Hub : Traits :

Prostate Cancer

327 significantly associated models · 91 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 24404988 24929676 1 1 2.1e-08 2.0e-05 3.0e-01 94 GRHL3
2 1 150527354 151021509 1 1 1.5e-08 5.4e-09 1.3e-01 93 CTSK
3 1 153220716 155699118 8 2 3.4e-09 3.8e-08 3.7e-02 86 CRTC2 DCST2
4 1 203692179 206329620 3 2 4.8e-13 2.3e-13 1.0e+00 100 MDM4 NUCKS1
5 2 10016627 11619674 2 1 2.7e-11 8.1e-12 8.6e-03 85 NOL10
6 2 20189015 21719583 1 1 1.1e-08 1.6e-10 1.6e-03 76 C2orf43
7 2 62211083 64747556 3 6 1.2e-17 5.0e-20 NaN NaN AC007098.1 EHBP1 WDPCP
8 2 84884961 86518249 6 1 2.5e-12 9.2e-11 8.3e-01 100 GGCX
9 3 86583852 87999964 1 1 8.7e-16 8.5e-21 5.3e-07 71 CHMP2B
10 3 112317291 114043692 3 1 7.2e-12 3.8e-09 5.9e-01 99 WDR52
11 3 127074386 128821807 3 1 8.7e-15 6.9e-14 6.8e-01 100 EEFSEC
12 3 169058009 170717996 4 4 8.1e-13 1.7e-11 1.0e+00 100 GPR160 PHC3 PRKCI SKIL
13 4 94674019 96286793 1 1 1.1e-09 1.8e-09 8.1e-02 92 PDLIM5
14 5 1635899 2131784 1 1 3.2e-12 1.4e-12 1.0e+00 100 IRX4
15 7 26010759 28573565 3 3 7.1e-17 1.3e-22 2.7e-07 72 SKAP2 TAX1BP1
16 7 97038925 98725348 7 2 2.6e-15 3.7e-18 1.2e-01 97 BHLHA15 LMTK2
17 8 22842752 24224911 1 2 6.4e-11 4.8e-28 7.1e-17 42 NKX3-1
18 9 18355044 19797850 2 1 4.1e-09 6.7e-10 5.4e-02 90 HAUS6
19 10 50336129 52456629 6 2 7.2e-68 6.1e-59 3.0e-03 97 AGAP6 NCOA4
20 10 103718818 105108455 1 1 1.7e-07 4.9e-06 6.4e-01 99 TRIM8
21 11 1938523 2541165 2 2 9.2e-12 7.2e-29 1.2e-14 52 ASCL2 TH
22 11 68227852 69623641 1 4 4.8e-38 2.5e-45 1.0e-11 77 RP11-554A11.9
23 11 75457950 76959598 1 1 3.0e-07 2.7e-08 1.0e+00 100 C11orf30
24 17 3587 1381005 5 1 3.2e-13 3.2e-12 1.0e+00 100 GEMIN4
25 17 35034943 36441093 2 4 2.2e-44 1.7e-73 1.7e-30 60 C17orf78 HNF1B
26 19 38052193 39476803 2 1 2.1e-21 4.9e-20 9.6e-03 92 PPP1R14A
27 19 41260831 42741124 3 1 2.0e-12 6.3e-12 1.0e+00 100 AC011526.1
28 20 61576647 62912463 6 2 6.6e-12 1.6e-11 1.0e+00 100 LIME1 STMN3
29 21 42591611 43141441 1 1 4.6e-08 2.4e-11 6.9e-05 64 TMPRSS2
30 22 42835727 44282307 5 1 5.0e-34 3.2e-43 8.4e-30 32 BIK

