Hub : Genes

ACSF2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.4260	0.0830	2.0e-05	0.192	NA	0.122	NA	0.161	4.9e-09	NA	4.1e-06	NA	1.1e-07
2	GTEx	Heart Left Ventricle	0.3607	0.0623	1.4e-08	0.335	NA	0.298	NA	0.337	1.7e-18	NA	2.6e-16	NA	1.3e-18
3	GTEx	Nerve Tibial	0.1153	0.0386	8.9e-04	0.032	NA	0.038	NA	0.051	2.4e-03	NA	9.9e-04	NA	1.6e-04
4	GTEx	Skin Not Sun Exposed Suprapubic	0.1620	0.0600	6.5e-03	0.076	NA	0.031	NA	0.054	5.6e-05	NA	8.1e-03	NA	6.0e-04
5	GTEx	Skin Sun Exposed Lower leg	0.1070	0.0360	1.3e-03	0.058	NA	0.052	NA	0.052	1.4e-05	NA	3.7e-05	NA	3.6e-05
6	GTEx	Testis	0.3130	0.0750	6.5e-05	0.172	NA	0.212	NA	0.260	4.5e-08	NA	8.7e-10	NA	6.1e-12
7	YFS	Blood	0.0656	0.0140	2.4e-13	0.025	0.037	0.042	0.039	0.033	1.0e-08	3.8e-12	1.5e-13	6.7e-13	4.2e-11
8	TCGA	Breast Invasive Carcinoma	0.0171	0.0094	2.3e-03	0.002	0.004	0.012	NA	0.008	1.0e-01	3.5e-02	1.5e-03	NA	8.0e-03
9	TCGA	Head and Neck Squamous Cell Carcinoma	0.0571	0.0249	1.3e-03	0.000	0.026	0.014	NA	0.012	3.7e-01	5.8e-04	8.8e-03	NA	1.5e-02
10	TCGA	Brain Lower Grade Glioma	0.0530	0.0246	1.9e-04	0.029	0.028	0.018	NA	0.023	2.8e-04	3.1e-04	3.1e-03	NA	1.1e-03
11	TCGA	Thyroid Carcinoma	0.0340	0.0210	1.0e-02	-0.001	0.019	0.008	NA	-0.001	4.7e-01	5.4e-03	5.2e-02	NA	4.0e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.7	2.7	7.0	-2.4	-2.6	0.3	0.1	0.4	-2.5	-2.4	-0.2	-0.3	2.0	0.2
Bipolar Disorder or Schizophrenia	1.0	2.5	9.9	-1.6	-1.8	-0.6	-0.8	-0.6	-2.3	-3.1	-1.2	-0.9	1.6	0.8
Depressed Affect (Nagel 2018)	0.3	0.7	1.5	-0.6	-0.8	-0.1	-0.2	-0.3	-1.1	-1.0	0.7	1.2	1.1	0.9
Depression (Nagel 2018)	0.3	0.5	1.7	-0.8	-0.7	-0.9	-0.2	-0.3	-0.9	-1.3	-0.3	0.1	0.6	0.7
Intelligence (Savage-Jansen 2018)	0.9	2.9	6.7	1.1	1.3	1.2	1.4	1.2	2.0	2.6	0.7	1.7	-2.3	-2.1
Neuroticism (Nagel 2018)	0.2	0.5	1.5	-0.8	-0.7	0.2	0.1	0.1	-0.9	-0.9	0.9	0.3	1.2	0.3
Schizophrenia (2018)	0.5	1.1	4.4	-0.1	-0.2	-1.1	-1.0	-1.1	-0.9	-2.1	-1.4	-1.0	0.4	0.9
Schizophrenia vs Biploar Disorder	1.7	2.3	6.0	2.3	0.0	-1.7	-1.1	-1.6	1.5	0.7	-2.4	0.5	-1.1	1.7
Worry (Nagel 2018)	0.8	1.6	3.5	-1.3	-1.2	1.2	1.7	1.9	-0.4	0.3	1.4	1.0	1.3	-1.1
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	-1.1	-0.8	-0.6	0.9	0.7	-0.5	0.5	1.6	1.2	0.5	-0.4
Alzheimer’s Disease (in father)	0.5	0.5	1.9	-0.5	-0.5	0.4	-0.0	0.1	-0.6	-1.4	1.0	0.6	0.5	0.9
Alzheimer’s Disease (including proxy)	1.2	1.7	5.0	-1.4	-1.2	0.8	1.7	1.5	-0.5	0.2	2.2	1.7	0.6	-0.8
Crohns Disease (2017)	0.1	0.3	1.6	-0.3	-0.3	1.3	-0.5	-0.3	-0.3	-0.7	-0.4	0.1	-0.4	-0.4
Irritable Bowel Disease (IBD)	0.5	1.2	3.3	-1.6	-1.5	1.8	0.4	0.6	-1.2	-1.4	0.3	0.7	0.5	-0.8
Ulcerative Colitis (UC)	1.5	2.9	6.4	-2.5	-2.5	1.8	1.3	1.5	-1.8	-1.3	1.7	1.0	1.3	-1.2
Major Depression (MDD)	1.1	1.4	6.4	-0.7	0.0	-0.2	-0.5	-0.5	-1.5	-2.5	-0.6	-0.7	1.7	1.4
Reaction Time	0.4	0.8	2.7	0.4	0.9	-0.8	0.8	0.5	1.3	0.9	-0.4	1.6	-1.1	-0.4
Verbal and Numeric Reasoning (VNR)	0.8	1.9	5.1	1.7	1.7	0.1	0.8	0.5	2.0	2.3	0.1	0.5	-1.8	-1.1
Breast Cancer	0.3	0.7	2.5	-1.2	-1.6	0.0	0.7	1.1	-1.1	-0.1	0.0	0.4	0.6	-0.6
Ovarian Cancer	0.5	0.6	2.5	0.1	0.1	-0.6	1.2	1.1	0.8	1.6	0.2	-0.0	-0.2	-0.9
Prostate Cancer	0.6	0.9	3.1	-1.3	-1.2	-1.0	-0.2	-0.1	-1.8	-1.1	0.4	-0.2	1.0	-0.0
Age at First Birth	1.6	2.3	8.1	0.3	0.8	0.6	1.3	1.5	1.4	2.9	1.1	1.4	-1.4	-2.1
Bipolar Disorder (2011)	0.2	0.2	1.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.7	0.2	1.2	0.6
Body Mass Index (BMI) (2010)	1.3	1.8	4.8	1.2	1.3	-1.0	-2.1	-2.2	0.3	-1.0	-1.4	-1.0	-0.9	1.3
Coronary Artery Disease (CAD)	0.4	0.5	1.7	-1.3	0.0	0.0	0.5	0.4	-1.2	-0.1	0.8	0.5	1.0	0.1
Crohns Disease (2012)	0.6	0.9	4.3	-0.3	0.0	2.1	0.0	1.0	0.4	0.1	-0.6	1.0	-1.1	-1.4
Mean Putamen Volume	0.6	0.7	2.4	0.9	0.8	-0.3	-1.5	-1.5	0.3	-0.1	-0.5	-0.6	-0.6	0.9
Fasting Glucose	0.5	0.6	1.2	-0.6	-0.8	-0.8	-0.9	-0.6	-1.1	-0.4	0.2	-0.5	1.1	1.1
HbA1C	0.8	0.9	2.5	-1.4	-1.0	1.1	0.7	0.8	-1.0	-0.3	1.6	-0.8	0.6	-0.4
HDL Cholesterol	0.3	0.5	1.4	-0.6	-0.7	1.2	0.8	0.9	0.1	-0.3	0.1	0.4	-0.2	-1.2
LDL Cholesterol	2.0	3.2	5.1	2.2	2.0	-1.6	-2.1	-2.3	0.8	-0.7	-2.2	-1.7	-1.1	2.0
Lupus	1.3	1.9	4.5	1.7	1.4	-1.2	-2.1	-1.8	0.7	1.2	-0.7	-2.1	-0.4	0.6
