Best TWAS P=3.15e-16 · Best GWAS P=4.7e-17 conditioned to 0.0168
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | RASGRP1 | 0.31 | 0.34 | lasso | 5 | 0.33 | 6.6e-23 | 7.8 | 7.8 | 5.1e-15 | 0.76 | 0.32 | 0.68 | FALSE |
| 2 | GTEx | Skin Not Sun Exposed Suprapubic | RASGRP1 | 0.37 | 0.44 | lasso | 5 | 0.42 | 3.6e-25 | 7.8 | 7.8 | 5.7e-15 | 0.75 | 0.32 | 0.68 | FALSE |
| 3 | GTEx | Skin Sun Exposed Lower leg | RASGRP1 | 0.37 | 0.33 | lasso | 6 | 0.38 | 1.2e-32 | 7.7 | 7.5 | 4.5e-14 | 0.73 | 0.34 | 0.66 | FALSE |
| 4 | GTEx | Spleen | RASGRP1 | 0.49 | 0.13 | lasso | 6 | 0.03 | 5.3e-02 | 7.7 | 6.3 | 3.1e-10 | 0.68 | 0.09 | 0.31 | FALSE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | RASGRP1 | 0.10 | 0.01 | blup | 67 | 0.02 | 1.9e-02 | 4.8 | 6.7 | 2.9e-11 | 0.64 | 0.03 | 0.32 | FALSE |
| 6 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RASGRP1 | 0.05 | 0.03 | lasso | 2 | 0.02 | 1.9e-03 | 8.4 | 8.2 | 3.1e-16 | 0.90 | 0.01 | 0.97 | TRUE |
| 7 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | RASGRP1 | 0.17 | -0.01 | blup | 72 | 0.03 | 5.8e-02 | 4.5 | 6.6 | 3.9e-11 | 0.79 | 0.01 | 0.43 | FALSE |