Hub : Genes

SYNGR1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Aorta 0.1650 0.0610 6.8e-04 0.079 NA 0.084 NA 0.092 3.8e-05 NA 2.1e-05 NA 9.3e-06
2 GTEx Nerve Tibial 0.2605 0.0538 1.9e-14 0.182 NA 0.214 NA 0.211 6.1e-13 NA 3.6e-15 NA 5.8e-15
3 GTEx Pituitary 0.3830 0.1120 3.0e-04 0.303 NA 0.248 NA 0.126 2.4e-08 NA 6.4e-07 NA 4.7e-04
4 GTEx Spleen 0.3620 0.1150 1.8e-03 0.412 NA 0.040 NA 0.362 9.8e-12 NA 3.4e-02 NA 3.4e-10
5 GTEx Testis 0.3880 0.0700 3.8e-10 0.305 NA 0.384 NA 0.383 5.0e-14 NA 3.7e-18 NA 4.3e-18
6 GTEx Thyroid 0.1390 0.0440 3.4e-05 0.172 NA 0.149 NA 0.072 3.9e-13 NA 1.6e-11 NA 3.7e-06
7 GTEx Whole Blood 0.1520 0.0390 1.9e-07 0.085 NA 0.084 NA 0.094 2.8e-08 NA 3.6e-08 NA 5.4e-09
8 NTR Blood 0.0312 0.0103 1.7e-05 0.032 0.019 0.032 0.026 0.032 1.3e-10 4.6e-07 9.9e-11 5.7e-09 1.7e-10
9 YFS Blood 0.3059 0.0330 0.0e+00 0.365 0.366 0.384 0.384 0.382 1.0e-126 4.7e-127 5.2e-135 3.9e-135 3.1e-134
10 TCGA Kidney Renal Papillary Cell Carcinoma 0.0940 0.0520 1.9e-03 0.049 0.038 0.056 NA 0.045 9.0e-04 3.1e-03 3.9e-04 NA 1.3e-03
11 TCGA Prostate Adenocarcinoma 0.1157 0.0740 1.9e-03 0.040 0.029 0.025 NA 0.030 4.8e-05 5.1e-04 1.0e-03 NA 3.5e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 1.5 2.3 4.5 -1.3 -0.1 -1.9 1.7 1.4 -1.4 1.7 1.6 1.2 -2.1 -1.3
Bipolar Disorder or Schizophrenia 1.0 2.5 7.5 -1.0 1.9 -0.9 1.6 1.2 -1.1 1.7 1.5 1.7 -2.7 -1.0
Depressed Affect (Nagel 2018) 1.4 2.9 6.6 -1.7 0.9 -1.0 1.5 1.2 -1.9 2.1 1.3 2.1 -2.6 -1.6
Depression (Nagel 2018) 0.7 1.1 3.1 -0.5 1.0 -0.4 0.9 0.7 -0.6 1.8 0.8 1.6 -1.5 -0.5
Intelligence (Savage-Jansen 2018) 2.6 8.0 39.0 3.4 -6.2 2.1 1.8 1.9 3.0 1.8 2.6 0.7 2.3 1.1
Neuroticism (Nagel 2018) 1.7 3.9 6.2 -2.0 -0.7 -1.2 1.9 1.6 -2.3 2.5 1.8 2.3 -2.4 -2.1
Schizophrenia (2018) 0.6 1.2 6.4 -0.2 2.5 0.3 0.7 0.4 -0.3 0.8 0.6 1.1 -1.8 -0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.9 -1.0 0.9 -0.6 -0.0 -0.3 -1.0 0.1 -0.3 0.2 -0.9 -0.5
Worry (Nagel 2018) 1.2 2.5 5.5 -2.1 -0.4 -1.6 1.0 1.1 -2.3 1.5 0.7 1.3 -2.1 -2.1
Alzheimer’s Disease (in mother) 1.9 2.3 5.6 1.0 -1.5 -0.1 1.6 2.4 0.9 1.9 2.3 1.9 0.3 0.1
Alzheimer’s Disease (in father) 2.0 2.1 5.2 -2.3 1.5 -0.5 -1.0 -1.4 -2.2 0.4 -1.2 -0.2 -1.8 -1.6
Alzheimer’s Disease (including proxy) 0.8 1.1 2.7 -0.7 -0.3 -0.5 1.1 1.0 -0.7 1.5 1.3 1.6 -1.2 -1.0
Crohns Disease (2017) 8.8 19.4 64.3 -1.2 -3.3 -2.1 5.3 8.0 -1.4 4.1 6.4 5.8 -0.9 -2.9
Irritable Bowel Disease (IBD) 11.2 26.7 85.1 -1.9 -4.2 -2.5 6.1 9.2 -2.1 5.2 7.3 6.4 -1.8 -3.8
Ulcerative Colitis (UC) 6.3 11.9 37.0 -1.3 -2.9 -1.5 4.0 6.1 -1.5 3.8 4.8 4.0 -1.4 -2.6
Major Depression (MDD) 0.8 0.9 2.9 1.3 1.2 1.3 -0.2 -0.7 1.1 0.4 0.2 -0.1 0.7 1.7
Reaction Time 0.5 0.9 2.4 -1.4 1.4 -1.3 -0.2 0.4 -1.6 0.3 -0.4 0.0 -0.5 -1.3
Verbal and Numeric Reasoning (VNR) 2.7 6.6 24.3 3.5 -4.9 2.8 1.3 1.3 3.2 0.5 2.0 0.1 2.6 1.9
Breast Cancer 0.6 1.5 3.1 -1.3 1.6 -1.4 0.7 0.6 -1.3 1.6 0.6 1.2 -1.8 -1.1
Ovarian Cancer 2.1 2.8 7.7 0.3 -1.4 -0.3 2.3 1.9 0.2 2.8 2.3 2.4 -0.8 -0.3
Prostate Cancer 3.2 4.5 7.6 1.5 0.5 2.5 -2.5 -2.0 1.6 -2.8 -2.2 -2.3 2.2 2.3
Age at First Birth 0.2 0.3 0.7 -0.8 0.9 -0.6 -0.4 -0.7 -0.7 -0.2 -0.6 -0.6 -0.2 0.0
Bipolar Disorder (2011) 0.8 0.8 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 -2.3 -1.3
Body Mass Index (BMI) (2010) 4.0 5.4 10.3 -2.1 -1.3 -1.4 2.6 2.1 -2.1 3.2 2.3 2.9 -2.5 -2.5
Coronary Artery Disease (CAD) 1.0 1.3 2.5 -1.2 1.2 -1.0 -1.4 -1.5 -1.2 -0.2 -1.6 -1.2 -0.3 -0.7
Crohns Disease (2012) 2.7 4.4 18.8 0.5 -2.6 -0.2 2.1 4.3 0.3 1.3 3.1 2.3 0.9 -0.7
Mean Putamen Volume 0.4 0.5 1.1 -0.9 0.6 -0.9 -0.2 -0.5 -0.7 -0.7 -0.7 0.1 -1.1 -0.4
Fasting Glucose 2.9 3.5 7.6 -1.1 -0.4 -0.7 2.6 2.7 -1.2 2.7 2.2 2.4 -0.6 -1.3
HbA1C 1.3 1.4 5.6 -1.4 2.4 -1.3 0.1 -0.1 -1.5 1.0 0.2 0.8 -1.4 -0.8
HDL Cholesterol 6.4 10.7 18.0 2.6 0.7 3.0 -3.7 -3.7 2.7 -4.2 -3.6 -4.2 2.8 3.2
LDL Cholesterol 0.1 0.1 0.4 -0.1 0.5 -0.1 -0.1 0.1 -0.1 0.6 0.2 0.3 0.3 -0.2
Lupus 5.1 7.7 11.1 -3.1 0.1 -2.4 2.4 2.7 -3.0 3.3 2.3 3.3 -3.1 -3.2
Neuroticism (2016) 0.9 1.2 4.2 -0.9 1.5 -1.0 1.3 0.2 -1.1 0.6 0.9 1.3 -2.0 -0.2
