Hub : Genes

FAM120AOS

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Heart Atrial Appendage 0.1040 0.0490 9.1e-03 0.042 NA 0.031 NA 0.043 5.8e-03 NA 0.01600 NA 5.1e-03
2 GTEx Skin Sun Exposed Lower leg 0.0910 0.0370 6.6e-03 0.005 NA 0.010 NA 0.003 1.2e-01 NA 0.04400 NA 1.8e-01
3 YFS Blood 0.0325 0.0126 4.4e-05 0.014 0.013 0.009 0.016 0.013 1.6e-05 2.4e-05 0.00032 5.3e-06 3.6e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.6 0.9 2.0 -0.6 0.6 -1.4
Bipolar Disorder or Schizophrenia 3.3 8.0 14.7 -3.0 -0.5 -3.8
Depressed Affect (Nagel 2018) 7.6 16.0 25.6 -5.1 -1.9 -4.3
Depression (Nagel 2018) 13.7 20.6 30.7 -5.2 -2.1 -5.5
Intelligence (Savage-Jansen 2018) 2.8 8.7 21.0 4.6 -0.4 2.2
Neuroticism (Nagel 2018) 8.0 18.9 26.6 -4.7 -2.7 -5.2
Schizophrenia (2018) 4.4 9.1 14.5 -3.4 -1.1 -3.8
Schizophrenia vs Biploar Disorder 1.8 2.4 3.4 -1.5 -1.9 -1.1
Worry (Nagel 2018) 6.8 14.3 26.1 -3.0 -2.8 -5.1
Alzheimer’s Disease (in mother) 0.6 0.8 1.2 1.0 0.4 1.1
Alzheimer’s Disease (in father) 1.4 1.6 2.5 -0.7 -1.3 -1.6
Alzheimer’s Disease (including proxy) 0.0 0.0 0.1 0.1 -0.2 0.1
Crohns Disease (2017) 0.6 1.2 2.2 -1.5 -0.2 -1.2
Irritable Bowel Disease (IBD) 0.6 1.5 3.1 -1.8 -0.4 -1.1
Ulcerative Colitis (UC) 0.5 0.9 1.9 -1.4 -0.7 -0.5
Major Depression (MDD) 9.5 11.5 19.9 -4.5 -2.0 -3.3
Reaction Time 0.2 0.4 0.8 -0.1 0.6 -0.9
Verbal and Numeric Reasoning (VNR) 5.3 12.8 27.3 5.2 0.7 3.3
Breast Cancer 0.2 0.4 1.1 0.5 0.0 1.0
Ovarian Cancer 0.3 0.4 1.2 -1.1 -0.3 -0.0
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.3 1.9 3.6 1.9 0.6 1.3
Bipolar Disorder (2011) 3.8 3.6 8.2 -1.4 -0.9 -2.9
Body Mass Index (BMI) (2010) 1.3 1.8 3.5 -0.1 1.9 1.4
Coronary Artery Disease (CAD) 0.7 0.9 0.9 -0.9 0.9 -1.0
Crohns Disease (2012) 0.5 0.9 1.2 -1.1 -0.7 -0.9
Mean Putamen Volume 0.1 0.1 0.2 -0.4 -0.4 -0.0
Fasting Glucose 0.3 0.4 0.8 0.1 0.5 0.9
HbA1C 0.5 0.5 0.9 0.9 0.7 0.5
HDL Cholesterol 1.6 2.7 5.6 -1.2 -2.4 -1.1
LDL Cholesterol 1.3 2.0 4.6 1.0 2.1 0.7
Lupus 3.2 4.8 8.4 -2.9 1.1 -2.1
Neuroticism (2016) 3.5 5.1 8.9 -2.5 0.2 -3.0
Primary Biliary Cirrhosis 0.1 0.1 0.2 -0.2 -0.3 0.5
Rheumatoid Arthritis 0.5 0.7 1.4 -1.2 -0.7 -0.5
Schizophrenia (2014) 3.8 8.4 10.8 -3.1 -2.2 -3.3
Triglycerides 2.1 3.4 4.0 1.7 2.0 1.8
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.6 0.3 0.4 0.8
Ulcerative Colitis 2.0 2.9 4.6 -2.1 -1.0 -1.8
Blood Eosinophil Count 0.5 3.9 5.8 1.7 2.4 1.7
Blood Platelet Count 1.0 11.3 23.2 -4.8 1.1 -3.0
