Hub : Traits :

Hypothyroidism (self reported)

856 significantly associated models · 248 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	752566	3261925	3	2	1.3e-11	2.3e-11	2.0e-02	88	MMEL1 SDF4
2	1	7792411	9190254	1	1	1.6e-07	2.2e-07	1.0e+00	100	RP5-1115A15.1
3	1	18932744	20503710	3	5	3.7e-11	9.1e-12	NaN	NaN	CAPZB PQLC2
4	1	23431777	24861704	2	1	5.3e-08	3.3e-07	5.6e-02	86	HMGCL
5	1	37577214	39186794	6	1	6.1e-12	1.9e-10	9.4e-01	100	INPP5B
6	1	107418424	109188382	1	1	1.5e-50	7.7e-51	1.0e+00	100	VAV3
7	1	113236087	115222434	11	10	7.8e-81	9.7e-176	NaN	NaN	AP4B1 BCL2L15 DCLRE1B HIPK1 OLFML3 PHTF1 RSBN1
8	1	151129254	152518294	1	1	1.8e-07	2.0e-06	8.0e-03	69	THEM5
9	1	156078249	157482371	1	1	7.4e-08	6.5e-08	3.4e-01	97	SH2D2A
10	1	166702558	168182443	1	1	7.1e-08	2.0e-08	1.0e+00	100	CD247
11	1	200462817	201079088	1	1	2.6e-07	1.3e-10	9.2e-05	63	CAMSAP1L1
12	1	212719366	213232555	1	1	1.1e-07	6.4e-06	7.5e-01	100	TATDN3
13	2	61725501	63149557	1	1	3.1e-08	4.2e-09	1.0e+00	100	B3GNT2
14	2	97098095	99306504	8	1	2.1e-09	1.2e-09	1.3e-01	94	ANKRD36B
15	2	159476732	161166234	2	1	1.6e-07	1.8e-07	1.0e+00	100	AC009506.1
16	2	161297929	162790882	1	1	2.2e-09	3.4e-09	1.0e+00	100	TANK
17	2	190521054	192712723	6	2	5.0e-14	1.9e-38	7.6e-24	40	NAB1 STAT4
18	3	11350553	12928762	2	1	1.2e-15	8.0e-14	4.1e-01	99	TIMP4
19	3	36339386	38174470	5	1	9.5e-09	1.2e-08	3.5e-01	97	LRRFIP2
20	3	104683753	106283820	1	1	8.0e-09	1.8e-18	1.5e-18	0	CBLB
21	3	191820205	193330022	1	1	5.5e-08	6.3e-08	1.0e+00	100	MB21D2
22	4	40097557	40605238	1	1	1.4e-08	1.2e-11	1.3e-07	40	CHRNA9
23	4	86236934	88754060	4	2	4.0e-10	1.1e-09	1.0e+00	100	AFF1 PTPN13
24	4	122961964	124352460	1	1	1.7e-07	3.9e-09	6.6e-03	79	BBS12
25	4	148303195	150060844	1	1	7.8e-32	2.0e-32	1.0e+00	100	NR3C2
26	5	35608310	36124514	1	1	2.4e-07	4.8e-08	6.7e-02	89	IL7R
27	5	68178407	68828296	1	1	1.6e-07	1.6e-06	5.5e-01	98	GTF2H2C
28	5	71557313	73125146	2	1	1.5e-08	1.2e-08	3.4e-06	34	FCHO2
29	5	75669474	77412011	2	1	1.2e-11	2.3e-13	3.4e-03	84	PDE8B
30	5	101392473	103244640	2	1	3.7e-10	2.1e-11	1.2e-02	86	PAM
31	6	35216296	35942313	2	1	9.1e-11	2.7e-10	4.4e-02	90	TULP1
32	6	89941356	91704536	1	2	3.0e-33	1.5e-38	7.8e-16	62	BACH2
33	6	134905567	136516257	3	1	3.7e-10	1.9e-09	6.3e-02	90	C6orf217
34	6	165045334	167841508	6	2	8.0e-36	2.6e-34	1.0e+00	100	PDE10A RNASET2
35	7	76506844	77966572	2	1	1.3e-07	9.6e-08	1.9e-01	94	PTPN12
36	7	99591418	100979310	2	1	2.8e-11	7.9e-11	1.0e+00	100	GIGYF1
37	7	127878155	129284182	1	1	8.1e-09	5.9e-08	7.7e-04	62	IRF5
38	8	23139436	23678000	1	1	3.7e-08	9.2e-08	3.2e-01	96	SLC25A37
39	8	60736025	62477554	2	1	2.1e-10	4.7e-10	1.0e+00	100	RAB2A
40	8	128107136	129812343	1	1	1.5e-07	9.1e-14	7.4e-14	-1	PVT1
41	8	132897005	134846363	4	2	2.0e-15	3.2e-16	1.5e-03	85	TG
42	8	140969818	142706843	1	1	2.3e-07	1.9e-10	9.7e-06	52	PTK2
43	9	4758022	6168335	1	1	9.3e-08	2.7e-11	3.3e-08	31	CD274
44	9	99581811	101652673	8	8	1.3e-67	6.6e-103	NaN	NaN	C9orf156 FOXE1 NANS NCBP1
45	9	122881960	124331465	4	1	1.3e-07	4.3e-07	1.0e+00	100	PSMD5
46	9	126321003	127872298	2	1	2.9e-09	1.3e-08	5.9e-01	99	NEK6
47	9	130769800	132289479	3	1	8.4e-09	8.5e-09	1.0e+00	100	PKN3
48	10	5027660	6677767	3	3	8.2e-19	4.7e-19	2.2e-04	83	FAM208B IL2RA
49	10	63253359	64724096	2	2	1.5e-17	2.1e-30	2.1e-19	38	ARID5B RTKN2
50	11	198510	1346802	8	2	3.8e-09	9.1e-10	1.0e+00	100	IRF7 RP11-326C3.11
51	11	34460769	35949179	2	1	3.0e-16	9.8e-19	9.2e-06	75	SLC1A2
52	11	46622392	48028343	1	1	2.3e-07	3.5e-07	1.0e+00	100	MADD