Primary Biliary Cirrhosis 22.2 31.6 47.1 -4.6 -1.8 -5.1 6.8 5.8 -4.9 6.4 6.2 6.9 -6.0 -5.6
Rheumatoid Arthritis 13.6 18.8 34.5 -4.3 0.3 -4.6 4.7 3.3 -4.5 4.3 3.9 5.0 -5.9 -4.5
Schizophrenia (2014) 0.8 1.7 6.6 -1.0 2.3 -0.6 0.7 0.4 -1.1 0.9 0.5 1.1 -2.6 -0.9
Triglycerides 1.3 2.2 3.8 -1.3 -0.4 -1.1 1.7 1.1 -1.3 1.8 1.6 1.9 -1.5 -1.9
Type 2 Diabetes (T2D) (2012) 0.3 0.4 1.3 -0.6 -1.0 -1.2 0.1 -0.4 -0.7 0.2 0.2 0.3 -0.4 -0.6
Ulcerative Colitis 3.3 4.7 18.8 -0.1 -2.3 0.0 2.4 4.3 -0.2 2.2 3.2 2.5 0.5 -1.1
Blood Eosinophil Count 0.1 0.9 2.2 -0.7 0.0 -1.5 0.7 -0.2 -0.7 1.5 0.3 1.0 -1.4 -1.0
Blood Platelet Count 1.1 12.9 25.2 -2.0 -0.7 -3.1 4.5 3.8 -2.1 5.0 3.9 4.5 -4.4 -2.8
Blood Red Count 0.1 1.0 4.8 -0.1 1.1 -0.3 -1.1 -1.0 -0.3 -2.2 -1.5 -0.8 0.2 0.1
Blood White Count 1.0 7.4 17.1 -2.9 3.8 -4.1 1.4 0.6 -2.9 1.6 0.5 2.5 -4.1 -2.1
Heel T-Score 0.7 5.6 13.5 -3.7 2.8 -3.0 0.0 -0.0 -3.5 1.3 -0.6 1.5 -2.9 -2.5
BMI 0.8 4.6 14.0 0.6 -1.8 0.1 3.7 1.5 0.4 2.6 3.1 2.7 -2.5 -0.2
Height 0.9 16.6 74.3 0.1 -8.6 -1.5 4.8 3.5 -0.2 4.5 5.4 4.0 0.1 -2.3
Waist Hip Ratio (WHR) 1.6 7.2 27.6 -1.2 5.2 0.2 -4.1 -2.7 -0.9 -2.3 -3.6 -2.5 0.8 0.9
Systolic Blood Pressure 0.9 4.5 13.3 -0.3 1.0 0.2 -2.7 -3.6 -0.0 -3.2 -2.9 -2.9 1.0 0.6
Smoking Status 0.3 0.7 1.3 1.2 0.2 0.5 0.9 0.4 1.0 0.6 1.2 0.9 -0.3 1.1
Allergy or Eczema 0.5 1.2 3.4 -1.0 -0.0 -0.2 -1.5 -1.3 -1.0 -0.4 -1.9 -1.6 -0.5 -1.0
Cardiovascular Disease 0.6 2.1 5.1 -0.5 0.3 0.1 -2.0 -1.8 -0.4 -2.3 -2.1 -2.2 0.9 0.2
Hypothyroidism (self reported) 7.4 16.9 25.2 -3.4 -1.4 -3.9 5.0 3.5 -3.6 5.0 4.3 4.7 -5.0 -4.1
Respiratory disease 0.1 0.2 2.2 -0.0 0.0 0.0 0.0 0.6 -0.1 1.5 0.1 0.1 -0.1 0.1
Type 2 Diabetes (T2D) (2018) 0.5 0.9 2.8 -1.2 -0.5 -0.5 0.1 1.2 -1.1 1.7 0.7 0.5 -0.4 -1.3
Lung FEV1/FVC ratio 0.7 3.6 7.0 -1.9 -2.2 -1.2 1.7 1.9 -1.9 1.9 2.2 1.7 -0.9 -2.6
Lung FVC 0.1 0.4 1.1 0.5 0.2 -0.8 -0.6 -0.5 0.5 -1.0 -0.9 -0.6 0.2 0.5
Neuroticism 2.5 6.0 11.5 -2.4 -0.7 -1.7 2.2 2.1 -2.8 3.4 2.2 2.6 -3.0 -2.8
Chronotype (morning person) 0.3 0.7 1.8 -0.5 -1.3 -0.2 1.0 1.2 -0.5 0.4 0.8 0.8 -0.6 -1.2
Hair Pigment 1.3 35.9 65.6 3.4 4.7 3.9 -7.8 -5.3 3.8 -8.1 -7.4 -7.4 6.1 5.4
Tanning 2.0 25.0 40.4 -5.6 0.2 -5.8 4.6 3.6 -5.8 5.0 3.8 5.4 -6.4 -5.8
Hand grip strength (left) 0.9 2.4 9.2 -0.5 -3.0 -0.7 1.5 1.9 -0.5 1.7 1.8 1.5 0.3 -1.3
Number of treatments/medications taken 0.7 1.3 6.9 0.5 2.6 0.7 -0.6 -0.9 0.6 -1.3 -0.9 -0.6 -0.7 1.3
Average weekly spirits intake 0.5 0.7 1.2 -0.7 -0.0 -0.4 0.7 1.1 -0.7 0.9 0.8 0.9 -0.9 -1.0
Sensitivity / hurt feelings 0.4 0.7 1.6 -1.2 0.5 -0.3 -0.8 -0.7 -1.3 0.7 -0.7 -0.2 -1.0 -1.0
Frequency of depressed mood in last 2 weeks 0.5 0.7 3.9 0.3 2.0 0.4 -0.6 -1.0 0.2 -0.2 -0.9 -0.2 -0.9 0.6
Hearing difficulty/problems: Yes 0.3 0.5 1.0 -0.8 -0.4 -0.2 1.0 0.8 -0.8 0.5 0.7 0.9 -0.8 -0.6
Relative age of first facial hair 0.1 0.1 0.3 -0.5 -0.4 -0.2 -0.3 -0.1 -0.5 0.2 -0.2 0.0 0.3 -0.5
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.3 0.7 -0.4 0.3 1.5 1.3 0.7 0.9 1.4 0.9 -0.5 0.2
Ever used hormone-replacement therapy (HRT) 0.4 0.6 2.3 0.2 -0.0 0.6 1.0 1.5 0.2 0.3 1.1 0.9 -0.5 -0.3
Ever had hysterectomy (womb removed) 0.4 0.4 1.0 1.0 0.3 0.7 0.5 0.7 0.9 0.3 0.8 -0.0 0.5 0.8
Systolic blood pressure, automated reading 0.2 0.6 2.1 0.4 0.2 0.1 -0.6 -1.4 0.5 -0.8 -0.8 -0.9 0.7 1.0
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.6 0.9 -0.4 0.6 -1.3 -0.8 0.9 -0.3 -0.7 -1.2 1.1 1.0
Angina 0.8 1.1 2.4 -1.1 -0.5 -1.2 0.3 1.6 -1.2 1.5 0.7 0.7 -0.5 -1.1
Medication for hormone replacement therapy 2.5 2.8 4.6 -1.5 2.0 -2.1 1.3 1.0 -1.4 1.9 1.0 2.0 -2.2 -1.3
Vitamin and mineral supplements 1.1 1.5 3.0 0.8 0.7 0.8 -1.2 -1.1 0.7 -1.7 -1.4 -1.5 1.7 1.3
Supplements: Zinc 0.2 0.2 0.6 0.2 -0.7 0.1 0.5 -0.1 0.1 0.5 0.5 0.5 0.0 -0.8
Medication: Co-codamol 0.3 0.3 0.7 0.5 0.8 0.3 0.6 0.8 0.4 0.0 0.7 0.6 0.1 0.4
Medication: Metformin 0.4 0.6 1.9 0.4 -0.1 0.8 -1.4 -0.7 0.4 0.1 -0.7 -0.8 1.4 0.4
Diabetes (father) 0.3 0.4 1.1 -1.1 0.2 -0.8 -0.2 0.6 -1.1 0.5 -0.2 0.2 -0.6 -0.8
Diabetes (mother) 1.9 2.4 4.4 0.6 2.0 0.6 -1.7 -2.1 0.6 -2.1 -2.1 -1.9 0.7 1.1