Blood Red Count 0.7 6.8 13.0 1.2 3.6 2.4
Blood White Count 0.5 3.9 10.9 0.2 3.3 0.9
Heel T-Score 2.9 22.9 62.1 -7.9 2.0 1.6
BMI 1.2 6.7 12.5 -1.3 2.4 3.5
Height 0.8 16.3 37.8 0.2 -6.2 -3.3
Waist Hip Ratio (WHR) 0.3 1.3 2.0 -1.4 1.4 -0.2
Systolic Blood Pressure 0.6 3.1 8.1 0.2 -2.8 -1.1
Smoking Status 1.0 2.3 3.6 1.7 -1.9 0.7
Allergy or Eczema 0.7 1.9 5.2 -0.7 -0.2 -2.3
Cardiovascular Disease 0.5 1.5 2.1 -0.9 -1.2 1.5
Hypothyroidism (self reported) 0.3 0.6 1.0 -0.9 -1.0 0.4
Respiratory disease 0.8 1.8 3.4 -1.3 0.4 -1.8
Type 2 Diabetes (T2D) (2018) 0.4 0.7 1.0 -0.6 -0.9 1.0
Lung FEV1/FVC ratio 2.0 10.1 22.4 -4.7 1.2 -2.5
Lung FVC 0.2 1.2 3.1 -0.2 -0.7 -1.8
Neuroticism 7.5 18.1 25.4 -5.0 -2.0 -5.0
Chronotype (morning person) 2.4 5.5 11.2 -3.3 -0.9 -2.1
Hair Pigment 0.0 1.1 3.1 1.8 -0.5 -0.2
Tanning 0.2 2.1 3.1 -1.0 -1.8 -1.5
Hand grip strength (left) 1.7 4.4 7.9 2.1 1.0 2.8
Number of treatments/medications taken 2.2 3.9 6.1 -1.9 -1.4 -2.5
Average weekly spirits intake 0.3 0.4 1.0 -0.1 -0.5 1.0
Sensitivity / hurt feelings 4.1 7.1 10.6 -1.4 -3.3 -3.0
Frequency of depressed mood in last 2 weeks 14.4 20.2 27.5 -5.1 -2.7 -5.2
Hearing difficulty/problems: Yes 6.3 9.6 19.2 -4.4 -2.5 -1.8
Relative age of first facial hair 1.1 2.3 5.4 -0.3 -1.1 -2.3
Other serious medical condition/disability diagnosed by doctor 4.4 5.7 9.7 -3.1 -2.3 -1.5
Ever used hormone-replacement therapy (HRT) 3.7 4.7 5.6 -2.4 -1.7 -2.4
Ever had hysterectomy (womb removed) 0.4 0.5 0.9 -0.9 -0.6 0.5
Systolic blood pressure, automated reading 0.2 0.7 2.0 -0.3 -1.4 0.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.2 0.0 1.5 0.3
Angina 1.4 1.8 3.9 -0.9 -2.0 -0.9
Medication for hormone replacement therapy 1.8 2.0 2.7 -1.3 -1.2 -1.7
Vitamin and mineral supplements 0.9 1.2 1.9 -0.1 1.3 1.4
Supplements: Zinc 0.5 0.6 1.4 1.2 -0.6 -0.1
Medication: Co-codamol 5.1 5.8 11.2 -3.3 -1.2 -2.2
Medication: Metformin 0.6 0.8 2.1 -1.5 -0.4 -0.4
Diabetes (father) 0.8 1.0 1.4 -1.1 1.2 -0.6
Diabetes (mother) 0.5 0.6 1.1 -0.9 -1.0 -0.2
Severe depression (siblings) 2.0 2.3 3.7 -1.9 -1.4 -1.1
Pack years adult smoking proportion 2.0 3.1 5.2 -2.3 0.4 -2.0
Impedance of leg (right) 2.1 10.0 19.9 -2.0 2.4 -4.5
Leg fat-free mass (left) 0.3 1.8 2.9 -0.1 -1.6 1.7
Trunk fat percentage 0.8 3.1 4.6 -1.7 2.1 1.3
Hand grip strength (right) 1.5 4.0 7.6 2.8 0.6 2.0
Townsend deprivation index at recruitment 5.0 7.1 10.9 -3.1 -0.7 -3.3
