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chr4:105,373,669-107,092,169

Best TWAS P=1.58e-17 · Best GWAS P=4.16e-23 conditioned to 4.38e-07

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex PPA2 0.08 0.03 bslmm 429 0.04 2.2e-05 -7.4 -7.9 2.0e-15 0.66 0.09 0.88 FALSE
2 GTEx Artery Aorta PPA2 0.11 -0.01 enet 24 0.01 1.6e-01 -9.0 -5.2 2.3e-07 0.63 0.06 0.43 FALSE
3 GTEx Brain Cortex PPA2 0.14 0.09 lasso 9 0.09 1.6e-03 -8.3 -8.5 1.6e-17 0.88 0.04 0.74 TRUE
4 GTEx Cells Transformed fibroblasts PPA2 0.11 0.03 lasso 3 0.01 6.5e-02 -6.0 -5.6 2.7e-08 0.67 0.39 0.15 FALSE
5 GTEx Esophagus Gastroesophageal Junction PPA2 0.29 0.15 lasso 5 0.14 8.8e-06 -9.0 -8.2 2.6e-16 0.88 0.02 0.96 FALSE
6 GTEx Esophagus Mucosa PPA2 0.18 0.06 enet 14 0.12 2.5e-08 5.0 -6.9 5.5e-12 0.72 0.32 0.66 FALSE
7 GTEx Heart Atrial Appendage PPA2 0.15 0.05 lasso 7 0.06 7.4e-04 -8.1 -6.8 1.2e-11 0.71 0.24 0.38 FALSE
8 GTEx Lung PPA2 0.09 0.02 enet 16 0.03 1.4e-03 1.4 -5.3 1.4e-07 0.45 0.22 0.25 FALSE
9 GTEx Muscle Skeletal PPA2 0.19 0.06 enet 28 0.11 8.7e-11 -8.4 -5.3 1.1e-07 0.60 0.95 0.05 FALSE
10 GTEx Nerve Tibial PPA2 0.13 0.07 enet 23 0.07 2.1e-05 -7.4 -5.8 7.5e-09 0.66 0.36 0.47 FALSE
11 GTEx Ovary PPA2 0.18 0.10 lasso 3 0.14 2.2e-04 -7.4 -6.1 1.1e-09 0.76 0.04 0.79 FALSE
12 GTEx Skin Sun Exposed Lower leg TET2 0.09 0.01 enet 18 0.02 3.6e-03 -9.8 -6.3 3.9e-10 0.69 0.01 0.95 FALSE
13 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma PPA2 0.11 0.03 blup 84 0.03 4.7e-04 -7.4 -5.4 8.8e-08 0.59 0.32 0.44 FALSE
14 The Cancer Genome Atlas Thyroid Carcinoma PPA2 0.04 0.02 blup 84 0.04 6.1e-05 -8.4 -7.2 6.2e-13 0.77 0.07 0.82 FALSE