Severe depression (siblings) 0.4 0.4 2.4 -0.3 -0.2 -0.3 0.2 1.5 -0.4 0.5 0.3 0.6 -0.9 -0.5
Pack years adult smoking proportion 0.4 0.6 1.3 1.1 0.3 0.9 -0.7 -1.0 1.1 -0.6 -0.3 -0.5 0.9 0.6
Impedance of leg (right) 1.1 5.5 9.2 -3.0 2.6 -2.3 -2.8 -1.6 -2.9 -1.3 -2.9 -1.7 -1.1 -2.4
Leg fat-free mass (left) 1.9 9.9 26.2 1.7 -5.1 0.5 4.8 3.1 1.3 3.3 4.8 3.3 -0.5 -0.2
Trunk fat percentage 1.8 7.0 14.8 -1.0 -1.4 -1.3 3.8 2.3 -1.2 3.6 3.3 3.2 -3.7 -2.0
Hand grip strength (right) 1.3 3.6 8.8 -1.0 -3.0 -1.0 2.0 2.4 -1.1 2.2 2.2 2.1 0.1 -1.8
Townsend deprivation index at recruitment 0.6 0.9 2.1 1.5 0.9 0.7 -0.0 -1.1 1.4 -1.2 -0.1 -0.0 0.4 1.1
Current tobacco smoking 0.5 0.9 2.4 1.5 1.2 0.9 0.6 0.3 1.5 -0.3 0.8 0.7 0.3 1.1
Average weekly fortified wine intake 1.2 1.4 4.5 1.4 -0.3 1.1 -1.0 -0.1 1.4 -0.8 -0.5 -1.3 2.1 1.4
Maternal smoking around birth 0.2 0.2 1.8 0.1 1.3 -0.1 -0.4 0.1 0.2 -0.5 -0.3 -0.1 0.6 0.2
Fed-up feelings 0.7 1.2 4.3 -0.8 2.1 -0.1 -0.9 -1.6 -0.9 -0.3 -1.2 -0.4 -1.5 -0.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 3.2 -1.2 0.4 -1.5 1.0 0.5 -1.2 1.4 0.7 1.6 -1.8 -1.2
Relative age voice broke 0.3 0.4 2.4 -0.1 -1.6 -0.2 -0.6 -0.3 0.0 0.3 -0.4 -0.3 1.0 -0.5
Taking other prescription medications 1.6 2.5 4.6 -0.9 0.5 -1.3 2.1 1.7 -1.1 2.2 1.7 2.2 -2.0 -0.9
Age when periods started (menarche) 0.7 1.6 4.0 -1.7 1.5 -2.0 0.5 -0.1 -1.7 0.3 0.2 0.9 -1.9 -1.1
Bilateral oophorectomy (both ovaries removed) 1.5 1.8 4.3 2.1 0.4 1.8 0.8 1.1 2.0 -0.3 1.1 0.2 0.9 1.9
Heel bone mineral density (BMD) T-score, automated (left) 1.5 3.3 7.9 -2.4 0.8 -2.3 1.2 1.2 -2.3 1.2 0.8 1.5 -2.8 -2.2
Tinnitus: Yes, but not now, but have in the past 0.6 0.6 2.1 -0.2 1.4 -0.3 -0.3 -1.4 -0.1 -0.9 -0.9 0.0 -0.9 0.4
Qualifications: CSEs or equivalent 0.3 0.4 1.4 0.8 0.6 1.2 -0.1 -0.5 0.7 -0.4 0.0 -0.3 0.5 0.7
Serious illness, injury or assault to yourself 0.3 0.4 3.5 -0.3 0.5 -1.9 0.0 -0.5 -0.2 0.1 -0.1 0.2 0.1 0.1
High blood pressure 0.3 0.9 2.2 -0.3 0.7 -0.7 -1.1 -1.5 -0.4 -1.5 -1.2 -1.2 0.2 0.1
Hayfever, allergic rhinitis or eczema 0.6 1.4 3.9 -0.7 0.4 0.2 -1.6 -1.8 -0.8 -1.0 -2.0 -1.7 -0.0 -0.7
Multivitamins +/- minerals 1.3 1.7 4.1 -1.1 -0.8 -0.6 1.0 0.8 -1.0 1.8 1.2 1.5 -2.0 -1.8
Stomach or abdominal pain in last month 0.3 0.3 1.1 0.3 -1.1 0.2 -0.4 -0.2 0.3 -0.8 -0.6 -0.7 0.9 0.0
Supplements: Glucosamine 0.5 0.6 2.0 -0.7 0.9 -0.3 0.4 0.7 -0.4 1.4 0.7 1.0 -0.5 -0.8
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 0.4 -0.2 0.6 -0.4 -0.6 -0.4 -0.1 0.6 -0.5 -0.5 0.2 0.3
Medication: Atenolol 1.1 1.4 3.8 -1.9 0.4 -1.6 0.3 0.3 -1.9 0.6 -0.0 0.5 -1.5 -1.5
Medication: Levothyroxine sodium 4.7 8.0 17.4 -1.7 -1.6 -2.2 4.2 3.2 -1.8 3.1 3.6 3.4 -2.7 -2.3
Sitting height 0.9 6.4 21.2 -1.1 -4.6 -1.8 3.1 2.0 -1.4 2.4 3.0 2.5 -1.3 -2.6
Chronic bronchitis/emphysema (father) 0.4 0.5 1.1 -0.1 0.7 -0.3 1.1 0.9 -0.2 0.5 0.9 1.1 -0.9 -0.4
High blood pressure (mother) 0.9 1.2 3.7 0.8 1.9 1.1 -1.1 -1.3 0.9 -0.9 -0.9 -0.8 0.7 1.1
Body mass index (BMI) 1.3 5.4 14.7 0.6 -1.8 -0.1 3.8 2.4 0.3 3.1 3.5 2.8 -2.3 -0.4
Impedance of leg (left) 1.2 5.9 10.3 -3.2 2.7 -2.7 -2.9 -1.6 -3.1 -1.0 -2.9 -1.5 -1.1 -2.6
Leg predicted mass (left) 1.9 10.0 26.8 1.7 -5.2 0.5 4.8 3.0 1.4 3.3 4.9 3.3 -0.5 -0.2
Trunk fat mass 2.2 9.5 21.4 -0.8 -2.5 -1.4 4.6 2.9 -1.1 4.2 4.2 3.8 -3.5 -2.1
Waist circumference 1.0 3.6 8.8 -0.3 -0.5 -0.9 3.0 1.4 -0.5 2.9 2.7 2.4 -2.5 -0.7
Number of incorrect matches in round 2.3 3.9 7.8 -2.6 1.6 -2.8 0.8 0.8 -2.7 1.6 0.4 1.6 -2.8 -1.9
Past tobacco smoking 0.1 0.3 0.6 -0.4 0.3 -0.5 -0.6 -0.5 -0.4 -0.7 -0.8 -0.4 0.0 -0.5
Alcohol usually taken with meals 0.8 1.3 3.6 1.5 0.0 1.6 0.1 0.4 1.7 -0.9 0.1 -0.6 1.4 1.9
Nervous feelings 1.5 2.7 6.9 -2.6 1.0 -2.4 -0.1 -0.1 -2.6 0.9 -0.5 0.6 -2.2 -1.9
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.5 -1.0 0.2 -0.8 0.5 -0.2 -1.0 0.9 0.4 1.1 -1.9 -1.2
Hearing difficulty/problems with background noise 0.7 1.1 2.8 -0.6 0.1 -0.7 1.3 1.4 -0.7 1.3 1.2 1.7 -0.8 -0.8
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 0.4 0.5 0.1 -0.3 -0.4 0.5 -0.8 -0.6 -0.9 0.4 0.5
