TWAS hub - SENP2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2080	0.0430	5.6e-17	0.177	0.156	0.186	0.176	0.177	5.1e-21	1.5e-18	4.2e-22	6.4e-21	4.8e-21
2	GTEx	Artery Aorta	0.1360	0.0520	7.6e-03	0.013	NA	0.003	NA	0.016	6.1e-02	NA	2.0e-01	NA	4.4e-02
3	GTEx	Breast Mammary Tissue	0.2130	0.0790	5.5e-03	-0.003	NA	0.048	NA	0.000	5.4e-01	NA	1.7e-03	NA	3.2e-01
4	GTEx	Breast Mammary Tissue (Female)	0.2905	0.1155	1.8e-02	0.067	NA	0.123	NA	0.032	4.8e-03	NA	1.7e-04	NA	4.0e-02
5	METSIM	Adipose	0.0582	0.0204	1.7e-05	0.040	0.025	0.024	0.027	0.034	1.2e-06	1.1e-04	1.2e-04	4.8e-05	6.2e-06
6	YFS	Blood	0.1108	0.0194	0.0e+00	0.140	0.143	0.150	0.147	0.150	2.0e-43	2.5e-44	9.7e-47	7.8e-46	1.2e-46

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Family relationship satisfaction	5.0	6.2	14.9	-2.2	2.0	0.2	-1.8	3.9	3.1
Systolic Blood Pressure	4.7	23.5	47.5	-6.5	4.1	1.7	1.3	6.9	5.5
Fluid intelligence score	4.5	9.3	16.7	4.1	-3.2	-1.6	-0.8	-3.4	-3.8
Birth weight	4.4	9.6	19.3	4.2	-1.1	-2.2	-1.5	-4.4	-3.6
Comparative height size at age 10	4.0	22.0	38.1	6.2	-3.2	-4.7	-4.6	-5.1	-3.8
Illnesses of siblings: Diabetes	3.8	4.7	8.0	-2.4	2.8	1.4	1.3	2.4	2.4
Pulse rate, automated reading	3.6	11.6	25.2	-5.0	2.7	1.0	0.8	4.7	3.7
Supplements: Glucosamine	3.3	4.4	6.3	1.9	-2.3	-2.5	-2.5	-1.8	-1.2
Birth weight of first child	3.3	5.9	10.0	2.1	-3.2	-2.8	-1.6	-2.7	-1.8
Diastolic blood pressure, automated reading	3.3	10.1	19.7	-4.1	1.8	1.8	2.2	4.4	3.7
Medication: Metformin	3.2	4.5	9.2	-2.2	3.0	1.0	0.6	2.4	2.5
Ovarian Cancer	3.1	4.1	8.0	2.7	-1.1	-0.5	-1.0	-2.8	-2.6
Cardiovascular Disease	3.1	10.1	14.3	-3.8	2.9	2.3	3.3	3.2	3.4
Diabetes (mother)	3.1	3.9	9.3	-1.7	3.0	2.1	1.3	2.0	1.2
Trunk fat-free mass	3.1	18.0	30.0	5.5	-3.6	-3.4	-3.4	-5.1	-4.0
Standing height	3.1	30.5	49.3	6.0	-3.5	-6.6	-7.0	-5.2	-3.8
Trunk predicted mass	3.0	17.4	29.9	5.5	-3.6	-3.2	-3.2	-5.0	-3.9
Leg predicted mass (left)	2.9	15.2	31.5	5.6	-2.6	-1.9	-1.5	-5.3	-4.3
Fractured/broken bones in last 5 years	2.9	3.7	7.7	2.3	-1.3	0.6	-0.6	-2.6	-2.8
Heel T-Score	2.8	22.1	30.9	-5.2	5.6	3.4	2.5	5.5	5.1
BMI	2.8	16.0	30.7	5.5	0.1	3.1	3.6	-4.6	-4.5
Leg fat-free mass (left)	2.8	14.9	31.5	5.6	-2.6	-1.8	-1.5	-5.3	-4.2
High blood pressure	2.8	7.9	10.2	-3.0	3.2	2.4	2.5	3.0	2.7
Illnesses of siblings	2.8	3.9	6.6	1.9	-1.4	-1.8	-2.1	-2.0	-2.6
Peak expiratory flow (PEF)	2.8	6.6	16.0	1.8	-4.0	-1.9	-1.5	-2.6	-2.9
Whole body fat-free mass	2.8	15.9	29.9	5.5	-3.2	-2.6	-2.5	-5.1	-4.0
Whole body water mass	2.8	16.0	30.3	5.5	-3.2	-2.6	-2.4	-5.1	-4.1
Basal metabolic rate	2.8	15.7	32.4	5.7	-2.8	-2.3	-2.0	-5.2	-4.2
Verbal and Numeric Reasoning (VNR)	2.7	6.6	11.0	3.3	-2.8	-1.4	-0.8	-3.0	-3.0
Height	2.7	51.3	79.6	8.3	-2.7	-8.8	-8.9	-6.4	-5.7
Age when periods started (menarche)	2.7	6.5	14.8	1.8	-1.7	-3.9	-2.4	-2.5	-2.4
Allergy	2.7	6.3	15.3	3.9	-1.9	0.2	0.7	-2.8	-3.3
Medication: Simvastatin	2.7	4.0	9.3	-1.4	2.1	2.3	3.0	1.3	1.3
Medication: Lansoprazole	2.7	3.1	6.7	-2.2	2.6	1.2	0.4	1.6	1.7
Medication for cholesterol, blood pressure or diabetes	2.7	4.4	10.0	3.2	-1.5	-0.2	-1.2	-2.6	-2.4
