[Hub]/) : Traits : Neuroticism (Nagel 2018) :

chr9:95,502,571-96,913,764

Best TWAS P=1.18e-10 · Best GWAS P=2.39e-10 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous RP11-165J3.6 0.22 0.13 enet 18 0.16 2.5e-13 6.1 5.2 2.5e-07 0.92 0.01 0.99 FALSE
2 GTEx Adipose Visceral Omentum RP11-165J3.6 0.26 0.13 lasso 6 0.13 4.2e-07 4.8 5.6 1.6e-08 0.69 0.25 0.74 FALSE
3 GTEx Artery Aorta RP11-165J3.6 0.23 0.22 enet 10 0.22 2.3e-12 6.1 6.1 9.7e-10 0.96 0.02 0.98 FALSE
4 GTEx Artery Tibial RP11-165J3.6 0.22 0.20 lasso 2 0.19 4.9e-15 6.1 6.1 9.3e-10 0.98 0.01 0.99 FALSE
5 GTEx Brain Caudate basal ganglia RP11-165J3.6 0.47 0.33 lasso 7 0.31 1.0e-09 6.1 5.6 2.3e-08 0.96 0.01 0.99 FALSE
6 GTEx Brain Cerebellum RP11-165J3.6 0.44 0.31 lasso 7 0.28 5.0e-09 6.1 5.8 6.3e-09 0.98 0.01 0.99 FALSE
7 GTEx Brain Frontal Cortex BA9 RP11-165J3.6 0.41 0.14 lasso 6 0.20 6.1e-06 6.1 5.9 4.1e-09 0.97 0.01 0.99 FALSE
8 GTEx Brain Nucleus accumbens basal ganglia RP11-165J3.6 0.31 0.11 lasso 6 0.16 5.4e-05 6.1 5.3 1.0e-07 0.85 0.02 0.92 FALSE
9 GTEx Breast Mammary Tissue RP11-165J3.6 0.28 0.11 enet 24 0.13 2.7e-07 6.0 5.7 9.4e-09 0.87 0.01 0.99 FALSE
10 GTEx Breast Mammary Tissue (Female) RP11-165J3.6 0.21 0.02 lasso 3 0.00 2.3e-01 6.0 6.2 6.2e-10 0.95 0.02 0.73 FALSE
11 GTEx Colon Sigmoid RP11-165J3.6 0.31 0.12 enet 17 0.16 1.8e-06 6.3 5.4 7.2e-08 0.88 0.01 0.99 FALSE
12 GTEx Colon Transverse RP11-165J3.6 0.37 0.20 lasso 4 0.18 3.6e-09 6.1 5.9 3.3e-09 0.96 0.01 0.99 FALSE
13 GTEx Esophagus Gastroesophageal Junction RP11-165J3.6 0.34 0.26 lasso 8 0.27 3.0e-10 6.1 6.3 3.9e-10 0.98 0.01 0.99 FALSE
14 GTEx Heart Atrial Appendage RP11-165J3.6 0.38 0.21 lasso 7 0.25 8.7e-12 6.1 6.4 1.6e-10 0.92 0.01 0.99 FALSE
15 GTEx Heart Left Ventricle RP11-165J3.6 0.13 0.06 lasso 5 0.05 1.9e-03 6.1 5.5 3.7e-08 0.92 0.02 0.96 FALSE
16 GTEx Lung RP11-165J3.6 0.25 0.16 lasso 7 0.17 4.1e-13 6.1 6.4 1.2e-10 0.96 0.01 0.99 TRUE
17 GTEx Pituitary RP11-165J3.6 0.49 0.22 lasso 8 0.29 6.9e-08 6.0 6.0 1.5e-09 0.92 0.01 0.98 FALSE
18 GTEx Skin Not Sun Exposed Suprapubic RP11-165J3.6 0.27 0.14 lasso 7 0.19 1.4e-10 6.2 6.1 1.1e-09 0.94 0.01 0.99 FALSE
19 GTEx Skin Sun Exposed Lower leg RP11-165J3.6 0.32 0.27 lasso 5 0.35 6.8e-30 6.0 6.2 4.3e-10 0.94 0.01 0.99 FALSE
20 GTEx Thyroid RP11-165J3.6 0.35 0.27 lasso 3 0.29 1.2e-22 6.1 6.3 2.2e-10 0.96 0.01 0.99 FALSE
21 YFS Blood FAM120AOS 0.03 0.01 bslmm 488 0.02 5.3e-06 6.0 -5.2 2.4e-07 -0.72 0.01 0.98 FALSE