Best TWAS P=4.77e-38 · Best GWAS P=2.55e-45 conditioned to 1.02e-11
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | RP11-554A11.9 | 0.34 | 0.13 | enet | 43 | 0.26 | 4.1e-21 | 4.167 | 6.5 | 7.8e-11 | 0.15 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-554A11.9 | 0.28 | 0.01 | enet | 27 | 0.13 | 4.3e-07 | 4.167 | 6.3 | 3.2e-10 | 0.22 | 0.36 | 0.03 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | RP11-554A11.9 | 0.49 | 0.17 | lasso | 9 | 0.20 | 8.5e-06 | 10.835 | 9.6 | 7.1e-22 | 0.30 | 0.53 | 0.04 | TRUE |
4 | GTEx | Brain Cerebellum | RP11-554A11.9 | 0.59 | 0.16 | enet | 29 | 0.33 | 1.4e-10 | 9.653 | 5.3 | 1.2e-07 | 0.04 | 0.40 | 0.03 | TRUE |
5 | GTEx | Breast Mammary Tissue | RP11-554A11.9 | 0.32 | 0.11 | lasso | 7 | 0.26 | 9.4e-14 | 4.167 | 7.7 | 1.4e-14 | 0.21 | 0.73 | 0.09 | FALSE |
6 | GTEx | Breast Mammary Tissue (Male) | RP11-554A11.9 | 0.23 | 0.08 | lasso | 4 | 0.08 | 6.7e-03 | 10.241 | 12.9 | 4.8e-38 | 0.47 | 0.04 | 0.38 | TRUE |
7 | GTEx | Breast Mammary Tissue (Female) | RP11-554A11.9 | 0.40 | 0.25 | enet | 18 | 0.30 | 1.5e-09 | 4.167 | 5.5 | 5.0e-08 | 0.18 | 0.58 | 0.02 | FALSE |
8 | GTEx | Colon Sigmoid | RP11-554A11.9 | 0.65 | 0.29 | enet | 36 | 0.41 | 8.3e-16 | 4.167 | 7.7 | 1.7e-14 | 0.26 | 0.99 | 0.00 | FALSE |
9 | GTEx | Colon Transverse | RP11-554A11.9 | 0.26 | 0.11 | lasso | 9 | 0.10 | 2.5e-05 | 9.653 | 9.6 | 1.1e-21 | 0.27 | 0.28 | 0.04 | FALSE |
10 | GTEx | Esophagus Muscularis | RP11-554A11.9 | 0.31 | 0.18 | lasso | 9 | 0.22 | 1.4e-13 | 4.167 | 6.9 | 3.7e-12 | 0.13 | 1.00 | 0.00 | FALSE |
11 | GTEx | Heart Atrial Appendage | RP11-554A11.9 | 0.24 | 0.05 | lasso | 8 | 0.09 | 9.5e-05 | 2.724 | 8.0 | 1.5e-15 | 0.04 | 0.15 | 0.04 | FALSE |
12 | GTEx | Heart Left Ventricle | RP11-554A11.9 | 0.16 | 0.11 | lasso | 3 | 0.09 | 2.2e-05 | 4.167 | 7.1 | 1.4e-12 | 0.22 | 0.39 | 0.03 | FALSE |
13 | GTEx | Lung | RP11-554A11.9 | 0.28 | 0.10 | enet | 34 | 0.20 | 1.6e-15 | 4.167 | 9.5 | 2.2e-21 | 0.28 | 1.00 | 0.00 | TRUE |
14 | GTEx | Nerve Tibial | RP11-554A11.9 | 0.43 | 0.10 | lasso | 11 | 0.33 | 8.7e-24 | 4.167 | 6.9 | 6.4e-12 | 0.18 | 1.00 | 0.00 | FALSE |
15 | GTEx | Prostate | RP11-554A11.9 | 0.44 | 0.11 | enet | 13 | 0.18 | 2.8e-05 | 7.911 | 9.6 | 8.8e-22 | 0.29 | 0.17 | 0.05 | FALSE |
16 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-554A11.9 | 0.28 | 0.13 | lasso | 9 | 0.21 | 1.5e-11 | 0.054 | 6.4 | 1.3e-10 | 0.17 | 0.83 | 0.01 | FALSE |
17 | GTEx | Thyroid | RP11-554A11.9 | 0.40 | 0.14 | lasso | 7 | 0.25 | 8.1e-19 | 4.167 | 6.8 | 8.2e-12 | 0.15 | 1.00 | 0.00 | FALSE |
18 | GTEx | Vagina | RP11-554A11.9 | 0.49 | 0.11 | lasso | 6 | 0.12 | 9.5e-04 | 10.835 | 9.1 | 7.2e-20 | 0.25 | 0.09 | 0.06 | FALSE |