Hub : Genes

SENP2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2080 0.0430 5.6e-17 0.177 0.156 0.186 0.176 0.177 5.1e-21 1.5e-18 4.2e-22 6.4e-21 4.8e-21
2 GTEx Artery Aorta 0.1360 0.0520 7.6e-03 0.013 NA 0.003 NA 0.016 6.1e-02 NA 2.0e-01 NA 4.4e-02
3 GTEx Breast Mammary Tissue 0.2130 0.0790 5.5e-03 -0.003 NA 0.048 NA 0.000 5.4e-01 NA 1.7e-03 NA 3.2e-01
4 GTEx Breast Mammary Tissue (Female) 0.2905 0.1155 1.8e-02 0.067 NA 0.123 NA 0.032 4.8e-03 NA 1.7e-04 NA 4.0e-02
5 METSIM Adipose 0.0582 0.0204 1.7e-05 0.040 0.025 0.024 0.027 0.034 1.2e-06 1.1e-04 1.2e-04 4.8e-05 6.2e-06
6 YFS Blood 0.1108 0.0194 0.0e+00 0.140 0.143 0.150 0.147 0.150 2.0e-43 2.5e-44 9.7e-47 7.8e-46 1.2e-46

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.9 1.5 4.1 -1.7 -0.2 0.2 0.5 2.0 1.3
Bipolar Disorder or Schizophrenia 0.2 0.5 1.6 -0.5 1.2 0.6 0.4 -0.1 0.8
Depressed Affect (Nagel 2018) 0.7 1.5 4.0 2.0 0.2 0.4 0.1 -1.6 -1.5
Depression (Nagel 2018) 2.0 3.0 5.3 2.3 1.0 2.0 1.6 -1.6 -1.6
Intelligence (Savage-Jansen 2018) 1.8 5.4 8.8 2.7 -2.9 -1.3 -0.3 -2.5 -3.0
Neuroticism (Nagel 2018) 1.0 2.2 5.7 2.4 0.2 1.1 -0.1 -2.0 -1.6
Schizophrenia (2018) 0.5 1.1 3.1 0.7 1.8 0.5 -0.2 -1.7 -0.0
Schizophrenia vs Biploar Disorder 1.6 2.1 3.9 1.5 0.6 -1.6 -1.7 -2.0 -1.1
Worry (Nagel 2018) 0.8 1.6 3.1 1.6 1.3 1.8 0.6 -1.0 -1.0
Alzheimer’s Disease (in mother) 1.4 1.6 4.5 0.8 0.6 -1.9 -2.1 -0.8 0.1
Alzheimer’s Disease (in father) 0.2 0.2 0.9 0.0 0.0 0.0 -0.1 -1.0 -0.2
Alzheimer’s Disease (including proxy) 0.7 1.0 2.0 0.6 1.0 -1.4 -1.4 -0.8 0.1
Crohns Disease (2017) 0.2 0.4 1.1 -0.3 0.1 0.0 -1.0 1.0 0.2
Irritable Bowel Disease (IBD) 0.8 2.0 6.3 -1.2 -0.7 -1.2 -2.5 1.3 0.9
Ulcerative Colitis (UC) 1.1 2.0 4.3 -1.6 -0.9 -1.4 -2.1 1.2 1.0
Major Depression (MDD) 1.3 1.6 4.0 1.5 0.1 2.0 0.6 -0.8 -1.6
Reaction Time 0.1 0.2 1.1 0.2 0.1 -0.5 -1.0 -0.3 0.2
Verbal and Numeric Reasoning (VNR) 2.7 6.6 11.0 3.3 -2.8 -1.4 -0.8 -3.0 -3.0
Breast Cancer 0.5 1.2 2.7 -1.3 1.2 -0.0 -0.2 1.1 1.6
Ovarian Cancer 3.1 4.1 8.0 2.7 -1.1 -0.5 -1.0 -2.8 -2.6
Prostate Cancer 0.6 0.9 1.5 -1.2 -1.0 -0.8 -0.5 1.2 0.8
Age at First Birth 0.1 0.1 0.3 -0.1 -0.3 -0.1 -0.1 -0.5 -0.4
Bipolar Disorder (2011) 0.1 0.1 0.5 0.2 0.1 0.0 0.0 0.7 0.2
Body Mass Index (BMI) (2010) 0.2 0.2 0.6 0.6 -0.6 -0.1 -0.0 -0.4 -0.8
Coronary Artery Disease (CAD) 0.3 0.4 0.7 -0.2 -0.7 -0.9 -0.9 0.5 0.4
Crohns Disease (2012) 0.7 1.1 2.8 -1.3 0.6 0.2 -0.4 1.7 1.2
Mean Putamen Volume 2.2 2.5 4.5 2.0 -2.1 -1.1 -0.5 -1.7 -1.6
Fasting Glucose 1.1 1.4 3.1 -0.3 1.6 1.8 0.5 1.1 1.0
HbA1C 0.2 0.2 0.6 -0.0 0.8 0.4 -0.2 -0.2 -0.5
HDL Cholesterol 1.0 1.7 4.0 1.1 -1.0 -0.7 -0.3 -2.0 -1.8
LDL Cholesterol 1.1 1.8 3.1 1.3 -1.8 1.3 1.1 -1.2 -1.3
Lupus 0.4 0.6 1.7 1.3 0.3 -0.7 -0.4 -0.4 -1.0
Neuroticism (2016) 0.2 0.2 0.6 0.5 0.3 0.8 0.1 -0.5 -0.4
Primary Biliary Cirrhosis 0.8 1.1 2.1 1.4 0.1 0.9 1.5 -0.6 -1.1
Rheumatoid Arthritis 0.4 0.5 1.2 0.7 0.4 -0.0 0.3 -1.1 -1.1
Schizophrenia (2014) 0.4 0.8 3.4 0.3 1.9 0.0 -0.2 -1.1 0.0
Triglycerides 0.2 0.3 0.7 0.8 -0.1 0.8 0.7 -0.1 -0.3