53	11	60549966	62346131	7	1	1.8e-11	3.0e-11	2.4e-01	97	TMEM258
54	11	63316786	64820283	2	1	1.1e-10	8.8e-11	1.0e+00	100	CCDC88B
55	11	93166368	94613754	1	1	2.3e-07	6.4e-09	5.7e-04	65	PANX1
56	11	116007539	117800682	5	1	1.2e-08	3.1e-11	6.6e-04	74	SIK3
57	12	55601472	57681122	8	1	6.5e-18	4.4e-15	3.7e-02	93	SUOX
58	12	109641978	113517494	21	9	8.8e-71	6.4e-117	NaN	NaN	AC003029.1 ADAM1A ALDH2 HECTD4 VPS29
59	13	23856997	25579336	1	1	5.6e-08	3.0e-40	2.9e-35	13	SPATA13
60	15	38088200	39556796	1	1	3.1e-16	4.7e-17	1.7e-02	92	RASGRP1
61	16	49488151	51097687	3	2	2.6e-10	6.0e-10	7.4e-01	100	BRD7
62	16	66666637	69084178	18	2	2.3e-10	3.8e-11	6.5e-02	92	HSD11B2 LCAT
63	17	6190353	7949434	2	1	2.2e-08	1.0e-13	3.7e-07	53	ACAP1
64	17	27222988	28629763	2	1	9.5e-08	1.7e-06	1.7e-02	75	ABHD15
65	17	39589083	41265776	3	1	1.8e-12	1.9e-12	1.0e+00	100	RAB5C
66	17	44788310	46704536	7	9	6.7e-16	7.4e-16	4.3e-02	94	C17orf57 EFCAB13 MRPL10 NPEPPS RP11-6N17.3 TBKBP1
67	17	73175294	74574103	2	1	1.1e-07	4.6e-07	8.1e-02	88	RP11-552F3.9
68	18	12090696	13687136	2	2	4.3e-08	4.0e-12	1.1e-05	60	PTPN2 SEH1L
69	18	66371289	68204223	2	1	1.4e-08	3.2e-09	7.2e-02	91	CD226
70	18	76907334	77535176	1	1	4.7e-11	1.5e-09	1.3e-06	36	NFATC1
71	19	4118871	5529588	2	2	1.0e-12	1.5e-23	4.8e-09	66	FEM1A TICAM1
72	19	9763152	11186711	1	1	1.1e-07	1.8e-11	1.4e-05	58	TYK2
73	19	17672385	19190906	3	1	1.7e-13	2.6e-13	1.0e+00	100	JUND
74	19	48525507	50909389	6	3	7.0e-13	7.0e-12	1.0e+00	100	ALDH16A1 CPT1C RASIP1
75	22	30233446	30820707	1	1	1.2e-08	2.0e-11	1.0e-04	66	HORMAD2
76	22	36867133	38292974	3	4	5.4e-22	6.6e-31	NaN	NaN	C1QTNF6 RP1-151B14.6 SSTR3
77	22	41071659	42614362	2	1	1.2e-07	1.5e-08	1.0e+00	100	TEF

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Hypothyroidism/myxoedema (self-reported)	21.12	99	59	131.1	1.00	3.4e-134	AC003029.1 AC009506.1 ACAP1 ADAM1A AFF1 ALDH16A1 ALDH2 ANKRD36B AP4B1 ARID5B B3GNT2 BACH2 BBS12 BCL2L15 BRD7 C17orf57 C1QTNF6 C6orf217 C9orf156 CAPZB CBLB CCDC88B CD226 CD247 CD274 CHRNA9 CPT1C DCLRE1B EFCAB13 FAM208B FCHO2 FEM1A FOXE1 GIGYF1 GTF2H2C HECTD4 HIPK1 HMGCL HORMAD2 HSD11B2 IL2RA IL7R INPP5B IRF5 IRF7 JUND LCAT LRRFIP2 MB21D2 MMEL1 MRPL10 NAB1 NANS NCBP1 NEK6 NFATC1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PKN3 PQLC2 PSMD5 PTK2 PTPN12 PTPN13 RAB2A RAB5C RASGRP1 RNASET2 RP11-326C3.11 RP1-151B14.6 RP11-552F3.9 RP11-6N17.3 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SH2D2A SIK3 SLC1A2 SPATA13 SSTR3 STAT4 SUOX TANK TATDN3 TBKBP1 TEF TG THEM5 TICAM1 TIMP4 TMEM258 TULP1 VAV3 VPS29
Medication: Levothyroxine sodium	18.43	75	40	88.9	0.99	1.9e-83	AC003029.1 AC009506.1 ACAP1 ADAM1A ALDH16A1 ALDH2 ANKRD36B AP4B1 ARID5B B3GNT2 BACH2 BCL2L15 BRD7 C17orf57 C1QTNF6 C6orf217 C9orf156 CAPZB CCDC88B CD226 CPT1C DCLRE1B EFCAB13 FAM208B FCHO2 FEM1A FOXE1 GIGYF1 HECTD4 HIPK1 HORMAD2 HSD11B2 IL2RA IL7R INPP5B IRF5 IRF7 JUND LRRFIP2 MMEL1 MRPL10 NAB1 NANS NCBP1 NFATC1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PQLC2 RAB2A RAB5C RASGRP1 RNASET2 RP1-151B14.6 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SH2D2A SLC1A2 SSTR3 STAT4 SUOX TATDN3 TBKBP1 TG TICAM1 TIMP4 TMEM258 TULP1 VAV3 VPS29
Rheumatoid Arthritis	8.95	16	8	17.8	0.96	1.0e-10	AP4B1 ARID5B BCL2L15 DCLRE1B FAM208B HECTD4 HIPK1 INPP5B MMEL1 NAB1 OLFML3 PAM PHTF1 PTPN2 RASGRP1 RSBN1
Blood Eosinophil Count	7.00	40	30	66.7	0.44	2.3e-03	AC003029.1 ACAP1 ADAM1A ALDH2 B3GNT2 BACH2 BBS12 C17orf57 C1QTNF6 CCDC88B CD226 CD247 EFCAB13 FAM208B FCHO2 GIGYF1 HECTD4 HMGCL HSD11B2 IL7R IRF5 JUND NAB1 NANS NEK6 NPEPPS PSMD5 PTPN2 PVT1 RASGRP1 RP5-1115A15.1 SSTR3 STAT4 SUOX TATDN3 TBKBP1 TEF TIMP4 TMEM258 VPS29
