[Hub]/) : Traits : Heel T-Score : ← →

chr17:47,805,311-49,684,265

Best TWAS P=1.86e-12 · Best GWAS P=5.76e-45 conditioned to 5.84e-41

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CACNA1G	0.12	0.02	blup	448	0.03	3.1e-04	-0.4	-7.0	2.0e-12	0.01	0.30	0.02	TRUE
2	GTEx	Adipose Subcutaneous	SPATA20	0.70	0.61	lasso	13	0.62	2.6e-63	-6.5	6.0	2.1e-09	0.00	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	SPATA20	0.58	0.50	enet	24	0.52	1.7e-31	-6.5	5.7	1.0e-08	0.02	1.00	0.00	FALSE
4	GTEx	Artery Aorta	SPATA20	0.56	0.46	lasso	10	0.44	1.9e-26	-6.5	6.3	2.4e-10	0.00	1.00	0.00	FALSE
5	GTEx	Artery Coronary	SPATA20	0.54	0.47	lasso	4	0.47	1.1e-17	-6.5	6.1	1.2e-09	0.01	1.00	0.00	FALSE
6	GTEx	Artery Tibial	SPATA20	0.51	0.44	lasso	3	0.45	4.3e-39	-6.5	5.6	2.3e-08	0.00	1.00	0.00	FALSE
7	GTEx	Brain Caudate basal ganglia	SPATA20	0.42	0.41	lasso	2	0.35	7.2e-11	-6.5	6.1	1.3e-09	-0.01	0.99	0.00	FALSE
8	GTEx	Brain Frontal Cortex BA9	SPATA20	0.58	0.39	lasso	10	0.39	1.7e-11	-6.6	5.4	7.4e-08	-0.05	0.98	0.00	FALSE
9	GTEx	Brain Hippocampus	SPATA20	0.37	0.39	lasso	3	0.32	2.6e-08	-6.5	6.2	7.1e-10	0.00	0.75	0.01	FALSE
10	GTEx	Brain Hypothalamus	SPATA20	0.29	0.18	lasso	3	0.16	1.1e-04	-6.5	6.7	1.5e-11	0.00	0.12	0.06	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	SPATA20	0.62	0.45	enet	17	0.50	3.2e-15	-6.5	6.0	1.6e-09	-0.04	0.99	0.00	FALSE
12	GTEx	Breast Mammary Tissue	SPATA20	0.52	0.48	lasso	4	0.47	1.2e-26	-6.5	6.5	7.8e-11	0.00	1.00	0.00	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	SPATA20	0.63	0.57	lasso	4	0.56	7.9e-22	-6.5	6.1	1.2e-09	0.00	1.00	0.00	FALSE
14	GTEx	Colon Transverse	SPATA20	0.47	0.38	lasso	4	0.39	1.1e-19	-6.5	6.9	6.1e-12	-0.02	1.00	0.00	FALSE
15	GTEx	Esophagus Gastroesophageal Junction	SPATA20	0.39	0.33	lasso	5	0.34	4.7e-13	-6.5	5.7	9.3e-09	0.02	1.00	0.00	FALSE
16	GTEx	Esophagus Mucosa	SPATA20	0.61	0.57	lasso	7	0.56	6.9e-45	-6.5	6.1	1.3e-09	-0.02	1.00	0.00	FALSE
17	GTEx	Esophagus Muscularis	SPATA20	0.59	0.50	lasso	6	0.52	6.0e-36	-6.5	5.4	5.9e-08	-0.01	1.00	0.00	FALSE
18	GTEx	Heart Atrial Appendage	SPATA20	0.64	0.40	lasso	7	0.44	2.3e-21	-6.5	5.6	1.8e-08	-0.03	1.00	0.00	FALSE
19	GTEx	Heart Atrial Appendage	ACSF2	0.43	0.19	lasso	5	0.16	1.1e-07	-5.5	5.3	1.1e-07	0.16	0.97	0.00	FALSE
20	GTEx	Heart Left Ventricle	ACSF2	0.36	0.34	lasso	2	0.34	1.3e-18	-5.5	5.6	1.8e-08	0.16	1.00	0.00	FALSE
21	GTEx	Lung	SPATA20	0.64	0.60	lasso	6	0.62	1.1e-60	-6.5	5.8	6.1e-09	-0.01	1.00	0.00	FALSE
22	GTEx	Muscle Skeletal	SPATA20	0.49	0.48	enet	45	0.49	6.1e-54	-6.5	6.0	1.5e-09	-0.01	1.00	0.00	FALSE
23	GTEx	Muscle Skeletal	TOB1-AS1	0.11	0.04	enet	18	0.07	5.1e-07	-2.4	-5.3	1.1e-07	0.01	0.80	0.08	TRUE
24	GTEx	Nerve Tibial	SPATA20	0.67	0.57	enet	35	0.60	6.2e-53	-6.5	6.4	1.7e-10	0.01	1.00	0.00	FALSE
25	GTEx	Nerve Tibial	TOB1-AS1	0.12	0.10	enet	10	0.12	3.9e-09	4.3	-5.1	2.8e-07	0.01	0.94	0.02	FALSE
26	GTEx	Ovary	SPATA20	0.48	0.34	lasso	6	0.42	1.7e-11	-6.6	6.5	1.2e-10	-0.03	0.91	0.00	TRUE
