[Hub]/) : Traits : Heel T-Score : ← →

chr2:159,129,143-160,842,361

Best TWAS P=4.26e-18 · Best GWAS P=6.69e-31 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	WDSUB1	0.33	0.42	lasso	5	0.41	1.6e-53	-6.6	6.6	3.4e-11	0.36	1.00	0.00	FALSE
2	GTEx	Adipose Subcutaneous	WDSUB1	0.29	0.25	lasso	7	0.25	2.5e-20	-6.6	7.0	2.8e-12	0.40	1.00	0.00	FALSE
3	GTEx	Adipose Visceral Omentum	WDSUB1	0.33	0.26	lasso	5	0.29	1.9e-15	-6.3	6.8	1.1e-11	0.40	1.00	0.00	FALSE
4	GTEx	Adrenal Gland	WDSUB1	0.21	0.26	lasso	5	0.23	1.0e-08	-7.0	7.2	6.2e-13	0.45	0.98	0.02	FALSE
5	GTEx	Artery Aorta	WDSUB1	0.31	0.14	lasso	10	0.25	8.5e-14	-6.6	8.7	4.3e-18	0.47	1.00	0.00	TRUE
6	GTEx	Artery Coronary	WDSUB1	0.45	0.21	enet	24	0.13	3.5e-05	-6.6	5.3	1.0e-07	0.35	0.64	0.12	FALSE
7	GTEx	Artery Tibial	WDSUB1	0.22	0.20	enet	14	0.19	1.4e-14	-6.6	6.5	7.1e-11	0.40	1.00	0.00	FALSE
8	GTEx	Brain Caudate basal ganglia	WDSUB1	0.25	0.10	enet	22	0.11	5.1e-04	-7.0	5.7	1.2e-08	0.42	0.24	0.05	TRUE
9	GTEx	Brain Cerebellar Hemisphere	WDSUB1	0.29	0.19	lasso	3	0.16	5.1e-05	-7.0	7.2	6.6e-13	0.40	0.46	0.03	FALSE
10	GTEx	Brain Cerebellum	TANC1	0.52	0.23	lasso	7	0.24	1.2e-07	-5.4	-5.6	1.9e-08	-0.47	0.40	0.06	TRUE
11	GTEx	Brain Cortex	WDSUB1	0.20	0.22	lasso	3	0.22	1.2e-06	-6.7	7.2	8.8e-13	0.45	0.64	0.05	FALSE
12	GTEx	Brain Hypothalamus	WDSUB1	0.21	0.02	enet	24	0.06	1.8e-02	-6.6	8.3	8.2e-17	0.48	0.13	0.16	FALSE
13	GTEx	Brain Nucleus accumbens basal ganglia	WDSUB1	0.36	0.22	lasso	10	0.20	3.7e-06	-6.8	7.7	1.2e-14	0.50	0.45	0.04	FALSE
14	GTEx	Breast Mammary Tissue	WDSUB1	0.19	0.07	lasso	5	0.10	9.7e-06	-6.8	5.8	9.0e-09	0.36	0.71	0.03	FALSE
15	GTEx	Cells Transformed fibroblasts	WDSUB1	0.38	0.41	lasso	11	0.46	1.5e-38	-6.8	7.1	9.6e-13	0.40	1.00	0.00	FALSE
16	GTEx	Colon Sigmoid	WDSUB1	0.25	0.18	enet	13	0.21	4.5e-08	-6.7	7.2	7.6e-13	0.45	0.99	0.00	TRUE
17	GTEx	Colon Transverse	WDSUB1	0.14	0.12	lasso	4	0.10	1.7e-05	-6.6	6.9	4.4e-12	0.38	0.85	0.01	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	WDSUB1	0.59	0.20	lasso	19	0.24	3.6e-09	-6.8	6.4	1.3e-10	0.43	0.98	0.01	TRUE
19	GTEx	Esophagus Muscularis	WDSUB1	0.45	0.29	lasso	6	0.34	4.1e-21	-6.8	6.1	9.7e-10	0.34	1.00	0.00	TRUE
20	GTEx	Heart Atrial Appendage	WDSUB1	0.24	0.13	lasso	3	0.19	6.2e-09	-6.3	6.9	5.1e-12	0.41	0.99	0.00	FALSE
21	GTEx	Heart Left Ventricle	WDSUB1	0.29	0.08	lasso	11	0.07	1.1e-04	-6.6	6.6	3.4e-11	0.38	0.91	0.01	FALSE
22	GTEx	Lung	WDSUB1	0.09	0.10	lasso	1	0.07	5.0e-06	-6.6	6.6	4.2e-11	0.36	0.91	0.00	FALSE
23	GTEx	Muscle Skeletal	WDSUB1	0.32	0.27	enet	41	0.28	5.7e-28	-6.6	7.8	9.4e-15	0.41	1.00	0.00	TRUE
24	GTEx	Nerve Tibial	WDSUB1	0.42	0.27	lasso	7	0.34	6.2e-25	-6.6	6.0	1.7e-09	0.35	1.00	0.00	FALSE
25	GTEx	Ovary	WDSUB1	0.40	0.19	lasso	4	0.26	4.2e-07	-6.6	6.7	1.6e-11	0.40	0.70	0.03	TRUE
26	GTEx	Pancreas	WDSUB1	0.38	0.21	enet	58	0.20	8.5e-09	-6.6	6.7	2.1e-11	0.30	0.99	0.00	FALSE
27	GTEx	Prostate	WDSUB1	0.62	0.18	lasso	9	0.34	2.6e-09	-6.6	7.6	3.1e-14	0.39	0.53	0.07	TRUE
