Best TWAS P=3.2e-36 · Best GWAS P=6.31e-41 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC66 | 0.25 | 0.12 | lasso | 9 | 0.19 | 1.8e-22 | 7.0 | -6.0 | 1.9e-09 | 0.12 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | FAM208A | 0.12 | 0.09 | enet | 11 | 0.12 | 1.1e-09 | 6.7 | -7.1 | 1.6e-12 | 0.29 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | CCDC66 | 0.23 | 0.07 | lasso | 2 | 0.12 | 7.0e-10 | 7.0 | -6.4 | 2.0e-10 | 0.23 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Artery Aorta | CCDC66 | 0.21 | 0.22 | lasso | 3 | 0.20 | 4.1e-11 | 7.0 | -7.2 | 4.8e-13 | 0.21 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Artery Tibial | CCDC66 | 0.32 | 0.22 | lasso | 5 | 0.25 | 1.6e-19 | 7.0 | -6.4 | 1.6e-10 | 0.23 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Brain Caudate basal ganglia | FLNB | 0.17 | 0.10 | lasso | 12 | 0.12 | 2.3e-04 | -7.1 | 5.8 | 8.6e-09 | 0.07 | 0.06 | 0.80 | FALSE |
| 7 | GTEx | Brain Caudate basal ganglia | CCDC66 | 0.18 | 0.16 | lasso | 5 | 0.16 | 3.3e-05 | 7.0 | -5.5 | 3.4e-08 | 0.20 | 0.30 | 0.04 | FALSE |
| 8 | GTEx | Brain Cerebellar Hemisphere | ASB14 | 0.27 | 0.28 | lasso | 4 | 0.28 | 8.6e-08 | -5.8 | -5.7 | 1.4e-08 | 0.00 | 0.90 | 0.03 | FALSE |
| 9 | GTEx | Brain Cerebellum | CCDC66 | 0.27 | 0.13 | enet | 14 | 0.18 | 6.3e-06 | 7.0 | -5.8 | 7.4e-09 | 0.29 | 0.66 | 0.09 | FALSE |
| 10 | GTEx | Brain Cerebellum | ASB14 | 0.21 | 0.18 | lasso | 4 | 0.14 | 8.7e-05 | -5.7 | -5.7 | 1.0e-08 | 0.00 | 0.61 | 0.06 | FALSE |
| 11 | GTEx | Brain Cortex | CCDC66 | 0.18 | 0.24 | lasso | 1 | 0.20 | 3.8e-06 | 7.0 | -7.0 | 1.9e-12 | 0.21 | 0.27 | 0.05 | FALSE |
| 12 | GTEx | Brain Frontal Cortex BA9 | CCDC66 | 0.16 | 0.18 | lasso | 3 | 0.14 | 1.3e-04 | 7.0 | -7.0 | 1.8e-12 | 0.22 | 0.24 | 0.04 | FALSE |
| 13 | GTEx | Brain Hypothalamus | CCDC66 | 0.18 | 0.26 | lasso | 3 | 0.22 | 5.6e-06 | 7.0 | -7.5 | 6.9e-14 | 0.23 | 0.15 | 0.14 | FALSE |
| 14 | GTEx | Brain Putamen basal ganglia | CCDC66 | 0.36 | 0.28 | lasso | 3 | 0.25 | 1.3e-06 | 7.0 | -6.5 | 1.1e-10 | 0.19 | 0.18 | 0.07 | FALSE |
| 15 | GTEx | Breast Mammary Tissue | CCDC66 | 0.19 | 0.21 | lasso | 3 | 0.19 | 5.7e-10 | 7.0 | -8.3 | 1.2e-16 | 0.31 | 0.99 | 0.01 | FALSE |
| 16 | GTEx | Breast Mammary Tissue (Male) | CCDC66 | 0.05 | 0.03 | lasso | 3 | 0.04 | 5.1e-02 | 3.6 | -6.2 | 7.6e-10 | 0.21 | 0.05 | 0.06 | TRUE |
| 17 | GTEx | Breast Mammary Tissue (Female) | CCDC66 | 0.16 | 0.06 | enet | 10 | 0.14 | 4.3e-05 | 7.0 | -12.6 | 3.2e-36 | 0.71 | 0.03 | 0.82 | TRUE |
| 18 | GTEx | Cells Transformed fibroblasts | FAM208A | 0.10 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | 9.2 | -8.1 | 5.1e-16 | 0.31 | 0.34 | 0.04 | FALSE |
