Best TWAS P=5.96e-10 · Best GWAS P=2.26e-10 conditioned to 0.0123
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adrenal Gland | MITD1 | 0.09 | 0.01 | lasso | 10 | 0.01 | 2.0e-01 | 4.7 | 5.2 | 2.3e-07 | 0.70 | 0.05 | 0.47 | FALSE |
2 | GTEx | Adrenal Gland | RP11-527J8.1 | 0.20 | 0.08 | lasso | 5 | 0.12 | 6.4e-05 | 4.7 | 6.2 | 6.0e-10 | 0.76 | 0.01 | 0.97 | TRUE |
3 | GTEx | Breast Mammary Tissue | LYG1 | 0.11 | 0.16 | lasso | 6 | 0.14 | 9.1e-08 | 6.3 | 6.0 | 2.4e-09 | 0.99 | 0.01 | 0.99 | FALSE |
4 | GTEx | Breast Mammary Tissue (Male) | LYG1 | 0.16 | 0.13 | lasso | 7 | 0.10 | 2.4e-03 | 6.0 | 6.0 | 2.5e-09 | 0.98 | 0.01 | 0.94 | FALSE |
5 | GTEx | Colon Sigmoid | LYG1 | 0.21 | 0.13 | lasso | 5 | 0.16 | 3.4e-06 | 5.8 | 5.3 | 1.1e-07 | 0.90 | 0.05 | 0.88 | FALSE |
6 | GTEx | Esophagus Mucosa | LYG1 | 0.16 | 0.05 | enet | 20 | 0.08 | 5.9e-06 | 4.0 | 5.6 | 1.8e-08 | 0.78 | 0.02 | 0.98 | FALSE |
7 | GTEx | Nerve Tibial | LYG1 | 0.10 | 0.12 | lasso | 2 | 0.14 | 6.2e-10 | 5.8 | 5.2 | 1.7e-07 | 0.90 | 0.04 | 0.96 | FALSE |