Best TWAS P=1.4e-08 · Best GWAS P=1.5e-07 conditioned to 0.0695
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Aorta | RTN1 | 0.35 | 0.30 | enet | 20 | 0.34 | 1.9e-19 | -4.7 | -5.2 | 1.7e-07 | -0.58 | 0.09 | 0.90 | FALSE |
| 2 | GTEx | Artery Coronary | RTN1 | 0.21 | 0.12 | lasso | 7 | 0.10 | 2.5e-04 | -4.7 | -5.6 | 2.2e-08 | -0.55 | 0.13 | 0.64 | FALSE |
| 3 | GTEx | Artery Tibial | RTN1 | 0.42 | 0.32 | enet | 34 | 0.45 | 3.2e-38 | -4.7 | -5.5 | 4.2e-08 | -0.56 | 0.09 | 0.90 | FALSE |
| 4 | GTEx | Artery Tibial | CCDC175 | 0.25 | 0.17 | enet | 11 | 0.25 | 9.0e-20 | -4.7 | -5.7 | 1.4e-08 | -0.70 | 0.09 | 0.90 | TRUE |
| 5 | GTEx | Artery Tibial | RP11-701B16.2 | 0.20 | 0.15 | lasso | 4 | 0.16 | 2.2e-12 | -4.7 | -5.3 | 1.5e-07 | -0.57 | 0.08 | 0.91 | FALSE |
| 6 | GTEx | Thyroid | RTN1 | 0.12 | 0.12 | lasso | 4 | 0.12 | 3.4e-09 | 5.1 | -5.3 | 1.3e-07 | -0.99 | 0.01 | 0.99 | FALSE |
| 7 | METSIM | Adipose | RTN1 | 0.08 | 0.07 | enet | 10 | 0.07 | 2.0e-10 | 4.2 | -5.3 | 1.0e-07 | -0.60 | 0.31 | 0.65 | FALSE |