Hub : Traits :

Hypothyroidism (self reported)

856 significantly associated models · 248 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 3261925 3 2 1.3e-11 2.3e-11 2.0e-02 88 MMEL1 SDF4
2 1 7792411 9190254 1 1 1.6e-07 2.2e-07 1.0e+00 100 RP5-1115A15.1
3 1 18932744 20503710 3 5 3.7e-11 9.1e-12 NaN NaN CAPZB PQLC2
4 1 23431777 24861704 2 1 5.3e-08 3.3e-07 5.6e-02 86 HMGCL
5 1 37577214 39186794 6 1 6.1e-12 1.9e-10 9.4e-01 100 INPP5B
6 1 107418424 109188382 1 1 1.5e-50 7.7e-51 1.0e+00 100 VAV3
7 1 113236087 115222434 11 10 7.8e-81 9.7e-176 NaN NaN AP4B1 BCL2L15 DCLRE1B HIPK1 OLFML3 PHTF1 RSBN1
8 1 151129254 152518294 1 1 1.8e-07 2.0e-06 8.0e-03 69 THEM5
9 1 156078249 157482371 1 1 7.4e-08 6.5e-08 3.4e-01 97 SH2D2A
10 1 166702558 168182443 1 1 7.1e-08 2.0e-08 1.0e+00 100 CD247
11 1 200462817 201079088 1 1 2.6e-07 1.3e-10 9.2e-05 63 CAMSAP1L1
12 1 212719366 213232555 1 1 1.1e-07 6.4e-06 7.5e-01 100 TATDN3
13 2 61725501 63149557 1 1 3.1e-08 4.2e-09 1.0e+00 100 B3GNT2
14 2 97098095 99306504 8 1 2.1e-09 1.2e-09 1.3e-01 94 ANKRD36B
15 2 159476732 161166234 2 1 1.6e-07 1.8e-07 1.0e+00 100 AC009506.1
16 2 161297929 162790882 1 1 2.2e-09 3.4e-09 1.0e+00 100 TANK
17 2 190521054 192712723 6 2 5.0e-14 1.9e-38 7.6e-24 40 NAB1 STAT4
18 3 11350553 12928762 2 1 1.2e-15 8.0e-14 4.1e-01 99 TIMP4
19 3 36339386 38174470 5 1 9.5e-09 1.2e-08 3.5e-01 97 LRRFIP2
20 3 104683753 106283820 1 1 8.0e-09 1.8e-18 1.5e-18 0 CBLB
21 3 191820205 193330022 1 1 5.5e-08 6.3e-08 1.0e+00 100 MB21D2
22 4 40097557 40605238 1 1 1.4e-08 1.2e-11 1.3e-07 40 CHRNA9
23 4 86236934 88754060 4 2 4.0e-10 1.1e-09 1.0e+00 100 AFF1 PTPN13
24 4 122961964 124352460 1 1 1.7e-07 3.9e-09 6.6e-03 79 BBS12
25 4 148303195 150060844 1 1 7.8e-32 2.0e-32 1.0e+00 100 NR3C2
26 5 35608310 36124514 1 1 2.4e-07 4.8e-08 6.7e-02 89 IL7R
27 5 68178407 68828296 1 1 1.6e-07 1.6e-06 5.5e-01 98 GTF2H2C
28 5 71557313 73125146 2 1 1.5e-08 1.2e-08 3.4e-06 34 FCHO2
29 5 75669474 77412011 2 1 1.2e-11 2.3e-13 3.4e-03 84 PDE8B
30 5 101392473 103244640 2 1 3.7e-10 2.1e-11 1.2e-02 86 PAM
31 6 35216296 35942313 2 1 9.1e-11 2.7e-10 4.4e-02 90 TULP1
32 6 89941356 91704536 1 2 3.0e-33 1.5e-38 7.8e-16 62 BACH2
33 6 134905567 136516257 3 1 3.7e-10 1.9e-09 6.3e-02 90 C6orf217
34 6 165045334 167841508 6 2 8.0e-36 2.6e-34 1.0e+00 100 PDE10A RNASET2
35 7 76506844 77966572 2 1 1.3e-07 9.6e-08 1.9e-01 94 PTPN12
36 7 99591418 100979310 2 1 2.8e-11 7.9e-11 1.0e+00 100 GIGYF1
37 7 127878155 129284182 1 1 8.1e-09 5.9e-08 7.7e-04 62 IRF5
38 8 23139436 23678000 1 1 3.7e-08 9.2e-08 3.2e-01 96 SLC25A37
39 8 60736025 62477554 2 1 2.1e-10 4.7e-10 1.0e+00 100 RAB2A
40 8 128107136 129812343 1 1 1.5e-07 9.1e-14 7.4e-14 -1 PVT1
41 8 132897005 134846363 4 2 2.0e-15 3.2e-16 1.5e-03 85 TG
42 8 140969818 142706843 1 1 2.3e-07 1.9e-10 9.7e-06 52 PTK2
43 9 4758022 6168335 1 1 9.3e-08 2.7e-11 3.3e-08 31 CD274
44 9 99581811 101652673 8 8 1.3e-67 6.6e-103 NaN NaN C9orf156 FOXE1 NANS NCBP1
45 9 122881960 124331465 4 1 1.3e-07 4.3e-07 1.0e+00 100 PSMD5
46 9 126321003 127872298 2 1 2.9e-09 1.3e-08 5.9e-01 99 NEK6
47 9 130769800 132289479 3 1 8.4e-09 8.5e-09 1.0e+00 100 PKN3
48 10 5027660 6677767 3 3 8.2e-19 4.7e-19 2.2e-04 83 FAM208B IL2RA
49 10 63253359 64724096 2 2 1.5e-17 2.1e-30 2.1e-19 38 ARID5B RTKN2
50 11 198510 1346802 8 2 3.8e-09 9.1e-10 1.0e+00 100 IRF7 RP11-326C3.11
51 11 34460769 35949179 2 1 3.0e-16 9.8e-19 9.2e-06 75 SLC1A2
52 11 46622392 48028343 1 1 2.3e-07 3.5e-07 1.0e+00 100 MADD
