TWAS hub - SYNGR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1650	0.0610	6.8e-04	0.079	NA	0.084	NA	0.092	3.8e-05	NA	2.1e-05	NA	9.3e-06
2	GTEx	Nerve Tibial	0.2605	0.0538	1.9e-14	0.182	NA	0.214	NA	0.211	6.1e-13	NA	3.6e-15	NA	5.8e-15
3	GTEx	Pituitary	0.3830	0.1120	3.0e-04	0.303	NA	0.248	NA	0.126	2.4e-08	NA	6.4e-07	NA	4.7e-04
4	GTEx	Spleen	0.3620	0.1150	1.8e-03	0.412	NA	0.040	NA	0.362	9.8e-12	NA	3.4e-02	NA	3.4e-10
5	GTEx	Testis	0.3880	0.0700	3.8e-10	0.305	NA	0.384	NA	0.383	5.0e-14	NA	3.7e-18	NA	4.3e-18
6	GTEx	Thyroid	0.1390	0.0440	3.4e-05	0.172	NA	0.149	NA	0.072	3.9e-13	NA	1.6e-11	NA	3.7e-06
7	GTEx	Whole Blood	0.1520	0.0390	1.9e-07	0.085	NA	0.084	NA	0.094	2.8e-08	NA	3.6e-08	NA	5.4e-09
8	NTR	Blood	0.0312	0.0103	1.7e-05	0.032	0.019	0.032	0.026	0.032	1.3e-10	4.6e-07	9.9e-11	5.7e-09	1.7e-10
9	YFS	Blood	0.3059	0.0330	0.0e+00	0.365	0.366	0.384	0.384	0.382	1.0e-126	4.7e-127	5.2e-135	3.9e-135	3.1e-134
10	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0940	0.0520	1.9e-03	0.049	0.038	0.056	NA	0.045	9.0e-04	3.1e-03	3.9e-04	NA	1.3e-03
11	TCGA	Prostate Adenocarcinoma	0.1157	0.0740	1.9e-03	0.040	0.029	0.025	NA	0.030	4.8e-05	5.1e-04	1.0e-03	NA	3.5e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Primary Biliary Cirrhosis	22.2	31.6	47.1	-4.6	-1.8	-5.1	6.8	5.8	-4.9	6.4	6.2	6.9	-6.0	-5.6
Rheumatoid Arthritis	13.6	18.8	34.5	-4.3	0.3	-4.6	4.7	3.3	-4.5	4.3	3.9	5.0	-5.9	-4.5
Irritable Bowel Disease (IBD)	11.2	26.7	85.1	-1.9	-4.2	-2.5	6.1	9.2	-2.1	5.2	7.3	6.4	-1.8	-3.8
Crohns Disease (2017)	8.8	19.4	64.3	-1.2	-3.3	-2.1	5.3	8.0	-1.4	4.1	6.4	5.8	-0.9	-2.9
Hypothyroidism/myxoedema (self-reported)	7.6	14.9	26.7	-2.9	-0.6	-3.3	5.2	3.6	-3.1	4.6	4.4	4.9	-4.4	-3.2
Hypothyroidism (self reported)	7.4	16.9	25.2	-3.4	-1.4	-3.9	5.0	3.5	-3.6	5.0	4.3	4.7	-5.0	-4.1
HDL Cholesterol	6.4	10.7	18.0	2.6	0.7	3.0	-3.7	-3.7	2.7	-4.2	-3.6	-4.2	2.8	3.2
Ulcerative Colitis (UC)	6.3	11.9	37.0	-1.3	-2.9	-1.5	4.0	6.1	-1.5	3.8	4.8	4.0	-1.4	-2.6
Lupus	5.1	7.7	11.1	-3.1	0.1	-2.4	2.4	2.7	-3.0	3.3	2.3	3.3	-3.1	-3.2
Medication: Levothyroxine sodium	4.7	8.0	17.4	-1.7	-1.6	-2.2	4.2	3.2	-1.8	3.1	3.6	3.4	-2.7	-2.3
Body Mass Index (BMI) (2010)	4.0	5.4	10.3	-2.1	-1.3	-1.4	2.6	2.1	-2.1	3.2	2.3	2.9	-2.5	-2.5
Mouth/teeth dental problems: Bleeding gums	3.5	4.5	6.7	2.1	0.7	2.1	-2.3	-2.5	2.2	-1.8	-1.9	-2.3	2.3	2.6
Illnesses of siblings: Diabetes	3.5	4.3	9.3	3.0	-1.7	2.0	2.1	1.7	2.8	1.5	2.5	1.6	1.2	1.9
Had major operations	3.4	4.0	7.2	2.4	0.7	2.7	-1.3	-2.1	2.4	-1.5	-1.3	-1.8	2.2	2.4
Ulcerative Colitis	3.3	4.7	18.8	-0.1	-2.3	0.0	2.4	4.3	-0.2	2.2	3.2	2.5	0.5	-1.1
Prostate Cancer	3.2	4.5	7.6	1.5	0.5	2.5	-2.5	-2.0	1.6	-2.8	-2.2	-2.3	2.2	2.3
Fluid intelligence score	3.2	6.6	23.6	3.5	-4.9	2.5	1.5	1.6	3.2	0.6	2.3	0.4	2.7	1.6
Fasting Glucose	2.9	3.5	7.6	-1.1	-0.4	-0.7	2.6	2.7	-1.2	2.7	2.2	2.4	-0.6	-1.3
Had other major operations	2.8	3.4	6.9	0.9	2.5	1.2	-2.2	-2.6	1.0	-1.7	-2.1	-2.0	1.4	1.9
Verbal and Numeric Reasoning (VNR)	2.7	6.6	24.3	3.5	-4.9	2.8	1.3	1.3	3.2	0.5	2.0	0.1	2.6	1.9
Crohns Disease (2012)	2.7	4.4	18.8	0.5	-2.6	-0.2	2.1	4.3	0.3	1.3	3.1	2.3	0.9	-0.7
Weight	2.7	13.4	32.4	0.1	-4.5	-1.1	5.7	3.6	-0.3	4.6	5.4	4.4	-2.7	-1.7
Knee pain experienced in last month	2.7	4.3	6.6	-2.4	0.2	-2.0	2.2	1.3	-2.4	1.7	1.8	2.5	-2.6	-2.4
Number of operations (self-reported)	2.7	3.9	7.2	1.6	1.5	2.2	-1.6	-2.7	1.7	-2.0	-1.8	-2.1	1.9	2.4
Intelligence (Savage-Jansen 2018)	2.6	8.0	39.0	3.4	-6.2	2.1	1.8	1.9	3.0	1.8	2.6	0.7	2.3	1.1
Neuroticism	2.5	6.0	11.5	-2.4	-0.7	-1.7	2.2	2.1	-2.8	3.4	2.2	2.6	-3.0	-2.8
Medication for hormone replacement therapy	2.5	2.8	4.6	-1.5	2.0	-2.1	1.3	1.0	-1.4	1.9	1.0	2.0	-2.2	-1.3
Hip circumference	2.5	10.8	26.6	0.2	-4.2	-1.1	5.2	3.1	-0.2	4.3	4.9	3.7	-2.4	-1.4
High cholesterol (Self-reported)	2.5	4.5	10.0	0.6	1.5	1.2	-3.1	-2.0	0.6	-2.6	-3.0	-3.2	1.8	1.5
Heart attack/myocardial infarction (self-reported)	2.5	3.3	7.1	-2.4	-0.2	-2.5	1.0	1.1	-2.4	1.7	1.0	1.5	-1.8	-2.7
Financial difficulties in last 2 years	2.4	3.3	7.4	-2.4	2.1	-1.9	0.0	-2.1	-2.4	0.5	-1.0	0.1	-2.7	-1.8
Arm predicted mass (right)	2.4	12.3	28.4	0.6	-5.2	-0.6	5.1	4.1	0.2	4.1	5.3	4.1	-1.0	-1.3
