[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr11:63,316,786-64,820,283

Best TWAS P=1.09e-10 · Best GWAS P=8.84e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	GTEx	Brain Cerebellum	CCDC88B	0.48	0.55	lasso	4	0.54	1.6e-18	-6.4	6.5	1.1e-10	-0.97	0.01	0.99	TRUE
14	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC88B	0.02	0.02	enet	9	0.02	2.4e-05	-6.4	6.5	1.1e-10	-0.96	0.01	0.99	FALSE
3	GTEx	Artery Aorta	PPP1R14B	0.12	0.03	lasso	4	0.08	3.0e-05	-6.4	6.4	1.5e-10	-0.83	0.01	0.98	FALSE
5	GTEx	Brain Cerebellar Hemisphere	CCDC88B	0.45	0.39	lasso	3	0.41	1.2e-11	-6.4	6.4	1.9e-10	-0.96	0.01	0.99	FALSE
10	ROSMAP	Brain Pre-frontal Cortex	CCDC88B	0.33	0.39	lasso	9	0.40	1.1e-54	-6.4	6.4	2.0e-10	-0.97	0.01	0.99	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CCDC88B	0.22	0.24	bslmm	358	0.25	5.8e-30	-6.4	6.3	2.4e-10	-0.95	0.01	0.99	FALSE
9	GTEx	Skin Sun Exposed Lower leg	CCDC88B	0.11	0.05	enet	14	0.05	2.5e-05	-6.5	6.3	2.9e-10	-0.85	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC88B	0.03	0.04	lasso	1	0.04	3.8e-05	-6.3	6.3	3.2e-10	-0.91	0.01	0.97	FALSE
4	GTEx	Artery Tibial	PPP1R14B	0.21	0.13	lasso	4	0.13	4.0e-10	-6.4	6.2	4.4e-10	-0.97	0.01	0.99	FALSE
2	CommonMind	Brain Pre-frontal Cortex	PPP1R14B	0.10	0.09	lasso	5	0.09	1.1e-10	-6.3	6.1	1.1e-09	-0.99	0.01	0.99	FALSE
15	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCDC88B	0.03	0.04	lasso	2	0.03	1.3e-04	-6.0	6.0	1.8e-09	-0.89	0.03	0.96	FALSE
12	YFS	Blood	CCDC88B	0.49	0.54	bslmm	346	0.59	1.9e-249	-5.7	5.9	3.7e-09	-0.85	0.51	0.49	FALSE
7	GTEx	Brain Frontal Cortex BA9	CCDC88B	0.23	0.10	lasso	10	0.09	2.4e-03	-6.0	5.9	4.8e-09	-0.85	0.04	0.93	FALSE
13	YFS	Blood	PPP1R14B	0.02	0.01	blup	333	0.01	1.8e-03	-6.4	5.8	6.8e-09	-0.77	0.01	0.97	FALSE
11	ROSMAP	Brain Pre-frontal Cortex	PPP1R14B	0.12	0.13	lasso	7	0.12	2.4e-15	-6.4	5.6	1.6e-08	-0.95	0.01	0.99	FALSE
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CCDC88B	0.02	0.04	lasso	3	0.04	6.2e-05	-5.5	5.6	1.6e-08	-0.80	0.11	0.75	FALSE
8	GTEx	Esophagus Mucosa	CCDC88B	0.18	0.04	lasso	3	0.05	2.9e-04	-6.4	5.2	2.4e-07	-0.75	0.01	0.92	FALSE