Type 2 Diabetes (T2D) (2012) 1.6 1.8 3.0 -1.0 1.7 1.6 0.8 1.7 1.0
Ulcerative Colitis 2.3 3.3 7.3 -2.7 -0.2 -1.2 -1.6 2.0 2.1
Blood Eosinophil Count 0.4 3.3 7.2 -1.1 2.0 2.7 2.5 0.8 0.9
Blood Platelet Count 0.6 6.7 14.2 2.6 -1.7 3.1 3.8 -0.6 -2.5
Blood Red Count 0.5 5.0 8.5 -2.9 2.4 1.5 1.7 2.4 2.3
Blood White Count 1.8 13.3 18.0 -3.8 1.8 4.1 4.0 4.2 3.4
Heel T-Score 2.8 22.1 30.9 -5.2 5.6 3.4 2.5 5.5 5.1
BMI 2.8 16.0 30.7 5.5 0.1 3.1 3.6 -4.6 -4.5
Height 2.7 51.3 79.6 8.3 -2.7 -8.8 -8.9 -6.4 -5.7
Waist Hip Ratio (WHR) 1.4 6.1 11.9 -3.0 1.9 1.8 1.5 3.5 2.5
Systolic Blood Pressure 4.7 23.5 47.5 -6.5 4.1 1.7 1.3 6.9 5.5
Smoking Status 1.2 2.9 5.8 2.2 -1.9 -0.4 0.3 -1.7 -2.4
Allergy or Eczema 2.2 5.9 12.2 -3.5 1.8 -0.2 -0.6 3.1 3.2
Cardiovascular Disease 3.1 10.1 14.3 -3.8 2.9 2.3 3.3 3.2 3.4
Hypothyroidism (self reported) 0.8 1.9 4.8 1.0 -2.2 -1.4 -1.5 -0.9 -0.6
Respiratory disease 1.0 2.2 3.8 -1.7 2.0 0.9 0.5 1.7 1.4
Type 2 Diabetes (T2D) (2018) 2.0 3.8 9.7 -1.4 3.1 1.7 1.8 1.6 1.6
Lung FEV1/FVC ratio 0.3 1.4 4.6 0.6 -2.1 -0.5 1.4 -0.8 -0.9
Lung FVC 0.8 4.0 9.7 -1.3 -1.8 -3.1 -2.9 0.1 0.7
Neuroticism 1.1 2.6 5.1 2.3 1.3 1.5 0.3 -1.8 -1.7
Chronotype (morning person) 2.6 6.1 14.8 0.5 3.9 3.5 3.0 0.1 -0.1
Hair Pigment 0.0 1.2 2.9 1.7 0.1 0.3 0.3 -1.0 -1.7
Tanning 0.2 2.0 5.3 1.6 -1.3 -0.3 -0.3 -1.5 -2.3
Hand grip strength (left) 0.7 1.7 4.8 -0.4 -1.0 -2.2 -2.0 -0.5 -0.1
Number of treatments/medications taken 1.3 2.4 4.4 -0.9 2.1 1.9 2.0 0.6 1.2
Average weekly spirits intake 0.3 0.4 1.5 -0.4 -1.2 -0.6 -0.1 -0.0 0.4
Sensitivity / hurt feelings 0.8 1.3 3.5 0.4 1.6 1.9 0.9 -0.9 -0.1
Frequency of depressed mood in last 2 weeks 1.6 2.2 4.7 2.2 -0.4 1.2 0.5 -1.8 -1.8
Hearing difficulty/problems: Yes 0.1 0.2 0.6 -0.4 -0.8 0.1 0.4 -0.2 -0.3
Relative age of first facial hair 0.5 1.1 3.3 0.1 -1.8 -1.3 -1.2 -0.6 0.2
Other serious medical condition/disability diagnosed by doctor 1.9 2.4 6.3 2.5 1.4 0.1 -0.4 -2.0 -1.5
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.8 1.0 0.5 1.2 1.3 -0.2 -0.5
Ever had hysterectomy (womb removed) 1.4 1.6 3.7 -1.6 -0.2 -1.0 -0.2 1.6 1.9
Systolic blood pressure, automated reading 2.1 6.1 12.7 -2.7 2.6 1.2 0.9 3.6 2.7
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 2.8 -0.1 0.1 1.2 1.7 0.9 -0.9
Angina 0.5 0.7 1.4 -0.7 1.2 0.8 0.9 0.9 0.5
Medication for hormone replacement therapy 1.5 1.7 3.7 -1.8 0.2 0.4 0.5 1.9 1.7
Vitamin and mineral supplements 1.1 1.5 4.1 -1.0 2.0 -1.2 -1.4 0.3 0.7
Supplements: Zinc 0.8 0.9 3.3 1.8 0.1 1.0 0.7 -0.5 -0.2
Medication: Co-codamol 2.4 2.7 7.0 0.8 1.6 2.6 2.5 -0.4 -0.3
Medication: Metformin 3.2 4.5 9.2 -2.2 3.0 1.0 0.6 2.4 2.5
Diabetes (father) 2.2 2.7 6.0 -1.3 2.5 2.0 1.3 1.0 1.4
Diabetes (mother) 3.1 3.9 9.3 -1.7 3.0 2.1 1.3 2.0 1.2
Severe depression (siblings) 1.8 2.1 3.9 1.3 -1.7 -1.0 -0.8 -2.0 -1.5
Pack years adult smoking proportion 1.2 1.9 4.3 1.1 2.1 -0.7 -0.5 -1.6 -1.6
Impedance of leg (right) 1.1 5.3 10.2 -3.2 1.2 -1.1 -2.0 2.8 2.7
Leg fat-free mass (left) 2.8 14.9 31.5 5.6 -2.6 -1.8 -1.5 -5.3 -4.2
