Best TWAS P=1.09e-10 · Best GWAS P=8.84e-11 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CCDC88B | 0.22 | 0.24 | bslmm | 358 | 0.25 | 5.8e-30 | -6.4 | 6.3 | 2.4e-10 | -0.95 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | PPP1R14B | 0.10 | 0.09 | lasso | 5 | 0.09 | 1.1e-10 | -6.3 | 6.1 | 1.1e-09 | -0.99 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Artery Aorta | PPP1R14B | 0.12 | 0.03 | lasso | 4 | 0.08 | 3.0e-05 | -6.4 | 6.4 | 1.5e-10 | -0.83 | 0.01 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | PPP1R14B | 0.21 | 0.13 | lasso | 4 | 0.13 | 4.0e-10 | -6.4 | 6.2 | 4.4e-10 | -0.97 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | CCDC88B | 0.45 | 0.39 | lasso | 3 | 0.41 | 1.2e-11 | -6.4 | 6.4 | 1.9e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Brain Cerebellum | CCDC88B | 0.48 | 0.55 | lasso | 4 | 0.54 | 1.6e-18 | -6.4 | 6.5 | 1.1e-10 | -0.97 | 0.01 | 0.99 | TRUE |
| 7 | GTEx | Brain Frontal Cortex BA9 | CCDC88B | 0.23 | 0.10 | lasso | 10 | 0.09 | 2.4e-03 | -6.0 | 5.9 | 4.8e-09 | -0.85 | 0.04 | 0.93 | FALSE |
| 8 | GTEx | Esophagus Mucosa | CCDC88B | 0.18 | 0.04 | lasso | 3 | 0.05 | 2.9e-04 | -6.4 | 5.2 | 2.4e-07 | -0.75 | 0.01 | 0.92 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | CCDC88B | 0.11 | 0.05 | enet | 14 | 0.05 | 2.5e-05 | -6.5 | 6.3 | 2.9e-10 | -0.85 | 0.01 | 0.99 | FALSE |
| 10 | ROSMAP | Brain Pre-frontal Cortex | CCDC88B | 0.33 | 0.39 | lasso | 9 | 0.40 | 1.1e-54 | -6.4 | 6.4 | 2.0e-10 | -0.97 | 0.01 | 0.99 | FALSE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | PPP1R14B | 0.12 | 0.13 | lasso | 7 | 0.12 | 2.4e-15 | -6.4 | 5.6 | 1.6e-08 | -0.95 | 0.01 | 0.99 | FALSE |
| 12 | YFS | Blood | CCDC88B | 0.49 | 0.54 | bslmm | 346 | 0.59 | 1.9e-249 | -5.7 | 5.9 | 3.7e-09 | -0.85 | 0.51 | 0.49 | FALSE |
| 13 | YFS | Blood | PPP1R14B | 0.02 | 0.01 | blup | 333 | 0.01 | 1.8e-03 | -6.4 | 5.8 | 6.8e-09 | -0.77 | 0.01 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC88B | 0.02 | 0.02 | enet | 9 | 0.02 | 2.4e-05 | -6.4 | 6.5 | 1.1e-10 | -0.96 | 0.01 | 0.99 | FALSE |
| 15 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC88B | 0.03 | 0.04 | lasso | 2 | 0.03 | 1.3e-04 | -6.0 | 6.0 | 1.8e-09 | -0.89 | 0.03 | 0.96 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC88B | 0.02 | 0.04 | lasso | 3 | 0.04 | 6.2e-05 | -5.5 | 5.6 | 1.6e-08 | -0.80 | 0.11 | 0.75 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC88B | 0.03 | 0.04 | lasso | 1 | 0.04 | 3.8e-05 | -6.3 | 6.3 | 3.2e-10 | -0.91 | 0.01 | 0.97 | FALSE |