Blood Platelet Count	3.95	33	22	48.9	0.34	3.0e-02	ABHD15 ACAP1 ADAM1A AFF1 ARID5B C9orf156 CAPZB CD226 FCHO2 FOXE1 HECTD4 IRF5 MADD MRPL10 NAB1 NANS NEK6 PAM PKN3 PQLC2 PSMD5 PTK2 PTPN13 RASIP1 RP11-552F3.9 SH2D2A SIK3 SLC25A37 TEF TIMP4 TMEM258 TYK2 VPS29
Lupus	3.80	7	3	6.7	0.70	5.4e-02	ARID5B DCLRE1B HECTD4 IRF5 IRF7 NAB1 RTKN2
Blood White Count	3.73	31	23	51.1	0.24	1.4e-01	AC003029.1 AC009506.1 ACAP1 ADAM1A AFF1 ALDH2 AP4B1 BACH2 BCL2L15 C6orf217 CD226 DCLRE1B GTF2H2C HECTD4 HORMAD2 INPP5B MADD PAM PDE8B PHTF1 PKN3 PSMD5 PVT1 RAB2A RAB5C RP11-326C3.11 RP5-1115A15.1 SIK3 TIMP4 TMEM258 VPS29
Taking other prescription medications	3.59	10	5	11.1	0.97	3.7e-07	ADAM1A BCL2L15 CCDC88B DCLRE1B FAM208B HECTD4 HIPK1 PHTF1 RAB5C RNASET2
Allergy or Eczema	3.55	14	12	26.7	-0.25	3.5e-01	ADAM1A BACH2 BBS12 C6orf217 CD247 HECTD4 IL7R NEK6 PSMD5 RP5-1115A15.1 SDF4 SEH1L SUOX TEF
Hayfever, allergic rhinitis or eczema	3.26	13	8	17.8	-0.22	4.4e-01	ADAM1A BACH2 BBS12 C6orf217 CD247 HECTD4 IL7R NEK6 PSMD5 RP5-1115A15.1 SDF4 SUOX TEF
Allergy	2.96	11	7	15.6	0.21	5.2e-01	ADAM1A BACH2 BBS12 C6orf217 CD247 IL7R NEK6 PSMD5 RP5-1115A15.1 SUOX TEF
Primary Biliary Cirrhosis	2.81	6	3	6.7	0.68	9.5e-02	CCDC88B HECTD4 IL7R IRF5 MMEL1 NAB1
Respiratory disease	2.79	11	7	15.6	-0.44	1.5e-01	BACH2 BBS12 C6orf217 CD247 FAM208B IL7R NEK6 RP5-1115A15.1 SUOX TEF TMEM258
Asthma (self-reported)	2.65	9	6	13.3	-0.48	1.6e-01	BACH2 BBS12 C6orf217 CD247 IL7R RP5-1115A15.1 SUOX TEF TMEM258
Asthma	2.59	9	6	13.3	-0.50	1.4e-01	BACH2 BBS12 C6orf217 CD247 IL7R RP5-1115A15.1 SUOX TEF TMEM258
Crohns Disease (2017)	2.53	9	4	8.9	-0.33	3.6e-01	BCL2L15 CCDC88B CPT1C DCLRE1B HIPK1 HORMAD2 RASIP1 RNASET2 TMEM258
LDL Cholesterol	2.53	5	4	8.9	-0.24	5.3e-01	C17orf57 HECTD4 RASIP1 TBKBP1 TMEM258
Long-standing illness, disability or infirmity	2.29	5	1	2.2	0.97	1.4e-03	BCL2L15 DCLRE1B FAM208B PHTF1 RNASET2
HDL Cholesterol	2.23	5	3	6.7	0.17	7.8e-01	AFF1 LCAT MADD SIK3 TMEM258
Number of self-reported non-cancer illnesses	2.21	4	1	2.2	0.96	1.1e-02	FAM208B HECTD4 RASIP1 RNASET2
Crohns Disease (2012)	2.20	6	1	2.2	0.21	6.8e-01	CCDC88B HIPK1 HORMAD2 RASIP1 RNASET2 TMEM258
Hayfever/allergic rhinitis (self-reported)	2.19	4	2	4.4	-0.46	5.4e-01	BACH2 CD247 IL7R SUOX
Number of treatments/medications taken	2.18	7	2	4.4	0.94	1.5e-04	ADAM1A BCL2L15 DCLRE1B FAM208B HECTD4 TANK TMEM258
Other serious medical condition/disability diagnosed by doctor	2.17	1	0	0.0	0.00	1.0e+00	DCLRE1B
Birth weight	2.15	11	3	6.7	-0.60	3.7e-02	ACAP1 ADAM1A ALDH2 C17orf57 DCLRE1B HECTD4 HORMAD2 PSMD5 RASIP1 SLC25A37 SUOX
Irritable Bowel Disease (IBD)	2.12	11	1	2.2	0.43	1.9e-01	BACH2 BBS12 BRD7 CAMSAP1L1 CCDC88B CPT1C HECTD4 HORMAD2 PTPN2 RNASET2 SDF4
Blood Red Count	2.01	22	18	40.0	0.30	1.3e-01	AC003029.1 ADAM1A AFF1 ALDH2 BACH2 C9orf156 CPT1C GIGYF1 HECTD4 HMGCL HSD11B2 LCAT MADD NANS NPEPPS PAM PKN3 RP11-6N17.3 SUOX TG TMEM258 VPS29
Birth weight of first child	2.00	5	2	4.4	-0.51	3.0e-01	AC003029.1 FCHO2 HECTD4 RAB2A SUOX
Diastolic blood pressure, automated reading	2.00	10	7	15.6	0.71	9.6e-03	AC003029.1 ADAM1A AFF1 ALDH2 GIGYF1 HECTD4 INPP5B RP5-1115A15.1 SLC25A37 VPS29
High cholesterol (Self-reported)	1.97	5	4	8.9	-0.44	2.8e-01	C17orf57 RASIP1 RP11-552F3.9 RP11-6N17.3 TBKBP1
Systolic Blood Pressure	1.86	19	14	31.1	0.25	2.8e-01	AC003029.1 ADAM1A ALDH2 ARID5B HECTD4 HMGCL IRF5 MADD NAB1 NEK6 PSMD5 PTPN12 PTPN13 RASIP1 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TBKBP1 VPS29