Had menopause 0.7 0.8 2.6 1.6 -0.5 1.3 0.1 0.3 1.5 0.4 0.6 0.0 0.5 1.1
Had other major operations 2.8 3.4 6.9 0.9 2.5 1.2 -2.2 -2.6 1.0 -1.7 -2.1 -2.0 1.4 1.9
Forced vital capacity (FVC) 0.4 1.6 8.3 -0.6 -2.9 -1.6 1.2 0.8 -0.7 0.7 1.0 0.8 -0.5 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 2.3 5.2 10.6 -2.5 -0.1 -2.8 2.1 1.8 -2.5 2.2 1.7 2.4 -3.2 -2.4
Ever unenthusiastic/disinterested for a whole week 0.6 0.8 2.2 1.5 0.9 0.8 -0.2 0.3 1.4 -0.5 0.0 0.1 0.7 1.3
Qualifications: None of the above 0.9 1.8 8.1 -0.2 2.9 0.6 -1.7 -1.5 -0.2 -1.2 -1.9 -1.2 -0.5 0.4
Financial difficulties in last 2 years 2.4 3.3 7.4 -2.4 2.1 -1.9 0.0 -2.1 -2.4 0.5 -1.0 0.1 -2.7 -1.8
Mouth/teeth dental problems 0.6 1.0 2.2 -1.5 0.7 -0.7 -0.5 -0.4 -1.5 -0.4 -1.0 -0.6 -1.2 -1.4
Heart attack 2.1 2.6 5.4 -2.1 -0.0 -2.3 0.9 1.1 -2.1 1.6 0.9 1.4 -1.6 -2.3
Allergy 0.3 0.7 2.1 0.3 -0.6 -0.7 1.5 1.0 0.3 0.2 1.4 1.3 -0.5 0.3
Pain all over the body in last month 0.7 0.8 1.9 0.7 1.4 0.5 -1.1 -0.2 0.7 -1.1 -0.8 -0.9 1.1 0.5
Diabetes (self-reported) 0.5 0.8 2.6 1.0 -0.3 1.2 -1.1 -0.1 1.0 0.5 -0.3 -0.7 1.6 0.9
Hayfever/allergic rhinitis (self-reported) 0.6 0.7 2.0 -1.3 -0.3 -0.7 -0.5 0.1 -1.4 -0.2 -0.9 -1.0 -0.8 -1.1
Medication: Ramipril 0.2 0.3 2.0 -0.3 1.4 -0.4 -0.6 -0.3 -0.2 0.0 -0.4 -0.1 -0.0 0.1
Medication: Simvastatin 2.2 3.3 8.4 0.0 1.4 0.3 -2.9 -2.4 -0.0 -1.9 -2.8 -2.5 1.5 0.8
Fluid intelligence score 3.2 6.6 23.6 3.5 -4.9 2.5 1.5 1.6 3.2 0.6 2.3 0.4 2.7 1.6
Illnesses of siblings 0.7 0.9 2.7 -1.6 0.3 0.2 -0.9 -0.4 -1.5 -0.3 -0.8 -0.6 -0.8 -1.6
Neuroticism score 0.8 1.6 3.5 -0.9 0.5 -0.8 1.1 0.7 -1.3 1.9 1.1 1.7 -1.8 -1.2
Weight 2.7 13.4 32.4 0.1 -4.5 -1.1 5.7 3.6 -0.3 4.6 5.4 4.4 -2.7 -1.7
Impedance of arm (right) 0.7 3.2 7.0 -1.4 2.2 -0.9 -2.2 -2.5 -1.2 -1.9 -2.6 -1.7 -1.0 -0.7
Arm fat percentage (right) 0.8 3.2 9.1 0.1 -1.0 -0.2 3.0 1.3 -0.1 2.3 2.4 2.0 -2.9 -0.7
Trunk fat-free mass 1.9 11.1 33.5 1.1 -5.8 -0.2 4.9 3.4 0.8 3.6 5.0 3.6 -0.2 -0.7
Hip circumference 2.5 10.8 26.6 0.2 -4.2 -1.1 5.2 3.1 -0.2 4.3 4.9 3.7 -2.4 -1.4
Time employed in main current job 0.2 0.2 1.0 0.1 0.5 -0.7 0.4 -0.4 0.1 0.1 0.1 0.4 -1.0 0.6
Alcohol intake versus 10 years previously 0.2 0.4 1.3 0.3 1.1 0.5 -0.5 -0.5 0.2 -1.0 -0.6 -0.2 -0.2 0.6
Father’s age at death 0.6 0.9 2.1 1.4 -1.1 1.4 0.2 0.4 1.3 -0.4 0.4 -0.1 0.8 1.2
Worrier / anxious feelings 0.5 0.9 2.6 -1.4 0.0 -0.5 -0.0 0.1 -1.6 0.7 -0.3 0.4 -1.5 -1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.5 2.2 -0.4 1.0 -0.6 -0.2 -0.8 -0.5 -0.5 -0.5 0.0 -1.5 -0.2
Falls in the last year 0.9 1.2 3.5 1.9 -0.1 1.1 0.9 0.5 1.8 0.6 1.1 0.9 -0.1 1.1
Hair/balding pattern: Pattern 3 0.6 0.8 2.5 -0.9 -0.9 -0.7 0.8 0.5 -1.0 0.6 0.6 0.7 -1.6 -1.2
Number of live births 0.7 1.0 2.3 -0.1 -0.1 -0.2 1.4 1.4 -0.3 1.4 1.5 1.5 -0.2 -0.2
Forced expiratory volume in 1-second (FEV1) 0.5 1.6 9.7 -0.5 -3.1 -1.3 1.1 0.7 -0.6 0.9 1.1 0.5 -0.1 -1.1
Pulse rate 0.2 0.4 2.4 0.3 1.6 -0.9 -0.2 -0.2 0.3 0.3 0.0 0.5 0.5 0.6
Happiness 0.4 0.5 1.5 -0.4 0.5 -0.5 1.1 0.3 -0.5 0.3 0.7 1.2 -1.0 -0.7
Noisy workplace 0.9 1.1 8.7 -0.4 3.0 -0.7 0.4 -0.6 -0.3 -0.1 0.2 0.5 -1.4 0.0
Qualifications: A levels/AS levels or equivalent 1.2 2.7 6.5 2.0 -2.2 1.7 -0.8 0.0 2.0 -1.8 -0.6 -1.3 2.5 1.4
Serious illness, injury or assault of a close relative in last 2 years 1.1 1.2 3.1 -0.1 0.8 -0.3 -1.5 -1.4 -0.1 -1.3 -1.8 -1.7 0.6 0.7
Mouth/teeth dental problems: Dentures 1.3 2.1 5.2 1.1 -1.1 -0.1 2.1 1.7 0.9 1.7 2.3 2.0 -0.4 0.7
Asthma 0.3 0.6 2.7 -0.3 -0.2 -0.0 0.6 1.4 -0.4 1.6 0.8 0.8 -0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.3 5.1 0.2 2.3 0.8 -0.9 -1.8 0.3 -1.4 -1.2 -0.6 0.0 0.8
Medication: Cholesterol lowering 0.7 1.1 2.6 0.3 -0.1 1.3 -1.6 -1.1 0.1 -0.8 -1.2 -1.5 1.3 0.4
Depression (self-reported) 0.2 0.3 1.3 -0.1 0.1 -0.4 0.6 0.4 -0.2 0.6 0.4 0.5 -1.1 -0.3
Medication: Lansoprazole 1.3 1.4 3.1 -0.2 1.7 -1.0 1.5 1.1 -0.4 0.9 1.3 1.8 -1.7 -0.3
Prospective memory result 1.0 1.2 4.2 -0.9 2.0 -0.7 -1.3 -1.4 -0.9 -0.5 -1.5 -0.7 -0.8 -0.5
Lung cancer (father) 0.4 0.4 2.1 0.7 -1.4 -0.2 0.2 0.8 0.4 0.6 0.5 -0.1 0.3 0.5