Neuroticism (2016)	1.0	1.4	3.5	1.5	1.2	-1.2	-1.1	-1.4	0.2	-1.1	-1.6	-0.2	0.0	1.9
Primary Biliary Cirrhosis	0.5	0.7	1.6	-1.3	-0.7	1.0	0.9	1.0	-0.3	0.1	0.9	0.2	0.1	-1.3
Rheumatoid Arthritis	0.9	1.2	6.2	-1.1	-1.2	-0.1	0.4	0.3	-1.2	-0.6	0.2	0.8	2.5	1.4
Schizophrenia (2014)	0.7	1.4	3.6	0.6	0.4	-1.0	-1.4	-1.3	-0.2	-1.9	-1.8	-1.8	-0.5	0.8
Triglycerides	0.2	0.4	1.1	0.2	0.4	-1.0	-0.4	-0.3	0.2	0.8	0.3	-0.9	0.6	0.7
Type 2 Diabetes (T2D) (2012)	2.0	2.3	8.3	0.9	1.4	1.0	1.1	0.9	2.2	2.9	1.0	0.2	-1.7	-1.3
Ulcerative Colitis	1.1	1.6	3.3	-1.5	-1.8	1.2	1.5	1.5	-1.1	-0.5	1.1	0.9	0.9	-1.1
Blood Eosinophil Count	0.2	1.3	3.4	-1.8	-1.9	-0.1	1.1	1.0	-1.4	-0.2	0.2	1.5	1.2	-0.4
Blood Platelet Count	0.3	3.0	8.2	-1.9	-2.2	-1.4	-0.3	-0.4	-2.6	-2.0	0.5	0.8	2.9	1.7
Blood Red Count	0.1	0.9	2.4	1.6	1.2	-0.2	0.1	0.0	1.3	1.0	-0.8	-1.1	-1.2	-0.4
Blood White Count	0.1	0.6	2.3	-0.3	-0.4	1.5	0.4	0.5	0.1	1.3	1.0	0.5	-0.0	-0.6
Heel T-Score	2.3	18.5	31.7	5.3	5.6	-4.3	-5.3	-5.4	3.0	3.3	-4.2	-0.7	-3.8	3.9
BMI	0.1	0.8	2.0	0.8	1.0	0.8	-0.5	-0.3	0.9	1.4	-0.9	-0.5	-1.3	-0.5
Height	0.1	1.8	5.1	1.2	1.4	1.7	-1.2	-1.1	0.9	-1.6	-0.3	-2.3	-1.3	0.6
Waist Hip Ratio (WHR)	0.8	3.5	7.9	-1.0	-1.6	-2.3	-1.3	-1.2	-2.4	-1.9	-0.9	0.7	2.8	2.7
Systolic Blood Pressure	0.4	2.1	5.3	1.3	1.5	-1.6	-0.2	-0.1	1.6	2.0	-1.5	-2.3	-1.4	-0.7
Smoking Status	1.6	3.8	9.6	-0.1	-0.3	-2.4	-2.6	-2.5	-1.8	-2.2	-1.0	-1.1	1.8	3.1
Allergy or Eczema	0.7	1.7	4.4	0.5	0.7	-1.9	-2.1	-2.0	-0.4	-1.2	-0.9	-0.6	-0.2	1.9
Cardiovascular Disease	0.1	0.2	1.6	0.2	0.1	-0.3	0.1	0.1	0.2	1.2	-0.3	-0.3	0.1	-0.1
Hypothyroidism (self reported)	0.3	0.6	1.6	1.3	1.2	0.2	-0.7	-0.6	0.8	0.2	-0.9	-0.6	-1.1	-0.2
Respiratory disease	0.4	0.8	2.1	-1.1	-1.0	0.3	-0.4	-0.2	-1.1	-1.4	1.2	0.4	1.1	0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.6	7.4	0.6	0.3	-1.1	-2.7	-2.4	-1.1	-1.1	-1.7	-1.4	0.7	2.5
Lung FEV1/FVC ratio	1.3	6.6	22.8	-3.2	-3.3	-2.8	1.2	1.3	-3.1	-0.9	1.8	1.0	4.8	1.7
Lung FVC	0.3	1.4	4.2	0.1	-0.1	-1.7	-0.8	-1.3	-0.6	-1.0	-2.1	0.7	0.7	1.7
Neuroticism	0.2	0.5	1.6	-0.6	-0.6	0.4	0.2	0.3	-0.7	-1.0	0.4	1.3	1.2	0.6
Chronotype (morning person)	0.8	1.9	6.4	0.9	1.2	-2.5	-1.5	-1.3	0.7	0.4	-0.7	-2.5	-0.6	0.4
Hair Pigment	0.2	4.5	11.8	2.2	2.5	2.9	-0.0	-0.1	2.6	1.7	-1.4	2.3	-3.4	-0.9
Tanning	0.5	5.8	16.1	-2.8	-3.2	-2.0	-0.2	-0.1	-3.6	-3.0	0.9	-0.4	4.0	1.5
Hand grip strength (left)	0.1	0.2	0.6	0.3	0.6	-0.8	-0.3	-0.3	0.3	0.1	-0.6	-0.5	0.0	0.3
Number of treatments/medications taken	0.7	1.3	3.5	1.0	0.6	-1.1	-1.5	-1.6	-0.1	-0.6	-1.3	-1.1	0.5	1.9
Average weekly spirits intake	0.1	0.1	0.3	-0.0	0.2	0.5	0.2	0.3	0.1	0.5	0.6	-0.2	0.5	0.5
Sensitivity / hurt feelings	0.5	0.8	3.1	-0.5	-0.6	-0.4	1.3	1.1	-0.3	0.7	0.3	1.8	1.1	-0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.2	0.5	0.6	-0.7	0.1	-0.0	0.7	1.2	0.1	1.5	-0.3	0.3
Hearing difficulty/problems: Yes	0.1	0.2	0.7	0.9	0.2	-0.1	-0.3	-0.6	0.3	0.2	-0.3	-0.3	-0.1	0.4
Relative age of first facial hair	0.4	0.8	3.7	-0.4	-0.1	1.9	0.1	0.2	-0.4	-1.9	0.3	0.6	-0.3	0.5
Other serious medical condition/disability diagnosed by doctor	1.5	1.9	5.8	2.1	2.2	0.4	0.2	-0.1	2.4	0.6	0.4	-1.7	-1.6	0.1
Ever used hormone-replacement therapy (HRT)	1.8	2.2	5.6	-0.4	-0.4	-1.7	-1.6	-1.9	-1.5	-1.8	-1.3	-0.3	1.6	2.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.0	-1.0	-0.8	0.6	0.4	0.7	-0.8	-1.0	0.4	0.4	0.7	0.3
Systolic blood pressure, automated reading	1.4	4.2	8.3	2.4	2.6	-0.6	-0.0	-0.1	2.9	2.6	-1.5	-2.3	-2.8	-1.6
Eye problems/disorders: Diabetes related eye disease	0.9	0.9	2.6	-0.3	-0.6	-0.8	-1.5	-1.1	-1.1	-1.3	-0.1	-1.6	0.4	0.5
Angina	1.6	2.1	4.8	1.5	1.3	-1.0	-2.1	-2.2	0.2	-0.8	-1.5	-1.7	-0.8	1.5
Medication for hormone replacement therapy	0.8	0.9	3.1	-1.2	-0.9	1.5	0.5	0.5	-0.6	-0.7	1.8	-0.0	0.5	-0.1
Vitamin and mineral supplements	0.2	0.2	0.5	0.6	0.5	-0.7	-0.4	-0.7	-0.1	0.0	-0.5	-0.2	-0.0	0.7
Supplements: Zinc	1.7	1.8	4.0	-1.7	-1.4	0.2	1.6	1.8	-0.6	-0.0	2.0	-0.9	1.9	-1.0
Medication: Co-codamol	3.1	3.6	9.8	-1.3	-1.8	-1.4	-1.2	-1.2	-2.7	-3.1	0.6	-0.6	2.7	2.3
Medication: Metformin	1.5	2.1	7.7	0.5	0.3	-1.2	-2.1	-1.9	-0.5	-0.4	-1.6	-2.8	0.5	1.6
Diabetes (father)	0.3	0.3	1.3	-0.3	-0.3	-0.9	-0.6	-0.5	-0.6	-0.1	0.2	-1.2	-0.0	-0.2
