.4 -0.9 -0.2
Leg fat-free mass (right) 0.1 0.6 4.2 -0.6 -0.8 0.1 -2.0 0.6 -0.2 -1.0 0.4 -0.6 -0.7 -0.2 -0.3 -0.7 0.2 -1.1 0.6
Arm fat percentage (left) 0.4 1.7 6.9 1.4 1.2 -1.7 2.5 0.3 1.3 1.2 0.2 1.3 -0.3 -0.0 1.1 1.4 0.1 -2.6 0.3
Average weekly red wine intake 0.5 0.7 2.2 -0.8 -0.9 -0.4 1.4 -0.1 0.1 -1.0 0.9 -0.8 -0.2 0.3 0.8 -1.3 0.0 0.9 1.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 6.1 -0.1 -0.1 -0.7 1.4 0.0 -0.5 0.1 0.3 0.1 -0.8 0.1 0.8 2.5 0.2 -0.2 0.9
Mood swings 0.4 0.7 3.5 0.9 1.2 -0.5 0.6 0.3 0.4 0.7 -0.9 1.1 1.9 0.6 0.2 0.5 0.8 -0.5 0.0
Loneliness, isolation 0.4 0.6 2.4 -0.8 -0.7 -0.5 0.0 0.3 -0.0 -1.1 0.0 -0.6 1.3 0.9 0.2 -0.2 0.1 -1.0 1.5
Long-standing illness, disability or infirmity 3.8 5.8 11.8 3.3 3.4 -1.1 2.4 2.3 2.7 2.9 1.3 3.2 1.7 2.5 1.4 2.4 3.3 -1.0 -1.1
Ever had bowel cancer screening 0.1 0.2 0.6 -0.2 -0.1 -0.5 0.8 -0.4 -0.6 0.0 -0.2 -0.2 -0.6 -0.7 -0.1 0.4 0.6 0.0 0.2
Diabetes diagnosed by doctor 0.9 1.4 6.5 1.1 0.8 1.4 1.2 1.8 2.2 0.6 -0.0 0.9 -0.4 0.4 0.4 0.4 0.5 -2.5 -0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 3.1 0.2 -0.0 1.0 1.3 0.6 1.0 0.1 1.8 0.1 0.3 1.1 1.3 0.1 -0.2 -0.4 0.1
Friendships satisfaction 1.1 1.4 4.6 0.6 0.6 -2.1 1.3 0.5 -1.3 0.8 -1.4 0.6 -1.8 0.7 0.0 1.8 1.2 0.8 1.1
Qualifications: nursing, teaching 1.1 1.8 3.7 -1.4 -1.3 1.2 1.2 0.5 -1.2 -1.4 1.6 -1.5 1.6 1.4 -0.0 0.5 -0.9 1.9 1.9
Commuting to job workplace: Walk 1.2 1.3 5.0 1.5 1.3 -0.1 -0.4 2.2 0.2 1.4 1.8 1.3 1.0 1.1 0.3 0.9 1.1 -0.2 -0.7
Eye problems/disorders: Cataract 0.3 0.4 1.1 -0.2 -0.1 0.2 -1.0 -1.0 -0.7 0.2 -0.4 -0.0 -1.0 -0.9 -1.0 -0.0 -0.8 -0.3 -0.1
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 3.2 -0.5 -0.4 -1.7 0.2 -0.3 -1.8 -0.3 -0.7 -0.4 -0.5 -0.4 -0.2 0.1 -0.3 0.5 0.1
Medication for cholesterol 0.7 1.1 2.8 -1.4 -1.3 1.7 0.0 -0.6 -0.7 -1.4 0.3 -1.3 0.7 -0.5 -0.1 -0.9 -1.6 -0.2 1.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 4.5 -0.0 0.1 0.2 -0.3 -0.7 -0.3 0.2 0.3 0.2 -0.3 -1.2 -1.4 0.7 -2.1 -0.7 -0.2