53 11 60549966 62346131 7 1 1.8e-11 3.0e-11 2.4e-01 97 TMEM258
54 11 63316786 64820283 2 1 1.1e-10 8.8e-11 1.0e+00 100 CCDC88B
55 11 93166368 94613754 1 1 2.3e-07 6.4e-09 5.7e-04 65 PANX1
56 11 116007539 117800682 5 1 1.2e-08 3.1e-11 6.6e-04 74 SIK3
57 12 55601472 57681122 8 1 6.5e-18 4.4e-15 3.7e-02 93 SUOX
58 12 109641978 113517494 21 9 8.8e-71 6.4e-117 NaN NaN AC003029.1 ADAM1A ALDH2 HECTD4 VPS29
59 13 23856997 25579336 1 1 5.6e-08 3.0e-40 2.9e-35 13 SPATA13
60 15 38088200 39556796 1 1 3.1e-16 4.7e-17 1.7e-02 92 RASGRP1
61 16 49488151 51097687 3 2 2.6e-10 6.0e-10 7.4e-01 100 BRD7
62 16 66666637 69084178 18 2 2.3e-10 3.8e-11 6.5e-02 92 HSD11B2 LCAT
63 17 6190353 7949434 2 1 2.2e-08 1.0e-13 3.7e-07 53 ACAP1
64 17 27222988 28629763 2 1 9.5e-08 1.7e-06 1.7e-02 75 ABHD15
65 17 39589083 41265776 3 1 1.8e-12 1.9e-12 1.0e+00 100 RAB5C
66 17 44788310 46704536 7 9 6.7e-16 7.4e-16 4.3e-02 94 C17orf57 EFCAB13 MRPL10 NPEPPS RP11-6N17.3 TBKBP1
67 17 73175294 74574103 2 1 1.1e-07 4.6e-07 8.1e-02 88 RP11-552F3.9
68 18 12090696 13687136 2 2 4.3e-08 4.0e-12 1.1e-05 60 PTPN2 SEH1L
69 18 66371289 68204223 2 1 1.4e-08 3.2e-09 7.2e-02 91 CD226
70 18 76907334 77535176 1 1 4.7e-11 1.5e-09 1.3e-06 36 NFATC1
71 19 4118871 5529588 2 2 1.0e-12 1.5e-23 4.8e-09 66 FEM1A TICAM1
72 19 9763152 11186711 1 1 1.1e-07 1.8e-11 1.4e-05 58 TYK2
73 19 17672385 19190906 3 1 1.7e-13 2.6e-13 1.0e+00 100 JUND
74 19 48525507 50909389 6 3 7.0e-13 7.0e-12 1.0e+00 100 ALDH16A1 CPT1C RASIP1
75 22 30233446 30820707 1 1 1.2e-08 2.0e-11 1.0e-04 66 HORMAD2
76 22 36867133 38292974 3 4 5.4e-22 6.6e-31 NaN NaN C1QTNF6 RP1-151B14.6 SSTR3
77 22 41071659 42614362 2 1 1.2e-07 1.5e-08 1.0e+00 100 TEF

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 1.19 2 0 0.0 0.00 1.0e+00 LRRFIP2 TMEM258
Bipolar Disorder or Schizophrenia 1.32 4 1 2.2 -0.84 1.6e-01 HSD11B2 LCAT LRRFIP2 RASIP1
Depressed Affect (Nagel 2018) 1.42 5 1 2.2 0.21 7.3e-01 HORMAD2 MADD RP5-1115A15.1 TANK TEF
Depression (Nagel 2018) 1.35 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Intelligence (Savage-Jansen 2018) 1.07 6 1 2.2 -0.56 2.4e-01 LCAT MADD PAM SUOX TANK TMEM258
Neuroticism (Nagel 2018) 1.38 6 2 4.4 0.37 4.7e-01 HORMAD2 MADD RNASET2 RP5-1115A15.1 TEF TIMP4
Schizophrenia (2018) 1.18 2 0 0.0 0.00 1.0e+00 LCAT RP5-1115A15.1
Worry (Nagel 2018) 1.35 5 1 2.2 0.24 7.0e-01 HORMAD2 MADD PAM TEF TIMP4
Alzheimer’s Disease (including proxy) 1.23 1 0 0.0 0.00 1.0e+00 MADD
Crohns Disease (2017) 2.53 9 4 8.9 -0.33 3.6e-01 BCL2L15 CCDC88B CPT1C DCLRE1B HIPK1 HORMAD2 RASIP1 RNASET2 TMEM258
Irritable Bowel Disease (IBD) 2.12 11 1 2.2 0.43 1.9e-01 BACH2 BBS12 BRD7 CAMSAP1L1 CCDC88B CPT1C HECTD4 HORMAD2 PTPN2 RNASET2 SDF4
Ulcerative Colitis (UC) 1.71 1 1 2.2 0.00 1.0e+00 IRF5
Reaction Time 1.56 3 2 4.4 0.95 5.0e-02 AC003029.1 ALDH2 HECTD4
Verbal and Numeric Reasoning (VNR) 1.20 4 1 2.2 -0.43 5.7e-01 MADD SUOX TANK TMEM258
Breast Cancer 1.27 4 2 4.4 -0.97 4.0e-04 AP4B1 BCL2L15 DCLRE1B PHTF1
Body Mass Index (BMI) (2010) 1.31 1 1 2.2 0.00 1.0e+00 MADD
Coronary Artery Disease (CAD) 1.65 2 0 0.0 0.00 1.0e+00 HECTD4 VPS29
Crohns Disease (2012) 2.20 6 1 2.2 0.21 6.8e-01 CCDC88B HIPK1 HORMAD2 RASIP1 RNASET2 TMEM258
Fasting Glucose 1.18 1 1 2.2 0.00 1.0e+00 TMEM258
HbA1C 0.99 1 0 0.0 0.00 1.0e+00 ADAM1A
HDL Cholesterol 2.23 5 3 6.7 0.17 7.8e-01 AFF1 LCAT MADD SIK3 TMEM258
LDL Cholesterol 2.53 5 4 8.9 -0.24 5.3e-01 C17orf57 HECTD4 RASIP1 TBKBP1 TMEM258
Lupus 3.80 7 3 6.7 0.70 5.4e-02 ARID5B DCLRE1B HECTD4 IRF5 IRF7 NAB1 RTKN2