Trunk fat percentage 1.5 5.9 14.6 3.8 0.5 1.0 1.8 -2.9 -2.8
Hand grip strength (right) 1.0 2.8 8.2 0.2 -0.9 -2.9 -2.5 -1.1 -0.5
Townsend deprivation index at recruitment 0.6 0.9 4.2 0.3 2.0 -0.2 0.5 -0.5 -0.7
Current tobacco smoking 0.6 1.1 2.0 1.4 0.2 0.4 1.2 -0.9 -1.4
Average weekly fortified wine intake 0.4 0.5 1.5 -0.2 0.7 0.4 1.2 0.9 0.2
Maternal smoking around birth 1.8 2.6 6.1 1.8 0.1 -0.7 0.4 -2.5 -2.3
Fed-up feelings 0.1 0.2 0.5 0.2 0.3 -0.0 -0.7 -0.7 -0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 1.3 1.1 0.7 1.0 0.9 -1.1 -0.9
Relative age voice broke 0.4 0.6 1.3 -1.1 -0.4 -0.4 -0.9 0.8 0.6
Taking other prescription medications 1.5 2.4 7.6 -1.2 2.8 1.4 0.4 0.9 1.4
Age when periods started (menarche) 2.7 6.5 14.8 1.8 -1.7 -3.9 -2.4 -2.5 -2.4
Bilateral oophorectomy (both ovaries removed) 1.9 2.2 3.1 -1.2 1.6 1.7 1.8 1.4 1.1
Heel bone mineral density (BMD) T-score, automated (left) 0.9 2.1 3.8 -1.8 1.4 0.5 -0.8 1.9 1.6
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 3.3 -0.4 1.8 -0.1 -0.2 0.3 -0.1
Qualifications: CSEs or equivalent 0.3 0.4 1.6 -1.3 0.3 0.6 -0.2 0.3 0.6
Serious illness, injury or assault to yourself 1.1 1.3 2.9 0.8 1.7 1.6 0.6 -1.1 -0.5
High blood pressure 2.8 7.9 10.2 -3.0 3.2 2.4 2.5 3.0 2.7
Hayfever, allergic rhinitis or eczema 1.7 3.6 8.1 -2.9 1.6 -0.8 -1.2 1.9 2.4
Multivitamins +/- minerals 0.8 1.0 2.8 0.3 -1.6 1.7 0.8 0.3 0.1
Stomach or abdominal pain in last month 0.9 1.2 2.3 -1.3 1.5 1.2 0.2 0.7 1.1
Supplements: Glucosamine 3.3 4.4 6.3 1.9 -2.3 -2.5 -2.5 -1.8 -1.2
Diverticular disease/diverticulitis (self-reported) 0.4 0.4 1.2 0.3 -0.6 -1.0 -1.1 -0.2 0.2
Medication: Atenolol 0.3 0.3 1.6 -0.2 -0.0 0.3 1.2 0.5 0.1
Medication: Levothyroxine sodium 0.4 0.7 2.1 -0.6 -0.5 -0.2 -1.0 0.7 1.4
Sitting height 1.7 12.1 31.6 2.4 -2.5 -5.0 -5.6 -2.0 -0.5
Chronic bronchitis/emphysema (father) 0.3 0.3 1.4 -0.1 1.2 0.6 0.1 0.4 -0.2
High blood pressure (mother) 0.6 0.8 3.1 -1.8 -0.1 0.1 0.2 1.0 1.0
Body mass index (BMI) 1.5 6.2 10.3 3.2 0.2 2.2 3.0 -2.6 -2.5
Impedance of leg (left) 1.4 6.7 12.5 -3.5 2.3 -0.3 -1.1 3.4 3.1
Leg predicted mass (left) 2.9 15.2 31.5 5.6 -2.6 -1.9 -1.5 -5.3 -4.3
Trunk fat mass 2.0 8.7 23.4 4.8 -0.4 0.1 1.0 -3.9 -3.5
Waist circumference 1.1 4.1 10.2 3.2 0.8 1.5 1.6 -2.1 -2.1
Number of incorrect matches in round 2.2 3.6 7.5 -2.7 0.5 -0.5 -0.2 2.6 2.5
Past tobacco smoking 0.4 0.7 3.7 -0.0 1.9 0.0 0.1 0.5 0.7
Alcohol usually taken with meals 0.4 0.7 1.3 0.8 -1.1 0.5 1.1 -0.5 -0.8
Nervous feelings 0.4 0.8 2.4 0.6 1.6 1.1 0.6 -0.1 -0.4
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.3 3.4 -0.2 1.8 1.7 1.0 -0.7 0.2
Hearing difficulty/problems with background noise 0.2 0.4 1.0 0.4 -0.5 -0.1 -0.8 -1.0 -0.4
Hair/balding pattern: Pattern 2 1.5 1.9 3.5 -1.1 1.9 0.1 -1.2 1.4 1.7
Had menopause 0.1 0.2 0.6 0.8 0.3 0.0 0.2 -0.6 -0.1
Had other major operations 0.5 0.6 1.5 -1.2 0.9 0.1 0.5 0.8 0.6
Forced vital capacity (FVC) 2.6 9.9 15.1 2.2 -2.9 -3.8 -3.9 -3.2 -2.4
Heel bone mineral density (BMD) T-score, automated (right) 0.4 0.9 2.4 -0.7 1.5 0.9 -0.4 1.0 0.9