Current tobacco smoking 0.5 0.8 1.9 -0.1 -0.7 -1.4
Average weekly fortified wine intake 0.9 1.1 1.6 0.5 1.3 1.1
Maternal smoking around birth 1.2 1.8 2.1 1.3 1.4 1.3
Fed-up feelings 4.5 8.2 12.7 -3.6 0.3 -3.4
Frequency of unenthusiasm / disinterest in last 2 weeks 8.1 10.8 18.4 -3.7 -0.4 -4.3
Relative age voice broke 1.4 2.2 5.1 -0.6 -1.0 -2.3
Taking other prescription medications 2.1 3.3 3.7 -1.9 -1.9 -1.6
Age when periods started (menarche) 1.9 4.5 10.8 -1.4 -0.8 -3.3
Bilateral oophorectomy (both ovaries removed) 1.1 1.2 2.8 -1.7 -0.9 0.0
Heel bone mineral density (BMD) T-score, automated (left) 2.3 5.3 11.2 -3.4 2.0 0.9
Tinnitus: Yes, but not now, but have in the past 2.3 2.4 4.7 -1.6 0.4 -2.2
Qualifications: CSEs or equivalent 0.6 0.8 1.7 -0.8 1.3 -0.1
Serious illness, injury or assault to yourself 2.8 3.4 4.7 -1.8 -1.5 -2.2
High blood pressure 0.6 1.6 2.6 -1.6 -0.8 1.2
Hayfever, allergic rhinitis or eczema 0.9 2.0 5.7 -0.2 0.3 -2.4
Multivitamins +/- minerals 0.7 0.8 2.4 0.3 -0.1 -1.5
Stomach or abdominal pain in last month 4.5 5.6 15.8 -0.3 1.0 -4.0
Supplements: Glucosamine 0.3 0.4 0.5 0.7 -0.4 -0.7
Diverticular disease/diverticulitis (self-reported) 1.7 2.0 2.9 -1.7 1.2 -1.3
Medication: Atenolol 0.9 1.1 2.9 -0.1 -0.5 1.7
Medication: Levothyroxine sodium 1.4 2.4 5.4 -2.3 -0.8 -1.0
Sitting height 0.7 4.7 5.8 -1.8 -2.2 -2.4
Chronic bronchitis/emphysema (father) 3.2 3.8 5.6 -1.9 -1.4 -2.4
High blood pressure (mother) 1.0 1.4 2.8 -0.9 0.8 -1.7
Body mass index (BMI) 1.2 5.0 7.2 -2.1 1.9 2.7
Impedance of leg (left) 2.1 10.2 21.0 -2.2 2.2 -4.6
Leg predicted mass (left) 0.3 1.7 2.6 -0.2 -1.5 1.6
Trunk fat mass 0.5 2.3 3.2 -1.8 1.4 1.4
Waist circumference 1.2 4.4 5.5 -1.9 2.0 2.3
Number of incorrect matches in round 1.2 1.9 3.8 -1.4 -0.3 -1.9
Past tobacco smoking 1.2 2.3 3.0 -1.7 1.1 -1.6
Alcohol usually taken with meals 1.0 1.7 3.8 1.1 -1.9 0.4
Nervous feelings 2.8 5.2 7.9 -1.6 -2.8 -2.3
Frequency of tenseness / restlessness in last 2 weeks 6.3 9.9 23.1 -2.3 -1.1 -4.8
Hearing difficulty/problems with background noise 2.7 4.3 7.6 -2.8 -2.3 -0.5
Hair/balding pattern: Pattern 2 1.0 1.3 1.7 1.3 -1.3 -0.7
Had menopause 0.3 0.3 0.9 0.0 0.9 0.3
Had other major operations 5.0 6.1 12.4 -2.2 -1.1 -3.5
Forced vital capacity (FVC) 0.7 2.8 4.5 1.3 -1.5 -2.1
Heel bone mineral density (BMD) T-score, automated (right) 2.0 4.7 13.0 -3.6 0.9 0.4
Ever unenthusiastic/disinterested for a whole week 5.1 6.2 8.7 -2.6 -1.8 -2.9
