[Hub]/) : Traits : Hypothyroidism (self reported) :

chr11:60,549,966-62,346,131

Best TWAS P=1.84e-11 · Best GWAS P=2.96e-11 conditioned to 0.237

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FADS1 0.14 0.16 lasso 2 0.16 7.2e-19 -6.20 6.2 4.6e-10 -0.97 0.02 0.98 FALSE
2 CommonMind Brain Pre-frontal Cortex FEN1 0.07 0.06 lasso 4 0.06 1.1e-07 -6.20 -6.3 3.5e-10 0.96 0.02 0.98 FALSE
3 GTEx Artery Tibial FADS2 0.08 0.02 lasso 4 0.02 6.9e-03 -6.41 -5.8 6.9e-09 0.79 0.02 0.96 FALSE
4 GTEx Artery Tibial TMEM258 0.08 0.05 lasso 5 0.02 1.1e-02 -6.54 -6.6 5.6e-11 0.98 0.01 0.99 FALSE
5 GTEx Brain Cerebellum FADS1 0.35 0.24 enet 16 0.30 2.1e-09 -5.91 5.8 7.7e-09 -0.91 0.03 0.97 FALSE
6 GTEx Brain Cerebellum FADS3 0.26 0.18 lasso 4 0.14 5.7e-05 -6.02 6.3 4.0e-10 -0.92 0.02 0.89 FALSE
7 GTEx Breast Mammary Tissue (Female) TMEM258 0.20 0.02 lasso 7 0.00 2.3e-01 -4.75 -5.4 7.7e-08 0.79 0.04 0.54 FALSE
8 GTEx Cells Transformed fibroblasts TMEM258 0.15 0.05 enet 15 0.07 1.1e-05 -6.41 -6.5 9.2e-11 0.77 0.02 0.97 FALSE
9 GTEx Colon Transverse FADS2 0.18 0.11 lasso 7 0.16 8.1e-08 -4.60 -5.3 1.1e-07 0.75 0.05 0.95 FALSE
10 GTEx Esophagus Mucosa FADS1 0.11 0.00 lasso 4 0.02 1.9e-02 -6.47 5.7 9.8e-09 -0.85 0.02 0.92 FALSE
11 GTEx Esophagus Muscularis FADS2 0.32 0.30 lasso 6 0.31 3.7e-19 -4.60 -5.4 6.3e-08 0.71 0.97 0.03 FALSE
12 GTEx Heart Left Ventricle FADS2 0.17 0.12 enet 3 0.13 1.5e-07 -5.17 -5.5 3.0e-08 0.73 0.20 0.80 FALSE
13 GTEx Muscle Skeletal FADS2 0.08 0.04 lasso 2 0.03 5.9e-04 -6.37 -6.4 1.4e-10 0.93 0.02 0.98 FALSE
14 GTEx Pancreas FADS1 0.17 0.13 lasso 6 0.12 1.2e-05 -6.02 6.2 4.5e-10 -0.91 0.04 0.96 FALSE
15 GTEx Spleen FADS2 0.30 0.27 lasso 3 0.27 1.6e-07 -4.60 -5.4 6.2e-08 0.72 0.07 0.92 FALSE
16 GTEx Uterus PPP1R32 0.66 -0.01 lasso 13 0.14 8.8e-04 -0.29 -5.9 3.5e-09 0.59 0.02 0.50 FALSE
17 NTR Blood C11orf10 0.06 0.08 bslmm 399 0.08 1.3e-24 -6.41 -6.6 3.7e-11 0.91 0.02 0.98 FALSE
18 ROSMAP Brain Pre-frontal Cortex TMEM258 0.14 0.16 lasso 4 0.15 4.7e-19 -6.41 -6.7 1.8e-11 0.92 0.02 0.98 TRUE
19 ROSMAP Brain Pre-frontal Cortex FADS1 0.08 0.08 enet 10 0.09 1.5e-11 -6.53 6.5 6.1e-11 -0.95 0.02 0.98 FALSE
20 YFS Blood FADS1 0.11 0.08 lasso 8 0.09 6.1e-29 -4.60 -5.8 7.5e-09 0.77 1.00 0.00 FALSE
21 The Cancer Genome Atlas Colon Adenocarcinoma FADS2 0.30 0.21 lasso 2 0.22 6.7e-13 -4.60 -5.7 1.5e-08 0.75 0.49 0.51 FALSE
22 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma FADS2 0.05 0.04 lasso 3 0.05 1.9e-06 -4.60 -5.2 2.0e-07 0.71 0.24 0.71 FALSE
23 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma FADS2 0.26 0.29 enet 15 0.29 2.9e-33 -4.60 -5.8 8.5e-09 0.73 1.00 0.00 FALSE
24 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FADS2 0.33 0.27 lasso 9 0.35 9.3e-21 -4.60 -5.7 1.4e-08 0.78 0.58 0.42 FALSE
25 The Cancer Genome Atlas Brain Lower Grade Glioma FADS1 0.05 0.05 blup 53 0.04 6.8e-05 -5.62 6.4 1.2e-10 -0.87 0.03 0.97 FALSE
26 The Cancer Genome Atlas Lung Squamous Cell Carcinoma FADS2 0.02 0.01 blup 71 0.02 1.9e-03 -6.37 -6.1 1.3e-09 0.91 0.02 0.83 FALSE
27 The Cancer Genome Atlas Rectum Adenocarcinoma FADS2 0.47 0.34 lasso 5 0.30 7.9e-08 -4.60 -5.2 1.5e-07 0.69 0.03 0.95 FALSE
28 The Cancer Genome Atlas Thyroid Carcinoma C11orf10 0.02 0.02 blup 44 0.02 1.8e-03 -5.93 -6.4 2.0e-10 0.95 0.02 0.74 FALSE
29 The Cancer Genome Atlas Thyroid Carcinoma FADS2 0.30 0.33 lasso 8 0.33 5.6e-33 -4.60 -5.3 9.5e-08 0.71 1.00 0.00 FALSE