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 2.8 -0.2 1.7 0.6 -0.7 0.2 0.6
Qualifications: None of the above 1.4 2.9 7.0 -0.2 2.2 2.6 2.1 0.8 0.7
Financial difficulties in last 2 years 0.9 1.2 2.7 0.7 1.6 1.1 1.0 -0.9 -1.1
Mouth/teeth dental problems 0.9 1.4 3.5 0.1 -1.9 -1.6 -1.4 -0.6 -0.5
Heart attack 2.0 2.5 5.4 -1.1 1.8 2.3 1.7 1.3 0.7
Allergy 2.7 6.3 15.3 3.9 -1.9 0.2 0.7 -2.8 -3.3
Pain all over the body in last month 1.7 1.8 4.2 1.7 0.3 -0.6 -0.1 -1.8 -2.0
Diabetes (self-reported) 2.3 3.5 9.6 -1.4 3.1 0.7 1.1 2.2 1.8
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.7 -0.8 -0.1 -0.6 -0.1 0.5 0.8
Medication: Ramipril 2.0 2.6 7.7 -1.5 2.8 1.3 0.4 1.5 1.3
Medication: Simvastatin 2.7 4.0 9.3 -1.4 2.1 2.3 3.0 1.3 1.3
Fluid intelligence score 4.5 9.3 16.7 4.1 -3.2 -1.6 -0.8 -3.4 -3.8
Illnesses of siblings 2.8 3.9 6.6 1.9 -1.4 -1.8 -2.1 -2.0 -2.6
Neuroticism score 0.9 1.9 4.2 2.1 0.9 0.5 -0.9 -1.8 -1.5
Weight 2.6 12.9 33.6 5.8 -1.4 -0.7 -0.3 -5.0 -4.1
Impedance of arm (right) 0.1 0.6 2.0 0.4 1.4 -0.2 -1.1 0.0 -0.1
Arm fat percentage (right) 2.0 7.8 14.9 3.9 0.5 2.3 2.9 -3.0 -2.9
Trunk fat-free mass 3.1 18.0 30.0 5.5 -3.6 -3.4 -3.4 -5.1 -4.0
Hip circumference 2.6 11.0 31.2 5.6 -1.6 -0.2 -0.2 -4.2 -3.9
Time employed in main current job 0.5 0.5 2.0 -0.3 -0.8 -1.4 -0.3 -0.5 -0.4
Alcohol intake versus 10 years previously 1.1 1.6 2.6 -1.6 0.5 1.6 1.3 0.4 1.6
Father’s age at death 2.2 3.0 5.7 1.4 -1.4 -2.2 -0.9 -2.4 -1.7
Worrier / anxious feelings 0.9 1.7 3.7 1.3 -0.2 -0.9 -1.9 -1.7 -1.1
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 2.7 0.5 1.5 0.4 -0.5 -1.6 -0.7
Falls in the last year 1.8 2.4 5.3 1.9 -0.7 1.0 0.7 -2.3 -1.9
Hair/balding pattern: Pattern 3 1.5 2.2 6.8 -1.2 0.7 2.6 2.0 0.5 0.2
Number of live births 0.1 0.2 0.4 -0.4 0.6 -0.2 -0.6 -0.3 0.1
Forced expiratory volume in 1-second (FEV1) 2.4 8.0 12.7 1.7 -3.2 -3.6 -3.0 -2.8 -2.3
Pulse rate 1.8 3.0 5.2 -2.3 1.8 1.5 1.0 2.1 1.2
Happiness 1.1 1.3 4.5 0.1 -0.1 1.1 -0.8 2.1 1.1
Noisy workplace 0.9 1.1 3.2 -1.8 -0.1 -0.7 0.1 0.8 1.5
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.0 0.7 -0.9 -1.6 -1.7 -0.2 -0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 0.8 -0.3 0.9 0.4 -0.5 0.8 0.3
Mouth/teeth dental problems: Dentures 0.8 1.3 4.2 1.1 0.3 1.3 2.0 -0.6 -0.6
Asthma 1.5 3.0 6.5 -2.5 1.1 1.2 0.8 2.3 1.7
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.5 0.1 0.7 0.5 0.6 -0.1 -0.4
Medication: Cholesterol lowering 1.7 2.7 4.4 -2.1 1.5 1.0 1.5 1.9 1.7
Depression (self-reported) 0.3 0.4 1.4 -0.2 1.2 0.1 0.8 -0.3 0.1
Medication: Lansoprazole 2.7 3.1 6.7 -2.2 2.6 1.2 0.4 1.6 1.7
Prospective memory result 2.5 3.0 6.3 -2.2 2.5 0.7 1.0 1.5 1.8
Lung cancer (father) 1.4 1.7 3.4 1.5 -1.8 -0.5 -1.0 -1.1 -1.3
Illnesses of mother 0.8 1.0 1.5 1.0 -1.1 -0.9 -0.8 -1.2 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.2 7.0 12.7 1.7 -2.6 -3.6 -2.6 -2.9 -2.2
Pulse wave Arterial Stiffness index 1.6 1.9 3.6 -1.8 1.1 1.2 -0.2 1.9 1.4
Impedance of arm (left) 0.2 1.0 2.2 0.5 1.5 -1.1 -1.4 -0.2 -0.1
