Hub : Traits :

Neuroticism (2016)

385 significantly associated models · 56 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	8	8092025	13120332	36	1	1.3e-16	4.2e-16	0.032	93	AF131215.9
2	11	9105636	11027552	2	1	6.5e-08	4.1e-08	0.023	83	ADM
3	11	46686260	48559571	5	1	4.2e-08	2.3e-07	0.039	84	MTCH2
4	17	42774693	45088455	13	1	1.9e-10	4.4e-10	1.000	100	KANSL1-AS1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Depressed Affect (Nagel 2018)	18.54	2	2	4.4	0.00	1.0000	KANSL1-AS1 MTCH2
Depression (Nagel 2018)	6.36	2	0	0.0	0.00	1.0000	KANSL1-AS1 MTCH2
Intelligence (Savage-Jansen 2018)	3.90	2	0	0.0	0.00	1.0000	KANSL1-AS1 MTCH2
Neuroticism (Nagel 2018)	21.70	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Worry (Nagel 2018)	13.71	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Alzheimer’s Disease (including proxy)	4.10	1	0	0.0	0.00	1.0000	MTCH2
Verbal and Numeric Reasoning (VNR)	4.73	2	0	0.0	0.00	1.0000	KANSL1-AS1 MTCH2
Breast Cancer	6.23	1	1	2.2	0.00	1.0000	KANSL1-AS1
Ovarian Cancer	8.87	1	1	2.2	0.00	1.0000	KANSL1-AS1
Body Mass Index (BMI) (2010)	7.51	1	1	2.2	0.00	1.0000	MTCH2
Crohns Disease (2012)	3.22	1	0	0.0	0.00	1.0000	KANSL1-AS1
HDL Cholesterol	3.83	1	0	0.0	0.00	1.0000	MTCH2
Lupus	6.73	1	1	2.2	0.00	1.0000	AF131215.9
Primary Biliary Cirrhosis	4.03	1	0	0.0	0.00	1.0000	KANSL1-AS1
Triglycerides	2.81	1	0	0.0	0.00	1.0000	AF131215.9
Blood Eosinophil Count	4.72	1	1	2.2	0.00	1.0000	KANSL1-AS1
Blood Platelet Count	1.85	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Blood Red Count	15.47	3	3	6.7	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Blood White Count	4.15	2	2	4.4	0.00	1.0000	KANSL1-AS1 MTCH2
Heel T-Score	3.84	1	1	2.2	0.00	1.0000	KANSL1-AS1
BMI	5.93	1	1	2.2	0.00	1.0000	MTCH2
Height	3.70	3	3	6.7	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Waist Hip Ratio (WHR)	9.52	2	2	4.4	0.00	1.0000	ADM KANSL1-AS1
Systolic Blood Pressure	8.86	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Hypothyroidism (self reported)	3.31	1	0	0.0	0.00	1.0000	MTCH2
Lung FEV1/FVC ratio	2.52	2	1	2.2	0.00	1.0000	ADM KANSL1-AS1
Lung FVC	11.91	1	1	2.2	0.00	1.0000	KANSL1-AS1
Neuroticism	19.16	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Hair Pigment	0.57	2	1	2.2	0.00	1.0000	ADM KANSL1-AS1
Tanning	0.90	1	0	0.0	0.00	1.0000	MTCH2
Hand grip strength (left)	8.73	2	2	4.4	0.00	1.0000	KANSL1-AS1 MTCH2
Sensitivity / hurt feelings	20.20	2	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1
Frequency of depressed mood in last 2 weeks	9.69	2	0	0.0	0.00	1.0000	KANSL1-AS1 MTCH2
Relative age of first facial hair	14.88	1	1	2.2	0.00	1.0000	KANSL1-AS1
Ever used hormone-replacement therapy (HRT)	3.75	1	0	0.0	0.00	1.0000	MTCH2
Systolic blood pressure, automated reading	8.17	3	2	4.4	0.00	1.0000	ADM AF131215.9 KANSL1-AS1
Vitamin and mineral supplements	4.55	1	0	0.0	0.00	1.0000	KANSL1-AS1
Medication: Metformin	4.09	1	0	0.0	0.00	1.0000	MTCH2
Impedance of leg (right)	9.18	4	2	4.4	0.69	0.3134	ADM AF131215.9 KANSL1-AS1 MTCH2
Leg fat-free mass (left)	3.17	2	1	2.2	0.00	1.0000	ADM AF131215.9
Trunk fat percentage	10.49	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Hand grip strength (right)	6.38	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Townsend deprivation index at recruitment	3.94	1	0	0.0	0.00	1.0000	MTCH2