Neuroticism (2016) 1.10 2 0 0.0 0.00 1.0e+00 MADD TANK
Primary Biliary Cirrhosis 2.81 6 3 6.7 0.68 9.5e-02 CCDC88B HECTD4 IL7R IRF5 MMEL1 NAB1
Rheumatoid Arthritis 8.95 16 8 17.8 0.96 1.0e-10 AP4B1 ARID5B BCL2L15 DCLRE1B FAM208B HECTD4 HIPK1 INPP5B MMEL1 NAB1 OLFML3 PAM PHTF1 PTPN2 RASGRP1 RSBN1
Schizophrenia (2014) 1.12 3 1 2.2 0.00 1.0e+00 GIGYF1 LCAT RP5-1115A15.1
Triglycerides 1.73 2 1 2.2 0.00 1.0e+00 AFF1 TMEM258
Ulcerative Colitis 1.66 2 0 0.0 0.00 1.0e+00 BRD7 IRF5
Blood Eosinophil Count 7.00 40 30 66.7 0.44 2.3e-03 AC003029.1 ACAP1 ADAM1A ALDH2 B3GNT2 BACH2 BBS12 C17orf57 C1QTNF6 CCDC88B CD226 CD247 EFCAB13 FAM208B FCHO2 GIGYF1 HECTD4 HMGCL HSD11B2 IL7R IRF5 JUND NAB1 NANS NEK6 NPEPPS PSMD5 PTPN2 PVT1 RASGRP1 RP5-1115A15.1 SSTR3 STAT4 SUOX TATDN3 TBKBP1 TEF TIMP4 TMEM258 VPS29
Blood Platelet Count 3.95 33 22 48.9 0.34 3.0e-02 ABHD15 ACAP1 ADAM1A AFF1 ARID5B C9orf156 CAPZB CD226 FCHO2 FOXE1 HECTD4 IRF5 MADD MRPL10 NAB1 NANS NEK6 PAM PKN3 PQLC2 PSMD5 PTK2 PTPN13 RASIP1 RP11-552F3.9 SH2D2A SIK3 SLC25A37 TEF TIMP4 TMEM258 TYK2 VPS29
Blood Red Count 2.01 22 18 40.0 0.30 1.3e-01 AC003029.1 ADAM1A AFF1 ALDH2 BACH2 C9orf156 CPT1C GIGYF1 HECTD4 HMGCL HSD11B2 LCAT MADD NANS NPEPPS PAM PKN3 RP11-6N17.3 SUOX TG TMEM258 VPS29
Blood White Count 3.73 31 23 51.1 0.24 1.4e-01 AC003029.1 AC009506.1 ACAP1 ADAM1A AFF1 ALDH2 AP4B1 BACH2 BCL2L15 C6orf217 CD226 DCLRE1B GTF2H2C HECTD4 HORMAD2 INPP5B MADD PAM PDE8B PHTF1 PKN3 PSMD5 PVT1 RAB2A RAB5C RP11-326C3.11 RP5-1115A15.1 SIK3 TIMP4 TMEM258 VPS29
Heel T-Score 1.24 18 14 31.1 0.10 6.7e-01 ABHD15 AFF1 ARID5B BACH2 CAPZB CCDC88B DCLRE1B FCHO2 HSD11B2 INPP5B IRF5 NAB1 NEK6 NFATC1 RP11-326C3.11 RP5-1115A15.1 TEF TMEM258
BMI 0.94 9 4 8.9 -0.08 8.3e-01 HECTD4 JUND MADD NEK6 PTPN12 RP11-552F3.9 SLC25A37 SUOX VPS29
Height 1.17 35 26 57.8 -0.13 4.0e-01 AC003029.1 ADAM1A ARID5B C17orf57 C9orf156 CAPZB CPT1C EFCAB13 HECTD4 HORMAD2 HSD11B2 INPP5B IRF5 LRRFIP2 MADD NAB1 NANS NCBP1 NFATC1 NPEPPS NR3C2 PAM PQLC2 PSMD5 PTPN12 PTPN13 RAB5C RASIP1 RP5-1115A15.1 SEH1L SIK3 TBKBP1 TG TMEM258 TULP1
Waist Hip Ratio (WHR) 1.57 9 7 15.6 -0.01 9.8e-01 ACAP1 ADAM1A BBS12 HSD11B2 JUND PAM PTPN12 RASIP1 TIMP4
Systolic Blood Pressure 1.86 19 14 31.1 0.25 2.8e-01 AC003029.1 ADAM1A ALDH2 ARID5B HECTD4 HMGCL IRF5 MADD NAB1 NEK6 PSMD5 PTPN12 PTPN13 RASIP1 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TBKBP1 VPS29
Smoking Status 1.42 6 3 6.7 0.17 7.5e-01 ADAM1A CCDC88B PHTF1 RP5-1115A15.1 SUOX TANK
Allergy or Eczema 3.55 14 12 26.7 -0.25 3.5e-01 ADAM1A BACH2 BBS12 C6orf217 CD247 HECTD4 IL7R NEK6 PSMD5 RP5-1115A15.1 SDF4 SEH1L SUOX TEF
Cardiovascular Disease 1.79 12 6 13.3 0.57 4.2e-02 AC003029.1 ADAM1A ALDH2 C17orf57 CCDC88B HECTD4 RASIP1 RP11-6N17.3 RP5-1115A15.1 SUOX TBKBP1 VPS29
Respiratory disease 2.79 11 7 15.6 -0.44 1.5e-01 BACH2 BBS12 C6orf217 CD247 FAM208B IL7R NEK6 RP5-1115A15.1 SUOX TEF TMEM258
Type 2 Diabetes (T2D) (2018) 1.13 1 0 0.0 0.00 1.0e+00 ADAM1A
Lung FEV1/FVC ratio 1.40 17 10 22.2 -0.08 7.5e-01 ABHD15 AC009506.1 BACH2 C9orf156 HSD11B2 IL7R JUND LCAT NANS NCBP1 PQLC2 RASIP1 RP11-326C3.11 RP5-1115A15.1 SIK3 SLC1A2 SUOX
Lung FVC 1.14 14 2 4.4 0.34 2.1e-01 AFF1 AP4B1 ARID5B C6orf217 CAPZB HECTD4 HORMAD2 JUND PDE8B PQLC2 RAB5C SIK3 SUOX TULP1
Neuroticism 1.27 5 1 2.2 0.19 7.6e-01 HORMAD2 MADD RP5-1115A15.1 TEF TIMP4
Chronotype (morning person) 1.34 5 0 0.0 0.23 7.1e-01 AC003029.1 HECTD4 HORMAD2 NEK6 TIMP4