Arm fat mass (right) 2.2 9.1 23.7 4.9 -0.4 1.0 1.5 -3.9 -3.5
Trunk predicted mass 3.0 17.4 29.9 5.5 -3.6 -3.2 -3.2 -5.0 -3.9
Standing height 3.1 30.5 49.3 6.0 -3.5 -6.6 -7.0 -5.2 -3.8
Length of working week for main job 0.9 1.0 2.4 -1.6 0.3 -0.0 1.3 1.0 0.8
Exposure to tobacco smoke at home 1.7 1.9 3.9 -2.0 0.9 -0.1 0.2 1.9 1.8
Breastfed as a baby 0.6 0.8 1.5 0.7 0.8 -1.0 -1.2 0.9 0.2
Tense / ‘highly strung’ 1.1 1.8 2.9 1.7 1.1 1.3 1.1 -1.5 -1.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.5 0.8 1.7 1.0 0.6 1.3 0.9 -0.5 -0.8
Hair/balding pattern: Pattern 4 0.6 1.4 5.5 0.6 0.3 -2.3 -1.3 -0.5 -0.4
Birth weight of first child 3.3 5.9 10.0 2.1 -3.2 -2.8 -1.6 -2.7 -1.8
Peak expiratory flow (PEF) 2.8 6.6 16.0 1.8 -4.0 -1.9 -1.5 -2.6 -2.9
Pulse wave reflection index 0.1 0.1 0.5 0.0 0.1 0.7 -0.3 0.1 0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.6 -0.4 -0.1 -0.3 -0.8 0.1 -0.1
Loud music exposure frequency 0.2 0.2 0.4 0.5 -0.4 0.1 -0.4 -0.6 -0.6
Qualifications: O levels/GCSEs or equivalent 1.2 1.9 3.8 0.9 -1.7 -1.2 -2.0 -1.0 -1.2
Mouth/teeth dental problems: Bleeding gums 1.7 2.2 4.4 -1.4 2.1 1.0 0.6 1.7 1.5
Blood clot in the leg (DVT) 0.1 0.2 0.8 -0.2 0.0 -0.9 0.0 -0.4 -0.0
Medication: Paracetamol 0.1 0.2 0.8 -0.9 0.1 -0.1 0.2 -0.3 0.4
Headache pain in last month 0.2 0.4 0.9 0.2 0.8 0.9 0.4 -0.7 0.1
Medication for cholesterol, blood pressure or diabetes 2.7 4.4 10.0 3.2 -1.5 -0.2 -1.2 -2.6 -2.4
Glaucoma (self-reported) 0.7 0.8 2.0 1.2 -1.4 0.7 0.3 -0.8 -0.5
Gout (self-reported) 2.0 2.7 4.9 -2.0 0.5 -0.6 -2.2 1.4 2.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.9 2.3 0.5 -1.3 -0.8 -1.5 -0.4 0.1
Medication: Amlodipine 1.5 2.1 6.0 -2.5 0.5 0.8 0.3 1.5 1.9
Medication: Ventolin 100micrograms inhaler 0.6 0.7 2.5 -0.4 0.6 0.9 1.6 0.5 0.5
Birth weight 4.4 9.6 19.3 4.2 -1.1 -2.2 -1.5 -4.4 -3.6
Chronic bronchitis/emphysema (mother) 1.0 1.1 2.7 0.5 1.3 1.6 0.9 1.0 0.3
High blood pressure (siblings) 1.2 1.7 2.6 -1.3 1.1 1.4 1.6 0.8 1.5
Forced vital capacity (FVC), Best measure 2.3 8.2 14.2 2.0 -2.1 -3.8 -3.6 -3.1 -2.1
Body fat percentage 1.5 5.8 12.2 3.5 0.7 1.5 2.4 -2.7 -2.6
Leg fat percentage (right) 0.9 3.4 6.6 2.2 0.5 1.8 2.6 -1.8 -1.6
Arm fat-free mass (right) 1.9 9.7 16.2 4.0 -2.8 -2.7 -2.2 -3.8 -2.8
Exposure to tobacco smoke outside home 2.5 3.3 7.3 1.5 1.1 2.7 2.1 -1.6 -1.5
Comparative body size at age 10 0.6 1.7 3.2 1.8 -0.8 0.4 1.6 -1.1 -1.6
Number of full brothers 1.9 2.3 3.9 1.9 -1.9 -0.3 0.8 -1.5 -2.0
Worry too long after embarrassment 0.5 0.8 2.3 0.9 0.9 -0.3 -1.5 -0.9 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 1.2 1.6 2.7 1.4 0.1 1.7 1.0 -1.6 -1.0
Wheeze or whistling in the chest in last year 0.6 1.0 4.0 -2.0 1.0 -0.4 -0.1 0.8 0.7
Number of children fathered 0.8 0.9 2.2 0.4 0.1 1.3 1.5 -0.6 -0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 2.0 0.1 -1.4 0.2 0.8 -0.2 -1.1
Age at first live birth 0.4 0.7 2.8 -0.1 -1.1 -1.7 0.2 -0.1 -0.5
Pulse wave peak to peak time 2.3 2.7 5.0 2.2 -1.2 -1.5 -0.3 -2.2 -1.6
