Best TWAS P=2.91e-11 · Best GWAS P=7.36e-11 conditioned to 0.279
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | UGGT1 | 0.07 | 0.05 | lasso | 3 | 0.06 | 1.7e-05 | -6.5 | 6.5 | 7.4e-11 | -1.00 | 0.01 | 0.99 | FALSE |
2 | GTEx | Artery Aorta | UGGT1 | 0.16 | 0.16 | lasso | 3 | 0.17 | 1.1e-09 | -6.5 | 6.6 | 3.7e-11 | -0.98 | 0.01 | 0.99 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | UGGT1 | 0.13 | 0.13 | lasso | 3 | 0.12 | 2.3e-09 | -6.4 | 6.5 | 9.9e-11 | -0.98 | 0.01 | 0.99 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | AMMECR1L | 0.08 | 0.00 | enet | 17 | 0.00 | 1.6e-01 | -3.8 | -5.3 | 8.8e-08 | 0.50 | 0.05 | 0.55 | FALSE |
5 | GTEx | Esophagus Muscularis | UGGT1 | 0.12 | 0.13 | lasso | 7 | 0.13 | 2.7e-08 | -6.5 | 6.5 | 7.4e-11 | -1.00 | 0.01 | 0.99 | FALSE |
6 | GTEx | Nerve Tibial | UGGT1 | 0.18 | 0.15 | enet | 18 | 0.13 | 1.6e-09 | -6.5 | 5.8 | 8.6e-09 | -0.91 | 0.01 | 0.99 | FALSE |
7 | GTEx | Skin Sun Exposed Lower leg | UGGT1 | 0.07 | 0.07 | lasso | 5 | 0.05 | 6.3e-05 | -6.5 | 6.4 | 1.5e-10 | -1.00 | 0.01 | 0.99 | FALSE |
8 | METSIM | Adipose | UGGT1 | 0.10 | 0.10 | enet | 17 | 0.10 | 2.5e-14 | -6.4 | 5.3 | 9.4e-08 | -0.93 | 0.01 | 0.99 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | UGGT1 | 0.02 | 0.02 | blup | 65 | 0.02 | 2.5e-04 | -5.8 | 5.3 | 1.2e-07 | -0.89 | 0.02 | 0.88 | FALSE |
10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UGGT1 | 0.06 | 0.02 | enet | 7 | 0.04 | 1.7e-05 | -4.4 | 5.6 | 1.8e-08 | -0.76 | 0.05 | 0.89 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | UGGT1 | 0.04 | 0.03 | blup | 65 | 0.02 | 9.4e-04 | -4.5 | 6.1 | 8.8e-10 | -0.74 | 0.03 | 0.48 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | UGGT1 | 0.04 | 0.00 | blup | 65 | 0.02 | 8.6e-03 | -6.4 | 6.7 | 2.9e-11 | -0.91 | 0.01 | 0.80 | TRUE |