Current tobacco smoking	7.08	2	0	0.0	0.00	1.0000	AF131215.9 MTCH2
Fed-up feelings	12.51	3	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Relative age voice broke	9.72	1	1	2.2	0.00	1.0000	KANSL1-AS1
Age when periods started (menarche)	5.39	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Heel bone mineral density (BMD) T-score, automated (left)	10.95	2	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1
High blood pressure	7.07	1	1	2.2	0.00	1.0000	AF131215.9
Medication: Levothyroxine sodium	5.28	1	0	0.0	0.00	1.0000	AF131215.9
Sitting height	8.61	3	2	4.4	0.00	1.0000	ADM KANSL1-AS1 MTCH2
Body mass index (BMI)	9.20	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Impedance of leg (left)	9.31	4	2	4.4	0.66	0.3412	ADM AF131215.9 KANSL1-AS1 MTCH2
Leg predicted mass (left)	3.17	2	1	2.2	0.00	1.0000	ADM AF131215.9
Trunk fat mass	6.38	3	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Waist circumference	5.04	1	1	2.2	0.00	1.0000	MTCH2
Nervous feelings	19.24	4	2	4.4	1.00	0.0036	ADM AF131215.9 KANSL1-AS1 MTCH2
Frequency of tenseness / restlessness in last 2 weeks	11.23	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Hearing difficulty/problems with background noise	4.78	1	0	0.0	0.00	1.0000	KANSL1-AS1
Hair/balding pattern: Pattern 2	6.46	1	0	0.0	0.00	1.0000	KANSL1-AS1
Forced vital capacity (FVC)	11.04	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Heel bone mineral density (BMD) T-score, automated (right)	10.95	2	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1
Ever unenthusiastic/disinterested for a whole week	3.99	1	0	0.0	0.00	1.0000	KANSL1-AS1
Mouth/teeth dental problems	4.44	1	0	0.0	0.00	1.0000	KANSL1-AS1
Fluid intelligence score	5.49	1	0	0.0	0.00	1.0000	MTCH2
Neuroticism score	29.51	4	3	6.7	0.99	0.0107	ADM AF131215.9 KANSL1-AS1 MTCH2
Weight	2.90	2	1	2.2	0.00	1.0000	AF131215.9 MTCH2
Impedance of arm (right)	10.54	3	3	6.7	0.00	1.0000	ADM AF131215.9 KANSL1-AS1
Arm fat percentage (right)	11.18	3	1	2.2	0.00	1.0000	ADM AF131215.9 MTCH2
Trunk fat-free mass	4.65	3	1	2.2	0.00	1.0000	ADM AF131215.9 MTCH2
Hip circumference	5.19	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Time employed in main current job	5.39	1	0	0.0	0.00	1.0000	KANSL1-AS1
Worrier / anxious feelings	18.82	2	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1
Hair/balding pattern: Pattern 3	14.26	1	1	2.2	0.00	1.0000	KANSL1-AS1
Number of live births	3.44	1	0	0.0	0.00	1.0000	KANSL1-AS1
Forced expiratory volume in 1-second (FEV1)	11.87	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Qualifications: A levels/AS levels or equivalent	3.29	1	0	0.0	0.00	1.0000	KANSL1-AS1
Serious illness, injury or assault of a close relative in last 2 years	4.95	1	0	0.0	0.00	1.0000	AF131215.9
Mouth/teeth dental problems: Dentures	3.00	1	0	0.0	0.00	1.0000	AF131215.9
Medication: Ibuprofen (e.g. Nurofen)	5.03	1	0	0.0	0.00	1.0000	KANSL1-AS1
Forced expiratory volume in 1-second (FEV1), Best measure	11.51	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Impedance of arm (left)	10.54	3	3	6.7	0.00	1.0000	ADM AF131215.9 KANSL1-AS1
Arm fat mass (right)	7.33	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Trunk predicted mass	4.59	2	1	2.2	0.00	1.0000	ADM AF131215.9
Standing height	4.34	4	2	4.4	0.16	0.8384	ADM AF131215.9 KANSL1-AS1 MTCH2
