Best TWAS P=5.4e-22 · Best GWAS P=6.58e-31 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 4 | GTEx | Muscle Skeletal | C1QTNF6 | 0.18 | 0.14 | lasso | 3 | 0.12 | 7.1e-12 | 9.6 | 9.6 | 5.4e-22 | 0.60 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | C1QTNF6 | 0.05 | 0.04 | lasso | 3 | 0.04 | 5.0e-09 | -8.0 | -8.5 | 2.9e-17 | -0.82 | 0.02 | 0.98 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SSTR3 | 0.04 | 0.00 | blup | 101 | 0.02 | 6.6e-03 | -4.6 | 6.8 | 8.1e-12 | 0.74 | 0.02 | 0.64 | TRUE |
| 1 | GTEx | Breast Mammary Tissue | RP1-151B14.6 | 0.18 | 0.07 | enet | 37 | 0.04 | 2.4e-03 | 9.6 | 5.2 | 2.2e-07 | 0.22 | 0.25 | 0.07 | TRUE |
| 7 | GTEx | Whole Blood | RP1-151B14.6 | 0.10 | 0.07 | lasso | 2 | 0.04 | 6.4e-05 | 9.5 | 9.6 | 1.2e-21 | 0.58 | 0.97 | 0.00 | FALSE |
| 5 | GTEx | Muscle Skeletal | RP1-151B14.6 | 0.21 | 0.14 | lasso | 4 | 0.12 | 3.0e-12 | 9.6 | 9.5 | 1.4e-21 | 0.58 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Liver | C1QTNF6 | 0.32 | 0.18 | lasso | 4 | 0.11 | 6.4e-04 | 9.6 | 8.8 | 1.1e-18 | 0.51 | 0.25 | 0.09 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | RP1-151B14.6 | 0.23 | -0.01 | lasso | 4 | 0.01 | 1.4e-01 | 9.6 | 8.2 | 3.5e-16 | 0.45 | 0.07 | 0.05 | FALSE |
| 6 | GTEx | Whole Blood | C1QTNF6 | 0.18 | 0.12 | enet | 20 | 0.16 | 7.8e-15 | 9.6 | 5.2 | 2.0e-07 | 0.18 | 1.00 | 0.00 | FALSE |