Diabetes diagnosed by doctor	2.7	4.5	14.2	-1.6	3.8	1.0	1.2	2.1	1.8
Chronotype (morning person)	2.6	6.1	14.8	0.5	3.9	3.5	3.0	0.1	-0.1
Forced vital capacity (FVC)	2.6	9.9	15.1	2.2	-2.9	-3.8	-3.9	-3.2	-2.4
Weight	2.6	12.9	33.6	5.8	-1.4	-0.7	-0.3	-5.0	-4.1
Hip circumference	2.6	11.0	31.2	5.6	-1.6	-0.2	-0.2	-4.2	-3.9
Medication: Allopurinol	2.6	3.4	8.2	-1.7	0.3	-1.6	-2.9	1.2	2.3
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.3	8.6	2.5	-1.1	-2.9	-2.3	-2.3	-2.3
Leg fat-free mass (right)	2.6	13.7	30.4	5.5	-2.3	-1.4	-1.1	-5.1	-4.1
Osteoporosis (self-reported)	2.6	3.2	6.5	2.4	-1.8	0.4	-0.5	-2.6	-1.8
Medication: Gliclazide	2.6	2.9	6.0	-2.5	2.2	0.2	0.2	1.4	2.2
Leg predicted mass (right)	2.6	14.1	31.1	5.6	-2.4	-1.5	-1.2	-5.2	-4.2
Prospective memory result	2.5	3.0	6.3	-2.2	2.5	0.7	1.0	1.5	1.8
Exposure to tobacco smoke outside home	2.5	3.3	7.3	1.5	1.1	2.7	2.1	-1.6	-1.5
Hypertension (Self-reported)	2.5	7.0	10.4	-2.5	3.2	2.5	2.6	2.6	2.4
Vascular/heart problems diagnosed by doctor	2.5	6.8	10.2	2.5	-3.2	-2.5	-2.5	-2.6	-2.3
Medication: Co-codamol	2.4	2.7	7.0	0.8	1.6	2.6	2.5	-0.4	-0.3
Forced expiratory volume in 1-second (FEV1)	2.4	8.0	12.7	1.7	-3.2	-3.6	-3.0	-2.8	-2.3
Arm predicted mass (left)	2.4	12.1	24.2	4.9	-3.0	-2.2	-1.9	-4.4	-3.5
Ulcerative Colitis	2.3	3.3	7.3	-2.7	-0.2	-1.2	-1.6	2.0	2.1
Diabetes (self-reported)	2.3	3.5	9.6	-1.4	3.1	0.7	1.1	2.2	1.8
Forced vital capacity (FVC), Best measure	2.3	8.2	14.2	2.0	-2.1	-3.8	-3.6	-3.1	-2.1
Pulse wave peak to peak time	2.3	2.7	5.0	2.2	-1.2	-1.5	-0.3	-2.2	-1.6
Friendships satisfaction	2.3	2.8	8.0	-1.6	-0.6	-0.2	-1.4	2.8	2.0
Arm fat-free mass (left)	2.3	11.6	23.5	4.8	-2.9	-1.9	-1.6	-4.3	-3.6
Heart disease (siblings)	2.3	2.8	5.1	-1.3	1.0	2.3	2.1	1.2	1.8
Mean Putamen Volume	2.2	2.5	4.5	2.0	-2.1	-1.1	-0.5	-1.7	-1.6
Allergy or Eczema	2.2	5.9	12.2	-3.5	1.8	-0.2	-0.6	3.1	3.2
Diabetes (father)	2.2	2.7	6.0	-1.3	2.5	2.0	1.3	1.0	1.4
Number of incorrect matches in round	2.2	3.6	7.5	-2.7	0.5	-0.5	-0.2	2.6	2.5
Father’s age at death	2.2	3.0	5.7	1.4	-1.4	-2.2	-0.9	-2.4	-1.7
Forced expiratory volume in 1-second (FEV1), Best measure	2.2	7.0	12.7	1.7	-2.6	-3.6	-2.6	-2.9	-2.2
Arm fat mass (right)	2.2	9.1	23.7	4.9	-0.4	1.0	1.5	-3.9	-3.5
Medication: Blood pressure	2.2	3.8	9.8	-3.1	0.9	0.5	1.2	2.4	2.2
Arm fat mass (left)	2.2	9.1	22.8	4.8	-0.6	0.8	1.7	-4.0	-3.5
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	5.9	2.1	1.6	-0.3	0.3	-1.8	-2.4
Systolic blood pressure, automated reading	2.1	6.1	12.7	-2.7	2.6	1.2	0.9	3.6	2.7
Illnesses of father: None of the above (group 1)	2.1	2.6	5.1	2.3	-0.6	-1.2	-1.5	-2.1	-1.4
Depression (Nagel 2018)	2.0	3.0	5.3	2.3	1.0	2.0	1.6	-1.6	-1.6
Type 2 Diabetes (T2D) (2018)	2.0	3.8	9.7	-1.4	3.1	1.7	1.8	1.6	1.6
Trunk fat mass	2.0	8.7	23.4	4.8	-0.4	0.1	1.0	-3.9	-3.5
Heart attack	2.0	2.5	5.4	-1.1	1.8	2.3	1.7	1.3	0.7
Medication: Ramipril	2.0	2.6	7.7	-1.5	2.8	1.3	0.4	1.5	1.3
Arm fat percentage (right)	2.0	7.8	14.9	3.9	0.5	2.3	2.9	-3.0	-2.9
Gout (self-reported)	2.0	2.7	4.9	-2.0	0.5	-0.6	-2.2	1.4	2.2
