Best TWAS P=4.19e-08 · Best GWAS P=2.27e-07 conditioned to 0.0392
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Cells Transformed fibroblasts | FNBP4 | 0.11 | 0.05 | lasso | 8 | 0.08 | 1.6e-06 | 4.6 | -5.1 | 3.0e-07 | -0.70 | 0.10 | 0.89 | FALSE |
| 2 | GTEx | Esophagus Gastroesophageal Junction | NUP160 | 0.18 | 0.02 | enet | 18 | 0.11 | 7.1e-05 | 2.6 | -5.3 | 1.4e-07 | -0.55 | 0.11 | 0.57 | FALSE |
| 3 | GTEx | Esophagus Muscularis | MTCH2 | 0.09 | 0.04 | lasso | 6 | 0.02 | 1.8e-02 | -4.7 | -5.5 | 4.2e-08 | -0.66 | 0.12 | 0.78 | TRUE |
| 4 | GTEx | Liver | C1QTNF4 | 0.25 | 0.14 | enet | 16 | 0.20 | 2.3e-06 | -3.7 | 5.3 | 1.2e-07 | 0.83 | 0.07 | 0.86 | FALSE |
| 5 | GTEx | Testis | C1QTNF4 | 0.14 | 0.12 | lasso | 4 | 0.11 | 1.6e-05 | 4.7 | 5.2 | 1.8e-07 | 0.74 | 0.06 | 0.92 | FALSE |
| 6 | YFS | Blood | SPI1 | 0.65 | 0.18 | enet | 75 | 0.27 | 1.6e-87 | -3.9 | 5.3 | 1.3e-07 | 0.26 | 0.56 | 0.38 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NUP160 | 0.03 | 0.02 | enet | 7 | 0.02 | 6.3e-03 | -4.3 | -5.2 | 2.4e-07 | -0.69 | 0.04 | 0.57 | FALSE |