Back pain experienced in last month 1.6 2.3 5.9 -1.6 -1.3 -0.6 -2.4 -2.1 -1.0 -1.1 -1.4 -1.6 -0.0 -2.1 -2.4 -1.9 0.1 1.1 0.3
Mineral and other dietary supplements 0.5 0.7 1.9 0.8 0.7 1.0 -0.8 0.4 1.4 0.4 -0.6 0.7 1.2 0.5 0.4 -0.8 0.3 -1.1 -1.4
Breast cancer (self-reported) 0.4 0.5 1.5 -0.4 -0.5 1.2 1.1 0.9 -0.6 -0.7 -0.1 -0.6 0.2 0.3 -0.0 -0.2 1.1 0.1 1.0
Asthma (self-reported) 1.4 2.8 5.1 2.0 2.0 0.4 1.3 1.8 1.9 1.7 1.6 1.9 2.0 2.2 1.5 1.6 2.3 -0.1 -0.7
Osteoporosis (self-reported) 0.9 1.1 3.2 -1.6 -1.5 -0.3 -0.9 -0.7 -1.0 -1.3 -0.5 -1.5 -0.5 -0.9 -0.7 -1.8 0.4 1.2 0.3
Osteoarthritis (self-reported) 0.6 0.8 3.2 -0.1 -0.0 -0.5 1.8 1.0 0.9 -0.5 0.3 -0.2 0.6 1.8 0.8 0.1 1.3 0.3 1.0
Medication: Aspirin 0.6 0.8 2.9 0.3 0.2 0.5 0.1 1.1 1.2 -0.2 1.7 0.2 0.9 1.4 0.8 -0.5 1.6 -0.1 -0.4
Medication: Gliclazide 1.0 1.1 2.8 1.5 1.5 -0.4 1.5 1.3 1.7 1.2 0.7 1.6 0.6 0.4 0.5 0.8 0.8 -0.8 -0.2
Illnesses of father: None of the above (group 1) 0.6 0.8 2.8 -0.6 -0.8 -0.2 -1.0 -0.2 -1.1 -0.3 -0.5 -0.8 -1.3 -1.7 -1.4 -0.4 -0.7 -0.8 -0.3
Smoking status: Current 0.4 0.7 2.9 -0.4 -0.2 0.2 -1.2 -0.4 -0.2 -0.3 -0.6 -0.4 1.2 -0.8 -1.7 -1.3 1.6 -0.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.9 0.3 0.3 0.9 -0.4 -2.0 -0.3 0.7 -1.6 0.4 -0.9 -2.0 -0.3 -0.5 -1.8 0.9 -1.3
Whole body water mass 0.2 1.0 8.2 -0.6 -0.9 0.2 -2.9 -0.2 -0.2 -0.9 0.4 -0.6 -1.3 -0.9 -0.2 -1.4 -0.5 -1.0 -0.2
Leg predicted mass (right) 0.1 0.6 4.1 -0.6 -0.8 0.1 -2.0 0.5 -0.2 -0.9 0.4 -0.6 -0.7 -0.1 -0.3 -0.7 0.3 -1.0 0.6
Arm fat mass (left) 0.3 1.0 6.8 1.1 0.8 -1.0 1.3 0.3 1.6 0.7 0.5 1.0 -0.3 -0.1 1.0 0.6 -0.1 -2.6 0.0
Number of self-reported non-cancer illnesses 0.5 0.9 2.9 0.9 1.0 -0.3 0.7 0.8 1.7 0.7 1.1 1.0 1.2 1.0 0.6 0.3 1.3 -0.3 -0.9
Average weekly champagne plus white wine intake 1.4 2.0 5.1 -1.7 -1.9 1.3 0.2 -0.1 -2.3 -2.0 -2.2 -1.7 -1.2 -0.1 -1.6 -0.3 -1.4 0.5 0.6
