[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr11:60,549,966-62,346,131

Best TWAS P=1.84e-11 · Best GWAS P=2.96e-11 conditioned to 0.237

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-6.41	-6.7	1.8e-11	0.92	0.02	0.98	TRUE
17	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-6.41	-6.6	3.7e-11	0.91	0.02	0.98	FALSE
4	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-6.54	-6.6	5.6e-11	0.98	0.01	0.99	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-6.53	6.5	6.1e-11	-0.95	0.02	0.98	FALSE
8	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-6.41	-6.5	9.2e-11	0.77	0.02	0.97	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-5.62	6.4	1.2e-10	-0.87	0.03	0.97	FALSE
13	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-6.37	-6.4	1.4e-10	0.93	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-5.93	-6.4	2.0e-10	0.95	0.02	0.74	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-6.20	-6.3	3.5e-10	0.96	0.02	0.98	FALSE
6	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-6.02	6.3	4.0e-10	-0.92	0.02	0.89	FALSE
14	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-6.02	6.2	4.5e-10	-0.91	0.04	0.96	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-6.20	6.2	4.6e-10	-0.97	0.02	0.98	FALSE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-6.37	-6.1	1.3e-09	0.91	0.02	0.83	FALSE
16	GTEx	Uterus	PPP1R32	0.66	-0.01	lasso	13	0.14	8.8e-04	-0.29	-5.9	3.5e-09	0.59	0.02	0.50	FALSE
3	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-6.41	-5.8	6.9e-09	0.79	0.02	0.96	FALSE
20	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-4.60	-5.8	7.5e-09	0.77	1.00	0.00	FALSE
5	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-5.91	5.8	7.7e-09	-0.91	0.03	0.97	FALSE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	FADS2	0.26	0.29	enet	15	0.29	2.9e-33	-4.60	-5.8	8.5e-09	0.73	1.00	0.00	FALSE
10	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-6.47	5.7	9.8e-09	-0.85	0.02	0.92	FALSE
24	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-4.60	-5.7	1.4e-08	0.78	0.58	0.42	FALSE
21	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-4.60	-5.7	1.5e-08	0.75	0.49	0.51	FALSE
12	GTEx	Heart Left Ventricle	FADS2	0.17	0.12	enet	3	0.13	1.5e-07	-5.17	-5.5	3.0e-08	0.73	0.20	0.80	FALSE
15	GTEx	Spleen	FADS2	0.30	0.27	lasso	3	0.27	1.6e-07	-4.60	-5.4	6.2e-08	0.72	0.07	0.92	FALSE
11	GTEx	Esophagus Muscularis	FADS2	0.32	0.30	lasso	6	0.31	3.7e-19	-4.60	-5.4	6.3e-08	0.71	0.97	0.03	FALSE
7	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-4.75	-5.4	7.7e-08	0.79	0.04	0.54	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	FADS2	0.30	0.33	lasso	8	0.33	5.6e-33	-4.60	-5.3	9.5e-08	0.71	1.00	0.00	FALSE
9	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-4.60	-5.3	1.1e-07	0.75	0.05	0.95	FALSE
27	The Cancer Genome Atlas	Rectum Adenocarcinoma	FADS2	0.47	0.34	lasso	5	0.30	7.9e-08	-4.60	-5.2	1.5e-07	0.69	0.03	0.95	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	FADS2	0.05	0.04	lasso	3	0.05	1.9e-06	-4.60	-5.2	2.0e-07	0.71	0.24	0.71	FALSE