Arm predicted mass (left)	2.4	12.0	30.2	0.9	-5.5	-0.3	5.0	3.8	0.5	4.2	5.3	3.9	-0.6	-1.0
Number of incorrect matches in round	2.3	3.9	7.8	-2.6	1.6	-2.8	0.8	0.8	-2.7	1.6	0.4	1.6	-2.8	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	2.3	5.2	10.6	-2.5	-0.1	-2.8	2.1	1.8	-2.5	2.2	1.7	2.4	-3.2	-2.4
Commuting to job workplace: Car/motor vehicle	2.3	2.6	6.9	-0.4	-0.7	-0.3	2.3	1.9	-0.3	1.7	2.2	1.9	-2.6	-0.9
Arm fat-free mass (left)	2.3	11.5	29.7	1.1	-5.5	-0.1	4.9	3.6	0.7	4.0	5.2	3.8	-0.7	-0.8
Trunk fat mass	2.2	9.5	21.4	-0.8	-2.5	-1.4	4.6	2.9	-1.1	4.2	4.2	3.8	-3.5	-2.1
Medication: Simvastatin	2.2	3.3	8.4	0.0	1.4	0.3	-2.9	-2.4	-0.0	-1.9	-2.8	-2.5	1.5	0.8
Neck or shoulder pain in last month	2.2	3.1	7.7	-0.3	-0.6	-1.3	2.6	1.2	-0.4	2.1	2.5	2.8	-2.0	-1.0
Supplements: Calcium	2.2	2.4	3.5	1.4	0.7	0.9	-1.9	-1.9	1.4	-1.7	-1.6	-1.9	1.8	1.5
Ovarian Cancer	2.1	2.8	7.7	0.3	-1.4	-0.3	2.3	1.9	0.2	2.8	2.3	2.4	-0.8	-0.3
Heart attack	2.1	2.6	5.4	-2.1	-0.0	-2.3	0.9	1.1	-2.1	1.6	0.9	1.4	-1.6	-2.3
Arm fat-free mass (right)	2.1	10.6	24.6	0.8	-4.9	-0.5	4.7	3.7	0.5	3.9	5.0	3.7	-0.6	-0.9
Basal metabolic rate	2.1	11.7	30.7	1.2	-5.5	-0.1	5.2	3.4	0.8	3.8	5.2	3.8	-0.9	-0.7
Alzheimer’s Disease (in father)	2.0	2.1	5.2	-2.3	1.5	-0.5	-1.0	-1.4	-2.2	0.4	-1.2	-0.2	-1.8	-1.6
Tanning	2.0	25.0	40.4	-5.6	0.2	-5.8	4.6	3.6	-5.8	5.0	3.8	5.4	-6.4	-5.8
Trunk predicted mass	2.0	11.5	34.1	1.1	-5.8	-0.2	4.9	3.5	0.8	3.7	5.1	3.7	-0.3	-0.8
Migraine (self-reported)	2.0	2.5	4.3	1.5	1.3	1.6	-1.5	-1.5	1.5	-2.1	-1.2	-1.6	1.6	1.9
Whole body fat-free mass	2.0	11.5	31.3	1.4	-5.6	0.0	5.0	3.4	1.0	3.7	5.2	3.7	-0.4	-0.5
Osteoporosis (self-reported)	2.0	2.5	5.9	1.0	-0.1	1.1	-1.9	-2.0	1.2	-2.0	-1.7	-2.4	1.4	0.9
Whole body water mass	2.0	11.6	31.6	1.3	-5.6	0.0	5.1	3.5	1.0	3.7	5.2	3.8	-0.5	-0.6
Ever taken oral contraceptive pill	2.0	2.2	4.9	0.1	-0.1	0.7	-2.1	-1.8	0.2	-2.1	-2.2	-2.2	1.4	-0.1
Hearing aid user	2.0	2.3	6.1	2.5	-1.3	2.4	0.5	-0.2	2.4	-1.3	0.4	-0.4	1.1	1.6
Mother’s age at death	2.0	2.5	6.9	2.0	-0.2	1.4	-1.2	-1.0	2.0	-1.1	-0.8	-1.6	2.6	2.0
Alzheimer’s Disease (in mother)	1.9	2.3	5.6	1.0	-1.5	-0.1	1.6	2.4	0.9	1.9	2.3	1.9	0.3	0.1
Diabetes (mother)	1.9	2.4	4.4	0.6	2.0	0.6	-1.7	-2.1	0.6	-2.1	-2.1	-1.9	0.7	1.1
Leg fat-free mass (left)	1.9	9.9	26.2	1.7	-5.1	0.5	4.8	3.1	1.3	3.3	4.8	3.3	-0.5	-0.2
Leg predicted mass (left)	1.9	10.0	26.8	1.7	-5.2	0.5	4.8	3.0	1.4	3.3	4.9	3.3	-0.5	-0.2
Trunk fat-free mass	1.9	11.1	33.5	1.1	-5.8	-0.2	4.9	3.4	0.8	3.6	5.0	3.6	-0.2	-0.7
Leg fat-free mass (right)	1.9	10.2	27.5	1.7	-5.2	0.4	4.7	3.1	1.4	3.4	4.9	3.4	-0.4	-0.2
Friendships satisfaction	1.9	2.4	6.3	0.7	-2.2	0.4	2.5	1.8	0.6	0.9	2.3	2.1	-0.6	-0.4
Leg predicted mass (right)	1.9	10.1	27.9	1.7	-5.3	0.3	4.7	3.0	1.4	3.4	4.9	3.4	-0.3	-0.2
Trunk fat percentage	1.8	7.0	14.8	-1.0	-1.4	-1.3	3.8	2.3	-1.2	3.6	3.3	3.2	-3.7	-2.0
Neuroticism (Nagel 2018)	1.7	3.9	6.2	-2.0	-0.7	-1.2	1.9	1.6	-2.3	2.5	1.8	2.3	-2.4	-2.1
Shortness of breath walking on level ground	1.7	2.0	3.9	-0.5	-0.9	-1.3	1.8	1.4	-0.7	2.0	1.6	1.9	-1.6	-0.9
Eye problems/disorders: None of the above	1.7	1.9	3.7	-1.3	0.0	-0.6	1.9	1.0	-1.3	1.6	1.6	1.9	-1.2	-1.8
Whole body fat mass	1.7	7.1	16.8	-0.3	-2.3	-0.9	4.1	2.4	-0.6	3.6	3.7	3.2	-3.0	-1.6
Waist Hip Ratio (WHR)	1.6	7.2	27.6	-1.2	5.2	0.2	-4.1	-2.7	-0.9	-2.3	-3.6	-2.5	0.8	0.9
Taking other prescription medications	1.6	2.5	4.6	-0.9	0.5	-1.3	2.1	1.7	-1.1	2.2	1.7	2.2	-2.0	-0.9
Headache pain in last month	1.6	2.8	8.5	0.2	1.2	1.0	-1.9	-2.9	0.2	-2.5	-2.2	-1.8	1.3	0.9
Qualifications: College or University degree	1.6	5.2	24.6	2.4	-5.0	1.7	1.6	2.2	2.5	-0.4	2.0	0.5	2.2	0.9
Chest pain or discomfort	1.6	2.3	9.8	1.9	-3.1	1.2	0.9	1.1	1.7	1.0	1.6	0.7	1.2	0.5
Bipolar Disorder (2018)	1.5	2.3	4.5	-1.3	-0.1	-1.9	1.7	1.4	-1.4	1.7	1.6	1.2	-2.1	-1.3
Bilateral oophorectomy (both ovaries removed)	1.5	1.8	4.3	2.1	0.4	1.8	0.8	1.1	2.0	-0.3	1.1	0.2	0.9	1.9
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.3	7.9	-2.4	0.8	-2.3	1.2	1.2	-2.3	1.2	0.8	1.5	-2.8	-2.2
Nervous feelings	1.5	2.7	6.9	-2.6	1.0	-2.4	-0.1	-0.1	-2.6	0.9	-0.5	0.6	-2.2	-1.9