Miserableness 0.4 0.6 2.2 -0.7 -0.5 -1.2 -1.5 -1.2 -1.1 -0.5 -1.4 -0.5 0.2 -0.3 -0.1 -0.3 -0.4 0.5 -0.4
Guilty feelings 0.7 1.1 5.5 -1.3 -1.1 -0.4 0.6 0.1 -1.5 -1.4 -0.7 -1.2 -0.1 0.1 -0.7 -0.6 -0.9 0.9 2.3
Wears glasses or contact lenses 0.8 0.9 2.7 1.2 1.2 0.5 0.3 0.8 -0.1 1.3 -0.6 1.3 0.3 1.1 0.0 1.6 1.7 -0.4 -0.4
Ever taken oral contraceptive pill 1.3 1.4 6.8 -1.3 -1.1 2.6 0.7 -1.2 -1.0 -1.2 -1.0 -1.2 0.5 -0.5 -1.9 -0.7 -0.5 1.0 0.5
Hearing aid user 0.7 0.8 3.5 -0.4 -0.5 -1.7 -0.4 0.6 -1.4 -0.3 -1.9 -0.6 -0.9 -0.1 0.1 -0.4 1.4 -0.2 0.5
Mother’s age at death 0.6 0.7 4.2 -0.7 -0.7 -0.5 0.3 1.0 -0.8 -0.8 -0.6 -1.0 -0.2 0.5 -0.4 0.2 1.2 0.2 2.0
Financial situation satisfaction 1.6 2.0 5.8 -1.6 -1.7 -2.0 -1.6 -0.5 -2.4 -1.7 -1.1 -1.6 -1.0 -0.3 -0.9 0.1 -1.9 0.0 1.3
Tinnitus: Yes, now most or all of the time 2.0 2.3 5.8 -0.6 -0.4 -1.0 -1.0 -2.4 -2.2 -0.1 -2.3 -0.5 -2.2 -2.3 -1.6 0.3 -0.4 0.8 -2.0
Commuting to job workplace: Public transport 0.3 0.4 1.6 0.0 0.1 -0.2 -1.2 0.3 -0.9 0.1 -0.9 0.0 0.2 -0.1 -0.9 0.1 0.4 1.1 0.5
Eye problems/disorders: Glaucoma 0.9 1.0 1.9 -1.4 -1.2 -0.4 -1.3 -0.9 -1.1 -1.0 0.9 -1.0 1.2 -0.3 -0.7 -1.1 -0.8 1.1 1.0
Medication: Blood pressure 1.6 3.0 5.5 2.3 2.2 -2.0 1.4 0.9 1.7 2.3 1.4 2.1 -0.2 1.5 1.2 2.1 2.0 0.9 -1.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 1.6 0.3 0.3 -1.3 0.8 0.7 0.8 -0.1 -0.1 0.0 0.4 0.5 0.8 -0.1 1.0 -0.8 0.1
Supplements: Fish oil (including cod liver oil) 0.4 0.6 2.2 0.3 0.3 -0.6 1.5 -0.2 -0.4 0.6 1.0 0.2 -0.7 -0.3 0.8 1.3 0.2 1.3 0.2
High cholesterol (Self-reported) 0.3 0.6 5.6 -0.8 -0.6 -0.1 -1.0 -0.4 0.1 -0.8 -0.2 -0.7 0.2 -0.1 0.0 -2.4 -0.3 0.6 -0.7
Medication: Bendroflumethiazide 2.3 3.5 5.6 2.4 2.3 -2.1 1.3 0.2 2.4 2.3 1.1 2.3 0.7 1.7 2.2 2.1 1.8 1.4 -1.7
Medication: Paracetamol 1.0 1.6 5.0 1.9 1.8 -1.1 -1.0 0.1 0.3 2.1 -0.1 2.0 -0.5 -0.2 0.6 1.2 0.5 -0.1 -2.2
Medication: Lisinopril 0.8 1.0 3.4 0.1 -0.3 0.8 1.7 1.9 0.1 -0.4 1.0 -0.2 0.8 1.7 1.0 -0.5 1.0 -0.8 1.3
