Best TWAS P=7.82e-12 · Best GWAS P=1.82e-10 conditioned to 0.32
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GRAMD1C | 0.05 | 0.03 | lasso | 2 | 0.02 | 1.4e-03 | -4.2 | 5.7 | 1.1e-08 | 0.59 | 0.08 | 0.86 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NAA50 | 0.06 | 0.03 | blup | 433 | 0.02 | 2.4e-03 | 6.1 | 6.8 | 7.8e-12 | 0.86 | 0.05 | 0.95 | TRUE |
| 3 | GTEx | Nerve Tibial | ATP6V1A | 0.10 | 0.09 | lasso | 4 | 0.09 | 3.4e-07 | 5.6 | 6.1 | 8.6e-10 | 0.97 | 0.04 | 0.96 | FALSE |
| 4 | GTEx | Stomach | QTRTD1 | 0.09 | 0.08 | lasso | 3 | 0.08 | 1.1e-04 | 5.9 | 6.0 | 2.3e-09 | 0.94 | 0.04 | 0.89 | FALSE |
| 5 | NTR | Blood | ATP6V1A | 0.04 | 0.05 | enet | 26 | 0.05 | 1.0e-16 | 6.1 | -6.5 | 7.9e-11 | -0.90 | 0.04 | 0.96 | FALSE |
| 6 | The Cancer Genome Atlas | Glioblastoma Multiforme | GRAMD1C | 0.15 | 0.01 | blup | 73 | 0.07 | 4.5e-03 | 1.2 | 6.0 | 2.3e-09 | 0.74 | 0.01 | 0.32 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ATP6V1A | 0.02 | 0.02 | lasso | 3 | 0.01 | 9.1e-03 | 3.8 | -5.3 | 1.2e-07 | -0.76 | 0.02 | 0.71 | FALSE |