Arm fat mass (right)	1.5	6.3	16.4	0.4	-2.8	-0.2	4.0	2.4	0.2	3.3	3.7	2.8	-2.4	-0.9
Medication: Ventolin 100micrograms inhaler	1.5	1.9	6.2	-0.8	-1.0	-1.8	1.2	1.6	-1.0	2.5	1.4	1.1	-1.1	-0.7
Leg fat mass (right)	1.5	5.7	13.2	-0.3	-2.2	-0.9	3.6	2.2	-0.6	3.3	3.3	2.7	-2.8	-1.5
Arm fat mass (left)	1.5	6.1	16.4	0.4	-2.6	-0.1	4.0	2.4	0.1	3.1	3.7	2.9	-2.4	-0.9
Leg fat mass (left)	1.5	5.9	12.7	-0.5	-2.2	-1.0	3.6	2.2	-0.8	3.4	3.2	2.7	-2.9	-1.6
Depressed Affect (Nagel 2018)	1.4	2.9	6.6	-1.7	0.9	-1.0	1.5	1.2	-1.9	2.1	1.3	2.1	-2.6	-1.6
Body fat percentage	1.4	5.6	12.3	-0.7	-1.2	-1.1	3.5	2.1	-0.9	3.1	3.0	2.8	-3.4	-1.7
Comparative height size at age 10	1.4	7.7	17.4	0.0	-4.0	-0.8	3.8	3.1	-0.2	3.6	4.2	3.3	-1.5	-1.1
Medication: Bendroflumethiazide	1.4	2.1	4.5	0.1	1.0	-0.5	-2.0	-2.1	0.2	-1.7	-2.1	-2.1	1.1	0.7
Leg fat percentage (left)	1.4	4.9	10.0	-1.1	-0.9	-1.4	2.9	2.1	-1.3	3.2	2.6	2.4	-3.1	-1.8
HbA1C	1.3	1.4	5.6	-1.4	2.4	-1.3	0.1	-0.1	-1.5	1.0	0.2	0.8	-1.4	-0.8
Triglycerides	1.3	2.2	3.8	-1.3	-0.4	-1.1	1.7	1.1	-1.3	1.8	1.6	1.9	-1.5	-1.9
Hair Pigment	1.3	35.9	65.6	3.4	4.7	3.9	-7.8	-5.3	3.8	-8.1	-7.4	-7.4	6.1	5.4
Hand grip strength (right)	1.3	3.6	8.8	-1.0	-3.0	-1.0	2.0	2.4	-1.1	2.2	2.2	2.1	0.1	-1.8
Multivitamins +/- minerals	1.3	1.7	4.1	-1.1	-0.8	-0.6	1.0	0.8	-1.0	1.8	1.2	1.5	-2.0	-1.8
Body mass index (BMI)	1.3	5.4	14.7	0.6	-1.8	-0.1	3.8	2.4	0.3	3.1	3.5	2.8	-2.3	-0.4
Mouth/teeth dental problems: Dentures	1.3	2.1	5.2	1.1	-1.1	-0.1	2.1	1.7	0.9	1.7	2.3	2.0	-0.4	0.7
Medication: Lansoprazole	1.3	1.4	3.1	-0.2	1.7	-1.0	1.5	1.1	-0.4	0.9	1.3	1.8	-1.7	-0.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	3.9	-1.7	-1.0	-0.4	0.9	0.6	-1.8	1.2	0.6	0.7	-1.5	-2.0
Ever had bowel cancer screening	1.3	1.5	3.3	-0.4	-1.4	-0.9	1.6	1.8	-0.6	1.7	1.6	1.3	-0.4	-0.7
Irritability	1.3	2.1	6.2	0.8	-0.5	0.2	2.2	1.9	0.6	1.5	2.5	2.0	-1.1	0.1
Worry (Nagel 2018)	1.2	2.5	5.5	-2.1	-0.4	-1.6	1.0	1.1	-2.3	1.5	0.7	1.3	-2.1	-2.1
Average weekly fortified wine intake	1.2	1.4	4.5	1.4	-0.3	1.1	-1.0	-0.1	1.4	-0.8	-0.5	-1.3	2.1	1.4
Impedance of leg (left)	1.2	5.9	10.3	-3.2	2.7	-2.7	-2.9	-1.6	-3.1	-1.0	-2.9	-1.5	-1.1	-2.6
Qualifications: A levels/AS levels or equivalent	1.2	2.7	6.5	2.0	-2.2	1.7	-0.8	0.0	2.0	-1.8	-0.6	-1.3	2.5	1.4
Standing height	1.2	12.3	38.7	-1.2	-6.2	-2.3	4.4	2.9	-1.5	3.9	4.5	3.8	-1.1	-3.1
Leg fat percentage (right)	1.2	4.4	9.3	-0.9	-0.9	-1.1	2.9	2.1	-1.2	2.9	2.5	2.2	-3.1	-1.7
Comparative body size at age 10	1.2	3.2	9.0	3.0	-1.7	2.3	0.9	0.5	2.9	-0.5	1.1	0.2	1.6	2.2
Medication for pain relief, constipation, heartburn	1.2	2.0	9.6	0.7	-3.1	0.1	0.7	2.0	0.8	1.1	1.4	0.3	1.8	-0.7
Medication: Blood pressure	1.2	2.1	5.2	0.3	1.4	0.6	-1.7	-2.3	0.3	-2.0	-1.9	-1.9	0.8	1.0
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	4.9	1.0	-2.2	1.4	0.7	1.9	1.0	0.4	1.3	0.5	1.1	0.1
Medication: Aspirin	1.2	1.6	3.4	0.6	1.7	0.7	-1.4	-1.9	0.6	-1.5	-1.5	-1.1	-0.4	1.3
Average weekly champagne plus white wine intake	1.2	1.6	2.5	1.6	-1.2	1.5	-0.7	-0.3	1.6	-1.5	-0.5	-1.4	1.5	1.3
Financial situation satisfaction	1.2	1.4	3.2	-1.6	1.0	-1.3	1.0	-0.1	-1.6	0.3	0.5	1.2	-1.8	-1.4
Commuting to job workplace: Cycle	1.2	1.4	2.8	1.5	-1.7	0.7	1.2	1.2	1.5	-0.1	1.4	0.9	0.6	1.3
Basal cell carcinoma (self-reported)	1.2	1.5	3.0	1.7	-0.2	1.4	-0.5	0.3	1.7	-1.2	-0.3	-0.7	1.7	1.7
Blood Platelet Count	1.1	12.9	25.2	-2.0	-0.7	-3.1	4.5	3.8	-2.1	5.0	3.9	4.5	-4.4	-2.8
Vitamin and mineral supplements	1.1	1.5	3.0	0.8	0.7	0.8	-1.2	-1.1	0.7	-1.7	-1.4	-1.5	1.7	1.3
Impedance of leg (right)	1.1	5.5	9.2	-3.0	2.6	-2.3	-2.8	-1.6	-2.9	-1.3	-2.9	-1.7	-1.1	-2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	3.2	-1.2	0.4	-1.5	1.0	0.5	-1.2	1.4	0.7	1.6	-1.8	-1.2
Medication: Atenolol	1.1	1.4	3.8	-1.9	0.4	-1.6	0.3	0.3	-1.9	0.6	-0.0	0.5	-1.5	-1.5
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	3.1	-0.1	0.8	-0.3	-1.5	-1.4	-0.1	-1.3	-1.8	-1.7	0.6	0.7
Breastfed as a baby	1.1	1.4	4.6	-1.6	0.0	-2.1	0.9	0.4	-1.5	0.8	0.4	1.1	-1.4	-1.2
Medication for cholesterol, blood pressure or diabetes	1.1	1.9	4.0	0.1	-0.7	-0.7	2.0	2.0	0.2	1.7	2.0	2.0	-1.0	-0.5