Arm fat percentage (left)	2.0	8.0	16.0	4.0	0.5	1.9	2.9	-3.3	-3.1
Other serious medical condition/disability diagnosed by doctor	1.9	2.4	6.3	2.5	1.4	0.1	-0.4	-2.0	-1.5
Bilateral oophorectomy (both ovaries removed)	1.9	2.2	3.1	-1.2	1.6	1.7	1.8	1.4	1.1
Arm fat-free mass (right)	1.9	9.7	16.2	4.0	-2.8	-2.7	-2.2	-3.8	-2.8
Number of full brothers	1.9	2.3	3.9	1.9	-1.9	-0.3	0.8	-1.5	-2.0
Whole body fat mass	1.9	8.1	21.7	4.7	-0.3	0.4	1.1	-3.8	-3.3
Arm predicted mass (right)	1.9	9.8	16.0	4.0	-2.7	-2.8	-2.3	-3.8	-2.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.9	2.2	5.8	2.4	-0.6	1.4	0.4	-1.4	-1.8
Intelligence (Savage-Jansen 2018)	1.8	5.4	8.8	2.7	-2.9	-1.3	-0.3	-2.5	-3.0
Blood White Count	1.8	13.3	18.0	-3.8	1.8	4.1	4.0	4.2	3.4
Severe depression (siblings)	1.8	2.1	3.9	1.3	-1.7	-1.0	-0.8	-2.0	-1.5
Maternal smoking around birth	1.8	2.6	6.1	1.8	0.1	-0.7	0.4	-2.5	-2.3
Falls in the last year	1.8	2.4	5.3	1.9	-0.7	1.0	0.7	-2.3	-1.9
Pulse rate	1.8	3.0	5.2	-2.3	1.8	1.5	1.0	2.1	1.2
Knee pain experienced in last month	1.8	2.7	8.5	-0.4	1.5	2.3	2.9	-0.1	0.1
Hayfever, allergic rhinitis or eczema	1.7	3.6	8.1	-2.9	1.6	-0.8	-1.2	1.9	2.4
Sitting height	1.7	12.1	31.6	2.4	-2.5	-5.0	-5.6	-2.0	-0.5
Pain all over the body in last month	1.7	1.8	4.2	1.7	0.3	-0.6	-0.1	-1.8	-2.0
Medication: Cholesterol lowering	1.7	2.7	4.4	-2.1	1.5	1.0	1.5	1.9	1.7
Exposure to tobacco smoke at home	1.7	1.9	3.9	-2.0	0.9	-0.1	0.2	1.9	1.8
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	4.4	-1.4	2.1	1.0	0.6	1.7	1.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.8	-1.4	2.0	1.1	0.1	2.0	1.1
Asthma (self-reported)	1.7	3.3	6.7	-2.6	1.1	1.4	1.0	2.4	1.8
Average weekly champagne plus white wine intake	1.7	2.3	8.6	1.2	-2.9	0.0	1.2	-0.7	-1.4
Heart attack/myocardial infarction (self-reported)	1.7	2.2	4.6	-1.0	1.9	2.1	1.6	1.2	0.5
Pack years of smoking	1.7	2.4	3.7	1.5	1.9	-1.1	-0.7	-1.9	-1.9
Schizophrenia vs Biploar Disorder	1.6	2.1	3.9	1.5	0.6	-1.6	-1.7	-2.0	-1.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.0	-1.0	1.7	1.6	0.8	1.7	1.0
Frequency of depressed mood in last 2 weeks	1.6	2.2	4.7	2.2	-0.4	1.2	0.5	-1.8	-1.8
Pulse wave Arterial Stiffness index	1.6	1.9	3.6	-1.8	1.1	1.2	-0.2	1.9	1.4
Medication for hormone replacement therapy	1.5	1.7	3.7	-1.8	0.2	0.4	0.5	1.9	1.7
Trunk fat percentage	1.5	5.9	14.6	3.8	0.5	1.0	1.8	-2.9	-2.8
Taking other prescription medications	1.5	2.4	7.6	-1.2	2.8	1.4	0.4	0.9	1.4
Body mass index (BMI)	1.5	6.2	10.3	3.2	0.2	2.2	3.0	-2.6	-2.5
Hair/balding pattern: Pattern 2	1.5	1.9	3.5	-1.1	1.9	0.1	-1.2	1.4	1.7
Hair/balding pattern: Pattern 3	1.5	2.2	6.8	-1.2	0.7	2.6	2.0	0.5	0.2
Asthma	1.5	3.0	6.5	-2.5	1.1	1.2	0.8	2.3	1.7
Medication: Amlodipine	1.5	2.1	6.0	-2.5	0.5	0.8	0.3	1.5	1.9
Body fat percentage	1.5	5.8	12.2	3.5	0.7	1.5	2.4	-2.7	-2.6
Number of self-reported non-cancer illnesses	1.5	2.6	6.6	-1.2	2.6	1.5	1.4	1.3	1.2
Alzheimer’s Disease (in mother)	1.4	1.6	4.5	0.8	0.6	-1.9	-2.1	-0.8	0.1
Waist Hip Ratio (WHR)	1.4	6.1	11.9	-3.0	1.9	1.8	1.5	3.5	2.5
Ever had hysterectomy (womb removed)	1.4	1.6	3.7	-1.6	-0.2	-1.0	-0.2	1.6	1.9
