Best TWAS P=8.15e-13 · Best GWAS P=3.81e-13 conditioned to 0.000817
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Visceral Omentum | CMSS1 | 0.12 | 0.01 | enet | 15 | 0.06 | 2.8e-04 | 1.7 | -6.0 | 2.3e-09 | -0.05 | 0.05 | 0.80 | TRUE |
2 | GTEx | Adipose Visceral Omentum | ZBTB11-AS1 | 0.13 | 0.02 | lasso | 3 | 0.03 | 1.5e-02 | 7.2 | -5.8 | 5.2e-09 | -0.42 | 0.02 | 0.93 | FALSE |
3 | GTEx | Artery Aorta | ZBTB11-AS1 | 0.19 | 0.13 | lasso | 6 | 0.12 | 5.3e-07 | 6.2 | -6.8 | 1.4e-11 | -0.54 | 0.03 | 0.97 | FALSE |
4 | GTEx | Artery Tibial | ZBTB11-AS1 | 0.19 | 0.13 | enet | 14 | 0.14 | 7.7e-11 | 6.2 | -5.6 | 2.1e-08 | -0.43 | 0.80 | 0.20 | FALSE |
5 | GTEx | Brain Cortex | TRMT10C | 0.18 | 0.01 | enet | 23 | 0.02 | 6.9e-02 | -2.9 | -5.3 | 9.0e-08 | -0.47 | 0.05 | 0.29 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | SENP7 | 0.30 | 0.08 | enet | 40 | 0.22 | 9.2e-08 | -3.0 | 5.7 | 1.4e-08 | 0.82 | 0.11 | 0.89 | FALSE |
7 | GTEx | Esophagus Muscularis | ZBTB11-AS1 | 0.16 | 0.10 | lasso | 5 | 0.10 | 7.2e-07 | 7.2 | -7.2 | 8.1e-13 | -0.60 | 0.02 | 0.98 | TRUE |
8 | GTEx | Heart Atrial Appendage | ZBTB11-AS1 | 0.10 | 0.08 | enet | 10 | 0.05 | 2.1e-03 | -4.7 | -5.6 | 2.3e-08 | -0.48 | 0.24 | 0.22 | FALSE |
9 | GTEx | Liver | RP11-234A1.1 | 0.25 | 0.00 | enet | 4 | 0.00 | 2.4e-01 | 7.2 | -6.8 | 1.5e-11 | -0.63 | 0.03 | 0.36 | FALSE |
10 | GTEx | Nerve Tibial | SENP7 | 0.20 | 0.17 | lasso | 5 | 0.18 | 2.0e-12 | -3.8 | 5.7 | 1.2e-08 | 0.75 | 0.69 | 0.31 | FALSE |
11 | GTEx | Nerve Tibial | ZBTB11-AS1 | 0.21 | 0.18 | lasso | 3 | 0.18 | 7.9e-13 | 6.2 | -6.8 | 1.3e-11 | -0.57 | 0.91 | 0.09 | FALSE |
12 | GTEx | Spleen | SENP7 | 0.25 | 0.09 | enet | 43 | 0.09 | 3.3e-03 | 4.8 | 5.9 | 3.5e-09 | 0.79 | 0.06 | 0.85 | FALSE |
13 | GTEx | Spleen | ZBTB11-AS1 | 0.27 | 0.17 | lasso | 3 | 0.11 | 8.2e-04 | 6.1 | -5.9 | 4.4e-09 | -0.47 | 0.07 | 0.09 | FALSE |
14 | GTEx | Whole Blood | SENP7 | 0.10 | 0.06 | enet | 42 | 0.06 | 7.3e-06 | 7.2 | 6.0 | 1.9e-09 | 0.87 | 0.02 | 0.98 | FALSE |
15 | METSIM | Adipose | SENP7 | 0.05 | 0.05 | blup | 478 | 0.07 | 2.5e-10 | -3.0 | 6.1 | 1.2e-09 | 0.75 | 0.13 | 0.87 | FALSE |
16 | YFS | Blood | PCNP | 0.02 | 0.01 | lasso | 4 | 0.01 | 3.4e-05 | 7.2 | -6.7 | 2.0e-11 | -0.59 | 0.02 | 0.98 | FALSE |
17 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SENP7 | 0.07 | 0.04 | enet | 17 | 0.07 | 9.3e-07 | -5.6 | 5.4 | 7.4e-08 | 0.78 | 0.04 | 0.94 | FALSE |
18 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | LOC100009676 | 0.18 | 0.05 | blup | 26 | 0.07 | 3.2e-04 | 6.1 | -6.0 | 1.8e-09 | -0.47 | 0.00 | 0.70 | FALSE |
19 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC100009676 | 0.06 | 0.04 | enet | 18 | 0.03 | 1.1e-04 | 6.2 | -5.5 | 3.2e-08 | -0.47 | 0.00 | 0.99 | FALSE |
20 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC100009676 | 0.06 | 0.00 | blup | 26 | 0.02 | 5.7e-03 | 6.2 | -5.9 | 3.8e-09 | -0.45 | 0.00 | 0.75 | FALSE |
21 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LOC100009676 | 0.11 | 0.09 | lasso | 2 | 0.06 | 1.8e-03 | 6.1 | -6.1 | 1.4e-09 | -0.52 | 0.00 | 0.92 | FALSE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC100009676 | 0.13 | 0.07 | blup | 26 | 0.09 | 6.5e-09 | 6.2 | -5.1 | 2.7e-07 | -0.47 | 0.00 | 1.00 | FALSE |