Commuting to job workplace: Walk	1.1	1.2	3.6	1.5	-1.4	0.7	-0.4	-0.5	1.5	-0.3	-0.2	-0.9	1.9	1.3
Commuting to job workplace: Public transport	1.1	1.3	3.7	1.0	0.1	0.8	-1.1	-1.0	0.9	-1.4	-1.1	-1.1	1.9	1.2
Bipolar Disorder or Schizophrenia	1.0	2.5	7.5	-1.0	1.9	-0.9	1.6	1.2	-1.1	1.7	1.5	1.7	-2.7	-1.0
Coronary Artery Disease (CAD)	1.0	1.3	2.5	-1.2	1.2	-1.0	-1.4	-1.5	-1.2	-0.2	-1.6	-1.2	-0.3	-0.7
Blood White Count	1.0	7.4	17.1	-2.9	3.8	-4.1	1.4	0.6	-2.9	1.6	0.5	2.5	-4.1	-2.1
Waist circumference	1.0	3.6	8.8	-0.3	-0.5	-0.9	3.0	1.4	-0.5	2.9	2.7	2.4	-2.5	-0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	5.1	0.2	2.3	0.8	-0.9	-1.8	0.3	-1.4	-1.2	-0.6	0.0	0.8
Prospective memory result	1.0	1.2	4.2	-0.9	2.0	-0.7	-1.3	-1.4	-0.9	-0.5	-1.5	-0.7	-0.8	-0.5
Birth weight of first child	1.0	1.9	4.8	2.2	-1.8	1.8	0.2	0.4	2.1	-0.6	0.5	-0.5	1.4	1.4
Pulse wave reflection index	1.0	1.2	4.5	-1.6	-0.8	0.4	0.1	0.6	-1.5	1.4	0.2	0.5	-0.6	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.0	1.2	4.4	-1.6	-0.8	-0.8	0.3	0.5	-1.6	1.2	0.4	0.7	-0.1	-2.1
Angina (self-reported)	1.0	1.3	2.8	-1.2	-0.7	-1.3	0.3	1.7	-1.3	1.6	0.8	0.8	-0.6	-1.3
Arm fat percentage (left)	1.0	3.8	10.5	-0.1	-0.9	-0.4	3.2	1.6	-0.2	2.5	2.6	2.3	-2.9	-0.9
Osteoarthritis (self-reported)	1.0	1.3	3.1	-0.6	0.4	-0.7	1.7	1.0	-0.6	0.8	1.3	1.7	-1.7	-0.8
Medication: Gliclazide	1.0	1.1	3.4	-0.2	-0.1	0.8	-1.8	-1.1	-0.1	-1.3	-1.6	-1.5	0.3	-0.4
Eye problems/disorders: Glaucoma	1.0	1.2	3.5	-0.1	0.5	-0.8	-1.6	-1.5	-0.1	-1.1	-1.9	-1.6	0.4	0.2
Pain type(s) experienced in last month: Hip pain	1.0	1.3	3.9	0.3	-0.7	-0.5	2.0	0.4	0.2	0.9	2.0	1.7	-1.0	-0.3
Medication: Lisinopril	1.0	1.3	2.4	-1.5	0.4	-1.0	-1.3	-1.1	-1.6	-0.6	-1.5	-1.1	-0.9	-1.1
Average weekly beer plus cider intake	1.0	1.4	6.8	-1.2	2.6	-1.2	-0.2	-0.3	-1.2	0.5	-0.4	0.6	-1.7	-0.8
Myopia	1.0	1.5	4.5	1.5	0.6	1.5	-0.7	-0.6	1.5	-1.3	-0.6	-0.9	2.1	1.2
Neuroticism (2016)	0.9	1.2	4.2	-0.9	1.5	-1.0	1.3	0.2	-1.1	0.6	0.9	1.3	-2.0	-0.2
Height	0.9	16.6	74.3	0.1	-8.6	-1.5	4.8	3.5	-0.2	4.5	5.4	4.0	0.1	-2.3
Systolic Blood Pressure	0.9	4.5	13.3	-0.3	1.0	0.2	-2.7	-3.6	-0.0	-3.2	-2.9	-2.9	1.0	0.6
Hand grip strength (left)	0.9	2.4	9.2	-0.5	-3.0	-0.7	1.5	1.9	-0.5	1.7	1.8	1.5	0.3	-1.3
Sitting height	0.9	6.4	21.2	-1.1	-4.6	-1.8	3.1	2.0	-1.4	2.4	3.0	2.5	-1.3	-2.6
High blood pressure (mother)	0.9	1.2	3.7	0.8	1.9	1.1	-1.1	-1.3	0.9	-0.9	-0.9	-0.8	0.7	1.1
Qualifications: None of the above	0.9	1.8	8.1	-0.2	2.9	0.6	-1.7	-1.5	-0.2	-1.2	-1.9	-1.2	-0.5	0.4
Falls in the last year	0.9	1.2	3.5	1.9	-0.1	1.1	0.9	0.5	1.8	0.6	1.1	0.9	-0.1	1.1
Noisy workplace	0.9	1.1	8.7	-0.4	3.0	-0.7	0.4	-0.6	-0.3	-0.1	0.2	0.5	-1.4	0.0
Blood clot in the leg (DVT)	0.9	1.2	3.0	0.4	1.1	1.1	-1.7	-0.2	0.5	-1.0	-1.3	-1.3	1.5	0.9
Worry too long after embarrassment	0.9	1.5	5.2	0.4	-2.3	0.0	1.2	1.5	0.2	1.7	1.6	1.1	0.5	-0.3
Miserableness	0.9	1.6	4.0	-0.8	0.6	-0.4	1.6	1.0	-1.0	1.4	1.4	1.9	-2.0	-0.8
Ever smoked	0.9	1.5	2.4	-0.8	-0.7	-1.0	1.5	1.6	-0.8	1.5	1.5	1.4	-1.5	-0.9
Cholesterol lowering medication	0.9	1.3	3.4	-0.5	1.8	-0.6	-1.7	-1.0	-0.4	-1.1	-1.8	-1.2	-0.1	0.2
Deep venous thrombosis (DVT) (self-reported)	0.9	1.1	2.7	0.5	0.7	1.1	-1.6	-0.1	0.6	-1.0	-1.2	-1.3	1.7	0.9
Impedance of whole body	0.9	4.4	7.7	-2.5	2.5	-2.0	-2.5	-2.0	-2.3	-1.5	-2.8	-1.5	-1.0	-1.8
Alzheimer’s Disease (including proxy)	0.8	1.1	2.7	-0.7	-0.3	-0.5	1.1	1.0	-0.7	1.5	1.3	1.6	-1.2	-1.0
Major Depression (MDD)	0.8	0.9	2.9	1.3	1.2	1.3	-0.2	-0.7	1.1	0.4	0.2	-0.1	0.7	1.7
Bipolar Disorder (2011)	0.8	0.8	5.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	1.4	-2.3	-1.3
Schizophrenia (2014)	0.8	1.7	6.6	-1.0	2.3	-0.6	0.7	0.4	-1.1	0.9	0.5	1.1	-2.6	-0.9
BMI	0.8	4.6	14.0	0.6	-1.8	0.1	3.7	1.5	0.4	2.6	3.1	2.7	-2.5	-0.2
Angina	0.8	1.1	2.4	-1.1	-0.5	-1.2	0.3	1.6	-1.2	1.5	0.7	0.7	-0.5	-1.1
Alcohol usually taken with meals	0.8	1.3	3.6	1.5	0.0	1.6	0.1	0.4	1.7	-0.9	0.1	-0.6	1.4	1.9
Neuroticism score	0.8	1.6	3.5	-0.9	0.5	-0.8	1.1	0.7	-1.3	1.9	1.1	1.7	-1.8	-1.2
Arm fat percentage (right)	0.8	3.2	9.1	0.1	-1.0	-0.2	3.0	1.3	-0.1	2.3	2.4	2.0	-2.9	-0.7
Illnesses of mother	0.8	1.0	3.5	-0.2	-1.9	0.1	1.1	1.1	-0.4	1.0	1.2	0.7	-1.0	-0.8