Hair Pigment 0.46 17 8 17.8 0.18 4.3e-01 AC003029.1 ALDH2 C9orf156 EFCAB13 GIGYF1 HECTD4 MRPL10 NANS PSMD5 RP11-326C3.11 RP11-552F3.9 RP5-1115A15.1 SDF4 SUOX TBKBP1 TEF TMEM258
Tanning 0.23 3 0 0.0 0.15 8.5e-01 HECTD4 JUND MADD
Hand grip strength (left) 1.00 1 1 2.2 0.00 1.0e+00 MADD
Number of treatments/medications taken 2.18 7 2 4.4 0.94 1.5e-04 ADAM1A BCL2L15 DCLRE1B FAM208B HECTD4 TANK TMEM258
Average weekly spirits intake 1.11 1 0 0.0 0.00 1.0e+00 RASIP1
Frequency of depressed mood in last 2 weeks 1.27 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Relative age of first facial hair 0.88 1 0 0.0 0.00 1.0e+00 MRPL10
Other serious medical condition/disability diagnosed by doctor 2.17 1 0 0.0 0.00 1.0e+00 DCLRE1B
Ever used hormone-replacement therapy (HRT) 1.04 1 0 0.0 0.00 1.0e+00 NEK6
Systolic blood pressure, automated reading 1.32 7 2 4.4 0.53 1.8e-01 AC003029.1 ALDH2 ARID5B HECTD4 NAB1 RASIP1 RP5-1115A15.1
Medication: Metformin 1.28 1 0 0.0 0.00 1.0e+00 MADD
Impedance of leg (right) 0.89 7 3 6.7 -0.52 2.3e-01 FCHO2 HSD11B2 JUND PAM PTK2 PTPN13 SUOX
Leg fat-free mass (left) 0.95 11 4 8.9 -0.38 2.3e-01 ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Trunk fat percentage 1.28 8 4 8.9 0.43 2.8e-01 JUND LRRFIP2 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TEF TULP1
Hand grip strength (right) 0.89 2 0 0.0 0.00 1.0e+00 IRF5 MADD
Townsend deprivation index at recruitment 1.09 1 0 0.0 0.00 1.0e+00 MADD
Current tobacco smoking 1.37 3 0 0.0 0.00 1.0e+00 MADD RP5-1115A15.1 TEF
Fed-up feelings 1.32 4 1 2.2 -0.84 7.7e-02 CCDC88B HECTD4 HORMAD2 TEF
Taking other prescription medications 3.59 10 5 11.1 0.97 3.7e-07 ADAM1A BCL2L15 CCDC88B DCLRE1B FAM208B HECTD4 HIPK1 PHTF1 RAB5C RNASET2
Age when periods started (menarche) 1.22 3 0 0.0 0.00 1.0e+00 DCLRE1B MADD SUOX
Heel bone mineral density (BMD) T-score, automated (left) 1.10 2 1 2.2 0.00 1.0e+00 CAPZB RP5-1115A15.1
High blood pressure 1.66 10 3 6.7 0.34 3.0e-01 AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SLC25A37 SUOX
Hayfever, allergic rhinitis or eczema 3.26 13 8 17.8 -0.22 4.4e-01 ADAM1A BACH2 BBS12 C6orf217 CD247 HECTD4 IL7R NEK6 PSMD5 RP5-1115A15.1 SDF4 SUOX TEF
Medication: Atenolol 1.66 1 1 2.2 0.00 1.0e+00 HECTD4
Medication: Levothyroxine sodium 18.43 75 40 88.9 0.99 1.9e-83 AC003029.1 AC009506.1 ACAP1 ADAM1A ALDH16A1 ALDH2 ANKRD36B AP4B1 ARID5B B3GNT2 BACH2 BCL2L15 BRD7 C17orf57 C1QTNF6 C6orf217 C9orf156 CAPZB CCDC88B CD226 CPT1C DCLRE1B EFCAB13 FAM208B FCHO2 FEM1A FOXE1 GIGYF1 HECTD4 HIPK1 HORMAD2 HSD11B2 IL2RA IL7R INPP5B IRF5 IRF7 JUND LRRFIP2 MMEL1 MRPL10 NAB1 NANS NCBP1 NFATC1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PQLC2 RAB2A RAB5C RASGRP1 RNASET2 RP1-151B14.6 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SH2D2A SLC1A2 SSTR3 STAT4 SUOX TATDN3 TBKBP1 TG TICAM1 TIMP4 TMEM258 TULP1 VAV3 VPS29
Sitting height 0.96 14 6 13.3 0.09 7.4e-01 C17orf57 C9orf156 CAPZB HORMAD2 INPP5B IRF7 MADD PQLC2 PTK2 PTPN12 PTPN13 RASIP1 TBKBP1 TMEM258
Body mass index (BMI) 0.97 6 1 2.2 -0.17 7.5e-01 HECTD4 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SUOX
Impedance of leg (left) 0.85 6 3 6.7 -0.48 3.4e-01 HSD11B2 JUND PAM PTK2 PTPN13 SUOX
Leg predicted mass (left) 0.95 11 3 6.7 -0.37 2.3e-01 ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Trunk fat mass 1.18 10 3 6.7 0.47 1.7e-01 JUND LRRFIP2 MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 TBKBP1 TEF TULP1
Waist circumference 1.02 3 2 4.4 0.00 1.0e+00 JUND MADD SLC25A37
Past tobacco smoking 1.49 5 0 0.0 -0.29 6.3e-01 ADAM1A HECTD4 PHTF1 SUOX TANK