Qualifications: None of the above 5.3 11.3 22.3 -4.7 -0.5 -3.4
Financial difficulties in last 2 years 4.2 5.6 11.8 -3.4 0.5 -2.2
Mouth/teeth dental problems 2.5 3.9 6.2 1.5 1.8 2.5
Heart attack 1.3 1.7 4.9 0.1 -2.2 -0.4
Allergy 0.8 1.9 4.1 -0.0 -1.3 2.0
Pain all over the body in last month 4.4 4.7 8.7 -2.3 0.0 -3.0
Diabetes (self-reported) 0.9 1.4 2.2 -1.2 -1.5 -0.8
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 4.7 -0.7 -0.9 -2.2
Medication: Ramipril 0.8 1.0 2.6 0.5 -1.6 0.4
Medication: Simvastatin 0.5 0.7 1.6 0.8 0.1 1.3
Fluid intelligence score 1.7 3.5 8.6 2.9 0.4 1.4
Illnesses of siblings 0.5 0.7 1.5 1.2 0.8 -0.1
Neuroticism score 8.5 17.7 30.2 -4.5 -1.6 -5.5
Weight 0.3 1.5 2.9 -1.7 0.3 1.2
Impedance of arm (right) 1.1 5.1 14.9 3.9 0.6 -0.1
Arm fat percentage (right) 1.3 5.0 9.0 -0.8 2.3 3.0
Trunk fat-free mass 0.4 2.4 4.7 -1.5 -2.2 -0.2
Hip circumference 0.4 1.9 4.5 -0.6 0.9 2.1
Time employed in main current job 2.4 2.8 4.7 2.2 1.7 0.9
Alcohol intake versus 10 years previously 0.9 1.4 2.2 -1.4 1.5 -0.3
Father’s age at death 2.5 3.3 6.6 1.2 2.6 1.4
Worrier / anxious feelings 4.3 8.1 15.1 -2.2 -2.1 -3.9
Frequency of tiredness / lethargy in last 2 weeks 6.3 10.2 18.1 -3.1 -1.7 -4.3
Falls in the last year 3.9 5.3 10.6 -2.3 -0.6 -3.2
Hair/balding pattern: Pattern 3 0.8 1.2 2.5 1.6 -0.2 1.0
Number of live births 2.1 3.0 7.6 -2.8 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1) 0.9 2.9 6.3 0.1 -1.5 -2.5
Pulse rate 0.6 1.1 2.4 -0.8 -1.6 0.3
Happiness 1.2 1.4 3.8 -0.7 0.2 -2.0
Noisy workplace 4.3 5.3 11.6 -3.4 1.5 -1.5
Qualifications: A levels/AS levels or equivalent 4.5 10.0 19.5 4.4 -0.6 3.2
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 1.0 0.4 -1.0 -0.3
Mouth/teeth dental problems: Dentures 1.2 2.0 4.7 0.2 -1.2 -2.2
Asthma 0.7 1.5 3.7 -0.3 0.8 -1.9
Medication: Ibuprofen (e.g. Nurofen) 4.2 5.3 10.4 -2.2 -1.0 -3.2
Medication: Cholesterol lowering 0.3 0.4 1.2 -1.1 -0.2 0.4
Depression (self-reported) 0.7 0.9 1.4 -0.2 -1.0 -1.2
Medication: Lansoprazole 0.3 0.3 0.5 0.7 0.3 0.7
Prospective memory result 1.2 1.5 2.2 -1.4 -1.5 0.6
Lung cancer (father) 0.0 0.1 0.1 -0.1 -0.2 0.3
Illnesses of mother 0.5 0.6 0.9 -0.5 -0.9 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 1.7 5.3 13.9 -0.9 -1.2 -3.7
Pulse wave Arterial Stiffness index 0.9 1.0 2.8 0.4 -1.7 -0.2
Impedance of arm (left) 0.9 4.3 12.8 3.6 -0.2 -0.3
Arm fat mass (right) 0.8 3.1 4.5 -1.7 1.4 2.1