| 19 | GTEx | Cells Transformed fibroblasts | ARF4 | 0.18 | 0.17 | lasso | 9 | 0.16 | 9.1e-12 | -7.4 | 7.7 | 1.4e-14 | 0.03 | 0.03 | 0.97 | FALSE |
| 20 | GTEx | Colon Sigmoid | ASB14 | 0.19 | 0.08 | lasso | 4 | 0.11 | 8.7e-05 | -5.7 | -6.0 | 1.6e-09 | 0.00 | 0.44 | 0.16 | FALSE |
| 21 | GTEx | Colon Transverse | ARF4 | 0.20 | 0.10 | lasso | 10 | 0.12 | 1.7e-06 | -7.4 | 7.0 | 2.3e-12 | 0.01 | 0.04 | 0.96 | FALSE |
| 22 | GTEx | Esophagus Mucosa | CCDC66 | 0.23 | 0.14 | lasso | 3 | 0.17 | 2.9e-11 | 7.0 | -6.3 | 2.6e-10 | 0.17 | 0.99 | 0.00 | FALSE |
| 23 | GTEx | Esophagus Muscularis | CCDC66 | 0.27 | 0.25 | lasso | 6 | 0.26 | 8.0e-16 | 7.0 | -8.0 | 1.6e-15 | 0.19 | 1.00 | 0.00 | TRUE |
| 24 | GTEx | Heart Atrial Appendage | CCDC66 | 0.29 | 0.20 | enet | 29 | 0.20 | 2.4e-09 | 7.0 | -5.9 | 3.7e-09 | 0.18 | 0.93 | 0.00 | FALSE |
| 25 | GTEx | Heart Left Ventricle | CCDC66 | 0.18 | 0.17 | lasso | 3 | 0.18 | 5.2e-10 | 7.0 | -6.7 | 1.8e-11 | 0.19 | 0.96 | 0.00 | FALSE |
| 26 | GTEx | Heart Left Ventricle | FLNB-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.0e-01 | -7.3 | -8.8 | 1.8e-18 | 0.03 | 0.03 | 0.71 | TRUE |
| 27 | GTEx | Lung | CCDC66 | 0.13 | 0.15 | lasso | 2 | 0.15 | 1.4e-11 | 7.0 | -7.0 | 3.2e-12 | 0.21 | 1.00 | 0.00 | FALSE |
| 28 | GTEx | Nerve Tibial | CCDC66 | 0.30 | 0.27 | lasso | 4 | 0.27 | 2.1e-19 | 7.0 | -7.8 | 5.6e-15 | 0.21 | 1.00 | 0.00 | FALSE |
| 29 | GTEx | Ovary | CCDC66 | 0.47 | 0.22 | lasso | 7 | 0.14 | 2.5e-04 | 7.0 | -8.4 | 4.9e-17 | 0.24 | 0.08 | 0.06 | TRUE |
| 30 | GTEx | Ovary | RP11-755B10.4 | 0.24 | 0.21 | lasso | 8 | 0.19 | 2.4e-05 | 5.7 | -6.0 | 1.8e-09 | -0.01 | 0.11 | 0.11 | TRUE |
| 31 | GTEx | Pancreas | CCDC66 | 0.19 | 0.16 | lasso | 3 | 0.15 | 9.1e-07 | 7.0 | -7.1 | 9.0e-13 | 0.21 | 0.44 | 0.06 | FALSE |
| 32 | GTEx | Pituitary | CCDC66 | 0.16 | 0.16 | enet | 31 | 0.12 | 6.8e-04 | 7.0 | -8.0 | 1.7e-15 | 0.29 | 0.23 | 0.16 | FALSE |
| 33 | GTEx | Skin Sun Exposed Lower leg | CCDC66 | 0.09 | 0.09 | lasso | 5 | 0.05 | 8.1e-05 | 7.0 | -7.1 | 1.5e-12 | 0.20 | 0.94 | 0.00 | FALSE |
| 34 | GTEx | Spleen | CCDC66 | 0.31 | 0.22 | lasso | 10 | 0.20 | 1.0e-05 | 7.0 | -5.8 | 6.5e-09 | 0.18 | 0.16 | 0.05 | FALSE |
| 35 | GTEx | Stomach | CCDC66 | 0.16 | 0.06 | lasso | 4 | 0.06 | 8.5e-04 | 7.0 | -7.2 | 4.8e-13 | 0.23 | 0.19 | 0.05 | FALSE |
| 36 | GTEx | Testis | CCDC66 | 0.20 | 0.01 | enet | 31 | 0.01 | 1.2e-01 | 6.0 | -6.9 | 5.2e-12 | 0.16 | 0.10 | 0.05 | TRUE |
| 37 | GTEx | Thyroid | CCDC66 | 0.22 | 0.26 | lasso | 4 | 0.26 | 5.9e-20 | 7.0 | -7.2 | 4.8e-13 | 0.21 | 1.00 | 0.00 | FALSE |