Medication: Atorvastatin 1.1 1.3 4.1 -1.6 -1.8 -0.2 -0.8 0.8 -0.9 -2.0 -0.5 -1.8 0.2 1.1 -0.9 -1.6 0.1 0.7 0.3
Illnesses of father: High blood pressure 0.8 1.0 3.0 0.9 0.8 1.1 0.3 1.2 1.0 0.8 -0.3 1.2 -0.3 1.5 0.7 -0.3 1.4 -0.4 -1.7
Alcohol drinker status: Never 0.8 1.0 2.4 -0.9 -0.9 1.5 -1.5 -0.5 -0.7 -0.9 -0.8 -0.8 1.2 -1.2 -1.4 -0.0 -1.1 -0.7 0.8
Ever smoked 0.5 0.9 4.6 -0.1 -0.3 -0.8 0.6 1.8 0.5 -0.6 -0.1 -0.2 0.3 1.4 -0.3 0.0 1.0 -2.1 1.5
Basal metabolic rate 0.1 0.8 5.7 -0.5 -0.8 0.1 -2.4 -0.1 0.0 -0.8 0.4 -0.5 -1.1 -0.8 -0.2 -1.3 -0.5 -1.2 -0.1
Leg fat percentage (left) 0.3 1.0 3.3 0.7 0.5 -1.0 1.4 -1.0 1.5 0.6 0.5 0.7 -0.2 -1.0 0.4 0.3 -0.8 -1.8 -1.4
Arm fat-free mass (left) 0.2 1.1 6.6 -0.4 -0.7 0.3 -2.6 -0.7 0.5 -0.6 0.6 -0.4 -1.2 -1.4 -0.1 -1.6 -0.8 -0.9 -0.9
Number of operations (self-reported) 0.8 1.1 3.7 0.9 0.9 -1.4 0.4 0.3 1.9 1.2 1.4 1.1 1.2 0.5 0.7 0.6 1.6 -0.8 -0.4
Average weekly beer plus cider intake 0.5 0.7 3.0 -0.6 -0.4 0.1 -1.7 -1.4 0.1 -0.2 -0.5 -0.5 0.4 -0.9 -0.5 -0.2 -1.5 0.8 -0.4
Irritability 0.5 0.8 2.7 -0.1 -0.2 -0.4 1.1 -0.4 -0.8 0.1 -1.4 0.1 -1.4 -1.0 -0.8 0.6 -1.6 -1.4 0.9
Risk taking 1.2 1.8 7.4 -1.4 -1.6 2.7 0.3 0.6 0.6 -1.9 0.8 -1.8 1.5 -0.1 -0.3 -1.0 -0.6 0.5 2.0
Ever had prostate specific antigen (PSA) test 0.9 1.0 5.7 -0.9 -0.8 -1.3 0.9 -1.0 -1.8 -0.5 -0.6 -0.8 -2.4 -0.8 -0.5 -0.8 0.0 0.0 0.3
Fractured/broken bones in last 5 years 2.2 2.8 6.1 -2.3 -2.1 -0.2 -1.4 -1.5 -1.9 -2.2 0.5 -2.3 0.5 -1.0 -1.4 -2.4 0.1 2.5 1.3
Age started oral contraceptive pill 1.3 1.6 4.8 1.4 1.2 -2.2 1.9 1.0 0.6 1.6 -0.4 1.3 -1.2 -0.0 0.8 2.0 1.0 -1.0 0.5
Diastolic blood pressure, automated reading 0.4 1.3 3.5 1.7 1.4 -1.9 1.0 0.6 1.4 1.4 -0.3 1.5 -1.0 0.4 1.5 1.0 0.8 -0.3 -0.4
Ever depressed for a whole week 1.6 1.9 4.3 1.6 1.8 -1.5 1.5 0.9 0.1 1.6 1.1 1.7 0.8 1.5 1.4 2.0 2.1 -0.2 -0.1