Illnesses of mother 0.8 1.0 3.5 -0.2 -1.9 0.1 1.1 1.1 -0.4 1.0 1.2 0.7 -1.0 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 7.0 -1.0 -2.6 -1.9 1.4 1.2 -1.1 1.5 1.5 1.2 -0.6 -1.6
Pulse wave Arterial Stiffness index 0.4 0.5 1.6 -0.3 -0.9 0.4 -0.3 0.8 -0.3 1.0 0.4 0.5 0.5 -1.3
Impedance of arm (left) 0.5 2.2 4.6 -1.4 1.9 -1.0 -1.7 -1.8 -1.2 -1.6 -2.2 -1.2 -0.9 -0.9
Arm fat mass (right) 1.5 6.3 16.4 0.4 -2.8 -0.2 4.0 2.4 0.2 3.3 3.7 2.8 -2.4 -0.9
Trunk predicted mass 2.0 11.5 34.1 1.1 -5.8 -0.2 4.9 3.5 0.8 3.7 5.1 3.7 -0.3 -0.8
Standing height 1.2 12.3 38.7 -1.2 -6.2 -2.3 4.4 2.9 -1.5 3.9 4.5 3.8 -1.1 -3.1
Length of working week for main job 0.8 0.9 2.5 0.8 -1.3 0.5 1.4 1.1 0.9 0.1 1.6 0.9 0.3 0.1
Exposure to tobacco smoke at home 0.7 0.8 1.6 1.1 -1.3 0.8 0.8 1.1 1.1 0.4 1.2 0.4 0.2 0.4
Breastfed as a baby 1.1 1.4 4.6 -1.6 0.0 -2.1 0.9 0.4 -1.5 0.8 0.4 1.1 -1.4 -1.2
Tense / ‘highly strung’ 0.1 0.1 0.4 -0.3 0.6 -0.1 -0.4 -0.1 -0.4 0.1 -0.4 0.0 -0.2 -0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.5 0.0 -0.7 0.7 -0.1 -0.1 -0.2 0.6 -0.0 0.2 -0.2 -0.1
Hair/balding pattern: Pattern 4 0.2 0.6 1.8 0.4 -0.4 0.2 -1.0 -0.5 0.6 -0.8 -0.8 -1.1 1.3 -0.0
Birth weight of first child 1.0 1.9 4.8 2.2 -1.8 1.8 0.2 0.4 2.1 -0.6 0.5 -0.5 1.4 1.4
Peak expiratory flow (PEF) 0.3 0.8 5.9 -0.6 -2.4 -0.8 0.5 -0.1 -0.6 0.3 0.5 -0.2 0.2 -0.8
Pulse wave reflection index 1.0 1.2 4.5 -1.6 -0.8 0.4 0.1 0.6 -1.5 1.4 0.2 0.5 -0.6 -2.1
Ever highly irritable/argumentative for 2 days 0.3 0.4 0.9 -0.3 0.1 0.2 0.5 1.0 -0.4 0.6 0.6 0.7 -0.9 -0.6
Loud music exposure frequency 0.2 0.2 0.6 0.7 0.5 0.4 0.2 -0.2 0.5 -0.5 0.0 -0.2 -0.5 0.8
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 2.5 0.5 -1.6 1.1 -0.4 -0.0 0.4 -0.5 -0.3 -0.6 1.6 0.3
Mouth/teeth dental problems: Bleeding gums 3.5 4.5 6.7 2.1 0.7 2.1 -2.3 -2.5 2.2 -1.8 -1.9 -2.3 2.3 2.6
Blood clot in the leg (DVT) 0.9 1.2 3.0 0.4 1.1 1.1 -1.7 -0.2 0.5 -1.0 -1.3 -1.3 1.5 0.9
Medication: Paracetamol 0.6 1.1 7.3 -0.4 2.7 -0.2 -0.4 -0.8 -0.4 -0.6 -0.7 -0.0 -1.5 0.5
Headache pain in last month 1.6 2.8 8.5 0.2 1.2 1.0 -1.9 -2.9 0.2 -2.5 -2.2 -1.8 1.3 0.9
Medication for cholesterol, blood pressure or diabetes 1.1 1.9 4.0 0.1 -0.7 -0.7 2.0 2.0 0.2 1.7 2.0 2.0 -1.0 -0.5
Glaucoma (self-reported) 0.2 0.2 0.8 -0.4 -0.8 -0.9 -0.3 -0.1 -0.4 -0.2 -0.6 -0.2 -0.2 -0.7
Gout (self-reported) 0.6 0.8 4.2 0.3 2.0 0.2 -0.8 -0.4 0.3 -1.1 -0.8 -0.6 -0.5 1.2
Hypothyroidism/myxoedema (self-reported) 7.6 14.9 26.7 -2.9 -0.6 -3.3 5.2 3.6 -3.1 4.6 4.4 4.9 -4.4 -3.2
Medication: Amlodipine 0.4 0.6 1.2 -0.5 1.0 -0.0 -1.0 -0.9 -0.6 -1.1 -1.0 -0.8 0.4 -0.2
Medication: Ventolin 100micrograms inhaler 1.5 1.9 6.2 -0.8 -1.0 -1.8 1.2 1.6 -1.0 2.5 1.4 1.1 -1.1 -0.7
Birth weight 0.7 1.5 6.4 0.6 -2.5 0.5 1.3 1.2 0.5 1.3 1.5 1.2 0.8 -0.3
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.9 -0.0 -1.0 -0.5 1.0 1.4 0.1 0.7 1.3 1.0 -0.6 -0.5
High blood pressure (siblings) 0.7 1.0 2.7 1.6 -0.4 0.8 0.0 -0.1 1.7 -0.8 0.2 -0.4 1.4 1.5
Forced vital capacity (FVC), Best measure 0.5 1.9 7.1 -0.8 -2.7 -1.6 1.3 1.3 -0.8 1.0 1.2 1.1 -0.4 -1.5
Body fat percentage 1.4 5.6 12.3 -0.7 -1.2 -1.1 3.5 2.1 -0.9 3.1 3.0 2.8 -3.4 -1.7
Leg fat percentage (right) 1.2 4.4 9.3 -0.9 -0.9 -1.1 2.9 2.1 -1.2 2.9 2.5 2.2 -3.1 -1.7
Arm fat-free mass (right) 2.1 10.6 24.6 0.8 -4.9 -0.5 4.7 3.7 0.5 3.9 5.0 3.7 -0.6 -0.9
Exposure to tobacco smoke outside home 0.3 0.5 0.9 0.9 0.6 0.1 0.6 0.7 0.8 0.5 0.8 0.7 -0.4 1.0
Comparative body size at age 10 1.2 3.2 9.0 3.0 -1.7 2.3 0.9 0.5 2.9 -0.5 1.1 0.2 1.6 2.2
Number of full brothers 0.5 0.6 1.4 1.2 -1.0 0.0 0.4 -0.2 1.1 -0.2 0.4 0.1 1.2 1.1
Worry too long after embarrassment 0.9 1.5 5.2 0.4 -2.3 0.0 1.2 1.5 0.2 1.7 1.6 1.1 0.5 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.1 0.1 0.3 0.2 -0.0 0.5 -0.1 0.4 -0.0 -0.6 -0.2 0.0 0.1 0.1
Wheeze or whistling in the chest in last year 0.1 0.2 0.5 0.6 -0.2 0.1 0.4 -0.1 0.5 0.7 0.5 0.5 -0.4 0.4
Number of children fathered 0.1 0.1 0.3 -0.4 0.3 -0.0 0.4 -0.2 -0.5 0.5 0.2 0.3 -0.0 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.4 -1.6 -0.8 -0.8 0.3 0.5 -1.6 1.2 0.4 0.7 -0.1 -2.1