Length of working week for main job	0.8	0.9	2.5	0.8	-1.3	0.5	1.4	1.1	0.9	0.1	1.6	0.9	0.3	0.1
Family relationship satisfaction	0.8	1.0	2.3	0.8	0.1	1.0	1.5	1.3	0.7	-0.5	1.4	1.3	-0.7	0.3
Illnesses of father: Heart disease	0.8	1.1	3.8	0.8	0.4	1.2	-1.4	-0.4	0.8	-1.0	-0.9	-1.1	2.0	0.8
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.9	1.0	-1.6	1.8	-0.5	0.8	1.0	-1.0	0.1	-0.4	2.0	0.6
Medication for cholesterol	0.8	1.2	6.3	1.0	-2.5	1.1	0.8	0.7	0.9	0.8	1.2	0.3	1.1	-0.0
Medication: Aspirin	0.8	1.1	2.8	0.0	1.7	-0.0	-1.2	-1.5	-0.0	-1.3	-1.4	-0.9	-0.8	0.7
Depression (Nagel 2018)	0.7	1.1	3.1	-0.5	1.0	-0.4	0.9	0.7	-0.6	1.8	0.8	1.6	-1.5	-0.5
Heel T-Score	0.7	5.6	13.5	-3.7	2.8	-3.0	0.0	-0.0	-3.5	1.3	-0.6	1.5	-2.9	-2.5
Lung FEV1/FVC ratio	0.7	3.6	7.0	-1.9	-2.2	-1.2	1.7	1.9	-1.9	1.9	2.2	1.7	-0.9	-2.6
Number of treatments/medications taken	0.7	1.3	6.9	0.5	2.6	0.7	-0.6	-0.9	0.6	-1.3	-0.9	-0.6	-0.7	1.3
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.6	0.9	-0.4	0.6	-1.3	-0.8	0.9	-0.3	-0.7	-1.2	1.1	1.0
Fed-up feelings	0.7	1.2	4.3	-0.8	2.1	-0.1	-0.9	-1.6	-0.9	-0.3	-1.2	-0.4	-1.5	-0.5
Age when periods started (menarche)	0.7	1.6	4.0	-1.7	1.5	-2.0	0.5	-0.1	-1.7	0.3	0.2	0.9	-1.9	-1.1
Hearing difficulty/problems with background noise	0.7	1.1	2.8	-0.6	0.1	-0.7	1.3	1.4	-0.7	1.3	1.2	1.7	-0.8	-0.8
Had menopause	0.7	0.8	2.6	1.6	-0.5	1.3	0.1	0.3	1.5	0.4	0.6	0.0	0.5	1.1
Pain all over the body in last month	0.7	0.8	1.9	0.7	1.4	0.5	-1.1	-0.2	0.7	-1.1	-0.8	-0.9	1.1	0.5
Illnesses of siblings	0.7	0.9	2.7	-1.6	0.3	0.2	-0.9	-0.4	-1.5	-0.3	-0.8	-0.6	-0.8	-1.6
Impedance of arm (right)	0.7	3.2	7.0	-1.4	2.2	-0.9	-2.2	-2.5	-1.2	-1.9	-2.6	-1.7	-1.0	-0.7
Number of live births	0.7	1.0	2.3	-0.1	-0.1	-0.2	1.4	1.4	-0.3	1.4	1.5	1.5	-0.2	-0.2
Medication: Cholesterol lowering	0.7	1.1	2.6	0.3	-0.1	1.3	-1.6	-1.1	0.1	-0.8	-1.2	-1.5	1.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.0	-1.0	-2.6	-1.9	1.4	1.2	-1.1	1.5	1.5	1.2	-0.6	-1.6
Exposure to tobacco smoke at home	0.7	0.8	1.6	1.1	-1.3	0.8	0.8	1.1	1.1	0.4	1.2	0.4	0.2	0.4
Birth weight	0.7	1.5	6.4	0.6	-2.5	0.5	1.3	1.2	0.5	1.3	1.5	1.2	0.8	-0.3
High blood pressure (siblings)	0.7	1.0	2.7	1.6	-0.4	0.8	0.0	-0.1	1.7	-0.8	0.2	-0.4	1.4	1.5
Loneliness, isolation	0.7	0.9	4.7	-0.3	2.2	-1.1	0.5	-0.5	-0.3	0.3	0.1	1.1	-1.5	-0.0
Eye problems/disorders: Cataract	0.7	0.8	2.6	0.9	1.0	-0.0	-1.0	-0.7	0.9	-0.6	-0.8	-0.7	0.5	1.6
Schizophrenia (2018)	0.6	1.2	6.4	-0.2	2.5	0.3	0.7	0.4	-0.3	0.8	0.6	1.1	-1.8	-0.2
Breast Cancer	0.6	1.5	3.1	-1.3	1.6	-1.4	0.7	0.6	-1.3	1.6	0.6	1.2	-1.8	-1.1
Cardiovascular Disease	0.6	2.1	5.1	-0.5	0.3	0.1	-2.0	-1.8	-0.4	-2.3	-2.1	-2.2	0.9	0.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.3	0.7	-0.4	0.3	1.5	1.3	0.7	0.9	1.4	0.9	-0.5	0.2
Townsend deprivation index at recruitment	0.6	0.9	2.1	1.5	0.9	0.7	-0.0	-1.1	1.4	-1.2	-0.1	-0.0	0.4	1.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	2.1	-0.2	1.4	-0.3	-0.3	-1.4	-0.1	-0.9	-0.9	0.0	-0.9	0.4
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.9	-0.7	0.4	0.2	-1.6	-1.8	-0.8	-1.0	-2.0	-1.7	-0.0	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	3.5	-1.0	0.2	-0.8	0.5	-0.2	-1.0	0.9	0.4	1.1	-1.9	-1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.8	2.2	1.5	0.9	0.8	-0.2	0.3	1.4	-0.5	0.0	0.1	0.7	1.3
Mouth/teeth dental problems	0.6	1.0	2.2	-1.5	0.7	-0.7	-0.5	-0.4	-1.5	-0.4	-1.0	-0.6	-1.2	-1.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	2.0	-1.3	-0.3	-0.7	-0.5	0.1	-1.4	-0.2	-0.9	-1.0	-0.8	-1.1
Father’s age at death	0.6	0.9	2.1	1.4	-1.1	1.4	0.2	0.4	1.3	-0.4	0.4	-0.1	0.8	1.2
Hair/balding pattern: Pattern 3	0.6	0.8	2.5	-0.9	-0.9	-0.7	0.8	0.5	-1.0	0.6	0.6	0.7	-1.6	-1.2
Medication: Paracetamol	0.6	1.1	7.3	-0.4	2.7	-0.2	-0.4	-0.8	-0.4	-0.6	-0.7	-0.0	-1.5	0.5
Gout (self-reported)	0.6	0.8	4.2	0.3	2.0	0.2	-0.8	-0.4	0.3	-1.1	-0.8	-0.6	-0.5	1.2
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.9	-0.0	-1.0	-0.5	1.0	1.4	0.1	0.7	1.3	1.0	-0.6	-0.5
Heart disease (mother)	0.6	0.7	1.4	1.1	-0.1	1.0	-0.2	0.2	1.2	-1.1	-0.3	-0.6	1.0	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	-0.9	1.0	-1.1	0.9	0.5	-0.8	1.0	0.7	0.8	-1.1	-0.6
