[Hub]/) : Traits : Intelligence (Savage-Jansen 2018) :

chr4:151,347,355-153,373,680

Best TWAS P=6.92e-13 · Best GWAS P=8.93e-13 conditioned to 0.0812

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex FAM160A1 0.04 0.04 blup 436 0.06 1.8e-07 -7.1 7.2 6.9e-13 -0.88 0.03 0.97 TRUE
2 CommonMind Brain Pre-frontal Cortex PET112 0.16 0.24 lasso 10 0.23 2.7e-27 -5.7 5.8 8.8e-09 -0.78 0.99 0.01 FALSE
3 GTEx Adipose Subcutaneous PET112 0.21 0.16 lasso 8 0.15 5.4e-12 -5.7 5.8 8.2e-09 -0.78 0.99 0.01 FALSE
4 GTEx Artery Aorta PET112 0.17 0.10 lasso 9 0.11 1.2e-06 -5.5 6.0 2.5e-09 -0.78 0.95 0.04 FALSE
5 GTEx Artery Coronary PET112 0.16 0.13 lasso 11 0.14 1.7e-05 -5.9 5.9 3.3e-09 -0.79 0.45 0.28 FALSE
6 GTEx Artery Tibial PET112 0.17 0.14 lasso 3 0.13 4.3e-10 -5.9 5.9 4.7e-09 -0.79 0.99 0.01 FALSE
7 GTEx Brain Caudate basal ganglia PET112 0.13 0.15 lasso 3 0.12 2.7e-04 -5.9 5.9 4.3e-09 -0.80 0.19 0.41 FALSE
8 GTEx Brain Cerebellar Hemisphere PET112 0.24 0.24 lasso 6 0.21 4.6e-06 -5.6 5.8 5.8e-09 -0.76 0.24 0.64 FALSE
9 GTEx Brain Cerebellar Hemisphere SH3D19 0.28 0.22 lasso 5 0.20 9.3e-06 4.9 -5.3 1.2e-07 0.79 0.71 0.03 FALSE
10 GTEx Brain Cerebellum PET112 0.13 0.15 lasso 8 0.13 1.3e-04 -6.1 6.1 1.3e-09 -0.81 0.19 0.42 FALSE
11 GTEx Brain Cerebellum RP11-164P12.3 0.21 0.02 enet 19 0.03 3.4e-02 5.1 5.8 7.2e-09 -0.75 0.23 0.16 FALSE
12 GTEx Brain Cerebellum RP11-164P12.4 0.48 0.40 lasso 17 0.49 2.2e-16 -6.5 6.0 1.7e-09 -0.87 0.88 0.11 FALSE
13 GTEx Brain Cortex PET112 0.11 0.13 enet 22 0.12 4.1e-04 -6.0 5.9 4.2e-09 -0.84 0.13 0.72 FALSE
14 GTEx Brain Frontal Cortex BA9 PET112 0.22 0.13 enet 14 0.05 1.6e-02 -7.1 5.5 4.9e-08 -0.87 0.03 0.86 FALSE
15 GTEx Breast Mammary Tissue PET112 0.12 0.03 enet 11 0.01 1.4e-01 -4.3 5.5 3.7e-08 -0.77 0.25 0.64 FALSE
16 GTEx Cells EBV-transformed lymphocytes PET112 0.26 0.20 enet 23 0.26 3.7e-09 -7.0 -5.1 3.1e-07 0.86 0.02 0.98 FALSE
17 GTEx Colon Sigmoid PET112 0.13 0.08 enet 18 0.03 2.6e-02 -5.7 5.4 5.0e-08 -0.81 0.11 0.76 FALSE
18 GTEx Esophagus Mucosa PET112 0.07 0.10 lasso 1 0.09 1.8e-06 -5.7 5.7 1.5e-08 -0.77 0.45 0.52 FALSE
19 GTEx Esophagus Muscularis PET112 0.13 0.12 lasso 1 0.13 3.9e-08 -5.6 5.6 1.7e-08 -0.77 0.95 0.02 FALSE
20 GTEx Heart Atrial Appendage PET112 0.20 0.11 enet 24 0.18 2.1e-08 -6.4 6.0 1.6e-09 -0.81 0.09 0.90 FALSE
21 GTEx Heart Atrial Appendage RP11-164P12.3 0.13 0.03 lasso 5 0.02 4.4e-02 -5.3 6.6 4.5e-11 -0.80 0.20 0.29 FALSE
22 GTEx Heart Left Ventricle PET112 0.14 0.06 lasso 4 0.04 5.0e-03 -7.1 7.1 1.3e-12 -0.99 0.03 0.90 FALSE
23 GTEx Muscle Skeletal PET112 0.10 0.07 lasso 5 0.07 3.6e-07 -5.7 5.7 9.7e-09 -0.78 0.91 0.08 FALSE
24 GTEx Nerve Tibial PET112 0.13 0.10 enet 13 0.10 9.7e-08 -6.7 6.7 1.7e-11 -0.93 0.04 0.96 FALSE
25 GTEx Nerve Tibial RP11-164P12.3 0.08 0.14 lasso 6 0.14 8.3e-10 -6.0 6.6 5.2e-11 -0.90 0.06 0.94 FALSE
26 ROSMAP Brain Pre-frontal Cortex PET112 0.04 0.02 bslmm 410 0.04 5.2e-06 -7.1 6.1 8.4e-10 -0.81 0.02 0.97 FALSE
27 The Cancer Genome Atlas Brain Lower Grade Glioma PET112L 0.05 0.02 enet 6 0.03 4.0e-04 -6.1 5.5 3.6e-08 -0.79 0.07 0.87 FALSE
28 The Cancer Genome Atlas Lung Adenocarcinoma PET112L 0.02 0.01 lasso 1 0.01 7.1e-02 -5.9 5.9 4.6e-09 -0.80 0.07 0.26 FALSE
29 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma FAM160A1 0.07 0.03 lasso 3 0.05 1.9e-04 -3.7 5.4 6.7e-08 -0.66 0.44 0.18 FALSE
30 The Cancer Genome Atlas Pancreatic Adenocarcinoma FAM160A1 0.08 0.05 blup 99 0.05 2.9e-03 -5.3 5.1 3.1e-07 -0.71 0.11 0.22 FALSE
31 The Cancer Genome Atlas Pancreatic Adenocarcinoma PET112L 0.09 0.04 blup 76 0.07 1.0e-03 -5.7 6.3 2.6e-10 -0.84 0.12 0.64 FALSE
32 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma PET112L 0.09 0.07 lasso 2 0.06 2.5e-03 -6.1 6.2 5.7e-10 -0.80 0.08 0.29 FALSE
33 The Cancer Genome Atlas Prostate Adenocarcinoma FAM160A1 0.09 0.10 lasso 2 0.10 3.3e-10 5.6 5.6 2.4e-08 -0.81 0.96 0.04 FALSE
34 The Cancer Genome Atlas Stomach Adenocarcinoma PET112L 0.04 0.03 blup 77 0.02 6.6e-03 -4.8 5.1 2.9e-07 -0.63 0.10 0.14 FALSE
35 The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma FAM160A1 0.16 0.14 enet 33 0.11 6.6e-04 4.9 5.3 1.1e-07 -0.75 0.24 0.69 FALSE