Age at first live birth 0.1 0.2 0.4 -0.3 -0.5 0.3 -0.4 -0.4 -0.3 -0.6 -0.5 -0.4 -0.1 -0.4
Pulse wave peak to peak time 0.2 0.3 1.0 0.3 0.2 -0.5 0.5 -0.6 0.3 -0.8 -0.0 -0.2 -0.4 1.0
Health satisfaction 0.1 0.1 0.4 0.2 -0.1 0.4 0.6 -0.4 0.1 -0.1 0.4 0.4 -0.5 0.2
Shortness of breath walking on level ground 1.7 2.0 3.9 -0.5 -0.9 -1.3 1.8 1.4 -0.7 2.0 1.6 1.9 -1.6 -0.9
Qualifications: College or University degree 1.6 5.2 24.6 2.4 -5.0 1.7 1.6 2.2 2.5 -0.4 2.0 0.5 2.2 0.9
Eye problems/disorders: None of the above 1.7 1.9 3.7 -1.3 0.0 -0.6 1.9 1.0 -1.3 1.6 1.6 1.9 -1.2 -1.8
Mouth/teeth dental problems: Loose teeth 0.3 0.3 0.8 0.4 0.6 -0.1 -0.3 -0.9 0.5 -0.7 -0.6 -0.4 0.2 0.8
Emphysema/chronic bronchitis 0.2 0.3 0.6 0.4 0.4 0.4 0.6 -0.1 0.5 0.6 0.6 0.8 -0.2 0.3
Medication for pain relief, constipation, heartburn 1.2 2.0 9.6 0.7 -3.1 0.1 0.7 2.0 0.8 1.1 1.4 0.3 1.8 -0.7
Neck or shoulder pain in last month 2.2 3.1 7.7 -0.3 -0.6 -1.3 2.6 1.2 -0.4 2.1 2.5 2.8 -2.0 -1.0
Medication: Blood pressure 1.2 2.1 5.2 0.3 1.4 0.6 -1.7 -2.3 0.3 -2.0 -1.9 -1.9 0.8 1.0
Angina (self-reported) 1.0 1.3 2.8 -1.2 -0.7 -1.3 0.3 1.7 -1.3 1.6 0.8 0.8 -0.6 -1.3
Migraine (self-reported) 2.0 2.5 4.3 1.5 1.3 1.6 -1.5 -1.5 1.5 -2.1 -1.2 -1.6 1.6 1.9
Medication: Ibuprofen 0.5 0.6 2.4 0.0 1.5 0.6 -0.3 -1.2 0.2 -1.2 -0.7 -0.3 -0.4 0.3
Medication: Allopurinol 0.5 0.6 1.1 0.7 1.0 0.3 1.1 0.5 0.6 0.1 0.9 0.8 -1.1 1.0
Medication: Omeprazole 0.5 0.6 1.2 1.0 -0.5 1.0 0.2 0.8 1.1 -0.8 0.2 -0.1 1.1 1.0
Medication: Seretide 50 evohaler 0.4 0.5 1.5 1.2 0.2 0.7 -0.6 -0.1 1.2 -0.2 -0.5 -0.5 0.3 1.0
Mean time to correctly identify matches 0.2 0.5 1.3 -0.9 0.9 -0.7 0.3 0.6 -1.0 0.4 -0.0 0.4 -0.2 -1.1
Heart disease (mother) 0.6 0.7 1.4 1.1 -0.1 1.0 -0.2 0.2 1.2 -1.1 -0.3 -0.6 1.0 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.5 2.4 -0.2 1.6 0.1 -0.4 -0.8 -0.1 -0.9 -0.5 -0.3 0.3 0.8
Whole body fat mass 1.7 7.1 16.8 -0.3 -2.3 -0.9 4.1 2.4 -0.6 3.6 3.7 3.2 -3.0 -1.6
Leg fat mass (right) 1.5 5.7 13.2 -0.3 -2.2 -0.9 3.6 2.2 -0.6 3.3 3.3 2.7 -2.8 -1.5
Arm predicted mass (right) 2.4 12.3 28.4 0.6 -5.2 -0.6 5.1 4.1 0.2 4.1 5.3 4.1 -1.0 -1.3
Pulse rate, automated reading 0.3 1.1 3.4 0.8 0.3 -0.1 0.9 1.1 0.8 1.6 1.5 1.8 0.1 0.5
Alcohol intake frequency. 0.3 0.6 1.8 -0.6 0.4 -0.7 -0.7 -1.3 -0.8 -0.5 -1.0 -1.1 -0.7 -0.3
Comparative height size at age 10 1.4 7.7 17.4 0.0 -4.0 -0.8 3.8 3.1 -0.2 3.6 4.2 3.3 -1.5 -1.1
Number of full sisters 0.2 0.2 0.5 0.5 -0.1 -0.0 0.6 0.2 0.4 0.6 0.6 0.7 0.0 0.3
Suffer from ‘nerves’ 0.1 0.1 0.4 -0.3 0.3 0.1 0.1 -0.6 -0.5 -0.3 -0.1 0.2 -0.6 -0.1
Overall health rating 0.3 0.6 3.7 0.6 1.9 -0.6 -0.1 -0.7 0.4 -0.2 -0.1 0.0 -0.6 1.1
Chest pain or discomfort 1.6 2.3 9.8 1.9 -3.1 1.2 0.9 1.1 1.7 1.0 1.6 0.7 1.2 0.5
Had major operations 3.4 4.0 7.2 2.4 0.7 2.7 -1.3 -2.1 2.4 -1.5 -1.3 -1.8 2.2 2.4
Age at last live birth 0.4 0.6 1.1 -0.9 -0.1 -0.6 0.5 0.8 -1.0 0.9 0.6 1.0 -0.6 -0.8
Family relationship satisfaction 0.8 1.0 2.3 0.8 0.1 1.0 1.5 1.3 0.7 -0.5 1.4 1.3 -0.7 0.3
Leg pain on walking 0.2 0.2 0.7 0.4 0.6 0.6 -0.2 -0.8 0.3 -0.1 -0.1 0.2 0.8 0.1
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.3 -0.9 1.0 -1.1 0.9 0.5 -0.8 1.0 0.7 0.8 -1.1 -0.6
Commuting to job workplace: Car/motor vehicle 2.3 2.6 6.9 -0.4 -0.7 -0.3 2.3 1.9 -0.3 1.7 2.2 1.9 -2.6 -0.9
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 4.9 1.0 -2.2 1.4 0.7 1.9 1.0 0.4 1.3 0.5 1.1 0.1
Medication: Aspirin 1.2 1.6 3.4 0.6 1.7 0.7 -1.4 -1.9 0.6 -1.5 -1.5 -1.1 -0.4 1.3
Supplements: Vitamin C 0.1 0.1 0.3 0.2 0.1 0.4 -0.2 -0.6 0.3 -0.4 -0.2 -0.0 -0.5 -0.2
Knee pain experienced in last month 2.7 4.3 6.6 -2.4 0.2 -2.0 2.2 1.3 -2.4 1.7 1.8 2.5 -2.6 -2.4
Hypertension (Self-reported) 0.2 0.5 1.2 -0.3 0.9 -0.6 -0.7 -1.0 -0.3 -1.1 -0.9 -0.8 0.2 0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.8 0.7 0.7 0.8 0.2 -0.3 0.6 -1.3 -0.2 -0.2 -0.0 0.8
Illnesses of father: Heart disease 0.8 1.1 3.8 0.8 0.4 1.2 -1.4 -0.4 0.8 -1.0 -0.9 -1.1 2.0 0.8