Health satisfaction 1.3 1.7 4.8 -0.5 2.2 1.4 0.2 1.3 1.1
Shortness of breath walking on level ground 0.5 0.6 3.7 -0.4 1.9 0.0 -0.2 -0.0 0.0
Qualifications: College or University degree 0.4 1.4 4.7 0.2 -2.2 -0.7 -1.7 -0.0 0.3
Eye problems/disorders: None of the above 0.1 0.2 0.5 0.2 0.4 0.5 0.7 0.0 -0.2
Mouth/teeth dental problems: Loose teeth 0.6 0.7 1.7 -0.7 0.7 -1.3 -1.0 0.3 0.5
Emphysema/chronic bronchitis 1.2 1.3 3.1 -1.8 1.0 -0.7 -0.8 0.9 1.5
Medication for pain relief, constipation, heartburn 0.7 1.3 3.4 0.4 -1.2 -1.5 -1.9 0.4 0.1
Neck or shoulder pain in last month 0.8 1.1 2.7 -1.6 0.7 0.9 0.3 1.0 1.3
Medication: Blood pressure 2.2 3.8 9.8 -3.1 0.9 0.5 1.2 2.4 2.2
Angina (self-reported) 0.6 0.8 1.4 -0.8 1.2 0.6 0.9 1.0 0.6
Migraine (self-reported) 1.4 1.7 5.9 -0.1 0.4 2.0 2.4 0.5 0.3
Medication: Ibuprofen 0.7 0.8 1.4 0.5 0.9 1.2 1.2 -0.7 -0.6
Medication: Allopurinol 2.6 3.4 8.2 -1.7 0.3 -1.6 -2.9 1.2 2.3
Medication: Omeprazole 1.4 1.7 4.3 1.8 0.7 -0.9 -0.1 -1.3 -2.1
Medication: Seretide 50 evohaler 0.6 0.7 2.2 0.1 -0.8 1.1 1.5 -0.2 -0.1
Mean time to correctly identify matches 0.1 0.2 0.4 0.5 -0.6 0.1 0.3 -0.6 -0.2
Heart disease (mother) 0.5 0.6 1.8 0.0 -0.0 1.2 1.3 0.2 -0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.9 0.3 -1.4 0.1 1.1 -0.2 -0.9
Whole body fat mass 1.9 8.1 21.7 4.7 -0.3 0.4 1.1 -3.8 -3.3
Leg fat mass (right) 1.4 5.2 12.4 3.5 -0.4 1.1 1.7 -3.0 -2.5
Arm predicted mass (right) 1.9 9.8 16.0 4.0 -2.7 -2.8 -2.3 -3.8 -2.8
Pulse rate, automated reading 3.6 11.6 25.2 -5.0 2.7 1.0 0.8 4.7 3.7
Alcohol intake frequency. 0.9 2.1 7.7 -0.8 2.8 1.9 0.6 -0.3 0.5
Comparative height size at age 10 4.0 22.0 38.1 6.2 -3.2 -4.7 -4.6 -5.1 -3.8
Number of full sisters 1.3 1.6 4.4 0.5 -0.4 -2.1 -1.5 -0.8 -1.4
Suffer from ‘nerves’ 0.4 0.6 1.4 1.1 0.7 1.2 0.5 -0.3 -0.4
Overall health rating 0.9 2.0 7.7 0.5 2.8 1.5 0.6 -1.3 -0.2
Chest pain or discomfort 0.7 1.0 3.1 -1.0 1.8 -0.2 -0.6 0.9 1.0
Had major operations 0.9 1.1 2.2 1.2 -0.6 -0.4 -1.2 -0.8 -1.5
Age at last live birth 0.3 0.4 0.9 0.2 -0.1 -0.9 0.9 0.3 -0.7
Family relationship satisfaction 5.0 6.2 14.9 -2.2 2.0 0.2 -1.8 3.9 3.1
Leg pain on walking 0.7 0.9 4.6 -0.4 2.1 0.5 0.3 -0.1 0.1
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 5.7 -2.4 0.6 -0.8 0.2 1.1 1.2
Commuting to job workplace: Car/motor vehicle 0.6 0.7 2.0 -0.3 0.8 -0.3 -1.4 1.1 -0.1
Illness, injury, bereavement, stress in last 2 years 0.7 0.9 2.9 0.3 -1.3 -1.7 -0.8 -0.2 0.0
Medication: Aspirin 0.9 1.2 2.7 -1.0 1.6 1.0 1.6 0.3 0.2
Supplements: Vitamin C 0.5 0.6 1.8 1.2 -1.3 -0.6 -0.1 -0.3 -0.5
Knee pain experienced in last month 1.8 2.7 8.5 -0.4 1.5 2.3 2.9 -0.1 0.1
Hypertension (Self-reported) 2.5 7.0 10.4 -2.5 3.2 2.5 2.6 2.6 2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.7 2.0 3.8 -1.4 2.0 1.1 0.1 2.0 1.1
Illnesses of father: Heart disease 0.2 0.2 0.6 0.6 -0.8 -0.2 0.4 0.5 -0.0
Illnesses of siblings: Diabetes 3.8 4.7 8.0 -2.4 2.8 1.4 1.3 2.4 2.4
Smoking status: Previous 0.7 1.0 5.1 -0.2 -2.3 -0.3 -0.7 -0.5 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 2.6 5.3 8.6 2.5 -1.1 -2.9 -2.3 -2.3 -2.3
