[Hub]/) : Traits : Heel T-Score :

chr2:117,881,707-120,718,322

Best TWAS P=3.13e-28 · Best GWAS P=7.89e-192 conditioned to 0

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CCDC93 0.04 0.00 blup 511 0.03 3.1e-04 7.34 7.6 2.4e-14 0.03 0.77 0.01 FALSE
2 CommonMind Brain Pre-frontal Cortex DDX18 0.30 0.34 lasso 11 0.38 2.7e-49 5.32 -5.9 2.9e-09 -0.01 1.00 0.00 FALSE
3 GTEx Artery Aorta AC009404.2 0.15 0.10 lasso 2 0.07 7.2e-05 -5.02 5.4 6.4e-08 0.02 0.46 0.03 FALSE
4 GTEx Cells Transformed fibroblasts DDX18 0.10 0.05 enet 19 0.06 5.7e-05 -1.65 -6.2 6.8e-10 -0.12 0.23 0.08 TRUE
5 GTEx Esophagus Mucosa INSIG2 0.09 0.00 lasso 4 0.00 5.2e-01 9.68 -9.4 3.9e-21 -0.08 0.21 0.04 FALSE
6 GTEx Heart Atrial Appendage HTR5BP 0.22 0.09 lasso 5 0.08 1.6e-04 -0.75 -5.7 1.2e-08 -0.12 0.51 0.05 TRUE
7 GTEx Liver INSIG2 0.26 0.00 lasso 3 0.00 2.3e-01 -4.92 -11.0 3.1e-28 -0.10 0.06 0.12 TRUE
8 GTEx Liver AC009404.2 0.23 0.20 lasso 2 0.20 3.6e-06 -5.02 5.5 4.4e-08 0.05 0.12 0.07 FALSE
9 GTEx Lung STEAP3 0.13 0.00 enet 18 0.01 4.0e-02 -2.78 -5.9 3.6e-09 0.00 0.16 0.05 TRUE
10 GTEx Nerve Tibial DDX18 0.19 0.03 lasso 7 0.06 2.9e-05 4.72 -6.3 3.9e-10 0.01 0.21 0.04 FALSE
11 GTEx Nerve Tibial INSIG2 0.13 0.05 lasso 5 0.02 7.0e-03 -6.71 -6.5 9.2e-11 -0.07 0.35 0.15 TRUE
12 GTEx Skin Sun Exposed Lower leg STEAP3-AS1 0.14 0.05 enet 14 0.08 6.6e-07 -1.21 7.9 2.2e-15 0.01 0.55 0.34 TRUE
13 GTEx Skin Sun Exposed Lower leg AC009404.2 0.10 0.12 lasso 2 0.09 4.8e-08 -5.02 5.2 2.1e-07 0.04 1.00 0.00 FALSE
14 GTEx Whole Blood INSIG2 0.07 0.06 lasso 4 0.04 9.4e-05 9.69 -10.1 3.8e-24 -0.08 0.78 0.01 TRUE
15 METSIM Adipose INSIG2 0.07 0.03 enet 26 0.04 6.6e-07 -4.50 -5.8 6.4e-09 -0.07 0.91 0.00 FALSE
16 METSIM Adipose MARCO 0.22 0.16 lasso 5 0.20 1.7e-29 -6.18 5.7 1.1e-08 0.09 1.00 0.00 FALSE
17 NTR Blood DDX18 0.03 0.00 bslmm 472 0.00 1.3e-01 4.68 -8.4 3.1e-17 -0.19 0.09 0.09 FALSE
18 NTR Blood MARCO 0.24 0.18 enet 18 0.19 6.3e-59 -6.18 5.6 1.8e-08 0.07 1.00 0.00 FALSE
19 The Cancer Genome Atlas Breast Invasive Carcinoma INSIG2 0.03 0.01 lasso 3 0.01 2.2e-02 9.34 -10.5 1.2e-25 -0.03 0.01 0.25 TRUE
20 The Cancer Genome Atlas Breast Invasive Carcinoma MARCO 0.07 0.03 blup 60 0.05 4.6e-10 -6.18 6.5 7.1e-11 0.04 1.00 0.00 FALSE
21 The Cancer Genome Atlas Cervical Squamous Cell Carcinoma DDX18 0.07 0.06 lasso 3 0.04 4.9e-03 -4.92 -5.3 1.4e-07 0.04 0.02 0.25 TRUE
22 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma INSIG2 0.04 0.01 blup 74 0.03 1.3e-04 10.48 -8.3 8.5e-17 -0.13 0.21 0.26 TRUE
23 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma MARCO 0.04 0.00 blup 60 0.02 3.5e-03 -6.18 7.8 4.4e-15 0.02 0.02 0.45 FALSE
24 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MARCO 0.06 0.07 lasso 2 0.07 2.9e-08 -6.18 6.1 1.3e-09 0.06 0.99 0.00 FALSE
25 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma MARCO 0.20 0.08 lasso 3 0.11 9.7e-07 -6.18 5.5 3.3e-08 0.07 0.97 0.00 FALSE
26 The Cancer Genome Atlas Lung Adenocarcinoma MARCO 0.06 0.03 blup 60 0.04 1.6e-05 -6.18 7.3 2.8e-13 0.01 0.25 0.62 FALSE
27 The Cancer Genome Atlas Lung Squamous Cell Carcinoma MARCO 0.05 0.04 lasso 1 0.03 4.5e-04 -6.18 6.2 6.3e-10 0.06 0.59 0.01 FALSE
28 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma MARCO 0.13 0.02 blup 61 0.04 7.5e-04 -6.18 8.2 3.6e-16 0.03 0.05 0.31 TRUE
29 The Cancer Genome Atlas Prostate Adenocarcinoma INSIG2 0.16 0.05 blup 74 0.12 2.7e-12 8.47 -10.6 1.8e-26 0.05 0.26 0.74 TRUE
30 The Cancer Genome Atlas Prostate Adenocarcinoma MARCO 0.08 0.06 lasso 3 0.06 1.0e-06 -4.70 5.4 5.5e-08 0.10 0.96 0.01 FALSE
31 The Cancer Genome Atlas Testicular Germ Cell Tumors MARCO 0.25 0.18 lasso 4 0.18 7.4e-07 -6.18 5.3 1.1e-07 0.06 0.29 0.08 FALSE