Mood swings	0.6	1.1	2.5	-1.2	1.1	-0.7	0.5	0.5	-1.4	0.9	0.5	0.9	-1.6	-1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	2.4	-0.9	1.6	-0.9	0.5	0.4	-0.9	0.1	0.3	0.7	-0.9	-0.1
Breast cancer (self-reported)	0.6	0.7	2.6	0.5	-1.6	1.1	0.2	0.9	0.6	-0.3	0.5	-0.1	1.3	0.2
Illnesses of father: None of the above (group 1)	0.6	0.7	2.1	-0.3	-1.5	-0.4	1.0	1.1	-0.2	0.8	1.1	0.7	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.4	-1.3	-0.3	-1.8	0.8	0.8	-1.4	1.2	0.8	1.0	-0.8	-1.2
Diastolic blood pressure, automated reading	0.6	1.9	3.8	1.5	-0.7	1.2	-0.9	-1.9	1.5	-1.3	-0.9	-1.5	1.3	1.7
Reaction Time	0.5	0.9	2.4	-1.4	1.4	-1.3	-0.2	0.4	-1.6	0.3	-0.4	0.0	-0.5	-1.3
Allergy or Eczema	0.5	1.2	3.4	-1.0	-0.0	-0.2	-1.5	-1.3	-1.0	-0.4	-1.9	-1.6	-0.5	-1.0
Type 2 Diabetes (T2D) (2018)	0.5	0.9	2.8	-1.2	-0.5	-0.5	0.1	1.2	-1.1	1.7	0.7	0.5	-0.4	-1.3
Average weekly spirits intake	0.5	0.7	1.2	-0.7	-0.0	-0.4	0.7	1.1	-0.7	0.9	0.8	0.9	-0.9	-1.0
Frequency of depressed mood in last 2 weeks	0.5	0.7	3.9	0.3	2.0	0.4	-0.6	-1.0	0.2	-0.2	-0.9	-0.2	-0.9	0.6
Current tobacco smoking	0.5	0.9	2.4	1.5	1.2	0.9	0.6	0.3	1.5	-0.3	0.8	0.7	0.3	1.1
Supplements: Glucosamine	0.5	0.6	2.0	-0.7	0.9	-0.3	0.4	0.7	-0.4	1.4	0.7	1.0	-0.5	-0.8
Diabetes (self-reported)	0.5	0.8	2.6	1.0	-0.3	1.2	-1.1	-0.1	1.0	0.5	-0.3	-0.7	1.6	0.9
Worrier / anxious feelings	0.5	0.9	2.6	-1.4	0.0	-0.5	-0.0	0.1	-1.6	0.7	-0.3	0.4	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	9.7	-0.5	-3.1	-1.3	1.1	0.7	-0.6	0.9	1.1	0.5	-0.1	-1.1
Impedance of arm (left)	0.5	2.2	4.6	-1.4	1.9	-1.0	-1.7	-1.8	-1.2	-1.6	-2.2	-1.2	-0.9	-0.9
Forced vital capacity (FVC), Best measure	0.5	1.9	7.1	-0.8	-2.7	-1.6	1.3	1.3	-0.8	1.0	1.2	1.1	-0.4	-1.5
Number of full brothers	0.5	0.6	1.4	1.2	-1.0	0.0	0.4	-0.2	1.1	-0.2	0.4	0.1	1.2	1.1
Medication: Ibuprofen	0.5	0.6	2.4	0.0	1.5	0.6	-0.3	-1.2	0.2	-1.2	-0.7	-0.3	-0.4	0.3
Medication: Allopurinol	0.5	0.6	1.1	0.7	1.0	0.3	1.1	0.5	0.6	0.1	0.9	0.8	-1.1	1.0
Medication: Omeprazole	0.5	0.6	1.2	1.0	-0.5	1.0	0.2	0.8	1.1	-0.8	0.2	-0.1	1.1	1.0
Back pain experienced in last month	0.5	0.7	2.3	0.5	-0.8	-0.1	1.5	0.7	0.4	0.6	1.4	0.9	-0.5	-0.1
Wears glasses or contact lenses	0.5	0.6	1.5	-0.0	-1.0	0.3	0.8	1.1	-0.0	1.2	1.0	0.8	0.5	-0.3
Medication: Blood pressure	0.5	0.9	2.8	-0.2	1.1	-0.1	-1.1	-1.3	-0.1	-1.7	-1.3	-1.2	0.0	0.4
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.4	-1.2	1.2	-1.0	-0.7	-0.1	-1.1	-0.1	-0.8	-0.0	-0.1	-0.5
Age started oral contraceptive pill	0.5	0.6	1.7	-0.5	-1.3	-0.7	0.7	0.4	-0.5	0.6	0.5	0.7	-1.1	-0.9
Pain experienced in last month	0.5	0.8	2.0	0.8	-0.6	0.7	-1.1	0.0	0.9	-0.8	-0.9	-1.4	0.9	1.1
Heart disease (siblings)	0.5	0.6	4.3	0.0	2.1	-0.9	-0.3	-0.6	0.0	-0.3	-0.6	0.3	0.0	0.9
Mean Putamen Volume	0.4	0.5	1.1	-0.9	0.6	-0.9	-0.2	-0.5	-0.7	-0.7	-0.7	0.1	-1.1	-0.4
Sensitivity / hurt feelings	0.4	0.7	1.6	-1.2	0.5	-0.3	-0.8	-0.7	-1.3	0.7	-0.7	-0.2	-1.0	-1.0
Ever used hormone-replacement therapy (HRT)	0.4	0.6	2.3	0.2	-0.0	0.6	1.0	1.5	0.2	0.3	1.1	0.9	-0.5	-0.3
Ever had hysterectomy (womb removed)	0.4	0.4	1.0	1.0	0.3	0.7	0.5	0.7	0.9	0.3	0.8	-0.0	0.5	0.8
Medication: Metformin	0.4	0.6	1.9	0.4	-0.1	0.8	-1.4	-0.7	0.4	0.1	-0.7	-0.8	1.4	0.4
Severe depression (siblings)	0.4	0.4	2.4	-0.3	-0.2	-0.3	0.2	1.5	-0.4	0.5	0.3	0.6	-0.9	-0.5
Pack years adult smoking proportion	0.4	0.6	1.3	1.1	0.3	0.9	-0.7	-1.0	1.1	-0.6	-0.3	-0.5	0.9	0.6
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	-0.1	0.7	-0.3	1.1	0.9	-0.2	0.5	0.9	1.1	-0.9	-0.4
Forced vital capacity (FVC)	0.4	1.6	8.3	-0.6	-2.9	-1.6	1.2	0.8	-0.7	0.7	1.0	0.8	-0.5	-1.2
Happiness	0.4	0.5	1.5	-0.4	0.5	-0.5	1.1	0.3	-0.5	0.3	0.7	1.2	-1.0	-0.7
Lung cancer (father)	0.4	0.4	2.1	0.7	-1.4	-0.2	0.2	0.8	0.4	0.6	0.5	-0.1	0.3	0.5
Pulse wave Arterial Stiffness index	0.4	0.5	1.6	-0.3	-0.9	0.4	-0.3	0.8	-0.3	1.0	0.4	0.5	0.5	-1.3
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	2.5	0.5	-1.6	1.1	-0.4	-0.0	0.4	-0.5	-0.3	-0.6	1.6	0.3
Medication: Amlodipine	0.4	0.6	1.2	-0.5	1.0	-0.0	-1.0	-0.9	-0.6	-1.1	-1.0	-0.8	0.4	-0.2