Nervous feelings 0.98 1 0 0.0 0.00 1.0e+00 MADD
Forced vital capacity (FVC) 1.03 5 4 8.9 -0.37 5.4e-01 C6orf217 HORMAD2 INPP5B MADD SIK3
Heel bone mineral density (BMD) T-score, automated (right) 1.29 4 1 2.2 0.59 3.0e-01 CAPZB NEK6 RP5-1115A15.1 TMEM258
Ever unenthusiastic/disinterested for a whole week 1.26 1 0 0.0 0.00 1.0e+00 TIMP4
Qualifications: None of the above 1.01 2 0 0.0 0.00 1.0e+00 SUOX TANK
Mouth/teeth dental problems 1.37 2 0 0.0 0.00 1.0e+00 IRF5 RASIP1
Allergy 2.96 11 7 15.6 0.21 5.2e-01 ADAM1A BACH2 BBS12 C6orf217 CD247 IL7R NEK6 PSMD5 RP5-1115A15.1 SUOX TEF
Hayfever/allergic rhinitis (self-reported) 2.19 4 2 4.4 -0.46 5.4e-01 BACH2 CD247 IL7R SUOX
Medication: Ramipril 1.11 1 0 0.0 0.00 1.0e+00 ADAM1A
Medication: Simvastatin 1.49 2 0 0.0 0.00 1.0e+00 RASIP1 TBKBP1
Fluid intelligence score 1.14 2 1 2.2 0.00 1.0e+00 MADD TANK
Illnesses of siblings 1.19 2 0 0.0 0.00 1.0e+00 ADAM1A HECTD4
Neuroticism score 1.39 5 2 4.4 0.16 8.0e-01 HORMAD2 MADD RP5-1115A15.1 TEF TIMP4
Weight 1.07 7 3 6.7 -0.61 1.1e-01 HECTD4 HORMAD2 PTPN12 RP11-552F3.9 SLC25A37 SUOX VPS29
Impedance of arm (right) 1.26 12 7 15.6 0.15 6.5e-01 ADAM1A BBS12 HECTD4 HSD11B2 JUND NEK6 PTK2 PTPN13 RTKN2 SUOX TEF VPS29
Arm fat percentage (right) 1.05 4 3 6.7 0.50 5.0e-01 JUND MADD RP11-552F3.9 RP5-1115A15.1
Trunk fat-free mass 1.11 13 4 8.9 -0.50 7.0e-02 ADAM1A ARID5B HECTD4 HORMAD2 INPP5B JUND MADD NEK6 PTK2 PTPN13 RASIP1 SUOX VPS29
Hip circumference 1.22 11 4 8.9 -0.23 4.8e-01 AC003029.1 C17orf57 EFCAB13 HECTD4 MADD PTPN12 RASIP1 RP11-552F3.9 SLC25A37 TBKBP1 VPS29
Alcohol intake versus 10 years previously 0.93 1 0 0.0 0.00 1.0e+00 RASIP1
Father's age at death 1.29 1 0 0.0 0.00 1.0e+00 HECTD4
Worrier / anxious feelings 1.05 2 0 0.0 0.00 1.0e+00 PAM TEF
Frequency of tiredness / lethargy in last 2 weeks 1.43 2 0 0.0 0.00 1.0e+00 RP5-1115A15.1 TEF
Falls in the last year 1.17 1 0 0.0 0.00 1.0e+00 PTK2
Hair/balding pattern: Pattern 3 0.98 1 0 0.0 0.00 1.0e+00 MRPL10
Number of live births 1.41 2 0 0.0 0.00 1.0e+00 HORMAD2 TMEM258
Forced expiratory volume in 1-second (FEV1) 1.00 4 1 2.2 -0.98 1.5e-02 C6orf217 HORMAD2 MADD SUOX
Pulse rate 1.39 2 2 4.4 0.00 1.0e+00 GIGYF1 TMEM258
Qualifications: A levels/AS levels or equivalent 0.98 2 1 2.2 0.00 1.0e+00 SUOX TANK
Mouth/teeth dental problems: Dentures 1.09 1 1 2.2 0.00 1.0e+00 RASIP1
Asthma 2.59 9 6 13.3 -0.50 1.4e-01 BACH2 BBS12 C6orf217 CD247 IL7R RP5-1115A15.1 SUOX TEF TMEM258
Medication: Ibuprofen (e.g. Nurofen) 1.32 1 0 0.0 0.00 1.0e+00 HECTD4
Medication: Cholesterol lowering 1.52 1 0 0.0 0.00 1.0e+00 RASIP1
Depression (self-reported) 1.03 1 0 0.0 0.00 1.0e+00 RP5-1115A15.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.93 3 0 0.0 0.00 1.0e+00 HORMAD2 MADD SUOX
Pulse wave Arterial Stiffness index 1.74 1 1 2.2 0.00 1.0e+00 ADAM1A
Impedance of arm (left) 1.19 9 7 15.6 0.33 3.5e-01 ADAM1A BBS12 HECTD4 JUND NEK6 PTPN13 SUOX TEF VPS29
Arm fat mass (right) 1.01 6 2 4.4 -0.18 7.4e-01 HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Trunk predicted mass 1.12 14 4 8.9 -0.53 4.2e-02 AC003029.1 ADAM1A ARID5B HECTD4 HORMAD2 INPP5B JUND MADD NEK6 PTK2 PTPN13 RASIP1 SUOX VPS29
Standing height 1.12 23 12 26.7 0.04 8.4e-01 C17orf57 C9orf156 CAPZB CBLB EFCAB13 HECTD4 HORMAD2 HSD11B2 INPP5B LRRFIP2 MADD NAB1 NPEPPS PQLC2 PSMD5 PTPN12 PTPN13 RAB5C RASIP1 RP5-1115A15.1 SIK3 TBKBP1 TMEM258
Breastfed as a baby 1.34 1 0 0.0 0.00 1.0e+00 NEK6