Cardiovascular Disease	1.79	12	6	13.3	0.57	4.2e-02	AC003029.1 ADAM1A ALDH2 C17orf57 CCDC88B HECTD4 RASIP1 RP11-6N17.3 RP5-1115A15.1 SUOX TBKBP1 VPS29
Pulse wave Arterial Stiffness index	1.74	1	1	2.2	0.00	1.0e+00	ADAM1A
Triglycerides	1.73	2	1	2.2	0.00	1.0e+00	AFF1 TMEM258
Mouth/teeth dental problems: Mouth ulcers	1.72	3	1	2.2	0.00	1.0e+00	BRD7 IRF5 PAM
Ulcerative Colitis (UC)	1.71	1	1	2.2	0.00	1.0e+00	IRF5
Ulcerative Colitis	1.66	2	0	0.0	0.00	1.0e+00	BRD7 IRF5
High blood pressure	1.66	10	3	6.7	0.34	3.0e-01	AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SLC25A37 SUOX
Medication: Atenolol	1.66	1	1	2.2	0.00	1.0e+00	HECTD4
Vascular/heart problems diagnosed by doctor	1.66	9	2	4.4	-0.44	2.1e-01	AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 SUOX TBKBP1
Coronary Artery Disease (CAD)	1.65	2	0	0.0	0.00	1.0e+00	HECTD4 VPS29
Chest pain or discomfort	1.65	2	0	0.0	-1.00	3.5e-05	C17orf57 TBKBP1
Pulse wave peak to peak time	1.64	1	1	2.2	0.00	1.0e+00	ADAM1A
Pulse rate, automated reading	1.63	5	3	6.7	-0.49	4.0e-01	GIGYF1 NAB1 PSMD5 TMEM258 VPS29
Hypertension (Self-reported)	1.58	10	2	4.4	0.30	3.8e-01	AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SLC25A37 SUOX
Waist Hip Ratio (WHR)	1.57	9	7	15.6	-0.01	9.8e-01	ACAP1 ADAM1A BBS12 HSD11B2 JUND PAM PTPN12 RASIP1 TIMP4
Reaction Time	1.56	3	2	4.4	0.95	5.0e-02	AC003029.1 ALDH2 HECTD4
Medication: Ventolin 100micrograms inhaler	1.54	2	0	0.0	0.00	1.0e+00	BACH2 CD247
Smoking status: Previous	1.53	1	0	0.0	0.00	1.0e+00	HECTD4
Medication: Cholesterol lowering	1.52	1	0	0.0	0.00	1.0e+00	RASIP1
Myopia	1.52	2	0	0.0	0.00	1.0e+00	MADD TMEM258
Suffer from 'nerves'	1.50	2	1	2.2	0.00	1.0e+00	MADD RP5-1115A15.1
Loneliness, isolation	1.50	2	1	2.2	0.00	1.0e+00	MADD RP5-1115A15.1
Past tobacco smoking	1.49	5	0	0.0	-0.29	6.3e-01	ADAM1A HECTD4 PHTF1 SUOX TANK
Medication: Simvastatin	1.49	2	0	0.0	0.00	1.0e+00	RASIP1 TBKBP1
Medication for cholesterol, blood pressure or diabetes	1.46	1	0	0.0	0.00	1.0e+00	RASIP1
Medication: Seretide 50 evohaler	1.44	2	0	0.0	0.00	1.0e+00	BACH2 LCAT
Mood swings	1.44	4	1	2.2	-0.63	3.7e-01	HORMAD2 MADD PTK2 TEF
Ever smoked	1.44	1	0	0.0	0.00	1.0e+00	PHTF1
Frequency of tiredness / lethargy in last 2 weeks	1.43	2	0	0.0	0.00	1.0e+00	RP5-1115A15.1 TEF
Depressed Affect (Nagel 2018)	1.42	5	1	2.2	0.21	7.3e-01	HORMAD2 MADD RP5-1115A15.1 TANK TEF
Smoking Status	1.42	6	3	6.7	0.17	7.5e-01	ADAM1A CCDC88B PHTF1 RP5-1115A15.1 SUOX TANK
Number of live births	1.41	2	0	0.0	0.00	1.0e+00	HORMAD2 TMEM258
Lung FEV1/FVC ratio	1.40	17	10	22.2	-0.08	7.5e-01	ABHD15 AC009506.1 BACH2 C9orf156 HSD11B2 IL7R JUND LCAT NANS NCBP1 PQLC2 RASIP1 RP11-326C3.11 RP5-1115A15.1 SIK3 SLC1A2 SUOX
Smoking status: Current	1.40	2	0	0.0	0.00	1.0e+00	AC003029.1 MADD
Neuroticism score	1.39	5	2	4.4	0.16	8.0e-01	HORMAD2 MADD RP5-1115A15.1 TEF TIMP4
Pulse rate	1.39	2	2	4.4	0.00	1.0e+00	GIGYF1 TMEM258
Neuroticism (Nagel 2018)	1.38	6	2	4.4	0.37	4.7e-01	HORMAD2 MADD RNASET2 RP5-1115A15.1 TEF TIMP4
Mean time to correctly identify matches	1.38	3	2	4.4	0.96	3.8e-02	AC003029.1 ALDH2 HECTD4
Cholesterol lowering medication	1.38	1	0	0.0	0.00	1.0e+00	RASIP1
Current tobacco smoking	1.37	3	0	0.0	0.00	1.0e+00	MADD RP5-1115A15.1 TEF
Mouth/teeth dental problems	1.37	2	0	0.0	0.00	1.0e+00	IRF5 RASIP1
Medication: Atorvastatin	1.37	1	0	0.0	0.00	1.0e+00	RASIP1
Medication for cholesterol	1.36	2	0	0.0	0.00	1.0e+00	HECTD4 RASIP1