Impedance of leg (left)	1.4	6.7	12.5	-3.5	2.3	-0.3	-1.1	3.4	3.1
Qualifications: None of the above	1.4	2.9	7.0	-0.2	2.2	2.6	2.1	0.8	0.7
Lung cancer (father)	1.4	1.7	3.4	1.5	-1.8	-0.5	-1.0	-1.1	-1.3
Migraine (self-reported)	1.4	1.7	5.9	-0.1	0.4	2.0	2.4	0.5	0.3
Medication: Omeprazole	1.4	1.7	4.3	1.8	0.7	-0.9	-0.1	-1.3	-2.1
Leg fat mass (right)	1.4	5.2	12.4	3.5	-0.4	1.1	1.7	-3.0	-2.5
Loneliness, isolation	1.4	1.9	4.7	2.2	1.4	1.6	0.6	-0.8	-1.0
Mother’s age at death	1.4	1.7	3.7	1.4	-1.9	0.1	-0.8	-1.6	-1.2
Medication: Blood pressure	1.4	2.7	6.7	-0.7	2.6	1.7	2.2	0.9	0.8
Ever had prostate specific antigen (PSA) test	1.4	1.7	3.1	1.5	0.7	-1.0	-0.8	-1.7	-1.6
Major Depression (MDD)	1.3	1.6	4.0	1.5	0.1	2.0	0.6	-0.8	-1.6
Number of treatments/medications taken	1.3	2.4	4.4	-0.9	2.1	1.9	2.0	0.6	1.2
Health satisfaction	1.3	1.7	4.8	-0.5	2.2	1.4	0.2	1.3	1.1
Number of full sisters	1.3	1.6	4.4	0.5	-0.4	-2.1	-1.5	-0.8	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	5.7	-2.4	0.6	-0.8	0.2	1.1	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	4.0	-2.0	0.8	-0.5	0.1	1.6	0.9
Medication for cholesterol	1.3	2.0	5.9	0.3	-1.6	-1.7	-2.4	-0.3	-0.5
Medication: Aspirin	1.3	1.7	3.7	-1.0	1.9	1.4	1.6	0.6	0.4
Smoking Status	1.2	2.9	5.8	2.2	-1.9	-0.4	0.3	-1.7	-2.4
Pack years adult smoking proportion	1.2	1.9	4.3	1.1	2.1	-0.7	-0.5	-1.6	-1.6
Qualifications: O levels/GCSEs or equivalent	1.2	1.9	3.8	0.9	-1.7	-1.2	-2.0	-1.0	-1.2
High blood pressure (siblings)	1.2	1.7	2.6	-1.3	1.1	1.4	1.6	0.8	1.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.2	1.6	2.7	1.4	0.1	1.7	1.0	-1.6	-1.0
Emphysema/chronic bronchitis	1.2	1.3	3.1	-1.8	1.0	-0.7	-0.8	0.9	1.5
Commuting to job workplace: Walk	1.2	1.3	4.9	-0.3	-1.5	-2.2	-0.7	0.0	0.1
Illnesses of father: High blood pressure	1.2	1.5	2.8	-1.7	-1.6	-0.8	-0.7	1.4	0.7
Cholesterol lowering medication	1.2	1.8	7.5	0.2	0.5	1.7	2.7	-0.1	0.2
Leg fat mass (left)	1.2	4.8	11.0	3.3	-0.2	1.2	1.8	-2.8	-2.2
Ulcerative Colitis (UC)	1.1	2.0	4.3	-1.6	-0.9	-1.4	-2.1	1.2	1.0
Fasting Glucose	1.1	1.4	3.1	-0.3	1.6	1.8	0.5	1.1	1.0
LDL Cholesterol	1.1	1.8	3.1	1.3	-1.8	1.3	1.1	-1.2	-1.3
Neuroticism	1.1	2.6	5.1	2.3	1.3	1.5	0.3	-1.8	-1.7
Vitamin and mineral supplements	1.1	1.5	4.1	-1.0	2.0	-1.2	-1.4	0.3	0.7
Impedance of leg (right)	1.1	5.3	10.2	-3.2	1.2	-1.1	-2.0	2.8	2.7
Serious illness, injury or assault to yourself	1.1	1.3	2.9	0.8	1.7	1.6	0.6	-1.1	-0.5
Waist circumference	1.1	4.1	10.2	3.2	0.8	1.5	1.6	-2.1	-2.1
Alcohol intake versus 10 years previously	1.1	1.6	2.6	-1.6	0.5	1.6	1.3	0.4	1.6
Happiness	1.1	1.3	4.5	0.1	-0.1	1.1	-0.8	2.1	1.1
Tense / ‘highly strung’	1.1	1.8	2.9	1.7	1.1	1.3	1.1	-1.5	-1.4
Back pain experienced in last month	1.1	1.6	4.8	1.3	-0.4	-0.1	0.3	-2.2	-1.6
Wears glasses or contact lenses	1.1	1.3	5.1	0.8	0.3	-2.3	-1.0	-0.7	-0.7
Leg fat percentage (left)	1.1	4.0	9.1	2.0	1.0	2.2	3.0	-1.6	-1.4
Age started oral contraceptive pill	1.1	1.3	3.5	1.2	-1.9	-1.4	-0.5	-0.6	-0.7
Neuroticism (Nagel 2018)	1.0	2.2	5.7	2.4	0.2	1.1	-0.1	-2.0	-1.6
HDL Cholesterol	1.0	1.7	4.0	1.1	-1.0	-0.7	-0.3	-2.0	-1.8