Tense / 'highly strung' 1.24 3 1 2.2 0.00 1.0e+00 RP5-1115A15.1 TEF TIMP4
Hair/balding pattern: Pattern 4 1.00 3 1 2.2 0.00 1.0e+00 HSD11B2 RP5-1115A15.1 TMEM258
Birth weight of first child 2.00 5 2 4.4 -0.51 3.0e-01 AC003029.1 FCHO2 HECTD4 RAB2A SUOX
Peak expiratory flow (PEF) 1.11 3 0 0.0 0.00 1.0e+00 NANS RASIP1 SDF4
Medication for cholesterol, blood pressure or diabetes 1.46 1 0 0.0 0.00 1.0e+00 RASIP1
Gout (self-reported) 1.24 1 0 0.0 0.00 1.0e+00 HECTD4
Hypothyroidism/myxoedema (self-reported) 21.12 99 59 131.1 1.00 3.4e-134 AC003029.1 AC009506.1 ACAP1 ADAM1A AFF1 ALDH16A1 ALDH2 ANKRD36B AP4B1 ARID5B B3GNT2 BACH2 BBS12 BCL2L15 BRD7 C17orf57 C1QTNF6 C6orf217 C9orf156 CAPZB CBLB CCDC88B CD226 CD247 CD274 CHRNA9 CPT1C DCLRE1B EFCAB13 FAM208B FCHO2 FEM1A FOXE1 GIGYF1 GTF2H2C HECTD4 HIPK1 HMGCL HORMAD2 HSD11B2 IL2RA IL7R INPP5B IRF5 IRF7 JUND LCAT LRRFIP2 MB21D2 MMEL1 MRPL10 NAB1 NANS NCBP1 NEK6 NFATC1 NPEPPS NR3C2 OLFML3 PAM PDE8B PHTF1 PKN3 PQLC2 PSMD5 PTK2 PTPN12 PTPN13 RAB2A RAB5C RASGRP1 RNASET2 RP11-326C3.11 RP1-151B14.6 RP11-552F3.9 RP11-6N17.3 RP5-1115A15.1 RSBN1 RTKN2 SDF4 SH2D2A SIK3 SLC1A2 SPATA13 SSTR3 STAT4 SUOX TANK TATDN3 TBKBP1 TEF TG THEM5 TICAM1 TIMP4 TMEM258 TULP1 VAV3 VPS29
Medication: Ventolin 100micrograms inhaler 1.54 2 0 0.0 0.00 1.0e+00 BACH2 CD247
Birth weight 2.15 11 3 6.7 -0.60 3.7e-02 ACAP1 ADAM1A ALDH2 C17orf57 DCLRE1B HECTD4 HORMAD2 PSMD5 RASIP1 SLC25A37 SUOX
High blood pressure (siblings) 1.25 1 0 0.0 0.00 1.0e+00 HECTD4
Forced vital capacity (FVC), Best measure 0.96 6 3 6.7 -0.28 6.0e-01 C6orf217 HORMAD2 INPP5B MADD SIK3 TBKBP1
Body fat percentage 1.23 7 3 6.7 0.45 3.2e-01 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TEF TULP1
Leg fat percentage (right) 1.24 5 3 6.7 0.40 5.1e-01 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Arm fat-free mass (right) 1.16 9 6 13.3 -0.61 6.0e-02 ADAM1A HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29
Comparative body size at age 10 0.96 4 1 2.2 0.30 7.0e-01 HORMAD2 MADD RASIP1 TEF
Worry too long after embarrassment 1.25 1 0 0.0 0.00 1.0e+00 C6orf217
Seen a psychiatrist for nerves, anxiety, tension or depression 1.28 1 0 0.0 0.00 1.0e+00 TIMP4
Wheeze or whistling in the chest in last year 1.33 4 0 0.0 -0.64 3.6e-01 BACH2 CD247 RP5-1115A15.1 TMEM258
Reason for reducing amount of alcohol drunk: Health precaution 1.20 1 0 0.0 0.00 1.0e+00 SUOX
Pulse wave peak to peak time 1.64 1 1 2.2 0.00 1.0e+00 ADAM1A
Qualifications: College or University degree 1.09 5 3 6.7 0.44 4.6e-01 JUND PAM PTK2 SUOX TANK
Neck or shoulder pain in last month 1.11 3 0 0.0 0.00 1.0e+00 NEK6 RP5-1115A15.1 SUOX
Medication: Blood pressure 1.34 2 1 2.2 0.00 1.0e+00 ADAM1A HECTD4
Medication: Seretide 50 evohaler 1.44 2 0 0.0 0.00 1.0e+00 BACH2 LCAT
Mean time to correctly identify matches 1.38 3 2 4.4 0.96 3.8e-02 AC003029.1 ALDH2 HECTD4
Whole body fat mass 1.13 7 4 8.9 -0.09 8.4e-01 HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 TULP1
Leg fat mass (right) 1.14 8 4 8.9 -0.31 4.2e-01 HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 SLC25A37 VPS29
Arm predicted mass (right) 1.16 10 7 15.6 -0.55 8.1e-02 ADAM1A HECTD4 HORMAD2 NEK6 PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Pulse rate, automated reading 1.63 5 3 6.7 -0.49 4.0e-01 GIGYF1 NAB1 PSMD5 TMEM258 VPS29
Alcohol intake frequency. 1.29 3 2 4.4 0.00 1.0e+00 MADD RASIP1 SUOX
Comparative height size at age 10 1.16 12 7 15.6 -0.67 3.3e-03 C9orf156 CAPZB HECTD4 HORMAD2 HSD11B2 INPP5B MADD NR3C2 PQLC2 PTPN13 RASIP1 RP5-1115A15.1