Diabetes (mother)	0.8	1.0	2.7	0.7	0.4	-1.6	-1.3	-1.4	-0.4	-0.8	-1.3	-0.8	0.2	1.0
Severe depression (siblings)	0.6	0.7	1.5	-0.9	-1.1	0.0	0.7	0.8	-0.8	-1.2	0.6	0.3	1.2	0.2
Pack years adult smoking proportion	1.4	2.2	5.0	2.0	2.1	-0.2	-0.2	-0.1	2.2	2.2	0.2	-0.5	-2.0	-1.0
Impedance of leg (right)	0.2	1.2	6.9	0.7	0.4	-2.6	-1.3	-1.3	-0.3	0.4	-0.1	-1.0	0.1	0.8
Leg fat-free mass (left)	0.1	0.8	4.9	-0.8	-0.6	2.2	0.2	0.4	-0.4	-0.9	1.0	-0.5	0.6	0.1
Trunk fat percentage	0.5	1.8	3.9	1.7	1.6	-0.4	-0.9	-0.8	1.6	2.0	-0.7	-1.9	-1.5	-0.4
Hand grip strength (right)	0.2	0.5	1.6	1.0	1.3	-0.6	0.0	-0.1	1.0	0.8	-0.5	0.1	-0.2	0.3
Townsend deprivation index at recruitment	1.3	1.8	4.9	-0.4	-0.5	2.2	2.0	1.9	0.6	1.3	1.4	1.2	0.0	-1.1
Current tobacco smoking	1.2	2.0	6.0	0.6	0.4	-1.2	-2.1	-2.0	-0.7	-1.3	-0.4	-1.6	0.8	2.5
Average weekly fortified wine intake	0.3	0.4	1.0	0.6	0.3	-0.3	-0.9	-0.7	0.0	-0.9	-0.7	-1.0	-0.3	0.4
Maternal smoking around birth	0.2	0.4	1.1	-0.3	-0.4	-0.0	-0.2	-0.5	-0.6	-0.8	0.3	-0.1	1.0	1.0
Fed-up feelings	1.1	2.0	5.5	0.5	0.5	2.4	1.7	1.4	1.3	1.7	0.8	1.9	-0.8	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.5	1.2	0.7	0.8	-0.4	-0.3	-0.6	0.5	-0.2	-1.0	-1.1	-0.8	0.4
Relative age voice broke	0.2	0.2	0.6	0.2	0.5	0.8	0.5	0.4	0.5	0.2	0.6	-0.4	-0.1	-0.8
Taking other prescription medications	0.7	1.0	2.1	1.1	0.7	-0.8	-1.4	-1.5	0.2	-0.8	-0.4	-1.4	0.4	1.4
Age when periods started (menarche)	0.1	0.4	0.8	-0.4	-0.4	-0.9	-0.5	-0.4	-0.9	-0.3	0.8	-0.0	0.8	-0.4
Bilateral oophorectomy (both ovaries removed)	1.1	1.3	2.9	1.1	1.0	-0.8	-1.7	-1.5	0.3	-0.7	-0.4	-1.6	-0.2	1.6
Heel bone mineral density (BMD) T-score, automated (left)	2.2	5.1	11.7	3.4	3.4	-1.8	-2.5	-2.7	2.1	1.4	-1.3	-0.5	-1.8	2.1
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.7	-0.0	-0.2	-0.7	-1.6	-1.6	-1.2	-1.4	0.6	0.5	0.7	1.4
Qualifications: CSEs or equivalent	1.6	2.2	4.4	-1.8	-1.6	0.9	1.6	1.8	-0.8	-0.1	2.1	-0.1	1.3	-2.0
Serious illness, injury or assault to yourself	0.4	0.5	2.4	0.4	0.1	-0.6	0.2	0.2	0.2	0.4	1.6	-1.4	0.1	-0.7
High blood pressure	1.1	2.9	8.4	0.6	0.9	1.8	2.2	2.1	2.0	2.9	0.8	0.3	-1.2	-2.0
Hayfever, allergic rhinitis or eczema	0.6	1.2	4.0	0.1	0.3	-2.0	-1.5	-1.5	-0.7	-0.6	-0.7	0.3	0.3	1.9
Multivitamins +/- minerals	0.3	0.4	1.1	-0.3	-0.2	0.9	0.8	0.9	0.3	0.0	0.6	0.2	-0.2	-1.0
Stomach or abdominal pain in last month	1.1	1.4	3.2	1.0	1.0	-1.2	-1.7	-1.8	0.2	-1.2	-1.3	-0.7	-0.1	1.5
Supplements: Glucosamine	0.3	0.4	1.4	-0.3	-0.3	-0.8	-0.4	-0.3	-0.6	-0.6	-0.4	-1.2	1.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.1	2.6	1.1	1.5	-0.7	-1.3	-1.6	0.8	-0.4	-0.8	-0.5	-1.1	0.8
Medication: Atenolol	1.1	1.3	4.1	1.6	1.3	-0.7	-1.5	-1.6	0.6	0.0	-0.9	0.1	-0.3	2.0
Medication: Levothyroxine sodium	0.1	0.2	0.7	0.3	0.4	-0.1	-0.2	-0.0	0.3	-0.0	-0.4	-0.7	-0.7	-0.8
Sitting height	0.1	1.0	3.7	-0.5	-0.5	0.4	-1.2	-1.1	-1.1	-1.9	0.1	-0.6	0.7	1.6
Chronic bronchitis/emphysema (father)	1.4	1.7	3.2	1.8	1.8	-1.2	-1.4	-1.6	1.2	0.1	-0.6	-1.4	-0.6	1.4
High blood pressure (mother)	0.2	0.3	0.7	-0.8	-0.9	-0.2	0.2	0.6	-0.4	0.8	-0.1	0.4	0.3	-0.6
Body mass index (BMI)	0.2	0.9	1.8	1.1	1.1	0.9	-0.1	-0.1	1.3	1.1	-0.9	-0.9	-1.4	-0.6
Impedance of leg (left)	0.2	0.8	5.4	0.4	0.1	-2.3	-0.9	-0.9	-0.3	0.7	-0.1	-0.4	0.3	0.6
Leg predicted mass (left)	0.2	0.8	4.9	-0.8	-0.7	2.2	0.2	0.3	-0.5	-1.1	0.9	-0.5	0.6	0.2
Trunk fat mass	0.3	1.3	3.2	1.4	1.4	0.4	-0.6	-0.5	1.4	1.5	-0.3	-1.8	-1.3	-0.4
Waist circumference	0.2	0.8	2.4	1.0	0.9	0.7	-0.6	-0.4	1.1	1.0	-0.4	-1.6	-0.8	-0.3
Number of incorrect matches in round	0.6	0.9	3.3	0.1	0.2	-0.4	-0.9	-0.8	-0.2	-1.8	-1.6	-1.1	0.3	1.3
Past tobacco smoking	1.5	2.8	6.3	-0.2	-0.1	2.5	2.2	2.2	1.1	1.5	1.6	1.7	-0.9	-2.3
Alcohol usually taken with meals	1.0	1.6	5.9	-1.0	-0.7	1.6	1.8	1.8	0.0	0.7	0.2	2.4	0.0	-0.9
Nervous feelings	1.7	3.2	7.4	0.7	0.7	2.0	2.1	2.0	2.0	2.5	1.3	1.1	-1.2	-2.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	0.5	0.6	-0.3	-1.3	-1.4	0.1	-0.3	-0.7	-0.3	0.6	1.1
Hearing difficulty/problems with background noise	0.3	0.5	1.4	1.2	0.8	-1.0	-0.7	-1.0	0.2	0.4	-0.8	0.1	-0.2	0.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	0.2	0.6	0.0	0.2	0.3	0.7	0.8	-0.3	-1.1	-1.1	-0.8
