Best TWAS P=3.8e-13 · Best GWAS P=3.33e-15 conditioned to 0.00187
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HNF1A | 0.19 | 0.13 | lasso | 15 | 0.12 | 1.7e-14 | 7.1 | 7.3 | 3.8e-13 | 0.89 | 0.45 | 0.55 | TRUE |
| 2 | GTEx | Testis | OASL | 0.17 | 0.04 | enet | 10 | 0.01 | 1.6e-01 | -4.4 | 5.6 | 2.3e-08 | 0.56 | 0.08 | 0.49 | FALSE |
| 3 | METSIM | Adipose | OASL | 0.06 | 0.04 | enet | 23 | 0.05 | 6.8e-08 | -4.2 | 5.4 | 7.4e-08 | 0.56 | 0.05 | 0.93 | FALSE |
| 4 | NTR | Blood | OASL | 0.03 | 0.01 | lasso | 7 | 0.01 | 3.3e-04 | 6.3 | 6.4 | 1.3e-10 | 0.74 | 0.35 | 0.63 | FALSE |
| 5 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C12orf27 | 0.03 | 0.01 | lasso | 4 | 0.01 | 1.1e-02 | 6.8 | 7.1 | 9.0e-13 | 0.81 | 0.04 | 0.42 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | HNF1A | 0.11 | 0.12 | blup | 58 | 0.12 | 7.7e-14 | -5.5 | 5.4 | 6.6e-08 | 0.59 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | HNF1A | 0.03 | 0.04 | lasso | 1 | 0.04 | 1.1e-04 | -5.3 | 5.3 | 1.0e-07 | 0.62 | 0.08 | 0.26 | FALSE |