Unable to work because of sickness or disability 3.0 3.9 8.7 2.8 2.9 -1.1 0.9 1.6 2.3 2.8 1.2 2.9 1.8 2.3 1.7 1.7 1.8 -1.3 -0.4
Commuting to job workplace: Cycle 0.6 0.8 3.7 -0.3 -0.4 0.4 0.6 0.1 1.0 -0.5 1.2 -0.6 1.9 0.3 1.1 -1.4 0.2 1.2 0.5
Myopia 0.8 1.2 4.8 -1.2 -1.4 1.4 -0.1 1.1 -2.2 -1.3 -1.5 -1.3 -0.7 0.3 -1.3 -0.1 -0.1 -0.1 0.0
Vascular/heart problems diagnosed by doctor 1.2 3.2 10.3 -1.9 -1.9 1.1 -1.2 -1.5 -2.3 -1.6 -2.1 -1.8 -1.8 -2.2 -1.8 -0.8 -3.2 -0.3 1.3
Cholesterol lowering medication 0.4 0.5 5.3 0.5 0.5 -2.3 0.1 0.7 0.2 0.5 -0.1 0.3 -0.1 0.4 0.9 0.4 0.6 0.6 -0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.0 -0.3 -0.2 0.9 -0.4 0.8 0.2 -0.5 0.3 -0.2 0.7 0.1 -1.7 -0.0 0.4 -0.8 1.0
Pain experienced in last month 0.7 1.2 7.5 0.4 0.4 2.7 0.3 -0.5 1.6 0.4 1.9 0.5 0.6 -0.1 1.0 -0.7 -1.4 1.0 0.6
Supplements: Calcium 0.5 0.6 1.9 -0.5 -0.3 -0.7 -0.1 1.0 -0.8 -0.4 -0.9 -0.6 -0.4 0.7 -0.5 -0.4 1.4 0.8 1.3
Basal cell carcinoma (self-reported) 0.7 0.9 2.9 0.0 -0.0 -1.0 0.6 1.7 -1.1 0.1 -1.5 -0.1 -0.8 1.1 -0.5 1.1 1.1 -0.0 1.4
Heart attack/myocardial infarction (self-reported) 0.5 0.6 2.5 0.8 0.8 -1.0 0.6 0.4 0.7 0.7 0.4 0.8 0.4 1.0 0.4 1.0 1.6 0.3 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.7 0.9 5.5 -1.1 -1.5 0.7 -0.8 0.4 0.4 -1.3 -0.5 -1.2 0.2 -0.2 -0.5 0.0 -0.8 -2.3 -0.7
Heart disease (siblings) 0.4 0.5 3.7 -0.1 -0.2 -0.5 0.3 1.4 -0.3 -0.5 0.0 -0.3 -0.7 0.4 0.0 0.4 0.7 -1.9 0.3
Alcohol drinker status: Previous 0.2 0.3 1.8 0.4 0.2 0.9 -0.2 0.2 1.4 0.4 0.6 0.2 0.2 -0.8 -0.4 -0.1 -0.1 -0.4 -0.2
Pack years of smoking 0.3 0.5 1.1 0.7 0.9 -0.8 -0.5 -0.6 0.1 0.9 0.8 0.7 0.6 -0.7 -0.4 1.0 0.7 -0.0 -1.1
Impedance of whole body 0.2 1.3 4.3 -1.2 -1.0 1.2 1.4 -0.1 -0.9 -1.1 0.0 -1.1 1.6 0.7 -0.9 -1.0 -0.9 1.0 2.1
Leg fat mass (left) 0.2 0.9 6.2 0.9 0.6 -0.8 0.7 -0.3 1.6 0.6 0.6 0.9 -0.6 -0.7 0.7 0.1 -0.5 -2.5 -0.9
Arm predicted mass (left) 0.2 1.2 7.1 -0.6 -1.0 0.4 -2.7 -0.7 0.4 -0.8 0.6 -0.6 -1.0 -1.5 -0.2 -1.7 -1.3 -1.0 -0.7