28	GTEx	Skin Sun Exposed Lower leg	WDSUB1	0.08	0.08	enet	9	0.07	1.4e-06	-6.8	6.7	1.9e-11	0.37	0.98	0.00	FALSE
29	GTEx	Testis	WDSUB1	0.52	0.43	lasso	5	0.42	1.8e-20	-6.6	6.9	6.6e-12	0.38	1.00	0.00	FALSE
30	GTEx	Thyroid	WDSUB1	0.19	0.10	lasso	9	0.10	2.8e-08	-6.8	7.3	3.3e-13	0.42	1.00	0.00	FALSE
31	GTEx	Vagina	WDSUB1	0.28	0.13	enet	4	0.14	3.8e-04	-6.8	6.9	4.4e-12	0.39	0.16	0.10	FALSE
32	GTEx	Whole Blood	WDSUB1	0.09	0.00	enet	4	0.00	1.1e-01	-6.7	6.0	1.5e-09	0.25	0.12	0.03	FALSE
33	METSIM	Adipose	WDSUB1	0.14	0.08	enet	19	0.12	2.3e-17	-6.6	8.1	7.5e-16	0.47	1.00	0.00	FALSE
34	YFS	Blood	WDSUB1	0.19	0.12	enet	54	0.16	7.3e-51	-6.6	6.0	2.5e-09	0.24	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	WDSUB1	0.15	0.14	lasso	1	0.13	1.9e-11	-6.7	6.7	2.6e-11	0.45	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	WDSUB1	0.10	0.10	blup	91	0.12	7.0e-23	-6.8	6.7	2.1e-11	0.36	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	WDSUB1	0.10	0.04	enet	11	0.06	2.9e-04	-6.8	6.5	7.0e-11	0.43	0.77	0.04	FALSE
38	The Cancer Genome Atlas	Glioblastoma Multiforme	WDSUB1	0.26	0.40	lasso	1	0.38	1.2e-12	-7.0	7.0	2.1e-12	0.37	1.00	0.00	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	WDSUB1	0.11	0.13	lasso	6	0.15	7.0e-17	-6.6	7.1	1.4e-12	0.42	1.00	0.00	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	WDSUB1	0.17	0.15	lasso	5	0.20	1.8e-21	-7.0	7.3	3.8e-13	0.43	1.00	0.00	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	WDSUB1	0.05	0.02	blup	80	0.03	1.1e-02	-2.8	6.7	2.5e-11	0.46	0.11	0.04	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	WDSUB1	0.38	0.39	enet	15	0.40	2.5e-48	-6.6	6.0	2.0e-09	0.32	1.00	0.00	FALSE
43	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	WDSUB1	0.08	0.02	blup	91	0.04	7.5e-03	-5.5	6.3	2.6e-10	0.43	0.15	0.03	FALSE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	WDSUB1	0.06	0.07	blup	92	0.06	2.6e-07	-6.7	7.4	1.2e-13	0.36	1.00	0.00	TRUE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	WDSUB1	0.10	0.11	enet	16	0.14	7.4e-16	-6.6	7.4	1.0e-13	0.43	1.00	0.00	FALSE
46	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	WDSUB1	0.20	0.06	enet	20	0.07	7.4e-04	-7.0	8.1	6.3e-16	0.35	0.19	0.04	FALSE
47	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	WDSUB1	0.20	0.24	lasso	7	0.23	1.1e-09	-6.8	7.1	1.7e-12	0.41	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	WDSUB1	0.17	0.22	lasso	7	0.22	8.0e-23	-6.6	7.6	2.9e-14	0.42	1.00	0.00	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	WDSUB1	0.08	0.06	blup	89	0.05	5.6e-04	-6.6	8.2	2.4e-16	0.43	0.40	0.05	FALSE
50	The Cancer Genome Atlas	Testicular Germ Cell Tumors	WDSUB1	0.27	0.14	enet	14	0.14	1.6e-05	-7.0	6.8	1.5e-11	0.44	0.80	0.02	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	TANC1	0.08	0.04	blup	180	0.04	1.9e-04	-5.5	-6.3	3.3e-10	-0.43	0.73	0.02	TRUE
52	The Cancer Genome Atlas	Thyroid Carcinoma	WDSUB1	0.12	0.12	blup	89	0.12	4.6e-12	-6.7	8.3	8.8e-17	0.40	1.00	0.00	FALSE