Respiratory disease	1.0	2.2	3.8	-1.7	2.0	0.9	0.5	1.7	1.4
Hand grip strength (right)	1.0	2.8	8.2	0.2	-0.9	-2.9	-2.5	-1.1	-0.5
Chronic bronchitis/emphysema (mother)	1.0	1.1	2.7	0.5	1.3	1.6	0.9	1.0	0.3
Medication: Atorvastatin	1.0	1.3	3.6	-1.9	0.4	-0.3	0.4	1.3	1.4
Commuting to job workplace: Cycle	1.0	1.2	3.5	0.7	-1.9	-0.5	-0.9	-0.8	-1.2
Bipolar Disorder (2018)	0.9	1.5	4.1	-1.7	-0.2	0.2	0.5	2.0	1.3
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	2.8	-0.1	0.1	1.2	1.7	0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.9	2.1	3.8	-1.8	1.4	0.5	-0.8	1.9	1.6
Stomach or abdominal pain in last month	0.9	1.2	2.3	-1.3	1.5	1.2	0.2	0.7	1.1
Financial difficulties in last 2 years	0.9	1.2	2.7	0.7	1.6	1.1	1.0	-0.9	-1.1
Mouth/teeth dental problems	0.9	1.4	3.5	0.1	-1.9	-1.6	-1.4	-0.6	-0.5
Neuroticism score	0.9	1.9	4.2	2.1	0.9	0.5	-0.9	-1.8	-1.5
Worrier / anxious feelings	0.9	1.7	3.7	1.3	-0.2	-0.9	-1.9	-1.7	-1.1
Noisy workplace	0.9	1.1	3.2	-1.8	-0.1	-0.7	0.1	0.8	1.5
Length of working week for main job	0.9	1.0	2.4	-1.6	0.3	-0.0	1.3	1.0	0.8
Leg fat percentage (right)	0.9	3.4	6.6	2.2	0.5	1.8	2.6	-1.8	-1.6
Alcohol intake frequency.	0.9	2.1	7.7	-0.8	2.8	1.9	0.6	-0.3	0.5
Overall health rating	0.9	2.0	7.7	0.5	2.8	1.5	0.6	-1.3	-0.2
Had major operations	0.9	1.1	2.2	1.2	-0.6	-0.4	-1.2	-0.8	-1.5
Medication: Aspirin	0.9	1.2	2.7	-1.0	1.6	1.0	1.6	0.3	0.2
Long-standing illness, disability or infirmity	0.9	1.3	3.7	1.1	1.3	-0.6	-0.5	-1.9	-0.9
Miserableness	0.9	1.5	3.0	1.6	-0.4	0.8	0.4	-1.7	-1.7
Average weekly beer plus cider intake	0.9	1.3	4.8	-0.2	2.2	1.4	0.8	-0.0	0.3
Worry (Nagel 2018)	0.8	1.6	3.1	1.6	1.3	1.8	0.6	-1.0	-1.0
Irritable Bowel Disease (IBD)	0.8	2.0	6.3	-1.2	-0.7	-1.2	-2.5	1.3	0.9
Primary Biliary Cirrhosis	0.8	1.1	2.1	1.4	0.1	0.9	1.5	-0.6	-1.1
Hypothyroidism (self reported)	0.8	1.9	4.8	1.0	-2.2	-1.4	-1.5	-0.9	-0.6
Lung FVC	0.8	4.0	9.7	-1.3	-1.8	-3.1	-2.9	0.1	0.7
Sensitivity / hurt feelings	0.8	1.3	3.5	0.4	1.6	1.9	0.9	-0.9	-0.1
Supplements: Zinc	0.8	0.9	3.3	1.8	0.1	1.0	0.7	-0.5	-0.2
Multivitamins +/- minerals	0.8	1.0	2.8	0.3	-1.6	1.7	0.8	0.3	0.1
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	3.4	-0.2	1.8	1.7	1.0	-0.7	0.2
Mouth/teeth dental problems: Dentures	0.8	1.3	4.2	1.1	0.3	1.3	2.0	-0.6	-0.6
Illnesses of mother	0.8	1.0	1.5	1.0	-1.1	-0.9	-0.8	-1.2	-1.0
Number of children fathered	0.8	0.9	2.2	0.4	0.1	1.3	1.5	-0.6	-0.9
Neck or shoulder pain in last month	0.8	1.1	2.7	-1.6	0.7	0.9	0.3	1.0	1.3
Risk taking	0.8	1.2	3.0	-1.0	1.1	-0.2	-1.0	1.7	1.0
Depressed Affect (Nagel 2018)	0.7	1.5	4.0	2.0	0.2	0.4	0.1	-1.6	-1.5
Alzheimer’s Disease (including proxy)	0.7	1.0	2.0	0.6	1.0	-1.4	-1.4	-0.8	0.1
Crohns Disease (2012)	0.7	1.1	2.8	-1.3	0.6	0.2	-0.4	1.7	1.2
Hand grip strength (left)	0.7	1.7	4.8	-0.4	-1.0	-2.2	-2.0	-0.5	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	1.3	1.1	0.7	1.0	0.9	-1.1	-0.9
Glaucoma (self-reported)	0.7	0.8	2.0	1.2	-1.4	0.7	0.3	-0.8	-0.5
Medication for pain relief, constipation, heartburn	0.7	1.3	3.4	0.4	-1.2	-1.5	-1.9	0.4	0.1
