[Hub]/) : Traits : Hypothyroidism (self reported) : ← →

chr15:38,088,200-39,556,796

Best TWAS P=3.15e-16 · Best GWAS P=4.7e-17 conditioned to 0.0168

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
6	The Cancer Genome Atlas	Prostate Adenocarcinoma	RASGRP1	0.05	0.03	lasso	2	0.02	1.9e-03	8.4	8.2	3.1e-16	0.90	0.01	0.97	TRUE
1	GTEx	Esophagus Mucosa	RASGRP1	0.31	0.34	lasso	5	0.33	6.6e-23	7.8	7.8	5.1e-15	0.76	0.32	0.68	FALSE
2	GTEx	Skin Not Sun Exposed Suprapubic	RASGRP1	0.37	0.44	lasso	5	0.42	3.6e-25	7.8	7.8	5.7e-15	0.75	0.32	0.68	FALSE
3	GTEx	Skin Sun Exposed Lower leg	RASGRP1	0.37	0.33	lasso	6	0.38	1.2e-32	7.7	7.5	4.5e-14	0.73	0.34	0.66	FALSE
5	The Cancer Genome Atlas	Colon Adenocarcinoma	RASGRP1	0.10	0.01	blup	67	0.02	1.9e-02	4.8	6.7	2.9e-11	0.64	0.03	0.32	FALSE
7	The Cancer Genome Atlas	Skin Cutaneous Melanoma	RASGRP1	0.17	-0.01	blup	72	0.03	5.8e-02	4.5	6.6	3.9e-11	0.79	0.01	0.43	FALSE
4	GTEx	Spleen	RASGRP1	0.49	0.13	lasso	6	0.03	5.3e-02	7.7	6.3	3.1e-10	0.68	0.09	0.31	FALSE