| 38 | ROSMAP | Brain Pre-frontal Cortex | ABHD6 | 0.10 | 0.01 | bslmm | 456 | 0.07 | 8.8e-09 | -2.2 | 5.6 | 2.0e-08 | -0.03 | 0.98 | 0.00 | FALSE |
| 39 | ROSMAP | Brain Pre-frontal Cortex | ARHGEF3 | 0.37 | 0.28 | bslmm | 525 | 0.29 | 6.6e-38 | 7.3 | 8.4 | 5.4e-17 | -0.01 | 1.00 | 0.00 | TRUE |
| 40 | ROSMAP | Brain Pre-frontal Cortex | ARF4 | 0.12 | 0.15 | lasso | 7 | 0.16 | 1.4e-19 | -7.3 | -7.5 | 7.0e-14 | -0.02 | 0.04 | 0.96 | FALSE |
| 41 | ROSMAP | Brain Pre-frontal Cortex | DNAH12 | 0.04 | 0.00 | blup | 448 | 0.02 | 1.0e-03 | 1.4 | 6.0 | 2.4e-09 | 0.01 | 0.10 | 0.47 | FALSE |
| 42 | ROSMAP | Brain Pre-frontal Cortex | CCDC66 | 0.24 | 0.24 | lasso | 6 | 0.25 | 1.0e-31 | 7.0 | -7.1 | 1.7e-12 | 0.17 | 1.00 | 0.00 | FALSE |
| 43 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ASB14 | 0.05 | 0.03 | enet | 7 | 0.03 | 3.7e-07 | -5.8 | -5.8 | 4.8e-09 | -0.01 | 0.03 | 0.96 | FALSE |
| 44 | The Cancer Genome Atlas | Colon Adenocarcinoma | CCDC66 | 0.14 | 0.12 | lasso | 2 | 0.10 | 1.2e-06 | 5.1 | 5.2 | 2.4e-07 | -0.02 | 0.66 | 0.12 | FALSE |
| 45 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC66 | 0.05 | 0.05 | blup | 56 | 0.06 | 1.0e-07 | 9.0 | 7.0 | 3.6e-12 | -0.19 | 0.00 | 1.00 | TRUE |
| 46 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf63 | 0.03 | 0.01 | enet | 4 | 0.01 | 1.3e-02 | 9.2 | -8.2 | 1.8e-16 | 0.28 | 0.00 | 0.93 | FALSE |
| 47 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC66 | 0.09 | 0.05 | blup | 56 | 0.06 | 5.3e-07 | 3.5 | 5.8 | 5.1e-09 | -0.09 | 0.94 | 0.06 | FALSE |
| 48 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ASB14 | 0.08 | 0.07 | enet | 5 | 0.07 | 1.1e-08 | -5.8 | -5.8 | 7.1e-09 | 0.00 | 0.04 | 0.96 | FALSE |
| 49 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SPATA12 | 0.04 | 0.02 | blup | 70 | 0.03 | 4.4e-04 | 5.3 | -6.0 | 2.1e-09 | 0.02 | 0.03 | 0.68 | FALSE |
| 50 | The Cancer Genome Atlas | Lung Adenocarcinoma | ASB14 | 0.03 | 0.02 | blup | 32 | 0.02 | 3.4e-03 | -5.7 | -5.5 | 3.4e-08 | 0.01 | 0.02 | 0.47 | FALSE |
| 51 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC66 | 0.05 | 0.06 | blup | 56 | 0.05 | 9.7e-07 | 9.0 | 6.5 | 6.3e-11 | -0.18 | 0.00 | 1.00 | FALSE |
| 52 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ASB14 | 0.06 | 0.06 | lasso | 1 | 0.06 | 7.8e-07 | -5.7 | -5.7 | 1.0e-08 | -0.01 | 0.04 | 0.96 | FALSE |
| 53 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CCDC66 | 0.20 | -0.01 | lasso | 3 | 0.00 | 3.0e-01 | 5.1 | 5.9 | 2.9e-09 | -0.07 | 0.03 | 0.17 | TRUE |
| 54 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC66 | 0.05 | 0.01 | blup | 57 | 0.02 | 8.4e-03 | 4.0 | 5.8 | 6.8e-09 | -0.15 | 0.06 | 0.57 | FALSE |