Medication: Ibuprofen	0.7	0.8	1.4	0.5	0.9	1.2	1.2	-0.7	-0.6
Chest pain or discomfort	0.7	1.0	3.1	-1.0	1.8	-0.2	-0.6	0.9	1.0
Leg pain on walking	0.7	0.9	4.6	-0.4	2.1	0.5	0.3	-0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.9	0.3	-1.3	-1.7	-0.8	-0.2	0.0
Smoking status: Previous	0.7	1.0	5.1	-0.2	-2.3	-0.3	-0.7	-0.5	-0.4
Guilty feelings	0.7	1.0	2.3	1.5	-0.4	0.1	-0.6	-1.5	-1.0
Eye problems/disorders: Glaucoma	0.7	0.9	4.0	0.4	-2.0	-0.1	-0.3	-0.8	-0.5
Supplements: Calcium	0.7	0.8	2.0	1.4	-0.7	-0.6	-0.8	-1.1	-0.3
Prostate Cancer	0.6	0.9	1.5	-1.2	-1.0	-0.8	-0.5	1.2	0.8
Blood Platelet Count	0.6	6.7	14.2	2.6	-1.7	3.1	3.8	-0.6	-2.5
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.8	1.0	0.5	1.2	1.3	-0.2	-0.5
Townsend deprivation index at recruitment	0.6	0.9	4.2	0.3	2.0	-0.2	0.5	-0.5	-0.7
Current tobacco smoking	0.6	1.1	2.0	1.4	0.2	0.4	1.2	-0.9	-1.4
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	3.3	-0.4	1.8	-0.1	-0.2	0.3	-0.1
High blood pressure (mother)	0.6	0.8	3.1	-1.8	-0.1	0.1	0.2	1.0	1.0
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	2.8	-0.2	1.7	0.6	-0.7	0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	2.7	0.5	1.5	0.4	-0.5	-1.6	-0.7
Breastfed as a baby	0.6	0.8	1.5	0.7	0.8	-1.0	-1.2	0.9	0.2
Hair/balding pattern: Pattern 4	0.6	1.4	5.5	0.6	0.3	-2.3	-1.3	-0.5	-0.4
Medication: Ventolin 100micrograms inhaler	0.6	0.7	2.5	-0.4	0.6	0.9	1.6	0.5	0.5
Comparative body size at age 10	0.6	1.7	3.2	1.8	-0.8	0.4	1.6	-1.1	-1.6
Wheeze or whistling in the chest in last year	0.6	1.0	4.0	-2.0	1.0	-0.4	-0.1	0.8	0.7
Mouth/teeth dental problems: Loose teeth	0.6	0.7	1.7	-0.7	0.7	-1.3	-1.0	0.3	0.5
Angina (self-reported)	0.6	0.8	1.4	-0.8	1.2	0.6	0.9	1.0	0.6
Medication: Seretide 50 evohaler	0.6	0.7	2.2	0.1	-0.8	1.1	1.5	-0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.9	0.3	-1.4	0.1	1.1	-0.2	-0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.0	-0.3	0.8	-0.3	-1.4	1.1	-0.1
Handedness (chirality/laterality): Left-handed	0.6	0.7	1.4	-0.9	-0.6	0.2	1.1	1.2	0.7
Ever taken oral contraceptive pill	0.6	0.6	1.2	0.8	-0.0	-1.1	-1.0	-0.2	-0.9
High cholesterol (Self-reported)	0.6	1.1	3.6	-1.2	0.2	0.4	1.9	0.3	1.2
Alcohol drinker status: Never	0.6	0.8	2.6	-0.3	1.2	0.5	1.6	-0.1	-0.4
Impedance of whole body	0.6	2.9	4.2	-1.9	1.8	-0.9	-1.3	2.0	1.8
Schizophrenia (2018)	0.5	1.1	3.1	0.7	1.8	0.5	-0.2	-1.7	-0.0
Breast Cancer	0.5	1.2	2.7	-1.3	1.2	-0.0	-0.2	1.1	1.6
Blood Red Count	0.5	5.0	8.5	-2.9	2.4	1.5	1.7	2.4	2.3
Relative age of first facial hair	0.5	1.1	3.3	0.1	-1.8	-1.3	-1.2	-0.6	0.2
Angina	0.5	0.7	1.4	-0.7	1.2	0.8	0.9	0.9	0.5
Had other major operations	0.5	0.6	1.5	-1.2	0.9	0.1	0.5	0.8	0.6
Time employed in main current job	0.5	0.5	2.0	-0.3	-0.8	-1.4	-0.3	-0.5	-0.4
Qualifications: A levels/AS levels or equivalent	0.5	1.2	3.0	0.7	-0.9	-1.6	-1.7	-0.2	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.7	1.0	0.6	1.3	0.9	-0.5	-0.8
Worry too long after embarrassment	0.5	0.8	2.3	0.9	0.9	-0.3	-1.5	-0.9	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	2.0	0.1	-1.4	0.2	0.8	-0.2	-1.1