Medication: Seretide 50 evohaler	0.4	0.5	1.5	1.2	0.2	0.7	-0.6	-0.1	1.2	-0.2	-0.5	-0.5	0.3	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	2.4	-0.2	1.6	0.1	-0.4	-0.8	-0.1	-0.9	-0.5	-0.3	0.3	0.8
Age at last live birth	0.4	0.6	1.1	-0.9	-0.1	-0.6	0.5	0.8	-1.0	0.9	0.6	1.0	-0.6	-0.8
Smoking status: Previous	0.4	0.5	1.4	1.0	-0.4	1.2	0.1	0.1	1.0	0.6	0.4	-0.2	0.7	1.1
Qualifications: nursing, teaching	0.4	0.6	1.9	-0.1	-1.1	-1.0	1.4	0.5	0.0	0.0	0.7	0.8	-0.7	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	1.6	-0.5	1.3	-0.8	0.1	-0.8	-0.6	0.4	-0.5	0.2	-1.1	-0.2
Mineral and other dietary supplements	0.4	0.5	1.3	-0.3	-0.6	-0.2	-0.8	-0.7	-0.5	-1.1	-1.1	-1.1	0.3	-0.2
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.8	-0.0	1.1	-0.2	0.8	0.5	0.1	1.0	1.0	1.3	-0.2	-0.0
Medication: Paracetamol	0.4	0.6	2.7	0.3	1.7	0.2	-0.3	-0.4	0.3	-1.0	-0.5	-0.3	-1.0	0.8
Medication: Atorvastatin	0.4	0.5	3.1	0.6	-0.2	1.8	-0.4	0.1	0.5	0.3	-0.1	-0.4	0.7	0.7
Illnesses of father: High blood pressure	0.4	0.5	0.8	0.7	0.5	0.6	-0.8	-0.6	0.8	-0.7	-0.8	-0.7	0.5	0.9
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.5	0.2	-0.6	0.2	1.0	1.2	0.2	-0.0	0.9	0.9	0.2	0.1
Schizophrenia vs Biploar Disorder	0.3	0.4	0.9	-1.0	0.9	-0.6	-0.0	-0.3	-1.0	0.1	-0.3	0.2	-0.9	-0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	1.3	-0.6	-1.0	-1.2	0.1	-0.4	-0.7	0.2	0.2	0.3	-0.4	-0.6
Smoking Status	0.3	0.7	1.3	1.2	0.2	0.5	0.9	0.4	1.0	0.6	1.2	0.9	-0.3	1.1
Chronotype (morning person)	0.3	0.7	1.8	-0.5	-1.3	-0.2	1.0	1.2	-0.5	0.4	0.8	0.8	-0.6	-1.2
Hearing difficulty/problems: Yes	0.3	0.5	1.0	-0.8	-0.4	-0.2	1.0	0.8	-0.8	0.5	0.7	0.9	-0.8	-0.6
Medication: Co-codamol	0.3	0.3	0.7	0.5	0.8	0.3	0.6	0.8	0.4	0.0	0.7	0.6	0.1	0.4
Diabetes (father)	0.3	0.4	1.1	-1.1	0.2	-0.8	-0.2	0.6	-1.1	0.5	-0.2	0.2	-0.6	-0.8
Relative age voice broke	0.3	0.4	2.4	-0.1	-1.6	-0.2	-0.6	-0.3	0.0	0.3	-0.4	-0.3	1.0	-0.5
Qualifications: CSEs or equivalent	0.3	0.4	1.4	0.8	0.6	1.2	-0.1	-0.5	0.7	-0.4	0.0	-0.3	0.5	0.7
Serious illness, injury or assault to yourself	0.3	0.4	3.5	-0.3	0.5	-1.9	0.0	-0.5	-0.2	0.1	-0.1	0.2	0.1	0.1
High blood pressure	0.3	0.9	2.2	-0.3	0.7	-0.7	-1.1	-1.5	-0.4	-1.5	-1.2	-1.2	0.2	0.1
Stomach or abdominal pain in last month	0.3	0.3	1.1	0.3	-1.1	0.2	-0.4	-0.2	0.3	-0.8	-0.6	-0.7	0.9	0.0
Allergy	0.3	0.7	2.1	0.3	-0.6	-0.7	1.5	1.0	0.3	0.2	1.4	1.3	-0.5	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	2.2	-0.4	1.0	-0.6	-0.2	-0.8	-0.5	-0.5	-0.5	0.0	-1.5	-0.2
Asthma	0.3	0.6	2.7	-0.3	-0.2	-0.0	0.6	1.4	-0.4	1.6	0.8	0.8	-0.3	-0.4
Peak expiratory flow (PEF)	0.3	0.8	5.9	-0.6	-2.4	-0.8	0.5	-0.1	-0.6	0.3	0.5	-0.2	0.2	-0.8
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.9	-0.3	0.1	0.2	0.5	1.0	-0.4	0.6	0.6	0.7	-0.9	-0.6
Exposure to tobacco smoke outside home	0.3	0.5	0.9	0.9	0.6	0.1	0.6	0.7	0.8	0.5	0.8	0.7	-0.4	1.0
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.8	0.4	0.6	-0.1	-0.3	-0.9	0.5	-0.7	-0.6	-0.4	0.2	0.8
Pulse rate, automated reading	0.3	1.1	3.4	0.8	0.3	-0.1	0.9	1.1	0.8	1.6	1.5	1.8	0.1	0.5
Alcohol intake frequency.	0.3	0.6	1.8	-0.6	0.4	-0.7	-0.7	-1.3	-0.8	-0.5	-1.0	-1.1	-0.7	-0.3
Overall health rating	0.3	0.6	3.7	0.6	1.9	-0.6	-0.1	-0.7	0.4	-0.2	-0.1	0.0	-0.6	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.8	0.7	0.7	0.8	0.2	-0.3	0.6	-1.3	-0.2	-0.2	-0.0	0.8
Diabetes diagnosed by doctor	0.3	0.5	1.1	0.8	0.1	1.0	-0.9	-0.1	0.8	0.4	-0.2	-0.6	1.0	0.9
Smoking status: Current	0.3	0.5	1.8	0.8	1.3	0.4	0.7	0.2	0.7	-0.1	0.7	0.9	-0.4	0.5
Fractured/broken bones in last 5 years	0.3	0.3	0.7	0.3	-0.8	-0.5	0.8	0.4	0.2	0.7	0.7	0.6	-0.6	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.9	1.8	0.4	-0.6	0.6	1.2	1.3	0.4	1.3	1.3	1.3	-0.2	-0.1
Pack years of smoking	0.3	0.4	0.9	1.0	-0.1	0.8	-0.5	-0.7	0.9	-0.2	-0.0	-0.3	0.8	0.3
Age at First Birth	0.2	0.3	0.7	-0.8	0.9	-0.6	-0.4	-0.7	-0.7	-0.2	-0.6	-0.6	-0.2	0.0
Systolic blood pressure, automated reading	0.2	0.6	2.1	0.4	0.2	0.1	-0.6	-1.4	0.5	-0.8	-0.8	-0.9	0.7	1.0
Supplements: Zinc	0.2	0.2	0.6	0.2	-0.7	0.1	0.5	-0.1	0.1	0.5	0.5	0.5	0.0	-0.8
Maternal smoking around birth	0.2	0.2	1.8	0.1	1.3	-0.1	-0.4	0.1	0.2	-0.5	-0.3	-0.1	0.6	0.2