Had menopause	0.4	0.5	1.8	-0.7	-0.6	0.7	0.8	0.5	-0.6	-1.3	-0.5	-0.7	-0.2	-0.3
Had other major operations	0.3	0.3	1.0	0.5	0.6	0.2	-0.5	-0.4	0.6	0.8	0.3	0.2	-1.0	-0.6
Forced vital capacity (FVC)	0.4	1.5	4.7	-0.8	-0.7	-1.3	-0.8	-1.1	-1.5	-1.4	-0.5	0.8	1.5	2.2
Heel bone mineral density (BMD) T-score, automated (right)	2.2	5.0	9.8	2.4	2.6	-2.9	-3.0	-3.1	0.9	0.4	-1.8	-1.4	-0.8	2.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	2.6	-0.3	-0.4	-0.5	0.1	0.4	-0.4	0.3	1.6	-0.4	0.4	-0.5
Qualifications: None of the above	0.3	0.6	1.9	-1.0	-1.4	0.1	0.1	0.0	-1.3	-1.0	0.0	-0.4	1.1	0.4
Financial difficulties in last 2 years	0.4	0.5	1.3	-0.7	-1.1	0.1	-0.1	-0.0	-0.9	-0.8	1.1	0.4	0.8	0.2
Mouth/teeth dental problems	0.9	1.3	4.0	-0.8	-0.7	-1.9	-0.5	-0.6	-1.2	-0.4	0.0	0.7	1.8	2.0
Heart attack	1.6	2.1	9.0	0.2	-0.2	-3.0	-1.4	-1.8	-1.2	-0.8	-0.4	-0.5	1.3	2.1
Allergy	0.6	1.4	3.5	-0.1	-0.3	1.4	1.9	1.8	0.6	1.5	0.9	0.5	-0.1	-1.8
Pain all over the body in last month	3.9	4.2	8.2	-0.4	-0.7	-1.8	-2.7	-2.8	-1.9	-2.6	-2.9	-1.0	0.7	2.6
Diabetes (self-reported)	0.6	0.9	2.5	0.3	0.2	-0.8	-1.6	-1.3	-0.4	0.3	-0.5	-1.5	0.9	1.3
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	5.9	0.5	0.3	-2.4	-1.8	-1.7	-0.6	-0.4	-0.7	0.3	0.7	2.0
Medication: Ramipril	0.7	0.9	4.8	1.1	0.7	-0.7	-0.6	-0.5	0.5	0.3	-1.5	-2.2	-0.0	0.5
Medication: Simvastatin	0.1	0.2	0.7	0.5	0.6	-0.0	-0.0	-0.3	0.5	0.8	-0.6	0.2	-0.7	-0.0
Fluid intelligence score	0.7	1.4	3.1	1.8	1.7	-0.7	0.1	-0.3	1.6	1.2	-1.5	0.4	-1.6	0.2
Illnesses of siblings	0.4	0.5	2.3	-0.7	-0.7	0.1	0.6	0.5	-0.6	-0.0	0.8	1.5	0.8	-0.2
Neuroticism score	0.4	0.8	3.0	-0.0	0.0	0.7	1.3	1.2	0.6	0.9	0.6	1.7	0.2	-0.8
Weight	0.1	0.7	3.1	0.6	0.8	1.8	-0.1	-0.1	1.0	0.3	-0.1	-1.3	-0.9	-0.3
Impedance of arm (right)	0.2	0.8	3.4	0.7	0.7	-1.8	-0.7	-0.5	0.5	1.6	0.6	-0.8	-0.5	-0.4
Arm fat percentage (right)	0.5	1.9	3.8	1.8	1.8	0.3	-0.6	-0.6	1.9	1.9	-0.9	-1.3	-2.0	-0.7
Trunk fat-free mass	0.2	1.2	7.3	-0.9	-0.7	2.7	0.6	0.5	-0.5	-1.8	0.8	-0.1	0.5	0.2
Hip circumference	0.5	2.1	4.2	1.3	1.4	2.0	0.0	0.3	1.8	1.9	0.4	-1.3	-1.9	-1.6
Time employed in main current job	0.9	1.0	3.0	1.7	1.6	0.5	0.3	-0.1	1.7	0.8	-0.6	0.1	-1.1	-0.0
Alcohol intake versus 10 years previously	1.2	1.8	4.5	1.8	1.9	0.2	-0.8	-0.7	1.9	0.8	-0.2	-2.1	-1.6	-0.6
Father’s age at death	0.5	0.7	1.7	-1.0	-1.0	0.3	0.7	0.5	-1.0	-1.0	1.3	0.6	1.0	0.2
Worrier / anxious feelings	0.3	0.5	1.0	0.4	0.3	0.5	1.0	0.9	0.9	1.0	0.9	0.3	0.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.1	-0.0	0.8	-0.3	-0.1	0.2	0.7	0.7	-0.1	0.3	-0.2
Falls in the last year	1.5	2.1	5.3	-0.7	-1.1	-0.7	-1.2	-1.3	-2.0	-2.3	-0.2	-0.5	1.8	2.1
Hair/balding pattern: Pattern 3	0.6	0.9	3.5	1.2	0.9	-1.9	-0.6	-0.7	0.6	-0.2	-0.6	-0.7	0.2	1.3
Number of live births	2.6	3.7	11.9	-0.5	-1.0	-1.9	-2.0	-2.2	-2.0	-3.5	-1.2	-1.2	1.7	2.2
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	4.8	-1.2	-1.2	-1.4	-0.1	-0.3	-1.7	-0.8	-0.1	1.1	2.2	1.7
Pulse rate	0.2	0.3	1.0	0.1	0.1	0.6	0.1	0.4	0.2	1.0	-0.3	-0.6	-0.5	-0.7
Happiness	0.2	0.2	0.7	0.8	0.4	0.5	-0.3	-0.4	0.0	-0.5	0.7	-0.2	-0.1	0.5
Noisy workplace	0.2	0.2	0.6	0.5	0.2	0.8	0.2	0.1	0.6	0.7	0.0	-0.8	-0.1	-0.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.7	0.8	1.1	0.2	-0.3	-0.2	0.9	0.5	-0.3	0.0	-1.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.9	1.1	5.1	0.7	0.7	0.2	0.7	0.8	1.2	2.2	0.6	-0.1	-0.8	-1.4
Mouth/teeth dental problems: Dentures	2.8	4.7	11.0	1.1	1.2	3.0	1.9	2.1	2.3	2.9	0.9	0.5	-2.5	-3.3
Asthma	0.6	1.2	3.6	-1.1	-1.2	-0.2	-0.7	-0.4	-1.4	-1.9	1.2	-1.1	1.5	0.4
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	3.5	-0.0	-0.3	-1.0	-1.9	-1.7	-1.1	-1.3	-1.3	0.1	1.1	1.5
Medication: Cholesterol lowering	0.6	0.9	1.9	1.4	1.0	0.2	-0.5	-0.9	0.8	0.7	-1.4	0.8	-1.0	1.0
Depression (self-reported)	0.2	0.2	0.5	0.2	0.5	0.7	0.1	0.0	0.7	0.2	0.5	-0.5	-0.5	-0.3
Medication: Lansoprazole	4.0	4.6	10.9	0.5	0.4	-2.5	-2.8	-2.9	-1.2	-1.9	-2.9	-1.5	1.1	3.3
Prospective memory result	1.2	1.5	4.0	-0.8	-0.9	2.0	1.1	1.4	-0.2	0.0	1.7	-1.5	0.5	-1.6
Lung cancer (father)	0.2	0.2	0.6	0.1	-0.2	0.8	0.2	0.3	0.2	0.7	0.2	-0.7	-0.1	-0.7
