Best TWAS P=1.47e-09 · Best GWAS P=1.51e-09 conditioned to 0.0078
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | GTEx | Skin Sun Exposed Lower leg | ALDH2 | 0.10 | 0.09 | enet | 13 | 0.13 | 6.7e-11 | 4.3 | -6.0 | 1.5e-09 | 0.67 | 0.36 | 0.64 | TRUE |
| 4 | GTEx | Artery Tibial | HECTD4 | 0.05 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -5.7 | -5.8 | 6.2e-09 | 0.85 | 0.02 | 0.90 | FALSE |
| 7 | GTEx | Thyroid | BRAP | 0.07 | 0.02 | lasso | 7 | 0.03 | 1.1e-03 | 4.9 | 5.5 | 4.9e-08 | -0.57 | 0.18 | 0.71 | FALSE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ERP29 | 0.11 | 0.03 | blup | 25 | 0.05 | 5.0e-03 | 4.6 | 5.3 | 9.0e-08 | -0.59 | 0.01 | 0.74 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | AC003029.1 | 0.08 | 0.07 | enet | 30 | 0.05 | 1.2e-04 | 4.7 | 5.2 | 1.7e-07 | -0.45 | 0.88 | 0.12 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | ALDH2 | 0.10 | 0.00 | enet | 6 | 0.00 | 2.6e-01 | -4.7 | -5.2 | 1.8e-07 | 0.26 | 0.01 | 0.23 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | HECTD4 | 0.06 | 0.00 | enet | 15 | 0.02 | 1.0e-02 | 4.5 | -5.2 | 2.3e-07 | 0.66 | 0.07 | 0.81 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | MAPKAPK5-AS1 | 0.04 | 0.00 | enet | 30 | 0.00 | 7.0e-01 | 4.6 | 5.1 | 2.7e-07 | -0.52 | 0.19 | 0.24 | FALSE |
| 1 | CommonMind | Brain Pre-frontal Cortex | ATXN2 | 0.02 | 0.03 | enet | 8 | 0.02 | 4.8e-04 | 4.1 | -5.1 | 2.8e-07 | 0.52 | 0.32 | 0.56 | FALSE |