Medication: Blood pressure	1.36	3	1	2.2	0.95	5.1e-02	AC003029.1 HECTD4 RASIP1
Depression (Nagel 2018)	1.35	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Worry (Nagel 2018)	1.35	5	1	2.2	0.24	7.0e-01	HORMAD2 MADD PAM TEF TIMP4
Chronotype (morning person)	1.34	5	0	0.0	0.23	7.1e-01	AC003029.1 HECTD4 HORMAD2 NEK6 TIMP4
Breastfed as a baby	1.34	1	0	0.0	0.00	1.0e+00	NEK6
Medication: Blood pressure	1.34	2	1	2.2	0.00	1.0e+00	ADAM1A HECTD4
Wheeze or whistling in the chest in last year	1.33	4	0	0.0	-0.64	3.6e-01	BACH2 CD247 RP5-1115A15.1 TMEM258
Bipolar Disorder or Schizophrenia	1.32	4	1	2.2	-0.84	1.6e-01	HSD11B2 LCAT LRRFIP2 RASIP1
Systolic blood pressure, automated reading	1.32	7	2	4.4	0.53	1.8e-01	AC003029.1 ALDH2 ARID5B HECTD4 NAB1 RASIP1 RP5-1115A15.1
Fed-up feelings	1.32	4	1	2.2	-0.84	7.7e-02	CCDC88B HECTD4 HORMAD2 TEF
Medication: Ibuprofen (e.g. Nurofen)	1.32	1	0	0.0	0.00	1.0e+00	HECTD4
Body Mass Index (BMI) (2010)	1.31	1	1	2.2	0.00	1.0e+00	MADD
Miserableness	1.31	4	0	0.0	0.58	4.2e-01	HORMAD2 MADD RP5-1115A15.1 TANK
Heel bone mineral density (BMD) T-score, automated (right)	1.29	4	1	2.2	0.59	3.0e-01	CAPZB NEK6 RP5-1115A15.1 TMEM258
Father's age at death	1.29	1	0	0.0	0.00	1.0e+00	HECTD4
Alcohol intake frequency.	1.29	3	2	4.4	0.00	1.0e+00	MADD RASIP1 SUOX
Medication: Metformin	1.28	1	0	0.0	0.00	1.0e+00	MADD
Trunk fat percentage	1.28	8	4	8.9	0.43	2.8e-01	JUND LRRFIP2 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TEF TULP1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.28	1	0	0.0	0.00	1.0e+00	TIMP4
Breast Cancer	1.27	4	2	4.4	-0.97	4.0e-04	AP4B1 BCL2L15 DCLRE1B PHTF1
Neuroticism	1.27	5	1	2.2	0.19	7.6e-01	HORMAD2 MADD RP5-1115A15.1 TEF TIMP4
Frequency of depressed mood in last 2 weeks	1.27	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Ever unenthusiastic/disinterested for a whole week	1.26	1	0	0.0	0.00	1.0e+00	TIMP4
Impedance of arm (right)	1.26	12	7	15.6	0.15	6.5e-01	ADAM1A BBS12 HECTD4 HSD11B2 JUND NEK6 PTK2 PTPN13 RTKN2 SUOX TEF VPS29
High blood pressure (siblings)	1.25	1	0	0.0	0.00	1.0e+00	HECTD4
Worry too long after embarrassment	1.25	1	0	0.0	0.00	1.0e+00	C6orf217
Heel T-Score	1.24	18	14	31.1	0.10	6.7e-01	ABHD15 AFF1 ARID5B BACH2 CAPZB CCDC88B DCLRE1B FCHO2 HSD11B2 INPP5B IRF5 NAB1 NEK6 NFATC1 RP11-326C3.11 RP5-1115A15.1 TEF TMEM258
Tense / 'highly strung'	1.24	3	1	2.2	0.00	1.0e+00	RP5-1115A15.1 TEF TIMP4
Gout (self-reported)	1.24	1	0	0.0	0.00	1.0e+00	HECTD4
Leg fat percentage (right)	1.24	5	3	6.7	0.40	5.1e-01	JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Alzheimer’s Disease (including proxy)	1.23	1	0	0.0	0.00	1.0e+00	MADD
Body fat percentage	1.23	7	3	6.7	0.45	3.2e-01	JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TEF TULP1
Irritability	1.23	2	0	0.0	0.00	1.0e+00	TEF TMEM258
Age when periods started (menarche)	1.22	3	0	0.0	0.00	1.0e+00	DCLRE1B MADD SUOX
Hip circumference	1.22	11	4	8.9	-0.23	4.8e-01	AC003029.1 C17orf57 EFCAB13 HECTD4 MADD PTPN12 RASIP1 RP11-552F3.9 SLC25A37 TBKBP1 VPS29
Leg fat percentage (left)	1.22	5	3	6.7	0.43	4.6e-01	JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Verbal and Numeric Reasoning (VNR)	1.20	4	1	2.2	-0.43	5.7e-01	MADD SUOX TANK TMEM258
Reason for reducing amount of alcohol drunk: Health precaution	1.20	1	0	0.0	0.00	1.0e+00	SUOX
Bipolar Disorder (2018)	1.19	2	0	0.0	0.00	1.0e+00	LRRFIP2 TMEM258
Illnesses of siblings	1.19	2	0	0.0	0.00	1.0e+00	ADAM1A HECTD4
Impedance of arm (left)	1.19	9	7	15.6	0.33	3.5e-01	ADAM1A BBS12 HECTD4 JUND NEK6 PTPN13 SUOX TEF VPS29