Trunk predicted mass 0.4 2.3 4.7 -1.5 -2.2 -0.2
Standing height 0.6 6.4 10.8 0.5 -3.3 -2.8
Length of working week for main job 0.5 0.5 1.2 0.7 1.1 0.1
Exposure to tobacco smoke at home 2.3 2.6 4.6 -0.9 -1.6 -2.1
Breastfed as a baby 0.8 1.0 2.6 -0.7 -1.6 0.2
Tense / ‘highly strung’ 9.0 14.8 28.6 -3.2 -2.4 -5.3
Seen doctor (GP) for nerves, anxiety, tension or depression 2.0 3.0 5.2 -1.4 -1.4 -2.3
Hair/balding pattern: Pattern 4 1.4 3.4 7.3 -1.2 2.7 -1.1
Birth weight of first child 0.8 1.4 3.4 1.8 -0.7 0.7
Peak expiratory flow (PEF) 0.2 0.5 1.0 0.3 -0.7 -1.0
Pulse wave reflection index 0.1 0.1 0.2 -0.1 -0.4 0.4
Ever highly irritable/argumentative for 2 days 3.8 4.6 10.4 -1.8 -0.2 -3.2
Loud music exposure frequency 0.9 1.0 2.1 -0.8 0.4 -1.4
Qualifications: O levels/GCSEs or equivalent 3.1 4.9 10.2 3.2 -1.0 1.8
Mouth/teeth dental problems: Bleeding gums 2.5 3.3 4.5 -2.0 1.1 -2.1
Blood clot in the leg (DVT) 0.7 0.9 2.1 -0.1 1.4 0.7
Medication: Paracetamol 5.3 8.8 15.2 -3.3 0.7 -3.9
Headache pain in last month 3.5 6.0 11.4 -2.3 -1.2 -3.4
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 1.8 1.3 -0.5 -1.2
Glaucoma (self-reported) 2.4 2.8 6.4 0.4 2.5 1.4
Gout (self-reported) 2.0 2.8 7.5 2.7 0.1 0.9
Hypothyroidism/myxoedema (self-reported) 1.7 3.3 6.9 -2.6 -1.1 -1.4
Medication: Amlodipine 1.0 1.4 1.8 -1.3 -0.9 -1.3
Medication: Ventolin 100micrograms inhaler 1.2 1.6 3.3 1.1 1.8 0.5
Birth weight 0.3 0.6 1.5 1.2 0.2 0.4
Chronic bronchitis/emphysema (mother) 1.2 1.5 2.5 1.6 -0.1 1.4
High blood pressure (siblings) 0.3 0.4 1.0 -1.0 -0.1 -0.4
Forced vital capacity (FVC), Best measure 1.1 3.9 8.7 0.5 -1.7 -2.9
Body fat percentage 1.1 4.2 5.7 -2.1 2.4 1.6
Leg fat percentage (right) 2.3 8.4 13.8 -3.3 3.7 0.7
Arm fat-free mass (right) 0.7 3.8 8.1 -2.8 -1.7 -0.6
Exposure to tobacco smoke outside home 0.3 0.4 1.0 -0.4 -0.4 -1.0
Comparative body size at age 10 11.4 31.5 53.3 5.4 3.5 7.3
Number of full brothers 3.3 4.2 8.4 -2.9 0.0 -2.0
Worry too long after embarrassment 1.5 2.5 4.7 -1.3 -1.1 -2.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.9 1.2 2.9 -0.7 -1.7 -0.2
Wheeze or whistling in the chest in last year 3.1 5.5 13.6 -1.4 -1.1 -3.7
Number of children fathered 0.2 0.3 0.7 -0.3 -0.0 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.5 0.5 0.5 0.7
Age at first live birth 2.2 3.9 6.4 2.5 -0.8 2.1
Pulse wave peak to peak time 0.5 0.6 1.6 -0.1 1.3 0.2
Health satisfaction 1.4 1.9 2.2 -1.3 -1.5 -1.2