Illnesses of mother	0.9	1.1	3.5	-0.1	-0.2	-0.9	-0.6	-0.7	-0.6	-1.9	-0.0	-1.2	1.6	1.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	7.7	-1.7	-1.6	-1.3	-0.1	-0.3	-2.0	-1.2	0.1	0.8	2.8	1.7
Pulse wave Arterial Stiffness index	0.6	0.6	1.5	0.6	0.9	0.6	0.3	0.4	1.0	1.2	0.3	-1.0	-0.8	-1.1
Impedance of arm (left)	0.4	1.8	5.2	1.5	1.5	-2.3	-1.6	-1.5	0.9	1.4	-0.3	-1.4	-0.8	0.4
Arm fat mass (right)	0.2	1.0	1.8	1.2	1.3	0.7	-0.6	-0.5	1.3	1.1	-0.7	-1.3	-1.4	-0.3
Trunk predicted mass	0.2	1.3	7.8	-0.9	-0.7	2.8	0.6	0.6	-0.4	-1.7	0.8	-0.2	0.4	0.1
Standing height	0.1	1.0	2.9	-0.8	-0.5	1.7	-0.1	-0.1	-0.7	-1.6	1.5	-0.8	0.8	0.7
Length of working week for main job	1.1	1.2	3.1	-1.1	-1.3	0.4	1.8	1.5	-0.4	0.2	1.4	0.8	1.5	-0.5
Exposure to tobacco smoke at home	1.2	1.3	3.2	0.7	0.7	-1.0	-1.4	-1.4	0.0	-1.0	-1.8	-1.7	0.2	1.3
Breastfed as a baby	0.2	0.2	0.5	0.3	0.7	-0.7	0.4	0.1	0.5	0.1	-0.7	0.5	-0.4	0.6
Tense / ‘highly strung’	0.2	0.3	1.6	-0.2	-0.4	-0.4	0.1	-0.1	-0.7	-0.8	-0.5	0.1	1.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.1	0.1	-0.1	0.2	0.2	0.3	0.4	0.3	0.4	0.1	0.3	-0.2	-0.3
Hair/balding pattern: Pattern 4	0.4	1.1	3.1	0.6	0.4	-1.1	-1.8	-1.5	-0.1	-0.8	-1.3	-1.4	-0.3	0.5
Birth weight of first child	1.5	2.6	6.8	-2.6	-2.3	1.4	0.8	1.1	-1.9	-1.5	1.5	0.7	2.0	-0.5
Peak expiratory flow (PEF)	0.4	1.0	3.4	-0.0	0.2	-1.5	-0.7	-1.0	-0.6	-1.1	-0.7	-0.3	1.1	1.8
Pulse wave reflection index	0.7	0.9	2.0	1.0	1.4	-0.6	-1.0	-1.2	1.1	-0.2	0.2	-1.1	-1.3	-0.4
Ever highly irritable/argumentative for 2 days	1.2	1.5	3.6	1.9	1.7	-0.4	-1.0	-1.0	1.6	1.0	0.2	-1.8	-1.0	-0.4
Loud music exposure frequency	0.7	0.8	2.2	1.5	1.3	0.4	-0.4	-0.5	1.3	0.0	-0.1	-1.1	-1.0	0.0
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.5	0.8	1.2	-0.0	0.2	0.3	1.0	1.2	0.4	-0.4	-1.2	-1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	2.7	0.4	0.3	-0.2	-0.8	-0.9	0.1	-1.6	-0.4	-1.5	-0.5	-0.1
Blood clot in the leg (DVT)	1.1	1.5	4.0	0.5	0.8	2.0	-1.0	-0.9	0.3	-2.0	-0.9	-1.3	-1.6	-0.4
Medication: Paracetamol	0.1	0.1	0.4	0.2	-0.2	0.3	-0.3	-0.3	-0.2	-0.5	0.6	-0.4	0.3	0.4
Headache pain in last month	1.6	2.7	5.8	1.7	1.4	2.1	0.7	1.0	2.1	1.9	1.7	-0.1	-1.5	-2.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.1	3.7	-1.0	-0.8	-0.5	-0.9	-0.6	-1.2	-1.9	0.8	-1.3	1.1	0.3
Glaucoma (self-reported)	0.5	0.6	2.4	1.0	1.1	0.2	-0.2	-0.1	0.9	-0.4	-0.5	-0.4	-1.5	-0.3
Gout (self-reported)	0.9	1.3	5.0	1.3	1.2	-0.1	0.4	0.4	1.9	2.2	0.5	0.6	-0.6	-0.8
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.2	0.8	0.8	0.6	-0.2	0.0	0.7	0.3	-0.7	-1.0	-1.5	-1.3
Medication: Amlodipine	1.1	1.5	4.2	-1.2	-1.0	1.6	1.7	1.7	-0.2	0.6	0.4	0.7	-0.7	-2.0
Medication: Ventolin 100micrograms inhaler	0.9	1.2	3.0	-1.2	-1.6	-0.3	-0.5	-0.3	-1.6	-1.7	0.6	0.1	1.4	0.7
Birth weight	1.2	2.6	6.8	-2.3	-2.1	0.3	0.6	0.6	-2.1	-2.6	0.1	1.1	2.1	0.8
Chronic bronchitis/emphysema (mother)	0.6	0.8	3.7	0.1	0.3	1.3	0.5	0.6	0.8	1.9	-0.0	0.9	-0.6	-0.8
High blood pressure (siblings)	0.1	0.2	0.8	-0.0	-0.2	-0.6	-0.5	-0.3	-0.3	-0.4	-0.1	-0.9	-0.0	-0.1
Forced vital capacity (FVC), Best measure	0.5	1.9	4.2	-1.1	-1.0	-1.4	-1.0	-1.2	-1.8	-1.8	-0.3	0.1	2.1	2.0
Body fat percentage	0.5	1.8	4.0	1.7	1.6	-0.2	-0.7	-0.6	1.7	2.0	-0.8	-1.8	-1.6	-0.6
Leg fat percentage (right)	0.3	1.1	3.5	1.1	1.0	0.2	-0.3	-0.0	1.2	1.5	-0.3	-1.9	-1.3	-0.9
Arm fat-free mass (right)	0.2	1.0	5.0	-0.9	-0.8	2.2	0.4	0.3	-0.6	-1.6	0.7	-0.4	0.6	0.3
Exposure to tobacco smoke outside home	0.7	0.9	3.5	-1.0	-0.9	-1.0	-0.0	-0.0	-1.1	-0.1	-0.8	0.4	1.9	1.2
Comparative body size at age 10	0.8	2.2	5.6	1.4	1.7	1.9	0.8	0.8	2.4	1.7	-0.7	-0.1	-2.0	-1.0
Number of full brothers	1.0	1.3	4.3	-1.4	-1.6	-0.1	-0.6	-0.5	-2.1	-1.8	-0.4	0.7	0.8	0.2
Worry too long after embarrassment	0.2	0.3	1.0	0.3	0.6	-0.7	0.3	0.2	0.6	0.6	0.3	1.0	0.2	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	3.0	-0.6	-0.5	-0.9	-0.8	-0.7	-1.0	-1.7	-1.6	0.1	0.6	1.4
Wheeze or whistling in the chest in last year	0.4	0.7	2.5	0.5	0.8	1.0	-0.4	-0.5	1.0	0.5	0.5	0.2	-1.6	-1.1
Number of children fathered	0.0	0.0	0.3	0.1	0.1	-0.0	0.1	-0.1	0.3	0.1	0.1	-0.1	-0.1	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	2.7	3.2	7.0	2.5	2.7	0.5	-0.3	-0.3	2.5	1.6	-1.3	-2.1	-2.5	-0.3
