[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr3:16,154,636-17,814,553

Best TWAS P=5.4e-10 · Best GWAS P=4.46e-11 conditioned to 0.00187

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Cells Transformed fibroblasts PLCL2 0.10 0.06 lasso 5 0.09 4.5e-07 6.0 5.8 6.6e-09 0.64 0.30 0.70 FALSE
2 GTEx Skin Sun Exposed Lower leg PLCL2 0.06 0.00 enet 1 0.00 5.0e-01 5.5 5.5 4.8e-08 0.82 0.04 0.77 FALSE
3 METSIM Adipose PLCL2 0.08 0.03 lasso 6 0.04 2.3e-06 6.4 6.2 5.4e-10 0.71 0.03 0.97 TRUE
4 YFS Blood PLCL2 0.10 0.10 lasso 7 0.11 3.7e-34 5.8 5.2 2.1e-07 0.64 0.20 0.80 FALSE