[Hub]/) : Traits : Primary Biliary Cirrhosis : ← →

chr7:127,878,155-129,284,182

Best TWAS P=2.2e-23 · Best GWAS P=5.08e-23 conditioned to 0.000422

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Visceral Omentum	IRF5	0.16	0.08	lasso	4	0.08	8.2e-05	8.2	8.4	3.5e-17	0.32	0.37	0.08	FALSE
2	GTEx	Colon Transverse	IRF5	0.21	0.22	lasso	4	0.22	8.0e-11	8.2	8.2	2.1e-16	0.31	1.00	0.00	FALSE
3	GTEx	Esophagus Mucosa	IRF5	0.13	0.14	lasso	4	0.13	4.6e-09	8.2	8.1	7.6e-16	0.29	0.99	0.00	FALSE
4	GTEx	Esophagus Muscularis	IRF5	0.21	0.12	lasso	5	0.11	3.9e-07	8.2	8.3	1.1e-16	0.32	0.85	0.02	FALSE
5	GTEx	Nerve Tibial	IRF5	0.13	0.09	enet	10	0.07	1.2e-05	8.2	8.2	1.7e-16	0.34	0.87	0.01	FALSE
6	GTEx	Skin Sun Exposed Lower leg	IRF5	0.10	0.14	lasso	2	0.12	1.9e-10	8.2	8.4	4.7e-17	0.32	1.00	0.00	FALSE
7	GTEx	Whole Blood	IRF5	0.17	0.06	lasso	4	0.09	1.2e-08	-5.7	7.7	1.4e-14	0.31	0.98	0.00	FALSE
8	METSIM	Adipose	IRF5	0.05	0.04	lasso	7	0.04	2.2e-06	8.2	8.7	4.4e-18	0.38	0.86	0.12	FALSE
9	ROSMAP	Brain Pre-frontal Cortex	IRF5	0.27	0.25	bslmm	336	0.25	7.1e-32	-5.7	6.2	4.5e-10	0.33	1.00	0.00	FALSE
10	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IRF5	0.09	0.06	blup	30	0.08	1.8e-07	-5.7	8.9	4.4e-19	0.43	0.74	0.22	FALSE
11	The Cancer Genome Atlas	Breast Invasive Carcinoma	IRF5	0.10	0.09	lasso	4	0.08	1.6e-16	8.2	8.2	1.9e-16	0.30	1.00	0.00	FALSE
12	The Cancer Genome Atlas	Colon Adenocarcinoma	IRF5	0.29	0.26	enet	6	0.29	3.1e-17	-8.2	8.7	2.3e-18	0.36	1.00	0.00	FALSE
13	The Cancer Genome Atlas	Glioblastoma Multiforme	IRF5	0.18	0.02	enet	8	0.04	2.4e-02	-5.0	10.0	2.2e-23	0.76	0.00	0.80	TRUE
14	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IRF5	0.14	0.12	enet	7	0.15	1.8e-16	8.1	7.0	2.0e-12	0.22	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IRF5	0.11	0.05	blup	30	0.07	2.2e-08	8.2	8.9	6.6e-19	0.40	1.00	0.00	FALSE
16	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	IRF5	0.09	0.04	lasso	4	0.06	2.3e-04	8.2	8.1	4.1e-16	0.30	0.38	0.20	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	IRF5	0.17	0.09	enet	6	0.15	1.8e-07	-5.9	8.1	4.5e-16	0.46	0.92	0.05	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	IRF5	0.18	0.11	enet	9	0.14	1.6e-15	8.2	8.1	3.9e-16	0.34	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	IRF5	0.14	0.15	enet	6	0.14	7.0e-10	-8.2	8.2	2.6e-16	0.36	1.00	0.00	FALSE
20	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IRF5	0.09	0.10	lasso	3	0.08	4.6e-04	-8.2	8.2	3.5e-16	0.34	0.06	0.18	FALSE
21	The Cancer Genome Atlas	Prostate Adenocarcinoma	IRF5	0.23	0.26	lasso	3	0.26	3.6e-27	-8.2	8.4	3.1e-17	0.34	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Rectum Adenocarcinoma	IRF5	0.41	0.13	blup	33	0.23	3.5e-06	-8.2	9.1	7.3e-20	0.46	0.19	0.19	FALSE
23	The Cancer Genome Atlas	Skin Cutaneous Melanoma	IRF5	0.22	0.03	enet	11	0.10	1.3e-03	-2.5	6.9	6.6e-12	0.28	0.01	0.17	TRUE
24	The Cancer Genome Atlas	Thyroid Carcinoma	IRF5	0.22	0.21	enet	9	0.26	4.6e-25	-8.2	8.8	1.9e-18	0.43	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	KCP	0.33	0.00	blup	53	0.00	3.0e-01	-1.9	-5.7	1.2e-08	-0.33	0.01	0.12	FALSE