Age at first live birth	0.1	0.1	0.4	0.0	-0.4	0.1	0.1	0.6	-0.1	0.2	-0.1	0.6	-0.2	-0.5
Pulse wave peak to peak time	0.8	0.9	3.0	-0.6	-1.0	-0.5	-0.5	-0.6	-1.3	-1.7	-0.3	0.7	1.0	1.3
Health satisfaction	0.2	0.3	1.0	-0.4	-0.6	0.5	0.4	0.3	-0.5	0.0	0.8	-0.5	1.0	-0.1
Shortness of breath walking on level ground	0.7	0.8	2.7	-1.0	-0.8	1.3	0.9	1.1	-0.1	-0.5	1.6	0.0	0.8	-0.7
Qualifications: College or University degree	1.0	3.0	7.6	2.2	2.8	-0.4	-1.7	-1.6	2.0	0.7	-1.8	0.5	-2.2	1.6
Eye problems/disorders: None of the above	0.8	0.9	2.5	-1.2	-1.2	0.1	0.8	0.8	-1.0	0.2	-0.1	1.4	1.6	-0.2
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.4	-0.6	-0.6	0.2	-0.5	-0.3	-1.1	-0.7	-0.1	0.8	0.8	1.2
Emphysema/chronic bronchitis	0.2	0.2	0.9	0.3	0.6	0.3	0.4	0.3	1.0	0.2	0.2	-0.2	-0.5	-0.3
Medication for pain relief, constipation, heartburn	1.4	2.4	5.8	-1.3	-0.8	1.9	2.4	2.3	0.2	0.9	1.3	1.3	-0.6	-2.2
Neck or shoulder pain in last month	1.8	2.5	8.1	1.3	0.9	-0.7	-2.9	-2.5	-0.1	-1.6	-1.6	-1.3	-0.3	1.8
Medication: Blood pressure	0.9	1.6	4.3	0.1	0.1	1.4	2.1	1.9	1.0	1.5	0.4	1.6	-0.8	-1.2
Angina (self-reported)	1.4	1.9	4.2	1.4	1.2	-0.9	-2.0	-2.1	0.2	-0.7	-1.6	-1.4	-0.8	1.6
Migraine (self-reported)	0.2	0.3	0.6	0.5	0.5	0.3	-0.3	-0.3	0.5	-0.5	-0.8	-0.5	0.2	0.7
Medication: Ibuprofen	1.0	1.2	2.2	-0.5	-0.6	-0.9	-1.3	-1.3	-1.3	-1.1	-1.1	0.4	1.5	1.4
Medication: Allopurinol	0.3	0.4	1.9	-0.3	-0.6	-0.2	0.5	0.7	0.2	0.8	0.7	0.0	1.4	-0.4
Medication: Omeprazole	0.6	0.7	1.6	-0.8	-1.2	0.9	0.5	0.9	-0.7	-0.5	1.3	-0.5	0.9	-0.8
Medication: Seretide 50 evohaler	0.5	0.6	2.8	-0.7	-0.8	-1.3	0.8	0.6	-0.3	-0.1	0.3	0.3	1.7	-0.2
Mean time to correctly identify matches	0.9	1.6	3.9	1.3	1.8	-1.0	0.7	0.2	2.0	1.2	-1.1	1.4	-1.8	-0.3
Heart disease (mother)	1.8	2.2	5.5	1.8	1.9	0.8	0.2	0.1	2.1	1.9	-1.1	1.1	-2.3	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.5	0.6	0.5	0.1	-1.0	-1.2	-0.2	-0.8	-1.2	-0.6	-0.6	0.6
Whole body fat mass	0.3	1.1	2.8	1.2	1.2	0.5	-0.6	-0.5	1.3	1.3	-0.5	-1.7	-1.2	-0.4
Leg fat mass (right)	0.2	0.6	2.1	0.7	0.7	0.7	-0.3	-0.1	0.8	1.0	-0.0	-1.4	-0.8	-0.5
Arm predicted mass (right)	0.2	1.1	5.7	-1.0	-0.9	2.4	0.6	0.6	-0.6	-1.5	0.8	-0.4	0.7	0.2
Pulse rate, automated reading	0.2	0.8	4.7	0.9	0.8	-0.2	-0.5	-0.4	0.7	2.2	0.5	-1.1	-0.1	-0.1
Alcohol intake frequency.	0.5	1.1	2.8	1.5	1.3	0.6	0.2	0.1	1.7	1.4	0.4	-0.9	-1.1	-0.9
Comparative height size at age 10	0.1	0.3	1.4	-0.1	-0.2	1.2	0.2	0.1	-0.1	-0.9	0.6	-0.2	0.6	0.6
Number of full sisters	0.2	0.2	0.6	0.5	0.1	0.6	0.7	0.4	0.4	0.1	-0.8	0.2	-0.3	-0.2
Suffer from ‘nerves’	0.4	0.7	2.1	-0.2	0.1	1.4	1.2	1.1	0.7	0.6	0.6	0.1	-0.5	-1.2
Overall health rating	0.2	0.4	0.8	0.2	-0.0	-0.8	-0.7	-0.8	-0.1	0.2	0.5	-0.9	0.7	0.7
Chest pain or discomfort	0.4	0.6	2.2	-0.5	-0.7	-0.1	-0.3	-0.5	-0.8	-1.1	0.1	0.2	1.5	1.1
Had major operations	1.3	1.5	4.2	-0.3	-0.6	-1.9	-1.1	-1.3	-1.2	-1.5	0.0	-0.4	1.3	2.1
Age at last live birth	0.4	0.6	1.9	-0.3	-0.9	-0.5	-0.9	-0.3	-1.0	-1.4	-0.7	-0.5	0.7	0.8
Family relationship satisfaction	0.6	0.8	2.1	0.6	0.3	-1.0	-1.5	-1.4	-0.6	-0.4	-0.2	0.7	0.5	1.3
Leg pain on walking	0.5	0.7	2.3	0.2	-0.2	-0.9	-1.0	-1.0	-0.6	-0.2	-0.7	-0.4	1.2	1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.5	-0.7	0.0	-0.7	-0.4	-0.9	-0.3	0.8	-0.5	1.1	0.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.4	0.6	0.2	-1.2	-1.2	-1.0	-0.0	-0.5	-0.5	-0.6	-0.3	0.5
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	-0.1	0.2	0.6	0.3	0.3	0.3	-0.0	-0.6	0.6	-0.7	-0.0
Medication: Aspirin	1.4	1.8	4.8	1.1	1.0	-2.1	-1.4	-1.8	0.2	-0.0	-1.7	-0.8	0.4	2.2
Supplements: Vitamin C	0.7	0.9	1.5	1.2	1.2	-1.0	-1.1	-1.0	1.0	0.1	-0.8	-1.1	-0.8	0.4
Knee pain experienced in last month	0.2	0.3	0.8	-0.4	-0.5	0.4	0.8	0.9	-0.2	0.3	0.1	0.4	0.6	-0.1
Hypertension (Self-reported)	0.8	2.3	7.4	0.8	1.0	1.4	1.9	1.8	1.9	2.7	0.6	0.2	-1.1	-1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.1	-1.9	-2.0	-1.1	-0.2	-0.0	-2.3	-1.8	-0.6	0.8	2.1	1.6
Illnesses of father: Heart disease	0.3	0.5	1.1	0.8	1.1	-1.0	-0.6	-0.9	0.4	0.6	-0.9	0.2	-0.0	0.2