Schizophrenia (2018)	1.18	2	0	0.0	0.00	1.0e+00	LCAT RP5-1115A15.1
Fasting Glucose	1.18	1	1	2.2	0.00	1.0e+00	TMEM258
Trunk fat mass	1.18	10	3	6.7	0.47	1.7e-01	JUND LRRFIP2 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TBKBP1 TEF TULP1
Number of operations (self-reported)	1.18	3	0	0.0	0.00	1.0e+00	NEK6 RP5-1115A15.1 TANK
Basal cell carcinoma (self-reported)	1.18	1	0	0.0	0.00	1.0e+00	TEF
Height	1.17	35	26	57.8	-0.13	4.0e-01	AC003029.1 ADAM1A ARID5B C17orf57 C9orf156 CAPZB CPT1C EFCAB13 HECTD4 HORMAD2 HSD11B2 INPP5B IRF5 LRRFIP2 MADD NAB1 NANS NCBP1 NFATC1 NPEPPS NR3C2 PAM PQLC2 PSMD5 PTPN12 PTPN13 RAB5C RASIP1 RP5-1115A15.1 SEH1L SIK3 TBKBP1 TG TMEM258 TULP1
Falls in the last year	1.17	1	0	0.0	0.00	1.0e+00	PTK2
Arm predicted mass (left)	1.17	11	6	13.3	-0.67	1.7e-02	AC003029.1 ADAM1A ALDH2 HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29
Arm fat-free mass (right)	1.16	9	6	13.3	-0.61	6.0e-02	ADAM1A HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29
Arm predicted mass (right)	1.16	10	7	15.6	-0.55	8.1e-02	ADAM1A HECTD4 HORMAD2 NEK6 PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Comparative height size at age 10	1.16	12	7	15.6	-0.67	3.3e-03	C9orf156 CAPZB HECTD4 HORMAD2 HSD11B2 INPP5B MADD NR3C2 PQLC2 PTPN13 RASIP1 RP5-1115A15.1
Arm fat-free mass (left)	1.16	10	7	15.6	-0.66	2.8e-02	ADAM1A ALDH2 HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29
Overall health rating	1.15	3	0	0.0	0.00	1.0e+00	BCL2L15 SUOX TANK
Lung FVC	1.14	14	2	4.4	0.34	2.1e-01	AFF1 AP4B1 ARID5B C6orf217 CAPZB HECTD4 HORMAD2 JUND PDE8B PQLC2 RAB5C SIK3 SUOX TULP1
Fluid intelligence score	1.14	2	1	2.2	0.00	1.0e+00	MADD TANK
Leg fat mass (right)	1.14	8	4	8.9	-0.31	4.2e-01	HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 VPS29
Leg fat mass (left)	1.14	7	4	8.9	-0.26	5.7e-01	HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 VPS29
Type 2 Diabetes (T2D) (2018)	1.13	1	0	0.0	0.00	1.0e+00	ADAM1A
Whole body fat mass	1.13	7	4	8.9	-0.09	8.4e-01	HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TULP1
Schizophrenia (2014)	1.12	3	1	2.2	0.00	1.0e+00	GIGYF1 LCAT RP5-1115A15.1
Trunk predicted mass	1.12	14	4	8.9	-0.53	4.2e-02	AC003029.1 ADAM1A ARID5B HECTD4 HORMAD2 INPP5B JUND MADD NEK6 PTK2 PTPN13 RASIP1 SUOX VPS29
Standing height	1.12	23	12	26.7	0.04	8.4e-01	C17orf57 C9orf156 CAPZB CBLB EFCAB13 HECTD4 HORMAD2 HSD11B2 INPP5B LRRFIP2 MADD NAB1 NPEPPS PQLC2 PSMD5 PTPN12 PTPN13 RAB5C RASIP1 RP5-1115A15.1 SIK3 TBKBP1 TMEM258
Average weekly spirits intake	1.11	1	0	0.0	0.00	1.0e+00	RASIP1
Medication: Ramipril	1.11	1	0	0.0	0.00	1.0e+00	ADAM1A
Trunk fat-free mass	1.11	13	4	8.9	-0.50	7.0e-02	ADAM1A ARID5B HECTD4 HORMAD2 INPP5B JUND MADD NEK6 PTK2 PTPN13 RASIP1 SUOX VPS29
Peak expiratory flow (PEF)	1.11	3	0	0.0	0.00	1.0e+00	NANS RASIP1 SDF4
Neck or shoulder pain in last month	1.11	3	0	0.0	0.00	1.0e+00	NEK6 RP5-1115A15.1 SUOX
Neuroticism (2016)	1.10	2	0	0.0	0.00	1.0e+00	MADD TANK
Heel bone mineral density (BMD) T-score, automated (left)	1.10	2	1	2.2	0.00	1.0e+00	CAPZB RP5-1115A15.1
Townsend deprivation index at recruitment	1.09	1	0	0.0	0.00	1.0e+00	MADD
Mouth/teeth dental problems: Dentures	1.09	1	1	2.2	0.00	1.0e+00	RASIP1
Qualifications: College or University degree	1.09	5	3	6.7	0.44	4.6e-01	JUND PAM PTK2 SUOX TANK
Average weekly champagne plus white wine intake	1.09	2	1	2.2	0.00	1.0e+00	SUOX TMEM258
Pain experienced in last month	1.09	2	0	0.0	0.00	1.0e+00	HECTD4 SUOX
Arm fat percentage (left)	1.08	4	3	6.7	0.55	4.5e-01	JUND MADD RP11-552F3.9 RP5-1115A15.1
