Best TWAS P=1.32e-15 · Best GWAS P=3.7e-18 conditioned to 0.00714
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PRPF40A | 0.16 | 0.18 | bslmm | 464 | 0.19 | 1.9e-22 | -7.14 | -8.0 | 1.3e-15 | 0.17 | 0.99 | 0.01 | TRUE |
| 2 | GTEx | Artery Coronary | STAM2 | 0.13 | 0.04 | lasso | 6 | 0.01 | 1.7e-01 | -5.17 | -6.7 | 3.0e-11 | 0.74 | 0.02 | 0.84 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | STAM2 | 0.24 | 0.07 | lasso | 2 | 0.04 | 2.4e-03 | -6.49 | -6.1 | 1.2e-09 | 0.44 | 0.42 | 0.04 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | STAM2 | 0.20 | -0.01 | enet | 9 | -0.01 | 7.1e-01 | -6.55 | -7.4 | 9.8e-14 | 0.63 | 0.06 | 0.34 | TRUE |
| 5 | GTEx | Nerve Tibial | STAM2 | 0.07 | 0.03 | lasso | 4 | 0.02 | 9.2e-03 | -5.17 | -5.6 | 1.8e-08 | 0.52 | 0.25 | 0.38 | FALSE |
| 6 | METSIM | Adipose | STAM2 | 0.05 | 0.02 | bslmm | 429 | 0.02 | 4.2e-04 | 2.91 | -5.1 | 2.9e-07 | 0.44 | 0.71 | 0.04 | FALSE |
| 7 | YFS | Blood | STAM2 | 0.03 | 0.01 | blup | 425 | 0.02 | 3.9e-07 | 0.93 | -6.1 | 1.1e-09 | 0.42 | 0.95 | 0.01 | TRUE |
| 8 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PRPF40A | 0.06 | 0.00 | blup | 66 | 0.04 | 9.3e-03 | -7.14 | -6.7 | 2.9e-11 | 0.08 | 0.02 | 0.69 | FALSE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | PRPF40A | 0.03 | 0.02 | blup | 66 | 0.02 | 5.2e-03 | -7.19 | -7.2 | 5.9e-13 | 0.12 | 0.01 | 0.78 | FALSE |