Shortness of breath walking on level ground 0.8 0.9 2.3 -1.5 0.2 -0.7
Qualifications: College or University degree 3.2 10.2 17.9 4.2 -0.3 3.5
Eye problems/disorders: None of the above 0.8 0.9 2.0 1.4 0.5 0.6
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.1 0.4 -2.0 0.5
Emphysema/chronic bronchitis 0.5 0.6 0.6 0.8 0.8 0.8
Medication for pain relief, constipation, heartburn 4.4 7.6 12.1 2.6 1.9 3.5
Neck or shoulder pain in last month 3.8 5.4 8.1 -2.9 -1.2 -2.6
Medication: Blood pressure 0.7 1.2 2.4 -1.5 0.1 1.1
Angina (self-reported) 1.3 1.7 3.7 -0.8 -1.9 -0.9
Migraine (self-reported) 0.8 1.0 2.1 -0.8 1.4 -0.3
Medication: Ibuprofen 1.6 1.9 4.5 -1.0 -0.0 -2.1
Medication: Allopurinol 0.6 0.9 1.9 1.4 -0.6 0.6
Medication: Omeprazole 0.8 1.0 2.7 0.4 -1.6 -0.2
Medication: Seretide 50 evohaler 1.1 1.3 2.5 1.6 0.7 1.0
Mean time to correctly identify matches 0.5 0.9 1.9 -0.5 1.4 -0.8
Heart disease (mother) 0.6 0.7 2.0 0.1 0.1 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 0.1 0.2 -0.1
Whole body fat mass 0.7 2.8 4.3 -2.1 1.4 1.4
Leg fat mass (right) 1.2 4.7 8.1 -2.8 2.2 1.1
Arm predicted mass (right) 0.8 4.2 9.6 -3.1 -1.7 -0.3
Pulse rate, automated reading 0.2 0.6 1.8 0.2 -1.3 0.1
Alcohol intake frequency. 0.9 2.1 3.6 -1.9 0.1 -1.6
Comparative height size at age 10 0.9 4.9 8.6 2.9 -0.8 2.3
Number of full sisters 0.3 0.4 0.6 -0.8 -0.6 -0.3
Suffer from ‘nerves’ 1.2 2.0 4.0 -0.7 -1.2 -2.0
Overall health rating 6.9 14.9 26.0 -5.1 -0.8 -4.3
Chest pain or discomfort 0.3 0.4 0.6 -0.6 -0.3 -0.8
Had major operations 2.5 2.9 6.1 -1.6 -2.5 -0.2
Age at last live birth 0.8 1.2 1.7 1.3 -0.6 1.2
Family relationship satisfaction 1.1 1.4 2.6 -1.6 0.7 -1.0
Leg pain on walking 2.3 2.9 4.6 -2.1 -0.9 -1.8
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 1.1 -0.6 -0.3 1.1
Commuting to job workplace: Car/motor vehicle 0.8 0.9 2.7 -0.2 -0.2 1.6
Illness, injury, bereavement, stress in last 2 years 4.2 5.1 9.5 2.1 1.2 3.1
Medication: Aspirin 0.8 1.1 1.4 -1.2 -1.1 -0.8
Supplements: Vitamin C 0.6 0.7 1.6 -0.2 -1.3 -0.7
Knee pain experienced in last month 1.8 2.8 4.4 -1.6 -1.2 -2.1
Hypertension (Self-reported) 0.8 2.3 3.3 -1.6 -1.0 1.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.6 3.1 8.2 1.0 -2.9 0.3
Illnesses of father: Heart disease 0.4 0.5 0.8 0.8 -0.3 0.9
Illnesses of siblings: Diabetes 2.5 3.1 7.9 -2.8 -0.7 -1.0
Smoking status: Previous 1.4 2.1 3.4 1.5 -0.8 1.8
Forced expiratory volume in 1-second (FEV1), predicted 0.7 1.5 2.3 -0.6 -1.3 -1.5
