Best TWAS P=4.26e-11 · Best GWAS P=2.8e-14 conditioned to 2.01e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | SENP2 | 0.21 | 0.18 | enet | 33 | 0.19 | 4.2e-22 | 5.2 | -5.2 | 1.7e-07 | -0.06 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Aorta | SENP2 | 0.14 | 0.01 | lasso | 1 | 0.02 | 4.4e-02 | 5.6 | 5.6 | 2.7e-08 | 0.09 | 0.05 | 0.04 | FALSE |
| 3 | METSIM | Adipose | SENP2 | 0.06 | 0.04 | lasso | 5 | 0.03 | 6.2e-06 | 5.6 | 5.5 | 3.2e-08 | 0.04 | 0.99 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | IGF2BP2 | 0.03 | 0.02 | lasso | 1 | 0.01 | 5.5e-02 | 6.6 | -6.6 | 4.3e-11 | -0.01 | 0.02 | 0.54 | TRUE |