Whole body fat-free mass 2.8 15.9 29.9 5.5 -3.2 -2.6 -2.5 -5.1 -4.0
Leg fat-free mass (right) 2.6 13.7 30.4 5.5 -2.3 -1.4 -1.1 -5.1 -4.1
Arm fat percentage (left) 2.0 8.0 16.0 4.0 0.5 1.9 2.9 -3.3 -3.1
Average weekly red wine intake 0.3 0.5 1.6 1.0 -1.3 -0.3 -0.2 -0.0 -0.5
Handedness (chirality/laterality): Left-handed 0.6 0.7 1.4 -0.9 -0.6 0.2 1.1 1.2 0.7
Mood swings 0.3 0.5 1.9 0.3 0.9 1.4 0.3 0.0 0.1
Loneliness, isolation 1.4 1.9 4.7 2.2 1.4 1.6 0.6 -0.8 -1.0
Long-standing illness, disability or infirmity 0.9 1.3 3.7 1.1 1.3 -0.6 -0.5 -1.9 -0.9
Ever had bowel cancer screening 0.5 0.6 1.2 -1.0 1.0 -0.7 -0.1 0.4 1.1
Diabetes diagnosed by doctor 2.7 4.5 14.2 -1.6 3.8 1.0 1.2 2.1 1.8
Ever had stillbirth, spontaneous miscarriage or termination 1.3 1.4 4.0 -2.0 0.8 -0.5 0.1 1.6 0.9
Friendships satisfaction 2.3 2.8 8.0 -1.6 -0.6 -0.2 -1.4 2.8 2.0
Qualifications: nursing, teaching 0.4 0.6 1.7 -0.3 0.2 -1.3 -1.2 0.2 0.4
Commuting to job workplace: Walk 1.2 1.3 4.9 -0.3 -1.5 -2.2 -0.7 0.0 0.1
Eye problems/disorders: Cataract 0.2 0.2 0.5 0.2 -0.6 0.2 0.7 -0.6 0.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.1 0.3 0.0 0.5 -0.4 -0.3 0.3 0.6
Medication for cholesterol 1.3 2.0 5.9 0.3 -1.6 -1.7 -2.4 -0.3 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.9 2.2 5.8 2.4 -0.6 1.4 0.4 -1.4 -1.8
Back pain experienced in last month 1.1 1.6 4.8 1.3 -0.4 -0.1 0.3 -2.2 -1.6
Mineral and other dietary supplements 0.3 0.4 1.1 -0.8 1.1 -0.0 0.5 0.4 -0.1
Breast cancer (self-reported) 0.4 0.4 2.0 0.3 0.1 1.4 0.7 -0.0 0.0
Asthma (self-reported) 1.7 3.3 6.7 -2.6 1.1 1.4 1.0 2.4 1.8
Osteoporosis (self-reported) 2.6 3.2 6.5 2.4 -1.8 0.4 -0.5 -2.6 -1.8
Osteoarthritis (self-reported) 0.1 0.1 0.4 0.4 0.6 -0.2 -0.1 -0.3 0.2
Medication: Aspirin 1.3 1.7 3.7 -1.0 1.9 1.4 1.6 0.6 0.4
Medication: Gliclazide 2.6 2.9 6.0 -2.5 2.2 0.2 0.2 1.4 2.2
Illnesses of father: None of the above (group 1) 2.1 2.6 5.1 2.3 -0.6 -1.2 -1.5 -2.1 -1.4
Smoking status: Current 0.5 0.8 1.6 1.2 0.4 0.6 1.3 -0.5 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.3 0.9 -0.4 -0.8 -0.4 0.1 -0.9 -0.3
Whole body water mass 2.8 16.0 30.3 5.5 -3.2 -2.6 -2.4 -5.1 -4.1
Leg predicted mass (right) 2.6 14.1 31.1 5.6 -2.4 -1.5 -1.2 -5.2 -4.2
Arm fat mass (left) 2.2 9.1 22.8 4.8 -0.6 0.8 1.7 -4.0 -3.5
Number of self-reported non-cancer illnesses 1.5 2.6 6.6 -1.2 2.6 1.5 1.4 1.3 1.2
Average weekly champagne plus white wine intake 1.7 2.3 8.6 1.2 -2.9 0.0 1.2 -0.7 -1.4
Miserableness 0.9 1.5 3.0 1.6 -0.4 0.8 0.4 -1.7 -1.7
Guilty feelings 0.7 1.0 2.3 1.5 -0.4 0.1 -0.6 -1.5 -1.0
Wears glasses or contact lenses 1.1 1.3 5.1 0.8 0.3 -2.3 -1.0 -0.7 -0.7
Ever taken oral contraceptive pill 0.6 0.6 1.2 0.8 -0.0 -1.1 -1.0 -0.2 -0.9
Hearing aid user 0.3 0.4 1.9 -0.0 -1.4 0.4 0.2 -0.4 -0.3
Mother’s age at death 1.4 1.7 3.7 1.4 -1.9 0.1 -0.8 -1.6 -1.2
Financial situation satisfaction 0.4 0.5 1.0 1.0 0.9 -0.3 -0.4 -0.5 -0.8
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.5 -0.2 -0.1 -0.7 -0.3 -0.2 -0.0