Whole body fat-free mass 0.3 1.9 4.1 -1.2 -2.0 0.5
Leg fat-free mass (right) 0.5 2.5 4.1 0.3 -2.0 1.8
Arm fat percentage (left) 1.1 4.3 8.8 -1.0 1.8 3.0
Average weekly red wine intake 0.5 0.7 1.2 0.5 -1.1 -0.8
Handedness (chirality/laterality): Left-handed 0.8 1.0 1.4 -1.1 0.7 1.2
Mood swings 6.5 11.8 18.3 -4.3 -0.5 -4.1
Loneliness, isolation 12.1 16.7 31.5 -5.6 -1.6 -4.0
Long-standing illness, disability or infirmity 5.1 7.9 12.6 -3.5 -1.4 -3.0
Ever had bowel cancer screening 0.7 0.9 1.8 -0.9 0.1 -1.3
Diabetes diagnosed by doctor 0.9 1.4 3.2 -1.0 -1.8 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 3.1 3.3 5.2 -1.8 -1.2 -2.3
Friendships satisfaction 1.6 2.0 5.6 -2.4 0.4 -0.5
Qualifications: nursing, teaching 2.2 3.4 5.1 2.2 1.7 1.5
Commuting to job workplace: Walk 1.2 1.2 1.8 1.1 1.3 -0.8
Eye problems/disorders: Cataract 0.8 0.9 1.4 -1.2 -1.1 -0.2
Mouth/teeth dental problems: Mouth ulcers 2.1 3.3 5.9 -0.7 -2.4 -1.9
Medication for cholesterol 1.5 2.3 5.6 1.1 2.4 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 3.9 -0.9 -1.2 -2.0
Back pain experienced in last month 2.4 3.5 7.9 -1.7 -0.0 -2.8
Mineral and other dietary supplements 0.2 0.3 0.7 -0.9 -0.1 0.4
Breast cancer (self-reported) 0.7 0.8 1.3 -1.1 0.0 -1.1
Asthma (self-reported) 0.6 1.2 3.0 -0.2 0.8 -1.7
Osteoporosis (self-reported) 0.9 1.1 1.7 -0.8 -1.3 -0.9
Osteoarthritis (self-reported) 3.6 4.7 8.6 -2.3 -0.4 -2.9
Medication: Aspirin 0.4 0.5 0.8 -0.9 -0.4 -0.6
Medication: Gliclazide 0.2 0.3 0.8 0.1 -0.9 -0.1
Illnesses of father: None of the above (group 1) 1.7 2.1 3.5 0.6 1.9 1.5
Smoking status: Current 0.6 1.0 1.7 -0.1 -1.1 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 1.1 0.7 1.0 -0.9
Whole body water mass 0.3 2.0 4.2 -1.1 -2.1 0.6
Leg predicted mass (right) 0.5 2.6 4.7 0.2 -2.2 1.7
Arm fat mass (left) 0.8 3.3 5.4 -1.8 1.1 2.3
Number of self-reported non-cancer illnesses 1.8 3.1 5.4 -2.3 -0.2 -2.0
Average weekly champagne plus white wine intake 1.6 2.2 3.6 1.3 -1.2 1.9
Miserableness 5.8 10.0 19.2 -2.7 -1.8 -4.4
Guilty feelings 4.5 6.8 12.5 -3.5 0.1 -2.8
Wears glasses or contact lenses 0.4 0.5 0.7 0.0 0.8 -0.8
Ever taken oral contraceptive pill 1.2 1.3 3.0 0.8 -1.7 -0.5
Hearing aid user 3.5 3.9 9.5 -1.3 -3.1 0.7
Mother’s age at death 0.2 0.3 0.4 -0.6 -0.4 -0.5
Financial situation satisfaction 2.1 2.6 3.9 -2.0 0.5 -1.9
Tinnitus: Yes, now most or all of the time 1.6 1.9 2.5 -1.0 -1.5 -1.6