Intelligence (Savage-Jansen 2018)	1.07	6	1	2.2	-0.56	2.4e-01	LCAT MADD PAM SUOX TANK TMEM258
Weight	1.07	7	3	6.7	-0.61	1.1e-01	HECTD4 HORMAD2 PTPN12 RP11-552F3.9 SLC25A37 SUOX VPS29
Whole body fat-free mass	1.06	14	4	8.9	-0.45	8.9e-02	ADAM1A ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B NEK6 PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Whole body water mass	1.06	13	4	8.9	-0.44	1.1e-01	ADAM1A ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B NEK6 PTK2 PTPN12 PTPN13 SUOX VPS29
Arm fat percentage (right)	1.05	4	3	6.7	0.50	5.0e-01	JUND MADD RP11-552F3.9 RP5-1115A15.1
Worrier / anxious feelings	1.05	2	0	0.0	0.00	1.0e+00	PAM TEF
Ever used hormone-replacement therapy (HRT)	1.04	1	0	0.0	0.00	1.0e+00	NEK6
Basal metabolic rate	1.04	12	4	8.9	-0.49	8.7e-02	ADAM1A ALDH2 EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Forced vital capacity (FVC)	1.03	5	4	8.9	-0.37	5.4e-01	C6orf217 HORMAD2 INPP5B MADD SIK3
Depression (self-reported)	1.03	1	0	0.0	0.00	1.0e+00	RP5-1115A15.1
Waist circumference	1.02	3	2	4.4	0.00	1.0e+00	JUND MADD SLC25A37
Qualifications: None of the above	1.01	2	0	0.0	0.00	1.0e+00	SUOX TANK
Arm fat mass (right)	1.01	6	2	4.4	-0.18	7.4e-01	HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Arm fat mass (left)	1.01	6	2	4.4	-0.16	7.6e-01	HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Impedance of whole body	1.01	10	7	15.6	-0.01	9.8e-01	BBS12 HECTD4 HSD11B2 JUND NEK6 PTK2 PTPN13 SUOX TEF VPS29
Hand grip strength (left)	1.00	1	1	2.2	0.00	1.0e+00	MADD
Forced expiratory volume in 1-second (FEV1)	1.00	4	1	2.2	-0.98	1.5e-02	C6orf217 HORMAD2 MADD SUOX
Hair/balding pattern: Pattern 4	1.00	3	1	2.2	0.00	1.0e+00	HSD11B2 RP5-1115A15.1 TMEM258
HbA1C	0.99	1	0	0.0	0.00	1.0e+00	ADAM1A
Leg fat-free mass (right)	0.99	9	5	11.1	-0.27	4.5e-01	EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Leg predicted mass (right)	0.99	9	4	8.9	-0.27	4.6e-01	EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Nervous feelings	0.98	1	0	0.0	0.00	1.0e+00	MADD
Hair/balding pattern: Pattern 3	0.98	1	0	0.0	0.00	1.0e+00	MRPL10
Qualifications: A levels/AS levels or equivalent	0.98	2	1	2.2	0.00	1.0e+00	SUOX TANK
Body mass index (BMI)	0.97	6	1	2.2	-0.17	7.5e-01	HECTD4 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SUOX
Sitting height	0.96	14	6	13.3	0.09	7.4e-01	C17orf57 C9orf156 CAPZB HORMAD2 INPP5B IRF7 MADD PQLC2 PTK2 PTPN12 PTPN13 RASIP1 TBKBP1 TMEM258
Forced vital capacity (FVC), Best measure	0.96	6	3	6.7	-0.28	6.0e-01	C6orf217 HORMAD2 INPP5B MADD SIK3 TBKBP1
Comparative body size at age 10	0.96	4	1	2.2	0.30	7.0e-01	HORMAD2 MADD RASIP1 TEF
Osteoporosis (self-reported)	0.96	1	0	0.0	0.00	1.0e+00	CCDC88B
Leg fat-free mass (left)	0.95	11	4	8.9	-0.38	2.3e-01	ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Leg predicted mass (left)	0.95	11	3	6.7	-0.37	2.3e-01	ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
BMI	0.94	9	4	8.9	-0.08	8.3e-01	HECTD4 JUND MADD NEK6 PTPN12 RP11-552F3.9 SLC25A37 SUOX VPS29
Alcohol intake versus 10 years previously	0.93	1	0	0.0	0.00	1.0e+00	RASIP1
Forced expiratory volume in 1-second (FEV1), Best measure	0.93	3	0	0.0	0.00	1.0e+00	HORMAD2 MADD SUOX
Impedance of leg (right)	0.89	7	3	6.7	-0.52	2.3e-01	FCHO2 HSD11B2 JUND PAM PTK2 PTPN13 SUOX
Hand grip strength (right)	0.89	2	0	0.0	0.00	1.0e+00	IRF5 MADD
Relative age of first facial hair	0.88	1	0	0.0	0.00	1.0e+00	MRPL10
Impedance of leg (left)	0.85	6	3	6.7	-0.48	3.4e-01	HSD11B2 JUND PAM PTK2 PTPN13 SUOX