Suffer from 'nerves' 1.50 2 1 2.2 0.00 1.0e+00 MADD RP5-1115A15.1
Overall health rating 1.15 3 0 0.0 0.00 1.0e+00 BCL2L15 SUOX TANK
Chest pain or discomfort 1.65 2 0 0.0 -1.00 3.5e-05 C17orf57 TBKBP1
Hypertension (Self-reported) 1.58 10 2 4.4 0.30 3.8e-01 AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 RTKN2 SLC25A37 SUOX
Smoking status: Previous 1.53 1 0 0.0 0.00 1.0e+00 HECTD4
Whole body fat-free mass 1.06 14 4 8.9 -0.45 8.9e-02 ADAM1A ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B NEK6 PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Leg fat-free mass (right) 0.99 9 5 11.1 -0.27 4.5e-01 EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Arm fat percentage (left) 1.08 4 3 6.7 0.55 4.5e-01 JUND MADD RP11-552F3.9 RP5-1115A15.1
Mood swings 1.44 4 1 2.2 -0.63 3.7e-01 HORMAD2 MADD PTK2 TEF
Loneliness, isolation 1.50 2 1 2.2 0.00 1.0e+00 MADD RP5-1115A15.1
Long-standing illness, disability or infirmity 2.29 5 1 2.2 0.97 1.4e-03 BCL2L15 DCLRE1B FAM208B PHTF1 RNASET2
Mouth/teeth dental problems: Mouth ulcers 1.72 3 1 2.2 0.00 1.0e+00 BRD7 IRF5 PAM
Medication for cholesterol 1.36 2 0 0.0 0.00 1.0e+00 HECTD4 RASIP1
Asthma (self-reported) 2.65 9 6 13.3 -0.48 1.6e-01 BACH2 BBS12 C6orf217 CD247 IL7R RP5-1115A15.1 SUOX TEF TMEM258
Osteoporosis (self-reported) 0.96 1 0 0.0 0.00 1.0e+00 CCDC88B
Smoking status: Current 1.40 2 0 0.0 0.00 1.0e+00 AC003029.1 MADD
Whole body water mass 1.06 13 4 8.9 -0.44 1.1e-01 ADAM1A ALDH2 ARID5B EFCAB13 HECTD4 HORMAD2 INPP5B NEK6 PTK2 PTPN12 PTPN13 SUOX VPS29
Leg predicted mass (right) 0.99 9 4 8.9 -0.27 4.6e-01 EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 SUOX VPS29
Arm fat mass (left) 1.01 6 2 4.4 -0.16 7.6e-01 HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Number of self-reported non-cancer illnesses 2.21 4 1 2.2 0.96 1.1e-02 FAM208B HECTD4 RASIP1 RNASET2
Average weekly champagne plus white wine intake 1.09 2 1 2.2 0.00 1.0e+00 SUOX TMEM258
Miserableness 1.31 4 0 0.0 0.58 4.2e-01 HORMAD2 MADD RP5-1115A15.1 TANK
Medication: Blood pressure 1.36 3 1 2.2 0.95 5.1e-02 AC003029.1 HECTD4 RASIP1
High cholesterol (Self-reported) 1.97 5 4 8.9 -0.44 2.8e-01 C17orf57 RASIP1 RP11-552F3.9 RP11-6N17.3 TBKBP1
Medication: Atorvastatin 1.37 1 0 0.0 0.00 1.0e+00 RASIP1
Ever smoked 1.44 1 0 0.0 0.00 1.0e+00 PHTF1
Basal metabolic rate 1.04 12 4 8.9 -0.49 8.7e-02 ADAM1A ALDH2 EFCAB13 HECTD4 HORMAD2 INPP5B PTK2 PTPN12 PTPN13 RASIP1 SUOX VPS29
Leg fat percentage (left) 1.22 5 3 6.7 0.43 4.6e-01 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1
Arm fat-free mass (left) 1.16 10 7 15.6 -0.66 2.8e-02 ADAM1A ALDH2 HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29
Number of operations (self-reported) 1.18 3 0 0.0 0.00 1.0e+00 NEK6 RP5-1115A15.1 TANK
Irritability 1.23 2 0 0.0 0.00 1.0e+00 TEF TMEM258
Diastolic blood pressure, automated reading 2.00 10 7 15.6 0.71 9.6e-03 AC003029.1 ADAM1A AFF1 ALDH2 GIGYF1 HECTD4 INPP5B RP5-1115A15.1 SLC25A37 VPS29
Myopia 1.52 2 0 0.0 0.00 1.0e+00 MADD TMEM258
Vascular/heart problems diagnosed by doctor 1.66 9 2 4.4 -0.44 2.1e-01 AC003029.1 ADAM1A ALDH2 HECTD4 PTPN12 RASIP1 RP5-1115A15.1 SUOX TBKBP1
Cholesterol lowering medication 1.38 1 0 0.0 0.00 1.0e+00 RASIP1
Pain experienced in last month 1.09 2 0 0.0 0.00 1.0e+00 HECTD4 SUOX
Basal cell carcinoma (self-reported) 1.18 1 0 0.0 0.00 1.0e+00 TEF
Impedance of whole body 1.01 10 7 15.6 -0.01 9.8e-01 BBS12 HECTD4 HSD11B2 JUND NEK6 PTK2 PTPN13 SUOX TEF VPS29