Commuting to job workplace: Public transport 1.1 1.3 2.0 1.4 -0.7 1.2
Eye problems/disorders: Glaucoma 2.0 2.3 5.9 0.3 2.4 1.0
Medication: Blood pressure 1.0 2.0 4.0 -1.1 -2.0 0.8
Pain type(s) experienced in last month: Hip pain 5.6 7.1 11.4 -3.4 -0.0 -3.1
Supplements: Fish oil (including cod liver oil) 0.7 1.0 2.1 0.9 1.5 -0.1
High cholesterol (Self-reported) 0.3 0.5 0.9 0.8 -0.3 0.9
Medication: Bendroflumethiazide 0.6 0.8 2.4 -1.5 -0.4 0.2
Medication: Paracetamol 3.8 5.9 8.0 -2.0 2.4 -2.8
Medication: Lisinopril 0.6 0.8 1.8 -1.3 -0.8 0.2
Medication: Atorvastatin 0.5 0.6 1.7 0.3 -0.1 1.3
Illnesses of father: High blood pressure 1.0 1.2 2.3 -1.5 0.7 -0.9
Alcohol drinker status: Never 0.8 1.0 1.7 -1.1 -1.3 0.1
Ever smoked 0.5 0.8 2.0 -0.0 -1.4 -0.6
Basal metabolic rate 0.3 1.5 2.0 -1.4 -1.4 0.6
Leg fat percentage (left) 2.2 7.8 12.2 -3.2 3.5 0.9
Arm fat-free mass (left) 0.6 3.1 8.1 -2.8 -0.9 -0.5
Number of operations (self-reported) 8.3 12.3 14.4 -3.8 -3.0 -3.7
Average weekly beer plus cider intake 0.9 1.3 2.8 -1.7 0.2 -1.0
Irritability 3.3 5.6 8.7 -3.0 -0.2 -2.8
Risk taking 3.3 4.8 10.5 -3.2 -1.2 -1.5
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.0 0.1 1.4 -0.2
Fractured/broken bones in last 5 years 1.7 2.2 5.4 0.3 -2.3 -1.1
Age started oral contraceptive pill 2.0 2.5 3.0 1.7 1.3 1.6
Diastolic blood pressure, automated reading 0.3 1.0 2.8 -1.7 0.0 -0.3
Ever depressed for a whole week 5.1 6.3 9.4 -2.1 -3.1 -2.3
Unable to work because of sickness or disability 4.8 6.3 10.4 -3.2 -0.2 -2.9
Commuting to job workplace: Cycle 1.5 1.8 4.5 0.3 2.1 0.9
Myopia 0.5 0.7 1.6 1.3 0.5 0.3
Vascular/heart problems diagnosed by doctor 0.7 2.0 2.4 1.4 1.5 -1.2
Cholesterol lowering medication 1.6 2.3 4.2 1.6 -0.2 2.1
Medication: Omeprazole (e.g. Zanprol) 1.7 2.0 3.8 1.5 -1.9 0.2
Pain experienced in last month 5.5 9.1 16.9 3.2 0.6 4.1
Supplements: Calcium 0.8 0.8 1.2 1.1 -1.1 -0.4
Basal cell carcinoma (self-reported) 1.2 1.4 2.7 -1.2 -1.6 0.3
Heart attack/myocardial infarction (self-reported) 1.0 1.3 3.6 0.5 -1.9 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.0 1.3 2.3 0.3 1.5 1.2
Heart disease (siblings) 2.0 2.5 6.2 -0.1 -2.5 -1.1
Alcohol drinker status: Previous 1.3 1.4 3.4 -0.6 -0.8 -1.8
Pack years of smoking 1.4 2.1 3.8 -2.0 0.5 -1.5
Impedance of whole body 0.6 3.2 7.7 1.0 0.8 -2.8
Leg fat mass (left) 1.2 4.5 7.8 -2.8 2.1 1.2
Arm predicted mass (left) 0.6 3.3 8.4 -2.9 -1.1 -0.4