Tense / 'highly strung'	10.36	1	1	2.2	0.00	1.0000	AF131215.9
Hair/balding pattern: Pattern 4	25.82	1	1	2.2	0.00	1.0000	KANSL1-AS1
Peak expiratory flow (PEF)	9.82	2	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1
Medication: Paracetamol	10.10	1	1	2.2	0.00	1.0000	KANSL1-AS1
Headache pain in last month	11.29	1	1	2.2	0.00	1.0000	KANSL1-AS1
Hypothyroidism/myxoedema (self-reported)	6.02	1	1	2.2	0.00	1.0000	AF131215.9
Birth weight	4.07	2	0	0.0	0.00	1.0000	ADM MTCH2
Forced vital capacity (FVC), Best measure	11.72	2	2	4.4	0.00	1.0000	KANSL1-AS1 MTCH2
Body fat percentage	9.86	2	2	4.4	0.00	1.0000	ADM MTCH2
Leg fat percentage (right)	7.81	3	1	2.2	0.00	1.0000	ADM AF131215.9 MTCH2
Arm fat-free mass (right)	4.10	2	2	4.4	0.00	1.0000	ADM AF131215.9
Comparative body size at age 10	10.62	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Worry too long after embarrassment	12.72	2	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1
Qualifications: College or University degree	3.73	1	1	2.2	0.00	1.0000	KANSL1-AS1
Medication for pain relief, constipation, heartburn	5.36	1	1	2.2	0.00	1.0000	KANSL1-AS1
Medication: Ibuprofen	4.62	1	0	0.0	0.00	1.0000	KANSL1-AS1
Whole body fat mass	6.16	2	1	2.2	0.00	1.0000	AF131215.9 MTCH2
Leg fat mass (right)	6.23	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Arm predicted mass (right)	4.07	2	2	4.4	0.00	1.0000	ADM AF131215.9
Alcohol intake frequency.	8.52	2	2	4.4	0.00	1.0000	KANSL1-AS1 MTCH2
Comparative height size at age 10	2.13	1	1	2.2	0.00	1.0000	KANSL1-AS1
Suffer from 'nerves'	18.29	3	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Overall health rating	2.90	1	0	0.0	0.00	1.0000	AF131215.9
Leg pain on walking	4.22	1	0	0.0	0.00	1.0000	KANSL1-AS1
Hypertension (Self-reported)	6.82	1	1	2.2	0.00	1.0000	AF131215.9
Whole body fat-free mass	3.75	2	2	4.4	0.00	1.0000	ADM AF131215.9
Leg fat-free mass (right)	3.27	2	2	4.4	0.00	1.0000	ADM AF131215.9
Arm fat percentage (left)	12.04	3	2	4.4	0.00	1.0000	ADM AF131215.9 MTCH2
Handedness (chirality/laterality): Left-handed	6.79	1	1	2.2	0.00	1.0000	KANSL1-AS1
Mood swings	17.83	3	3	6.7	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Loneliness, isolation	11.63	2	1	2.2	0.00	1.0000	KANSL1-AS1 MTCH2
Mouth/teeth dental problems: Mouth ulcers	8.32	1	1	2.2	0.00	1.0000	KANSL1-AS1
Smoking status: Current	7.64	2	0	0.0	0.00	1.0000	AF131215.9 MTCH2
Forced expiratory volume in 1-second (FEV1), predicted percentage	10.00	1	1	2.2	0.00	1.0000	KANSL1-AS1
Whole body water mass	3.85	2	2	4.4	0.00	1.0000	ADM AF131215.9
Leg predicted mass (right)	3.20	2	2	4.4	0.00	1.0000	ADM AF131215.9
Arm fat mass (left)	7.52	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Average weekly champagne plus white wine intake	5.42	1	0	0.0	0.00	1.0000	KANSL1-AS1
Miserableness	17.65	3	3	6.7	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Guilty feelings	13.60	3	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1 MTCH2
Medication: Blood pressure	8.29	2	1	2.2	0.00	1.0000	AF131215.9 KANSL1-AS1
Medication: Bendroflumethiazide	6.73	1	0	0.0	0.00	1.0000	AF131215.9
Medication: Paracetamol	10.23	1	1	2.2	0.00	1.0000	KANSL1-AS1
Basal metabolic rate	3.07	2	2	4.4	0.00	1.0000	ADM AF131215.9
Leg fat percentage (left)	8.32	3	1	2.2	0.00	1.0000	ADM AF131215.9 MTCH2