Shortness of breath walking on level ground	0.5	0.6	3.7	-0.4	1.9	0.0	-0.2	-0.0	0.0
Heart disease (mother)	0.5	0.6	1.8	0.0	-0.0	1.2	1.3	0.2	-0.5
Supplements: Vitamin C	0.5	0.6	1.8	1.2	-1.3	-0.6	-0.1	-0.3	-0.5
Ever had bowel cancer screening	0.5	0.6	1.2	-1.0	1.0	-0.7	-0.1	0.4	1.1
Smoking status: Current	0.5	0.8	1.6	1.2	0.4	0.6	1.3	-0.5	-1.1
Medication: Bendroflumethiazide	0.5	0.8	1.6	-1.0	0.8	0.3	0.8	0.9	1.3
Irritability	0.5	0.8	1.4	1.0	-1.2	-0.0	-0.3	-1.2	-0.8
Basal cell carcinoma (self-reported)	0.5	0.5	1.2	-0.5	0.8	0.3	1.1	0.6	0.9
Lupus	0.4	0.6	1.7	1.3	0.3	-0.7	-0.4	-0.4	-1.0
Rheumatoid Arthritis	0.4	0.5	1.2	0.7	0.4	-0.0	0.3	-1.1	-1.1
Schizophrenia (2014)	0.4	0.8	3.4	0.3	1.9	0.0	-0.2	-1.1	0.0
Blood Eosinophil Count	0.4	3.3	7.2	-1.1	2.0	2.7	2.5	0.8	0.9
Average weekly fortified wine intake	0.4	0.5	1.5	-0.2	0.7	0.4	1.2	0.9	0.2
Relative age voice broke	0.4	0.6	1.3	-1.1	-0.4	-0.4	-0.9	0.8	0.6
Diverticular disease/diverticulitis (self-reported)	0.4	0.4	1.2	0.3	-0.6	-1.0	-1.1	-0.2	0.2
Medication: Levothyroxine sodium	0.4	0.7	2.1	-0.6	-0.5	-0.2	-1.0	0.7	1.4
Past tobacco smoking	0.4	0.7	3.7	-0.0	1.9	0.0	0.1	0.5	0.7
Alcohol usually taken with meals	0.4	0.7	1.3	0.8	-1.1	0.5	1.1	-0.5	-0.8
Nervous feelings	0.4	0.8	2.4	0.6	1.6	1.1	0.6	-0.1	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.9	2.4	-0.7	1.5	0.9	-0.4	1.0	0.9
Hypothyroidism/myxoedema (self-reported)	0.4	0.9	2.3	0.5	-1.3	-0.8	-1.5	-0.4	0.1
Age at first live birth	0.4	0.7	2.8	-0.1	-1.1	-1.7	0.2	-0.1	-0.5
Qualifications: College or University degree	0.4	1.4	4.7	0.2	-2.2	-0.7	-1.7	-0.0	0.3
Suffer from ‘nerves’	0.4	0.6	1.4	1.1	0.7	1.2	0.5	-0.3	-0.4
Qualifications: nursing, teaching	0.4	0.6	1.7	-0.3	0.2	-1.3	-1.2	0.2	0.4
Breast cancer (self-reported)	0.4	0.4	2.0	0.3	0.1	1.4	0.7	-0.0	0.0
Financial situation satisfaction	0.4	0.5	1.0	1.0	0.9	-0.3	-0.4	-0.5	-0.8
Medication: Lisinopril	0.4	0.5	1.1	0.2	0.4	1.0	1.1	0.4	0.4
Ever smoked	0.4	0.7	1.4	0.6	-1.0	0.6	0.4	-1.1	-1.2
Unable to work because of sickness or disability	0.4	0.5	1.3	0.2	1.1	0.5	-0.0	-0.9	-0.7
Pain experienced in last month	0.4	0.6	1.9	0.2	-1.4	-1.1	-0.8	0.2	-0.1
Coronary Artery Disease (CAD)	0.3	0.4	0.7	-0.2	-0.7	-0.9	-0.9	0.5	0.4
Lung FEV1/FVC ratio	0.3	1.4	4.6	0.6	-2.1	-0.5	1.4	-0.8	-0.9
Average weekly spirits intake	0.3	0.4	1.5	-0.4	-1.2	-0.6	-0.1	-0.0	0.4
Qualifications: CSEs or equivalent	0.3	0.4	1.6	-1.3	0.3	0.6	-0.2	0.3	0.6
Medication: Atenolol	0.3	0.3	1.6	-0.2	-0.0	0.3	1.2	0.5	0.1
Chronic bronchitis/emphysema (father)	0.3	0.3	1.4	-0.1	1.2	0.6	0.1	0.4	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.8	-0.3	0.9	0.4	-0.5	0.8	0.3
Depression (self-reported)	0.3	0.4	1.4	-0.2	1.2	0.1	0.8	-0.3	0.1
Age at last live birth	0.3	0.4	0.9	0.2	-0.1	-0.9	0.9	0.3	-0.7
Average weekly red wine intake	0.3	0.5	1.6	1.0	-1.3	-0.3	-0.2	-0.0	-0.5
Mood swings	0.3	0.5	1.9	0.3	0.9	1.4	0.3	0.0	0.1
Mineral and other dietary supplements	0.3	0.4	1.1	-0.8	1.1	-0.0	0.5	0.4	-0.1
Hearing aid user	0.3	0.4	1.9	-0.0	-1.4	0.4	0.2	-0.4	-0.3
Myopia	0.3	0.4	1.2	0.7	-1.1	-0.3	-0.6	-0.4	-0.6