Hair Pigment	0.46	17	8	17.8	0.18	4.3e-01	AC003029.1 ALDH2 C9orf156 EFCAB13 GIGYF1 HECTD4 MRPL10 NANS PSMD5 RP11-326C3.11 RP11-552F3.9 RP5-1115A15.1 SDF4 SUOX TBKBP1 TEF TMEM258
Tanning	0.23	3	0	0.0	0.15	8.5e-01	HECTD4 JUND MADD

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Whole Blood	20	1.01	2.7
NTR	Blood	22	0.92	2.7
The Cancer Genome Atlas	Esophageal Carcinoma	3	0.44	2.7
GTEx	Brain Putamen basal ganglia	2	0.32	2.6
GTEx	Ovary	6	0.66	2.6
GTEx	Brain Cerebellar Hemisphere	9	0.60	2.5
GTEx	Brain Frontal Cortex BA9	6	0.65	2.5
GTEx	Stomach	10	0.69	2.5
GTEx	Thyroid	30	0.75	2.5
YFS	Blood	34	0.74	2.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	9	0.68	2.5
GTEx	Adrenal Gland	10	0.69	2.4
GTEx	Artery Tibial	26	0.69	2.4
GTEx	Brain Cerebellum	10	0.50	2.4
GTEx	Breast Mammary Tissue	9	0.46	2.4
GTEx	Breast Mammary Tissue (Female)	12	0.73	2.4
GTEx	Colon Sigmoid	10	0.68	2.4
GTEx	Colon Transverse	15	0.73	2.4
GTEx	Esophagus Gastroesophageal Junction	10	0.69	2.4
GTEx	Nerve Tibial	30	0.69	2.4
GTEx	Skin Not Sun Exposed Suprapubic	14	0.57	2.4
GTEx	Skin Sun Exposed Lower leg	16	0.44	2.4
GTEx	Testis	15	0.48	2.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	24	0.54	2.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	3	0.59	2.4
GTEx	Adipose Subcutaneous	11	0.32	2.3
GTEx	Artery Aorta	13	0.44	2.3
GTEx	Brain Cortex	3	0.29	2.3
GTEx	Brain Hypothalamus	2	0.34	2.3
GTEx	Brain Nucleus accumbens basal ganglia	3	0.35	2.3
GTEx	Cells EBV-transformed lymphocytes	9	0.63	2.3
GTEx	Cells Transformed fibroblasts	26	0.62	2.3
GTEx	Esophagus Mucosa	16	0.48	2.3
GTEx	Esophagus Muscularis	19	0.59	2.3
GTEx	Lung	14	0.49	2.3
GTEx	Muscle Skeletal	20	0.69	2.3
GTEx	Pituitary	8	0.72	2.3
GTEx	Prostate	4	0.48	2.3
GTEx	Small Intestine Terminal Ileum	4	0.87	2.3
GTEx	Uterus	2	0.35	2.3
GTEx	Vagina	2	0.31	2.3
METSIM	Adipose	28	0.61	2.3
The Cancer Genome Atlas	Colon Adenocarcinoma	9	0.44	2.3
The Cancer Genome Atlas	Glioblastoma Multiforme	3	0.29	2.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	10	0.49	2.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	25	0.58	2.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	9	0.54	2.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	4	0.57	2.3
The Cancer Genome Atlas	Thyroid Carcinoma	30	0.58	2.3
GTEx	Adipose Visceral Omentum	9	0.44	2.2
GTEx	Artery Coronary	6	0.51	2.2
GTEx	Brain Caudate basal ganglia	2	0.22	2.2
GTEx	Brain Hippocampus	1	0.19	2.2
GTEx	Breast Mammary Tissue (Male)	7	0.59	2.2
GTEx	Heart Atrial Appendage	5	0.32	2.2
GTEx	Heart Left Ventricle	6	0.39	2.2
GTEx	Liver	2	0.28	2.2
GTEx	Pancreas	8	0.49	2.2
GTEx	Spleen	9	0.64	2.2
ROSMAP	Brain Pre-frontal Cortex	17	0.39	2.2
CommonMind	Brain Pre-frontal Cortex	31	0.58	2.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.27	2.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	18	0.66	2.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	6	0.54	2.2
The Cancer Genome Atlas	Lung Adenocarcinoma	16	0.54	2.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	12	0.48	2.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	7	0.44	2.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	21	0.45	2.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.28	2.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	2	0.37	2.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	4	0.31	2.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	5	0.30	2.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	21	0.51	2.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	6	0.36	2.1