Illnesses of siblings: Diabetes	0.3	0.3	1.3	-0.3	-0.1	0.2	-1.1	-0.7	-0.5	-0.2	0.3	-0.4	0.5	1.1
Smoking status: Previous	1.4	2.1	4.9	0.8	0.9	-2.2	-2.0	-2.0	-0.1	-0.9	-1.7	-1.7	0.3	1.6
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.5	4.1	-1.7	-1.6	1.5	0.5	1.1	-1.2	-0.6	2.0	-0.0	1.2	-0.7
Whole body fat-free mass	0.2	1.1	7.3	-0.9	-0.7	2.7	0.4	0.4	-0.5	-1.5	0.7	-0.1	0.4	0.2
Leg fat-free mass (right)	0.2	1.0	6.1	-1.1	-0.8	2.5	0.4	0.5	-0.5	-1.1	0.9	-0.1	0.8	0.1
Arm fat percentage (left)	0.6	2.3	4.2	2.0	2.1	-0.1	-1.2	-1.2	1.8	1.6	-1.3	-1.7	-1.9	-0.1
Average weekly red wine intake	0.6	0.8	2.5	0.4	0.2	-1.1	-1.0	-1.2	-0.7	-0.4	-0.8	1.3	0.1	1.6
Handedness (chirality/laterality): Left-handed	1.7	2.0	7.3	1.9	2.0	0.6	-0.5	-0.5	1.8	1.3	-1.2	0.2	-2.7	-0.6
Mood swings	0.5	0.8	3.4	0.5	0.3	0.7	0.9	1.0	0.8	1.8	1.1	0.8	0.2	-0.7
Loneliness, isolation	1.2	1.7	6.5	-0.3	-0.2	-1.4	-1.3	-1.4	-1.0	-1.7	-1.0	0.3	1.2	2.6
Long-standing illness, disability or infirmity	0.7	1.1	5.3	1.4	1.2	-0.5	-0.9	-0.9	1.0	-0.0	0.3	-2.3	-0.1	0.8
Ever had bowel cancer screening	0.3	0.4	1.1	0.5	0.4	0.3	0.1	-0.3	0.5	-0.3	-1.0	-1.0	-0.1	1.0
Diabetes diagnosed by doctor	1.1	1.8	4.2	1.1	0.9	-1.0	-2.1	-1.9	0.1	0.1	-1.5	-2.1	0.2	1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	4.0	1.2	1.2	-2.0	-1.6	-1.6	0.5	0.2	0.4	-1.9	0.3	0.7
Friendships satisfaction	0.7	0.9	2.2	0.6	0.3	-1.2	-1.3	-1.4	-0.6	-1.1	-0.2	-0.3	0.5	1.5
Qualifications: nursing, teaching	1.2	1.8	3.9	1.6	2.0	-1.5	-1.1	-1.2	1.6	0.5	-1.6	-0.1	-1.3	1.2
Commuting to job workplace: Walk	0.6	0.7	2.6	-0.8	-0.2	0.8	1.6	1.3	-0.1	-0.3	0.8	0.3	0.2	-0.8
Eye problems/disorders: Cataract	1.7	2.0	5.3	1.5	1.6	-0.8	-1.3	-1.3	1.0	-1.1	-1.7	-2.3	-1.0	1.2
Mouth/teeth dental problems: Mouth ulcers	0.4	0.7	3.0	-0.0	-0.1	1.7	1.0	0.8	0.4	0.3	1.5	0.3	0.1	-0.7
Medication for cholesterol	0.2	0.3	1.1	-0.1	-0.4	0.7	0.6	0.7	-0.1	-0.3	-0.2	1.1	-0.3	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.5	0.3	0.2	0.9	0.3	0.4	0.8	1.3	-0.4	-0.1	-1.4	-1.6
Back pain experienced in last month	3.0	4.4	12.2	-1.9	-2.3	-0.9	-0.9	-0.7	-3.0	-3.2	0.7	-0.9	3.5	2.2
Mineral and other dietary supplements	0.2	0.3	1.0	0.7	0.6	0.5	-0.3	-0.5	0.3	0.1	-0.7	0.7	-1.0	0.3
Breast cancer (self-reported)	1.4	1.6	4.1	1.6	2.0	-0.9	-0.1	-0.3	2.0	1.5	-0.8	-1.1	-1.5	-0.3
Asthma (self-reported)	0.5	1.0	4.4	-0.8	-1.0	0.2	-0.7	-0.5	-1.2	-2.1	0.9	-0.9	1.2	0.4
Osteoporosis (self-reported)	0.4	0.5	1.2	-0.7	-0.6	0.6	1.1	1.1	-0.0	-0.0	1.1	-0.4	0.7	-0.2
Osteoarthritis (self-reported)	0.1	0.2	0.4	-0.3	-0.5	-0.5	-0.1	-0.2	-0.6	-0.2	-0.1	-0.6	0.5	0.4
Medication: Aspirin	1.6	2.0	4.0	1.6	1.5	-1.7	-1.4	-1.8	0.7	0.1	-2.0	-1.2	-0.2	1.8
Medication: Gliclazide	0.3	0.4	1.4	0.6	0.3	-0.3	-0.7	-0.6	0.2	0.5	-0.9	-1.2	-0.3	0.1
Illnesses of father: None of the above (group 1)	1.9	2.4	8.2	-1.6	-1.7	2.9	1.9	2.1	-0.5	-0.6	0.8	0.4	0.4	-1.6
Smoking status: Current	1.1	1.8	5.9	0.0	-0.2	-1.2	-1.7	-1.7	-1.1	-1.4	-0.1	-1.4	1.2	2.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.5	-0.1	-0.6	0.3	0.0	-0.2	0.2	-0.6	0.1	0.6	0.5
Whole body water mass	0.2	1.2	7.5	-0.9	-0.7	2.7	0.4	0.4	-0.5	-1.6	0.7	-0.2	0.5	0.2
Leg predicted mass (right)	0.2	1.1	6.3	-1.1	-0.8	2.5	0.5	0.6	-0.5	-1.1	0.9	-0.2	0.8	0.1
Arm fat mass (left)	0.3	1.4	2.6	1.5	1.6	0.7	-0.7	-0.7	1.6	1.1	-0.8	-1.5	-1.5	-0.2
Number of self-reported non-cancer illnesses	0.7	1.3	3.0	0.4	0.2	-1.2	-1.4	-1.5	-0.5	-1.4	-0.4	-1.4	1.0	1.7
Average weekly champagne plus white wine intake	0.3	0.4	0.9	-0.7	-0.7	-0.1	0.9	1.0	-0.3	0.3	0.4	0.5	0.4	-0.8
Miserableness	1.1	1.8	7.7	-0.5	-0.6	1.0	1.7	1.4	0.3	1.4	1.7	2.8	0.7	-0.7
Guilty feelings	2.3	3.4	9.6	2.8	3.1	-0.3	-0.6	-1.0	2.8	1.2	-1.7	-0.0	-2.5	0.6
Wears glasses or contact lenses	1.3	1.5	4.4	-0.2	0.5	1.4	1.5	1.3	1.2	1.4	0.6	0.5	-1.4	-2.1
Ever taken oral contraceptive pill	0.7	0.8	2.6	-0.6	-0.6	-0.2	-1.6	-1.3	-1.1	-1.3	-0.2	-0.7	0.3	0.4
Hearing aid user	0.4	0.5	1.8	0.1	-0.1	1.4	1.0	0.9	-0.0	0.2	-0.2	1.1	-0.7	-0.4
Mother’s age at death	0.3	0.4	1.0	-0.2	-0.1	0.9	0.7	0.8	0.3	0.4	1.0	1.0	0.3	-0.6