Leg fat mass (left) 1.14 7 4 8.9 -0.26 5.7e-01 HECTD4 JUND MADD PTPN12 RP11-552F3.9 RP5-1115A15.1 VPS29
Arm predicted mass (left) 1.17 11 6 13.3 -0.67 1.7e-02 AC003029.1 ADAM1A ALDH2 HECTD4 HORMAD2 NEK6 PTPN12 PTPN13 RASIP1 SUOX VPS29

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 11 0.32 2.3
GTEx Adipose Visceral Omentum 9 0.44 2.2
GTEx Adrenal Gland 10 0.69 2.4
GTEx Artery Aorta 13 0.44 2.3
GTEx Artery Coronary 6 0.51 2.2
GTEx Artery Tibial 26 0.69 2.4
GTEx Brain Caudate basal ganglia 2 0.22 2.2
GTEx Brain Cerebellar Hemisphere 9 0.60 2.5
GTEx Brain Cerebellum 10 0.50 2.4
GTEx Brain Cortex 3 0.29 2.3
GTEx Brain Frontal Cortex BA9 6 0.65 2.5
GTEx Brain Hippocampus 1 0.19 2.2
GTEx Brain Hypothalamus 2 0.34 2.3
GTEx Brain Nucleus accumbens basal ganglia 3 0.35 2.3
GTEx Brain Putamen basal ganglia 2 0.32 2.6
GTEx Breast Mammary Tissue 9 0.46 2.4
GTEx Breast Mammary Tissue (Male) 7 0.59 2.2
GTEx Breast Mammary Tissue (Female) 12 0.73 2.4
GTEx Cells EBV-transformed lymphocytes 9 0.63 2.3
GTEx Cells Transformed fibroblasts 26 0.62 2.3
GTEx Colon Sigmoid 10 0.68 2.4
GTEx Colon Transverse 15 0.73 2.4
GTEx Esophagus Gastroesophageal Junction 10 0.69 2.4
GTEx Esophagus Mucosa 16 0.48 2.3
GTEx Esophagus Muscularis 19 0.59 2.3
GTEx Heart Atrial Appendage 5 0.32 2.2
GTEx Heart Left Ventricle 6 0.39 2.2
GTEx Liver 2 0.28 2.2
GTEx Lung 14 0.49 2.3
GTEx Muscle Skeletal 20 0.69 2.3
GTEx Nerve Tibial 30 0.69 2.4
GTEx Ovary 6 0.66 2.6
GTEx Pancreas 8 0.49 2.2
GTEx Pituitary 8 0.72 2.3
GTEx Prostate 4 0.48 2.3
GTEx Skin Not Sun Exposed Suprapubic 14 0.57 2.4
GTEx Skin Sun Exposed Lower leg 16 0.44 2.4
GTEx Small Intestine Terminal Ileum 4 0.87 2.3
GTEx Spleen 9 0.64 2.2
GTEx Stomach 10 0.69 2.5
GTEx Testis 15 0.48 2.4
GTEx Thyroid 30 0.75 2.5
GTEx Uterus 2 0.35 2.3
GTEx Vagina 2 0.31 2.3
GTEx Whole Blood 20 1.01 2.7
METSIM Adipose 28 0.61 2.3
NTR Blood 22 0.92 2.7
ROSMAP Brain Pre-frontal Cortex 17 0.39 2.2
YFS Blood 34 0.74 2.5
CommonMind Brain Pre-frontal Cortex 31 0.58 2.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 5 0.30 2.1
The Cancer Genome Atlas Breast Invasive Carcinoma 24 0.54 2.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 3 0.27 2.2
The Cancer Genome Atlas Colon Adenocarcinoma 9 0.44 2.3
The Cancer Genome Atlas Esophageal Carcinoma 3 0.44 2.7
The Cancer Genome Atlas Glioblastoma Multiforme 3 0.29 2.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 18 0.66 2.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 21 0.51 2.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 10 0.49 2.3
The Cancer Genome Atlas Brain Lower Grade Glioma 25 0.58 2.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 6 0.54 2.2
The Cancer Genome Atlas Lung Adenocarcinoma 16 0.54 2.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 12 0.48 2.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 7 0.44 2.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 9 0.54 2.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 9 0.68 2.5
The Cancer Genome Atlas Prostate Adenocarcinoma 21 0.45 2.2
The Cancer Genome Atlas Rectum Adenocarcinoma 4 0.57 2.3
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.28 2.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 2 0.37 2.2
The Cancer Genome Atlas Stomach Adenocarcinoma 6 0.36 2.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 4 0.31 2.2
The Cancer Genome Atlas Thyroid Carcinoma 30 0.58 2.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 3 0.59 2.4