Alcohol drinker status: Previous	0.3	0.3	1.3	0.3	0.6	0.1	-1.1	-0.2	0.2
Bipolar Disorder or Schizophrenia	0.2	0.5	1.6	-0.5	1.2	0.6	0.4	-0.1	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.9	0.0	0.0	0.0	-0.1	-1.0	-0.2
Crohns Disease (2017)	0.2	0.4	1.1	-0.3	0.1	0.0	-1.0	1.0	0.2
Body Mass Index (BMI) (2010)	0.2	0.2	0.6	0.6	-0.6	-0.1	-0.0	-0.4	-0.8
HbA1C	0.2	0.2	0.6	-0.0	0.8	0.4	-0.2	-0.2	-0.5
Neuroticism (2016)	0.2	0.2	0.6	0.5	0.3	0.8	0.1	-0.5	-0.4
Triglycerides	0.2	0.3	0.7	0.8	-0.1	0.8	0.7	-0.1	-0.3
Tanning	0.2	2.0	5.3	1.6	-1.3	-0.3	-0.3	-1.5	-2.3
Hearing difficulty/problems with background noise	0.2	0.4	1.0	0.4	-0.5	-0.1	-0.8	-1.0	-0.4
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.7	-0.8	-0.1	-0.6	-0.1	0.5	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.5	0.1	0.7	0.5	0.6	-0.1	-0.4
Impedance of arm (left)	0.2	1.0	2.2	0.5	1.5	-1.1	-1.4	-0.2	-0.1
Loud music exposure frequency	0.2	0.2	0.4	0.5	-0.4	0.1	-0.4	-0.6	-0.6
Headache pain in last month	0.2	0.4	0.9	0.2	0.8	0.9	0.4	-0.7	0.1
Illnesses of father: Heart disease	0.2	0.2	0.6	0.6	-0.8	-0.2	0.4	0.5	-0.0
Eye problems/disorders: Cataract	0.2	0.2	0.5	0.2	-0.6	0.2	0.7	-0.6	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.9	-0.4	-0.8	-0.4	0.1	-0.9	-0.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.6	0.1	0.3	0.9	-0.7	-0.1
Ever depressed for a whole week	0.2	0.3	0.6	0.3	0.2	0.5	-0.8	0.7	0.4
Deep venous thrombosis (DVT) (self-reported)	0.2	0.3	1.1	-0.4	-0.6	-1.0	-0.1	-0.5	-0.0
Reaction Time	0.1	0.2	1.1	0.2	0.1	-0.5	-1.0	-0.3	0.2
Age at First Birth	0.1	0.1	0.3	-0.1	-0.3	-0.1	-0.1	-0.5	-0.4
Bipolar Disorder (2011)	0.1	0.1	0.5	0.2	0.1	0.0	0.0	0.7	0.2
Hearing difficulty/problems: Yes	0.1	0.2	0.6	-0.4	-0.8	0.1	0.4	-0.2	-0.3
Fed-up feelings	0.1	0.2	0.5	0.2	0.3	-0.0	-0.7	-0.7	-0.1
Had menopause	0.1	0.2	0.6	0.8	0.3	0.0	0.2	-0.6	-0.1
Impedance of arm (right)	0.1	0.6	2.0	0.4	1.4	-0.2	-1.1	0.0	-0.1
Number of live births	0.1	0.2	0.4	-0.4	0.6	-0.2	-0.6	-0.3	0.1
Pulse wave reflection index	0.1	0.1	0.5	0.0	0.1	0.7	-0.3	0.1	0.1
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.6	-0.4	-0.1	-0.3	-0.8	0.1	-0.1
Blood clot in the leg (DVT)	0.1	0.2	0.8	-0.2	0.0	-0.9	0.0	-0.4	-0.0
Medication: Paracetamol	0.1	0.2	0.8	-0.9	0.1	-0.1	0.2	-0.3	0.4
Eye problems/disorders: None of the above	0.1	0.2	0.5	0.2	0.4	0.5	0.7	0.0	-0.2
Mean time to correctly identify matches	0.1	0.2	0.4	0.5	-0.6	0.1	0.3	-0.6	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.3	0.0	0.5	-0.4	-0.3	0.3	0.6
Osteoarthritis (self-reported)	0.1	0.1	0.4	0.4	0.6	-0.2	-0.1	-0.3	0.2
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.5	-0.2	-0.1	-0.7	-0.3	-0.2	-0.0
Commuting to job workplace: Public transport	0.1	0.1	0.4	0.3	-0.1	-0.3	0.2	-0.6	0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	0.5	-0.8	0.3	0.2	0.0	0.2
Medication: Paracetamol	0.1	0.2	0.6	-0.8	-0.2	-0.1	0.3	-0.2	0.5
Number of operations (self-reported)	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.4	0.2	0.4
Hair Pigment	0.0	1.2	2.9	1.7	0.1	0.3	0.3	-1.0	-1.7

Hub : Genes

SENP2

Models

Trait associations