Best TWAS P=6.61e-20 · Best GWAS P=1.83e-24 conditioned to 0.027
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Breast Mammary Tissue (Male) | PFKL | 0.27 | 0.09 | lasso | 2 | 0.09 | 3.5e-03 | -6.34 | 6.2 | 4.6e-10 | 0.43 | 0.06 | 0.14 | TRUE |
| 2 | GTEx | Cells Transformed fibroblasts | ICOSLG | 0.13 | 0.08 | lasso | 3 | 0.06 | 1.8e-05 | 5.80 | 5.7 | 1.5e-08 | 0.69 | 0.45 | 0.21 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | ICOSLG | 0.21 | 0.08 | enet | 27 | 0.10 | 1.8e-08 | -4.46 | -5.9 | 3.1e-09 | -0.42 | 0.89 | 0.11 | FALSE |
| 4 | NTR | Blood | ICOSLG | 0.05 | 0.01 | enet | 17 | 0.03 | 2.9e-10 | -1.61 | -6.1 | 1.4e-09 | -0.57 | 0.08 | 0.92 | FALSE |
| 5 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | ICOSLG | 0.15 | 0.02 | blup | 65 | 0.04 | 8.9e-03 | -5.14 | -6.7 | 2.6e-11 | -0.42 | 0.04 | 0.15 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ICOSLG | 0.05 | 0.00 | blup | 68 | 0.02 | 2.4e-03 | -0.34 | -5.4 | 5.7e-08 | -0.45 | 0.06 | 0.11 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ICOSLG | 0.05 | 0.01 | enet | 12 | 0.02 | 9.7e-04 | -0.78 | -5.3 | 1.2e-07 | -0.35 | 0.06 | 0.04 | FALSE |
| 8 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ICOSLG | 0.14 | 0.07 | blup | 68 | 0.10 | 8.2e-05 | -5.15 | -7.0 | 3.1e-12 | -0.47 | 0.14 | 0.21 | FALSE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ICOSLG | 0.14 | 0.06 | lasso | 4 | 0.12 | 9.9e-13 | -5.15 | -5.3 | 9.4e-08 | -0.40 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | ICOSLG | 0.11 | 0.03 | blup | 68 | 0.08 | 5.6e-08 | -6.57 | -9.1 | 6.6e-20 | -0.70 | 0.01 | 0.98 | TRUE |