27	GTEx	Pituitary	SPATA20	0.42	0.34	lasso	5	0.30	3.5e-08	-6.5	6.2	4.3e-10	-0.01	0.73	0.02	FALSE
28	GTEx	Prostate	SPATA20	0.54	0.38	lasso	7	0.38	1.1e-10	-6.7	5.9	3.8e-09	-0.03	0.91	0.00	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SPATA20	0.57	0.44	enet	25	0.45	5.1e-27	-6.5	5.5	4.4e-08	-0.02	1.00	0.00	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	ACSF2	0.16	0.08	lasso	2	0.05	6.0e-04	5.4	-5.3	9.9e-08	-0.06	0.50	0.02	FALSE
31	GTEx	Skin Sun Exposed Lower leg	SPATA20	0.57	0.47	enet	18	0.50	2.0e-46	-6.5	6.4	2.0e-10	0.00	1.00	0.00	FALSE
32	GTEx	Skin Sun Exposed Lower leg	ACSF2	0.11	0.06	lasso	3	0.05	3.6e-05	5.4	-5.4	5.5e-08	-0.07	0.92	0.00	FALSE
33	GTEx	Testis	SPATA20	0.20	0.07	lasso	3	0.08	1.6e-04	-6.5	6.3	3.7e-10	-0.01	0.71	0.01	FALSE
34	GTEx	Thyroid	SPATA20	0.49	0.41	enet	27	0.44	3.7e-36	-6.5	5.7	1.5e-08	0.03	1.00	0.00	FALSE
35	GTEx	Vagina	SPATA20	0.72	0.30	lasso	14	0.17	1.1e-04	-6.5	6.7	1.8e-11	-0.01	0.33	0.04	FALSE
36	GTEx	Whole Blood	SPATA20	0.49	0.44	lasso	5	0.44	1.0e-43	-6.5	6.3	2.7e-10	0.00	1.00	0.00	FALSE
37	METSIM	Adipose	MYCBPAP	0.30	0.13	bslmm	451	0.20	3.5e-29	-4.8	6.9	3.8e-12	0.19	1.00	0.00	FALSE
38	METSIM	Adipose	SPATA20	0.38	0.36	lasso	3	0.36	1.2e-55	-6.5	6.5	7.3e-11	0.00	1.00	0.00	FALSE
39	NTR	Blood	SPATA20	0.08	0.07	lasso	3	0.06	5.2e-20	-6.5	6.5	1.2e-10	-0.03	1.00	0.00	FALSE
40	YFS	Blood	SPATA20	0.66	0.71	enet	46	0.71	0.0e+00	-6.5	5.9	4.2e-09	-0.02	1.00	0.00	FALSE
41	YFS	Blood	TOB1	0.09	0.03	bslmm	366	0.08	1.8e-24	4.6	5.5	3.9e-08	0.06	1.00	0.00	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MYCBPAP	0.08	0.01	blup	63	0.03	9.4e-04	-5.7	7.0	1.9e-12	0.12	0.03	0.10	TRUE
43	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	NME1-NME2	0.06	0.01	blup	43	0.04	1.6e-04	3.7	5.2	1.7e-07	0.08	0.02	0.30	FALSE
44	The Cancer Genome Atlas	Colon Adenocarcinoma	MYCBPAP	0.08	0.03	blup	63	0.07	9.4e-05	2.2	6.0	2.3e-09	0.08	0.01	0.85	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MYCBPAP	0.14	0.07	blup	63	0.13	3.8e-14	-5.7	5.2	2.0e-07	0.15	0.78	0.22	FALSE
46	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NME2	0.09	0.05	lasso	4	0.05	1.0e-06	-4.6	-5.3	1.3e-07	-0.06	0.50	0.46	FALSE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYCBPAP	0.07	0.07	blup	63	0.07	2.2e-08	-5.7	6.4	1.8e-10	0.17	0.73	0.25	FALSE
48	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MYCBPAP	0.11	0.01	blup	63	0.05	2.2e-06	-4.9	5.8	5.6e-09	0.16	0.06	0.07	FALSE
49	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPAG9	0.05	0.00	blup	75	0.01	1.1e-02	6.0	5.7	1.5e-08	0.05	0.03	0.47	FALSE
50	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYCBPAP	0.10	0.02	blup	63	0.04	1.7e-03	-5.7	6.4	1.9e-10	0.13	0.04	0.41	FALSE
51	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NME1-NME2	0.14	0.04	blup	43	0.07	8.6e-04	3.3	5.7	1.5e-08	0.08	0.05	0.17	TRUE
52	The Cancer Genome Atlas	Thyroid Carcinoma	MYCBPAP	0.17	0.08	enet	13	0.13	1.3e-12	-4.9	5.9	4.2e-09	0.18	0.96	0.03	FALSE