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Traits
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Traits
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Hypothyroidism (self reported)
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chr18:12,090,696-13,687,136
Best TWAS P=4.29e-08 · Best GWAS P=4e-12 conditioned to 1.14e-05
12M
12.2M
12.4M
12.6M
12.8M
13M
13.2M
13.4M
13.6M
0
2
4
6
8
10
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
ROSMAP
Brain Pre-frontal Cortex
PTPN2
0.1
0.08
lasso
4
0.07
1.1e-09
-5.4
5.5
4.3e-08
0.52
0.84
0.16
TRUE
1
GTEx
Adrenal Gland
SEH1L
0.2
0.03
lasso
3
0.02
6.0e-02
-5.4
-5.5
5.1e-08
-0.38
0.10
0.12
TRUE