Illnesses of siblings: Diabetes 3.5 4.3 9.3 3.0 -1.7 2.0 2.1 1.7 2.8 1.5 2.5 1.6 1.2 1.9
Smoking status: Previous 0.4 0.5 1.4 1.0 -0.4 1.2 0.1 0.1 1.0 0.6 0.4 -0.2 0.7 1.1
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.8 0.5 -1.3 0.4 0.2 -0.4 0.4 -0.1 0.3 -0.4 0.6 0.0
Whole body fat-free mass 2.0 11.5 31.3 1.4 -5.6 0.0 5.0 3.4 1.0 3.7 5.2 3.7 -0.4 -0.5
Leg fat-free mass (right) 1.9 10.2 27.5 1.7 -5.2 0.4 4.7 3.1 1.4 3.4 4.9 3.4 -0.4 -0.2
Arm fat percentage (left) 1.0 3.8 10.5 -0.1 -0.9 -0.4 3.2 1.6 -0.2 2.5 2.6 2.3 -2.9 -0.9
Average weekly red wine intake 0.1 0.2 1.3 -0.0 0.3 -0.2 0.2 0.7 0.2 -0.2 0.2 -0.2 1.1 0.4
Handedness (chirality/laterality): Left-handed 1.3 1.5 3.9 -1.7 -1.0 -0.4 0.9 0.6 -1.8 1.2 0.6 0.7 -1.5 -2.0
Mood swings 0.6 1.1 2.5 -1.2 1.1 -0.7 0.5 0.5 -1.4 0.9 0.5 0.9 -1.6 -1.2
Loneliness, isolation 0.7 0.9 4.7 -0.3 2.2 -1.1 0.5 -0.5 -0.3 0.3 0.1 1.1 -1.5 -0.0
Long-standing illness, disability or infirmity 0.2 0.3 0.7 0.3 -0.8 0.6 0.9 -0.0 0.1 0.0 0.7 0.6 -0.6 -0.3
Ever had bowel cancer screening 1.3 1.5 3.3 -0.4 -1.4 -0.9 1.6 1.8 -0.6 1.7 1.6 1.3 -0.4 -0.7
Diabetes diagnosed by doctor 0.3 0.5 1.1 0.8 0.1 1.0 -0.9 -0.1 0.8 0.4 -0.2 -0.6 1.0 0.9
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 2.4 -0.9 1.6 -0.9 0.5 0.4 -0.9 0.1 0.3 0.7 -0.9 -0.1
Friendships satisfaction 1.9 2.4 6.3 0.7 -2.2 0.4 2.5 1.8 0.6 0.9 2.3 2.1 -0.6 -0.4
Qualifications: nursing, teaching 0.4 0.6 1.9 -0.1 -1.1 -1.0 1.4 0.5 0.0 0.0 0.7 0.8 -0.7 -0.3
Commuting to job workplace: Walk 1.1 1.2 3.6 1.5 -1.4 0.7 -0.4 -0.5 1.5 -0.3 -0.2 -0.9 1.9 1.3
Eye problems/disorders: Cataract 0.7 0.8 2.6 0.9 1.0 -0.0 -1.0 -0.7 0.9 -0.6 -0.8 -0.7 0.5 1.6
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.9 1.0 -1.6 1.8 -0.5 0.8 1.0 -1.0 0.1 -0.4 2.0 0.6
Medication for cholesterol 0.8 1.2 6.3 1.0 -2.5 1.1 0.8 0.7 0.9 0.8 1.2 0.3 1.1 -0.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 1.6 -0.5 1.3 -0.8 0.1 -0.8 -0.6 0.4 -0.5 0.2 -1.1 -0.2
Back pain experienced in last month 0.5 0.7 2.3 0.5 -0.8 -0.1 1.5 0.7 0.4 0.6 1.4 0.9 -0.5 -0.1
Mineral and other dietary supplements 0.4 0.5 1.3 -0.3 -0.6 -0.2 -0.8 -0.7 -0.5 -1.1 -1.1 -1.1 0.3 -0.2
Breast cancer (self-reported) 0.6 0.7 2.6 0.5 -1.6 1.1 0.2 0.9 0.6 -0.3 0.5 -0.1 1.3 0.2
Asthma (self-reported) 0.2 0.4 1.9 -0.3 -0.2 -0.0 0.4 1.1 -0.4 1.4 0.5 0.5 -0.2 -0.4
Osteoporosis (self-reported) 2.0 2.5 5.9 1.0 -0.1 1.1 -1.9 -2.0 1.2 -2.0 -1.7 -2.4 1.4 0.9
Osteoarthritis (self-reported) 1.0 1.3 3.1 -0.6 0.4 -0.7 1.7 1.0 -0.6 0.8 1.3 1.7 -1.7 -0.8
Medication: Aspirin 0.8 1.1 2.8 0.0 1.7 -0.0 -1.2 -1.5 -0.0 -1.3 -1.4 -0.9 -0.8 0.7
Medication: Gliclazide 1.0 1.1 3.4 -0.2 -0.1 0.8 -1.8 -1.1 -0.1 -1.3 -1.6 -1.5 0.3 -0.4
Illnesses of father: None of the above (group 1) 0.6 0.7 2.1 -0.3 -1.5 -0.4 1.0 1.1 -0.2 0.8 1.1 0.7 -0.6 -0.8
Smoking status: Current 0.3 0.5 1.8 0.8 1.3 0.4 0.7 0.2 0.7 -0.1 0.7 0.9 -0.4 0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.2 3.4 -1.3 -0.3 -1.8 0.8 0.8 -1.4 1.2 0.8 1.0 -0.8 -1.2
Whole body water mass 2.0 11.6 31.6 1.3 -5.6 0.0 5.1 3.5 1.0 3.7 5.2 3.8 -0.5 -0.6
Leg predicted mass (right) 1.9 10.1 27.9 1.7 -5.3 0.3 4.7 3.0 1.4 3.4 4.9 3.4 -0.3 -0.2
Arm fat mass (left) 1.5 6.1 16.4 0.4 -2.6 -0.1 4.0 2.4 0.1 3.1 3.7 2.9 -2.4 -0.9
Number of self-reported non-cancer illnesses 0.1 0.3 0.7 0.3 0.5 0.4 0.8 0.6 0.2 0.6 0.6 0.7 -0.3 0.1
Average weekly champagne plus white wine intake 1.2 1.6 2.5 1.6 -1.2 1.5 -0.7 -0.3 1.6 -1.5 -0.5 -1.4 1.5 1.3
Miserableness 0.9 1.6 4.0 -0.8 0.6 -0.4 1.6 1.0 -1.0 1.4 1.4 1.9 -2.0 -0.8
Guilty feelings 0.2 0.3 0.6 0.6 -0.2 0.6 0.1 -0.2 0.4 0.7 0.4 0.8 0.5 0.4
Wears glasses or contact lenses 0.5 0.6 1.5 -0.0 -1.0 0.3 0.8 1.1 -0.0 1.2 1.0 0.8 0.5 -0.3
Ever taken oral contraceptive pill 2.0 2.2 4.9 0.1 -0.1 0.7 -2.1 -1.8 0.2 -2.1 -2.2 -2.2 1.4 -0.1
Hearing aid user 2.0 2.3 6.1 2.5 -1.3 2.4 0.5 -0.2 2.4 -1.3 0.4 -0.4 1.1 1.6
Mother’s age at death 2.0 2.5 6.9 2.0 -0.2 1.4 -1.2 -1.0 2.0 -1.1 -0.8 -1.6 2.6 2.0
Financial situation satisfaction 1.2 1.4 3.2 -1.6 1.0 -1.3 1.0 -0.1 -1.6 0.3 0.5 1.2 -1.8 -1.4