Commuting to job workplace: Public transport 0.1 0.1 0.4 0.3 -0.1 -0.3 0.2 -0.6 0.1
Eye problems/disorders: Glaucoma 0.7 0.9 4.0 0.4 -2.0 -0.1 -0.3 -0.8 -0.5
Medication: Blood pressure 1.4 2.7 6.7 -0.7 2.6 1.7 2.2 0.9 0.8
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.8 0.6 0.1 0.3 0.9 -0.7 -0.1
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.7 0.5 -0.8 0.3 0.2 0.0 0.2
High cholesterol (Self-reported) 0.6 1.1 3.6 -1.2 0.2 0.4 1.9 0.3 1.2
Medication: Bendroflumethiazide 0.5 0.8 1.6 -1.0 0.8 0.3 0.8 0.9 1.3
Medication: Paracetamol 0.1 0.2 0.6 -0.8 -0.2 -0.1 0.3 -0.2 0.5
Medication: Lisinopril 0.4 0.5 1.1 0.2 0.4 1.0 1.1 0.4 0.4
Medication: Atorvastatin 1.0 1.3 3.6 -1.9 0.4 -0.3 0.4 1.3 1.4
Illnesses of father: High blood pressure 1.2 1.5 2.8 -1.7 -1.6 -0.8 -0.7 1.4 0.7
Alcohol drinker status: Never 0.6 0.8 2.6 -0.3 1.2 0.5 1.6 -0.1 -0.4
Ever smoked 0.4 0.7 1.4 0.6 -1.0 0.6 0.4 -1.1 -1.2
Basal metabolic rate 2.8 15.7 32.4 5.7 -2.8 -2.3 -2.0 -5.2 -4.2
Leg fat percentage (left) 1.1 4.0 9.1 2.0 1.0 2.2 3.0 -1.6 -1.4
Arm fat-free mass (left) 2.3 11.6 23.5 4.8 -2.9 -1.9 -1.6 -4.3 -3.6
Number of operations (self-reported) 0.1 0.1 0.3 -0.5 -0.1 0.1 -0.4 0.2 0.4
Average weekly beer plus cider intake 0.9 1.3 4.8 -0.2 2.2 1.4 0.8 -0.0 0.3
Irritability 0.5 0.8 1.4 1.0 -1.2 -0.0 -0.3 -1.2 -0.8
Risk taking 0.8 1.2 3.0 -1.0 1.1 -0.2 -1.0 1.7 1.0
Ever had prostate specific antigen (PSA) test 1.4 1.7 3.1 1.5 0.7 -1.0 -0.8 -1.7 -1.6
Fractured/broken bones in last 5 years 2.9 3.7 7.7 2.3 -1.3 0.6 -0.6 -2.6 -2.8
Age started oral contraceptive pill 1.1 1.3 3.5 1.2 -1.9 -1.4 -0.5 -0.6 -0.7
Diastolic blood pressure, automated reading 3.3 10.1 19.7 -4.1 1.8 1.8 2.2 4.4 3.7
Ever depressed for a whole week 0.2 0.3 0.6 0.3 0.2 0.5 -0.8 0.7 0.4
Unable to work because of sickness or disability 0.4 0.5 1.3 0.2 1.1 0.5 -0.0 -0.9 -0.7
Commuting to job workplace: Cycle 1.0 1.2 3.5 0.7 -1.9 -0.5 -0.9 -0.8 -1.2
Myopia 0.3 0.4 1.2 0.7 -1.1 -0.3 -0.6 -0.4 -0.6
Vascular/heart problems diagnosed by doctor 2.5 6.8 10.2 2.5 -3.2 -2.5 -2.5 -2.6 -2.3
Cholesterol lowering medication 1.2 1.8 7.5 0.2 0.5 1.7 2.7 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 2.2 2.7 5.9 2.1 1.6 -0.3 0.3 -1.8 -2.4
Pain experienced in last month 0.4 0.6 1.9 0.2 -1.4 -1.1 -0.8 0.2 -0.1
Supplements: Calcium 0.7 0.8 2.0 1.4 -0.7 -0.6 -0.8 -1.1 -0.3
Basal cell carcinoma (self-reported) 0.5 0.5 1.2 -0.5 0.8 0.3 1.1 0.6 0.9
Heart attack/myocardial infarction (self-reported) 1.7 2.2 4.6 -1.0 1.9 2.1 1.6 1.2 0.5
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 1.1 -0.4 -0.6 -1.0 -0.1 -0.5 -0.0
Heart disease (siblings) 2.3 2.8 5.1 -1.3 1.0 2.3 2.1 1.2 1.8
Alcohol drinker status: Previous 0.3 0.3 1.3 0.3 0.6 0.1 -1.1 -0.2 0.2
Pack years of smoking 1.7 2.4 3.7 1.5 1.9 -1.1 -0.7 -1.9 -1.9
Impedance of whole body 0.6 2.9 4.2 -1.9 1.8 -0.9 -1.3 2.0 1.8
Leg fat mass (left) 1.2 4.8 11.0 3.3 -0.2 1.2 1.8 -2.8 -2.2
Arm predicted mass (left) 2.4 12.1 24.2 4.9 -3.0 -2.2 -1.9 -4.4 -3.5