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	-0.2	0.6	-0.4	-0.6	-0.4	-0.1	0.6	-0.5	-0.5	0.2	0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	0.4	0.5	0.1	-0.3	-0.4	0.5	-0.8	-0.6	-0.9	0.4	0.5
Medication: Ramipril	0.2	0.3	2.0	-0.3	1.4	-0.4	-0.6	-0.3	-0.2	0.0	-0.4	-0.1	-0.0	0.1
Time employed in main current job	0.2	0.2	1.0	0.1	0.5	-0.7	0.4	-0.4	0.1	0.1	0.1	0.4	-1.0	0.6
Alcohol intake versus 10 years previously	0.2	0.4	1.3	0.3	1.1	0.5	-0.5	-0.5	0.2	-1.0	-0.6	-0.2	-0.2	0.6
Pulse rate	0.2	0.4	2.4	0.3	1.6	-0.9	-0.2	-0.2	0.3	0.3	0.0	0.5	0.5	0.6
Depression (self-reported)	0.2	0.3	1.3	-0.1	0.1	-0.4	0.6	0.4	-0.2	0.6	0.4	0.5	-1.1	-0.3
Hair/balding pattern: Pattern 4	0.2	0.6	1.8	0.4	-0.4	0.2	-1.0	-0.5	0.6	-0.8	-0.8	-1.1	1.3	-0.0
Loud music exposure frequency	0.2	0.2	0.6	0.7	0.5	0.4	0.2	-0.2	0.5	-0.5	0.0	-0.2	-0.5	0.8
Glaucoma (self-reported)	0.2	0.2	0.8	-0.4	-0.8	-0.9	-0.3	-0.1	-0.4	-0.2	-0.6	-0.2	-0.2	-0.7
Pulse wave peak to peak time	0.2	0.3	1.0	0.3	0.2	-0.5	0.5	-0.6	0.3	-0.8	-0.0	-0.2	-0.4	1.0
Emphysema/chronic bronchitis	0.2	0.3	0.6	0.4	0.4	0.4	0.6	-0.1	0.5	0.6	0.6	0.8	-0.2	0.3
Mean time to correctly identify matches	0.2	0.5	1.3	-0.9	0.9	-0.7	0.3	0.6	-1.0	0.4	-0.0	0.4	-0.2	-1.1
Number of full sisters	0.2	0.2	0.5	0.5	-0.1	-0.0	0.6	0.2	0.4	0.6	0.6	0.7	0.0	0.3
Leg pain on walking	0.2	0.2	0.7	0.4	0.6	0.6	-0.2	-0.8	0.3	-0.1	-0.1	0.2	0.8	0.1
Hypertension (Self-reported)	0.2	0.5	1.2	-0.3	0.9	-0.6	-0.7	-1.0	-0.3	-1.1	-0.9	-0.8	0.2	0.2
Long-standing illness, disability or infirmity	0.2	0.3	0.7	0.3	-0.8	0.6	0.9	-0.0	0.1	0.0	0.7	0.6	-0.6	-0.3
Asthma (self-reported)	0.2	0.4	1.9	-0.3	-0.2	-0.0	0.4	1.1	-0.4	1.4	0.5	0.5	-0.2	-0.4
Guilty feelings	0.2	0.3	0.6	0.6	-0.2	0.6	0.1	-0.2	0.4	0.7	0.4	0.8	0.5	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.8	0.5	0.9	0.5	0.2	0.3	0.6	0.3	0.4	0.3	0.1	0.8
Alcohol drinker status: Never	0.2	0.3	0.9	-0.0	-0.9	-0.2	-0.2	-0.8	-0.1	0.3	-0.4	-0.6	-0.8	-0.1
Risk taking	0.2	0.2	1.3	-0.3	0.2	0.7	-0.3	0.4	-0.2	-0.2	-0.1	-0.2	1.1	-0.6
LDL Cholesterol	0.1	0.1	0.4	-0.1	0.5	-0.1	-0.1	0.1	-0.1	0.6	0.2	0.3	0.3	-0.2
Blood Eosinophil Count	0.1	0.9	2.2	-0.7	0.0	-1.5	0.7	-0.2	-0.7	1.5	0.3	1.0	-1.4	-1.0
Blood Red Count	0.1	1.0	4.8	-0.1	1.1	-0.3	-1.1	-1.0	-0.3	-2.2	-1.5	-0.8	0.2	0.1
Respiratory disease	0.1	0.2	2.2	-0.0	0.0	0.0	0.0	0.6	-0.1	1.5	0.1	0.1	-0.1	0.1
Lung FVC	0.1	0.4	1.1	0.5	0.2	-0.8	-0.6	-0.5	0.5	-1.0	-0.9	-0.6	0.2	0.5
Relative age of first facial hair	0.1	0.1	0.3	-0.5	-0.4	-0.2	-0.3	-0.1	-0.5	0.2	-0.2	0.0	0.3	-0.5
Past tobacco smoking	0.1	0.3	0.6	-0.4	0.3	-0.5	-0.6	-0.5	-0.4	-0.7	-0.8	-0.4	0.0	-0.5
Tense / ‘highly strung’	0.1	0.1	0.4	-0.3	0.6	-0.1	-0.4	-0.1	-0.4	0.1	-0.4	0.0	-0.2	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.5	0.0	-0.7	0.7	-0.1	-0.1	-0.2	0.6	-0.0	0.2	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.2	-0.0	0.5	-0.1	0.4	-0.0	-0.6	-0.2	0.0	0.1	0.1
Wheeze or whistling in the chest in last year	0.1	0.2	0.5	0.6	-0.2	0.1	0.4	-0.1	0.5	0.7	0.5	0.5	-0.4	0.4
Number of children fathered	0.1	0.1	0.3	-0.4	0.3	-0.0	0.4	-0.2	-0.5	0.5	0.2	0.3	-0.0	-0.1
Age at first live birth	0.1	0.2	0.4	-0.3	-0.5	0.3	-0.4	-0.4	-0.3	-0.6	-0.5	-0.4	-0.1	-0.4
Health satisfaction	0.1	0.1	0.4	0.2	-0.1	0.4	0.6	-0.4	0.1	-0.1	0.4	0.4	-0.5	0.2
Suffer from ‘nerves’	0.1	0.1	0.4	-0.3	0.3	0.1	0.1	-0.6	-0.5	-0.3	-0.1	0.2	-0.6	-0.1
Supplements: Vitamin C	0.1	0.1	0.3	0.2	0.1	0.4	-0.2	-0.6	0.3	-0.4	-0.2	-0.0	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	1.8	0.5	-1.3	0.4	0.2	-0.4	0.4	-0.1	0.3	-0.4	0.6	0.0
Average weekly red wine intake	0.1	0.2	1.3	-0.0	0.3	-0.2	0.2	0.7	0.2	-0.2	0.2	-0.2	1.1	0.4
Number of self-reported non-cancer illnesses	0.1	0.3	0.7	0.3	0.5	0.4	0.8	0.6	0.2	0.6	0.6	0.7	-0.3	0.1
Ever depressed for a whole week	0.1	0.1	0.3	0.5	-0.1	0.4	0.4	0.4	0.3	-0.1	0.4	0.5	-0.4	0.0
Unable to work because of sickness or disability	0.1	0.2	0.9	0.5	-0.5	0.5	-0.1	0.2	0.3	0.9	0.3	-0.0	0.1	0.1
Alcohol drinker status: Previous	0.1	0.2	0.7	0.3	-0.5	0.5	-0.3	0.2	0.3	0.4	0.0	-0.2	0.8	0.0

Hub : Genes

SYNGR1

Models

Trait associations