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.8 0.5 0.9 0.5 0.2 0.3 0.6 0.3 0.4 0.3 0.1 0.8
Commuting to job workplace: Public transport 1.1 1.3 3.7 1.0 0.1 0.8 -1.1 -1.0 0.9 -1.4 -1.1 -1.1 1.9 1.2
Eye problems/disorders: Glaucoma 1.0 1.2 3.5 -0.1 0.5 -0.8 -1.6 -1.5 -0.1 -1.1 -1.9 -1.6 0.4 0.2
Medication: Blood pressure 0.5 0.9 2.8 -0.2 1.1 -0.1 -1.1 -1.3 -0.1 -1.7 -1.3 -1.2 0.0 0.4
Pain type(s) experienced in last month: Hip pain 1.0 1.3 3.9 0.3 -0.7 -0.5 2.0 0.4 0.2 0.9 2.0 1.7 -1.0 -0.3
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.8 -0.0 1.1 -0.2 0.8 0.5 0.1 1.0 1.0 1.3 -0.2 -0.0
High cholesterol (Self-reported) 2.5 4.5 10.0 0.6 1.5 1.2 -3.1 -2.0 0.6 -2.6 -3.0 -3.2 1.8 1.5
Medication: Bendroflumethiazide 1.4 2.1 4.5 0.1 1.0 -0.5 -2.0 -2.1 0.2 -1.7 -2.1 -2.1 1.1 0.7
Medication: Paracetamol 0.4 0.6 2.7 0.3 1.7 0.2 -0.3 -0.4 0.3 -1.0 -0.5 -0.3 -1.0 0.8
Medication: Lisinopril 1.0 1.3 2.4 -1.5 0.4 -1.0 -1.3 -1.1 -1.6 -0.6 -1.5 -1.1 -0.9 -1.1
Medication: Atorvastatin 0.4 0.5 3.1 0.6 -0.2 1.8 -0.4 0.1 0.5 0.3 -0.1 -0.4 0.7 0.7
Illnesses of father: High blood pressure 0.4 0.5 0.8 0.7 0.5 0.6 -0.8 -0.6 0.8 -0.7 -0.8 -0.7 0.5 0.9
Alcohol drinker status: Never 0.2 0.3 0.9 -0.0 -0.9 -0.2 -0.2 -0.8 -0.1 0.3 -0.4 -0.6 -0.8 -0.1
Ever smoked 0.9 1.5 2.4 -0.8 -0.7 -1.0 1.5 1.6 -0.8 1.5 1.5 1.4 -1.5 -0.9
Basal metabolic rate 2.1 11.7 30.7 1.2 -5.5 -0.1 5.2 3.4 0.8 3.8 5.2 3.8 -0.9 -0.7
Leg fat percentage (left) 1.4 4.9 10.0 -1.1 -0.9 -1.4 2.9 2.1 -1.3 3.2 2.6 2.4 -3.1 -1.8
Arm fat-free mass (left) 2.3 11.5 29.7 1.1 -5.5 -0.1 4.9 3.6 0.7 4.0 5.2 3.8 -0.7 -0.8
Number of operations (self-reported) 2.7 3.9 7.2 1.6 1.5 2.2 -1.6 -2.7 1.7 -2.0 -1.8 -2.1 1.9 2.4
Average weekly beer plus cider intake 1.0 1.4 6.8 -1.2 2.6 -1.2 -0.2 -0.3 -1.2 0.5 -0.4 0.6 -1.7 -0.8
Irritability 1.3 2.1 6.2 0.8 -0.5 0.2 2.2 1.9 0.6 1.5 2.5 2.0 -1.1 0.1
Risk taking 0.2 0.2 1.3 -0.3 0.2 0.7 -0.3 0.4 -0.2 -0.2 -0.1 -0.2 1.1 -0.6
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.4 -1.2 1.2 -1.0 -0.7 -0.1 -1.1 -0.1 -0.8 -0.0 -0.1 -0.5
Fractured/broken bones in last 5 years 0.3 0.3 0.7 0.3 -0.8 -0.5 0.8 0.4 0.2 0.7 0.7 0.6 -0.6 -0.1
Age started oral contraceptive pill 0.5 0.6 1.7 -0.5 -1.3 -0.7 0.7 0.4 -0.5 0.6 0.5 0.7 -1.1 -0.9
Diastolic blood pressure, automated reading 0.6 1.9 3.8 1.5 -0.7 1.2 -0.9 -1.9 1.5 -1.3 -0.9 -1.5 1.3 1.7
Ever depressed for a whole week 0.1 0.1 0.3 0.5 -0.1 0.4 0.4 0.4 0.3 -0.1 0.4 0.5 -0.4 0.0
Unable to work because of sickness or disability 0.1 0.2 0.9 0.5 -0.5 0.5 -0.1 0.2 0.3 0.9 0.3 -0.0 0.1 0.1
Commuting to job workplace: Cycle 1.2 1.4 2.8 1.5 -1.7 0.7 1.2 1.2 1.5 -0.1 1.4 0.9 0.6 1.3
Myopia 1.0 1.5 4.5 1.5 0.6 1.5 -0.7 -0.6 1.5 -1.3 -0.6 -0.9 2.1 1.2
Vascular/heart problems diagnosed by doctor 0.3 0.9 1.8 0.4 -0.6 0.6 1.2 1.3 0.4 1.3 1.3 1.3 -0.2 -0.1
Cholesterol lowering medication 0.9 1.3 3.4 -0.5 1.8 -0.6 -1.7 -1.0 -0.4 -1.1 -1.8 -1.2 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 0.4 0.4 1.5 0.2 -0.6 0.2 1.0 1.2 0.2 -0.0 0.9 0.9 0.2 0.1
Pain experienced in last month 0.5 0.8 2.0 0.8 -0.6 0.7 -1.1 0.0 0.9 -0.8 -0.9 -1.4 0.9 1.1
Supplements: Calcium 2.2 2.4 3.5 1.4 0.7 0.9 -1.9 -1.9 1.4 -1.7 -1.6 -1.9 1.8 1.5
Basal cell carcinoma (self-reported) 1.2 1.5 3.0 1.7 -0.2 1.4 -0.5 0.3 1.7 -1.2 -0.3 -0.7 1.7 1.7
Heart attack/myocardial infarction (self-reported) 2.5 3.3 7.1 -2.4 -0.2 -2.5 1.0 1.1 -2.4 1.7 1.0 1.5 -1.8 -2.7
Deep venous thrombosis (DVT) (self-reported) 0.9 1.1 2.7 0.5 0.7 1.1 -1.6 -0.1 0.6 -1.0 -1.2 -1.3 1.7 0.9
Heart disease (siblings) 0.5 0.6 4.3 0.0 2.1 -0.9 -0.3 -0.6 0.0 -0.3 -0.6 0.3 0.0 0.9
Alcohol drinker status: Previous 0.1 0.2 0.7 0.3 -0.5 0.5 -0.3 0.2 0.3 0.4 0.0 -0.2 0.8 0.0
Pack years of smoking 0.3 0.4 0.9 1.0 -0.1 0.8 -0.5 -0.7 0.9 -0.2 -0.0 -0.3 0.8 0.3
Impedance of whole body 0.9 4.4 7.7 -2.5 2.5 -2.0 -2.5 -2.0 -2.3 -1.5 -2.8 -1.5 -1.0 -1.8
Leg fat mass (left) 1.5 5.9 12.7 -0.5 -2.2 -1.0 3.6 2.2 -0.8 3.4 3.2 2.7 -2.9 -1.6
Arm predicted mass (left) 2.4 12.0 30.2 0.9 -5.5 -0.3 5.0 3.8 0.5 4.2 5.3 3.9 -0.6 -1.0