Arm fat-free mass (left)	3.87	2	2	4.4	0.00	1.0000	ADM AF131215.9
Average weekly beer plus cider intake	7.05	1	0	0.0	0.00	1.0000	AF131215.9
Irritability	15.72	2	2	4.4	0.00	1.0000	AF131215.9 KANSL1-AS1
Risk taking	4.48	1	0	0.0	0.00	1.0000	AF131215.9
Diastolic blood pressure, automated reading	6.97	2	1	2.2	0.00	1.0000	ADM AF131215.9
Vascular/heart problems diagnosed by doctor	4.91	1	1	2.2	0.00	1.0000	AF131215.9
Pain experienced in last month	3.53	1	0	0.0	0.00	1.0000	KANSL1-AS1
Impedance of whole body	11.10	3	3	6.7	0.00	1.0000	ADM AF131215.9 KANSL1-AS1
Leg fat mass (left)	6.49	2	2	4.4	0.00	1.0000	AF131215.9 MTCH2
Arm predicted mass (left)	3.97	2	2	4.4	0.00	1.0000	ADM AF131215.9

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	8	0.230	1.4
GTEx	Adipose Visceral Omentum	8	0.394	1.5
GTEx	Adrenal Gland	5	0.344	1.5
GTEx	Artery Aorta	10	0.336	1.5
GTEx	Artery Coronary	7	0.595	1.6
GTEx	Artery Tibial	8	0.213	1.5
GTEx	Brain Caudate basal ganglia	4	0.435	1.6
GTEx	Brain Cerebellar Hemisphere	6	0.403	1.6
GTEx	Brain Cerebellum	5	0.253	1.5
GTEx	Brain Cortex	6	0.581	1.7
GTEx	Brain Frontal Cortex BA9	5	0.543	1.6
GTEx	Brain Hippocampus	3	0.571	1.7
GTEx	Brain Hypothalamus	3	0.508	1.6
GTEx	Brain Nucleus accumbens basal ganglia	4	0.462	1.5
GTEx	Brain Putamen basal ganglia	3	0.481	1.6
GTEx	Breast Mammary Tissue	9	0.456	1.5
GTEx	Breast Mammary Tissue (Male)	7	0.592	1.6
GTEx	Breast Mammary Tissue (Female)	6	0.367	1.4
GTEx	Cells EBV-transformed lymphocytes	7	0.493	1.7
GTEx	Cells Transformed fibroblasts	8	0.191	1.4
GTEx	Colon Sigmoid	9	0.616	1.5
GTEx	Colon Transverse	10	0.485	1.5
GTEx	Esophagus Gastroesophageal Junction	7	0.485	1.6
GTEx	Esophagus Mucosa	9	0.271	1.4
GTEx	Esophagus Muscularis	12	0.372	1.6
GTEx	Heart Atrial Appendage	6	0.380	1.6
GTEx	Heart Left Ventricle	7	0.458	1.6
GTEx	Liver	3	0.421	1.6
GTEx	Lung	10	0.349	1.5
GTEx	Muscle Skeletal	8	0.277	1.5
GTEx	Nerve Tibial	8	0.185	1.4
GTEx	Ovary	4	0.441	1.5
GTEx	Pancreas	7	0.429	1.5
GTEx	Pituitary	4	0.359	1.5
GTEx	Prostate	4	0.481	1.6
GTEx	Skin Not Sun Exposed Suprapubic	10	0.407	1.6
GTEx	Skin Sun Exposed Lower leg	11	0.303	1.5
GTEx	Small Intestine Terminal Ileum	5	1.087	1.7
GTEx	Spleen	6	0.426	1.6
GTEx	Stomach	6	0.413	1.5
GTEx	Testis	12	0.381	1.5
GTEx	Thyroid	10	0.251	1.5
GTEx	Uterus	8	1.413	1.8
GTEx	Vagina	4	0.632	1.5
GTEx	Whole Blood	5	0.252	1.5
METSIM	Adipose	1	0.022	1.3
NTR	Blood	6	0.250	1.5
ROSMAP	Brain Pre-frontal Cortex	16	0.365	1.5
YFS	Blood	1	0.022	1.3
CommonMind	Brain Pre-frontal Cortex	8	0.149	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	6	0.137	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.049	1.4
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.147	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.196	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	3	0.070	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.091	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.061	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	3	0.227	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.095	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.060	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	2	0.158	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.059	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2