[Hub]/) : Traits : LDL Cholesterol :

chr12:120,722,064-122,167,693

Best TWAS P=3.8e-13 · Best GWAS P=3.33e-15 conditioned to 0.00187

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex HNF1A 0.19 0.13 lasso 15 0.12 1.7e-14 7.1 7.3 3.8e-13 0.89 0.45 0.55 TRUE
2 GTEx Testis OASL 0.17 0.04 enet 10 0.01 1.6e-01 -4.4 5.6 2.3e-08 0.56 0.08 0.49 FALSE
3 METSIM Adipose OASL 0.06 0.04 enet 23 0.05 6.8e-08 -4.2 5.4 7.4e-08 0.56 0.05 0.93 FALSE
4 NTR Blood OASL 0.03 0.01 lasso 7 0.01 3.3e-04 6.3 6.4 1.3e-10 0.74 0.35 0.63 FALSE
5 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma C12orf27 0.03 0.01 lasso 4 0.01 1.1e-02 6.8 7.1 9.0e-13 0.81 0.04 0.42 FALSE
6 The Cancer Genome Atlas Brain Lower Grade Glioma HNF1A 0.11 0.12 blup 58 0.12 7.7e-14 -5.5 5.4 6.6e-08 0.59 1.00 0.00 FALSE
7 The Cancer Genome Atlas Prostate Adenocarcinoma HNF1A 0.03 0.04 lasso 1 0.04 1.1e-04 -5.3 5.3 1.0e-07 0.62 0.08 0.26 FALSE