Best TWAS P=2.01e-09 · Best GWAS P=1.22e-08 conditioned to 0.771
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | IRF6 | 0.09 | 0.05 | enet | 18 | 0.07 | 1.9e-08 | 5.5 | -5.6 | 1.9e-08 | -0.90 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | IRF6 | 0.36 | 0.28 | lasso | 6 | 0.34 | 2.1e-09 | 5.1 | -5.9 | 3.1e-09 | -0.92 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | RP3-434O14.8 | 0.30 | 0.18 | lasso | 5 | 0.23 | 1.5e-06 | 5.6 | -6.0 | 2.0e-09 | -0.93 | 0.01 | 0.99 | TRUE |
| 4 | GTEx | Nerve Tibial | IRF6 | 0.29 | 0.21 | lasso | 4 | 0.22 | 1.8e-15 | 5.1 | -5.3 | 1.1e-07 | -0.96 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Nerve Tibial | RP3-434O14.8 | 0.11 | 0.06 | enet | 8 | 0.05 | 1.8e-04 | 5.1 | -5.1 | 3.1e-07 | -0.83 | 0.01 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Soft Tissue Sarcoma | IRF6 | 0.07 | 0.01 | blup | 85 | 0.03 | 4.0e-03 | 4.8 | -5.8 | 7.3e-09 | -0.75 | 0.02 | 0.70 | FALSE |