Financial situation satisfaction	0.4	0.4	1.8	0.2	-0.3	0.6	-0.7	-0.5	-0.3	-1.4	-0.3	-0.1	0.6	1.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	4.6	0.5	0.6	-1.0	-2.1	-1.8	-0.7	-0.8	-0.9	-1.1	0.3	1.9
Commuting to job workplace: Public transport	0.4	0.4	1.4	-0.7	-0.6	0.3	0.7	0.5	-0.6	0.1	-1.0	1.2	0.5	0.3
Eye problems/disorders: Glaucoma	1.3	1.6	7.2	1.2	1.3	1.0	0.5	0.5	1.5	0.5	0.1	-0.5	-2.7	-1.7
Medication: Blood pressure	0.2	0.4	2.9	-0.7	-0.4	-0.3	-0.1	0.1	-0.4	0.2	0.1	-1.7	0.5	-0.2
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	0.2	-0.3	-0.6	-0.2	-0.4	-0.4	-1.0	0.4	1.1	1.1	1.1
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.4	0.2	-0.1	0.2	0.0	0.2	0.0	0.4	0.6	-0.3	-0.1	-0.6
High cholesterol (Self-reported)	0.3	0.6	1.6	0.4	0.4	-0.4	-1.1	-1.3	-0.4	-0.7	-1.2	-0.5	-0.3	1.1
Medication: Bendroflumethiazide	0.9	1.4	2.5	1.5	1.5	-1.3	-1.2	-1.1	0.8	1.1	-0.8	-0.5	-1.0	1.6
Medication: Paracetamol	0.1	0.1	0.6	-0.1	-0.4	0.7	0.1	0.2	-0.2	-0.2	0.3	0.2	0.4	0.3
Medication: Lisinopril	0.6	0.8	1.8	-1.3	-1.2	0.7	0.8	0.9	-0.9	0.0	0.9	1.2	0.3	-0.6
Medication: Atorvastatin	0.9	1.1	3.1	0.2	0.0	-0.8	-0.9	-1.3	-0.9	-1.6	-1.6	-0.4	0.3	1.8
Illnesses of father: High blood pressure	0.6	0.7	1.9	-0.1	-0.2	-1.4	-0.8	-1.0	-0.8	-0.7	-1.4	-0.1	0.5	1.0
Alcohol drinker status: Never	1.0	1.2	3.5	0.3	0.5	0.0	1.2	1.2	1.1	1.9	0.9	-1.0	-0.6	-1.6
Ever smoked	1.0	1.8	3.7	0.1	-0.0	-1.7	-1.9	-1.9	-1.1	-1.6	-1.1	-1.0	0.4	1.9
Basal metabolic rate	0.1	0.8	6.1	-0.6	-0.4	2.5	0.3	0.3	-0.2	-1.0	0.7	-0.4	0.3	0.1
Leg fat percentage (left)	0.3	1.0	2.6	1.0	0.9	0.3	-0.1	0.1	1.2	1.6	-0.4	-1.5	-1.2	-0.9
Arm fat-free mass (left)	0.2	1.0	6.5	-0.8	-0.7	2.5	0.8	0.7	-0.4	-1.2	0.8	-0.1	0.4	-0.1
Number of operations (self-reported)	1.9	2.8	6.2	0.3	0.3	-2.5	-2.3	-2.2	-0.9	-1.7	-1.0	-1.8	0.6	2.4
Average weekly beer plus cider intake	1.7	2.5	6.4	1.7	1.7	1.0	-0.1	0.0	1.9	2.0	-1.2	-1.5	-2.5	-1.7
Irritability	0.3	0.6	1.9	-0.0	0.0	-0.4	-1.4	-1.3	-0.5	-0.7	-0.9	0.4	-0.1	1.1
Risk taking	1.4	2.0	4.5	1.2	1.3	-1.4	-2.1	-2.1	0.1	-1.1	-0.8	-1.7	0.2	2.0
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.6	1.2	1.3	0.1	-0.4	-0.8	0.8	0.0	-0.4	-0.1	-1.1	0.7
Fractured/broken bones in last 5 years	0.9	1.1	3.1	-1.3	-1.4	-0.4	0.4	0.2	-1.3	-1.7	0.6	-0.4	1.8	0.2
Age started oral contraceptive pill	0.3	0.4	1.1	0.4	0.4	0.6	0.9	1.1	0.8	0.3	-0.5	0.5	-0.6	-0.3
Diastolic blood pressure, automated reading	0.8	2.6	7.2	1.1	1.5	0.3	0.9	0.9	2.1	2.1	-0.2	-1.1	-2.7	-2.4
Ever depressed for a whole week	0.7	0.8	4.1	0.1	0.1	0.6	1.4	1.2	0.5	0.5	-0.3	2.0	-0.6	-0.6
Unable to work because of sickness or disability	0.7	0.9	2.9	-0.1	-0.4	-1.7	-0.9	-1.0	-0.6	-0.4	0.7	-1.0	1.4	1.0
Commuting to job workplace: Cycle	0.3	0.4	0.9	0.5	0.7	0.8	-0.7	-0.8	0.4	-0.5	0.3	0.3	-0.9	0.4
Myopia	1.5	2.1	4.1	1.7	2.0	-1.4	-1.7	-1.6	1.2	1.2	-1.6	-0.2	-0.8	1.6
Vascular/heart problems diagnosed by doctor	0.8	2.1	6.2	-1.1	-1.4	-1.2	-1.5	-1.3	-2.1	-2.5	-0.0	0.3	1.3	1.4
Cholesterol lowering medication	1.0	1.4	3.1	-0.4	-0.4	-1.8	-1.2	-1.4	-1.2	-1.1	-0.9	-1.4	1.0	1.5
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.1	-0.3	-0.7	0.4	-0.2	0.1	-0.5	-1.0	0.7	-1.4	0.6	-0.4
Pain experienced in last month	0.9	1.5	3.2	-0.2	0.5	0.8	1.7	1.6	1.3	1.3	1.0	0.1	-1.4	-1.8
Supplements: Calcium	2.7	3.0	8.0	-1.9	-2.3	0.6	1.6	1.7	-1.3	-0.7	2.8	1.2	2.6	-0.1
Basal cell carcinoma (self-reported)	0.3	0.3	2.6	0.0	0.1	-0.5	0.2	-0.0	-0.3	0.3	-0.6	1.6	0.2	0.3
Heart attack/myocardial infarction (self-reported)	1.7	2.2	8.6	0.0	-0.5	-2.9	-1.3	-1.7	-1.4	-1.1	-0.3	-0.6	1.6	2.1
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	4.7	0.6	0.9	2.2	-0.6	-0.6	0.6	-1.6	-0.7	-1.1	-1.7	-0.5
Heart disease (siblings)	1.6	2.0	5.7	1.5	1.8	1.6	0.3	0.4	2.2	1.2	-0.3	-0.4	-2.4	-0.9
Alcohol drinker status: Previous	0.4	0.5	1.6	0.3	0.3	-0.9	0.7	0.4	0.6	1.1	1.2	0.3	-0.1	-0.8
Pack years of smoking	1.6	2.4	5.5	2.2	2.3	-0.6	-0.4	-0.3	2.3	2.2	-0.2	-0.8	-2.0	-0.6
Impedance of whole body	0.2	1.1	6.3	0.8	0.7	-2.5	-1.1	-1.1	0.2	1.3	0.1	-0.8	-0.1	0.3
Leg fat mass (left)	0.1	0.5	1.9	0.7	0.7	0.8	-0.2	-0.0	0.8	1.0	-0.1	-1.4	-0.7	-0.4
Arm predicted mass (left)	0.2	1.1	7.2	-0.8	-0.8	2.7	0.8	0.8	-0.3	-1.3	0.8	-0.4	0.3	-0.3