Best TWAS P=6.72e-12 · Best GWAS P=2.23e-11 conditioned to 0.442
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Pituitary | SYNGR1 | 0.38 | 0.30 | enet | 11 | 0.25 | 6.3e-07 | 5.1 | -5.1 | 3.0e-07 | -0.36 | 0.52 | 0.32 | FALSE |
| 2 | GTEx | Spleen | SYNGR1 | 0.36 | 0.41 | lasso | 2 | 0.36 | 3.4e-10 | 6.7 | 6.8 | 1.1e-11 | 1.00 | 0.00 | 1.00 | FALSE |
| 3 | GTEx | Testis | SYNGR1 | 0.39 | 0.30 | enet | 21 | 0.38 | 3.7e-18 | 6.7 | 5.8 | 7.4e-09 | 0.80 | 0.00 | 1.00 | FALSE |
| 4 | GTEx | Whole Blood | SYNGR1 | 0.15 | 0.09 | lasso | 5 | 0.09 | 5.4e-09 | 5.1 | 6.4 | 1.9e-10 | 0.77 | 0.05 | 0.95 | FALSE |
| 5 | NTR | Blood | SYNGR1 | 0.03 | 0.03 | enet | 6 | 0.03 | 1.0e-10 | 6.7 | 6.2 | 4.5e-10 | 0.95 | 0.00 | 1.00 | FALSE |
| 6 | YFS | Blood | SYNGR1 | 0.31 | 0.36 | bslmm | 371 | 0.38 | 3.9e-135 | 6.7 | 6.9 | 6.7e-12 | 0.94 | 0.00 | 1.00 | TRUE |
| 7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SYNGR1 | 0.09 | 0.05 | enet | 3 | 0.06 | 3.9e-04 | -5.8 | -6.0 | 1.7e-09 | -0.56 | 0.04 | 0.75 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SYNGR1 | 0.12 | 0.04 | lasso | 4 | 0.03 | 3.5e-04 | 5.1 | -5.6 | 2.4e-08 | -0.45 | 0.08 | 0.16 | FALSE |