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 0.89 2 0 0.0 0.00 1.000 DCST2 EEFSEC
Intelligence (Savage-Jansen 2018) 0.75 2 0 0.0 0.00 1.000 AC007098.1 CRTC2
Neuroticism (Nagel 2018) 1.02 2 0 0.0 0.00 1.000 BHLHA15 LMTK2
Worry (Nagel 2018) 1.05 2 0 0.0 0.00 1.000 BHLHA15 LMTK2
Crohns Disease (2017) 1.75 3 2 4.4 0.00 1.000 C11orf30 LIME1 STMN3
Irritable Bowel Disease (IBD) 1.70 3 3 6.7 0.00 1.000 C11orf30 LIME1 STMN3
Ulcerative Colitis (UC) 1.12 2 0 0.0 0.00 1.000 C11orf30 STMN3
Reaction Time 1.32 1 0 0.0 0.00 1.000 RP11-554A11.9
Verbal and Numeric Reasoning (VNR) 0.84 2 0 0.0 0.00 1.000 AC007098.1 CRTC2
Breast Cancer 1.50 2 1 2.2 0.46 0.543 BIK RP11-554A11.9
Age at First Birth 0.85 1 1 2.2 0.00 1.000 CRTC2
Coronary Artery Disease (CAD) 0.93 1 0 0.0 0.00 1.000 GGCX
Crohns Disease (2012) 1.65 1 0 0.0 0.00 1.000 STMN3
Ulcerative Colitis 1.53 2 0 0.0 0.00 1.000 LIME1 STMN3
Blood Eosinophil Count 0.91 8 4 8.9 0.22 0.594 C11orf30 DCST2 GEMIN4 GGCX GPR160 MDM4 NKX3-1 PHC3
Blood Platelet Count 1.26 13 11 24.4 0.24 0.386 BIK C11orf30 C17orf78 CRTC2 DCST2 EEFSEC HAUS6 LIME1 PPP1R14A RP11-554A11.9 STMN3 TRIM8 WDR52
Blood Red Count 0.50 4 2 4.4 0.53 0.467 C17orf78 LIME1 NKX3-1 STMN3
Blood White Count 0.71 6 2 4.4 0.29 0.573 C11orf30 C17orf78 GGCX STMN3 TH TRIM8
Heel T-Score 0.92 5 3 6.7 -0.92 0.001 GPR160 PDLIM5 PHC3 RP11-554A11.9 TAX1BP1
BMI 1.00 4 2 4.4 -0.88 0.048 ASCL2 DCST2 EHBP1 WDPCP
Height 0.88 12 6 13.3 0.08 0.811 C11orf30 DCST2 GGCX HAUS6 LIME1 MDM4 NKX3-1 NUCKS1 SKAP2 TH TRIM8 WDR52
Waist Hip Ratio (WHR) 1.04 6 2 4.4 0.02 0.965 CTSK DCST2 RP11-554A11.9 SKAP2 TRIM8 WDR52
Systolic Blood Pressure 1.61 6 3 6.7 -0.13 0.737 C11orf30 C2orf43 CTSK LIME1 SKAP2 WDPCP
Smoking Status 1.65 3 1 2.2 0.00 1.000 LMTK2 TRIM8 WDPCP
Allergy or Eczema 3.04 8 4 8.9 0.72 0.028 AGAP6 C11orf30 DCST2 LIME1 NCOA4 STMN3 TRIM8 WDPCP
Cardiovascular Disease 1.26 1 0 0.0 0.00 1.000 CRTC2
Hypothyroidism (self reported) 0.70 1 0 0.0 0.00 1.000 DCST2
Respiratory disease 1.93 3 1 2.2 -0.32 0.594 C11orf30 EEFSEC WDPCP
Type 2 Diabetes (T2D) (2018) 1.52 1 0 0.0 0.00 1.000 HNF1B
Lung FEV1/FVC ratio 1.49 5 2 4.4 0.65 0.231 BIK DCST2 EEFSEC HNF1B NUCKS1
Lung FVC 1.64 8 3 6.7 -0.48 0.160 AC007098.1 EHBP1 LIME1 MDM4 NUCKS1 STMN3 TAX1BP1 WDPCP
Chronotype (morning person) 0.64 1 0 0.0 0.00 1.000 CTSK
Hair Pigment 1.69 5 4 8.9 0.52 0.099 DCST2 GRHL3 NUCKS1 RP11-554A11.9 WDPCP
Tanning 0.93 5 3 6.7 -0.04 0.926 DCST2 EHBP1 LMTK2 RP11-554A11.9 WDPCP
Hand grip strength (left) 1.54 4 1 2.2 -0.38 0.617 ASCL2 NUCKS1 TAX1BP1 TRIM8
Number of treatments/medications taken 1.07 1 0 0.0 0.00 1.000 NUCKS1
Relative age of first facial hair 1.42 1 0 0.0 0.00 1.000 MDM4
Systolic blood pressure, automated reading 0.94 2 0 0.0 0.00 1.000 LIME1 SKAP2
Angina 1.19 1 0 0.0 0.00 1.000 GGCX
Vitamin and mineral supplements 1.67 1 0 0.0 0.00 1.000 NUCKS1
Medication: Metformin 1.81 1 0 0.0 0.00 1.000 HAUS6
Impedance of leg (right) 1.39 6 1 2.2 -0.11 0.835 AC007098.1 ASCL2 DCST2 HAUS6 NOL10 NUCKS1
Leg fat-free mass (left) 1.33 5 2 4.4 -0.45 0.376 ASCL2 DCST2 GGCX NUCKS1 WDPCP
Trunk fat percentage 0.85 1 0 0.0 0.00 1.000 TAX1BP1
Hand grip strength (right) 1.42 2 1 2.2 0.00 1.000 NUCKS1 TAX1BP1
Current tobacco smoking 1.56 1 0 0.0 0.00 1.000 BHLHA15
Age when periods started (menarche) 1.28 4 1 2.2 -0.37 0.631 C11orf30 CRTC2 EEFSEC NUCKS1
Heel bone mineral density (BMD) T-score, automated (left) 0.86 1 0 0.0 0.00 1.000 TAX1BP1
High blood pressure 1.50 4 0 0.0 0.60 0.403 CRTC2 CTSK MDM4 SKAP2
Hayfever, allergic rhinitis or eczema 2.66 6 2 4.4 0.71 0.111 C11orf30 DCST2 LIME1 NCOA4 STMN3 TRIM8
Multivitamins +/- minerals 1.30 1 0 0.0 0.00 1.000 NUCKS1
Diverticular disease/diverticulitis (self-reported) 1.20 1 0 0.0 0.00 1.000 PPP1R14A
Sitting height 0.90 3 2 4.4 0.00 1.000 DCST2 NUCKS1 TRIM8
High blood pressure (mother) 0.86 1 0 0.0 0.00 1.000 MDM4
Body mass index (BMI) 1.14 4 0 0.0 0.62 0.268 AC007098.1 DCST2 EHBP1 WDPCP
Impedance of leg (left) 1.44 5 2 4.4 0.41 0.489 ASCL2 DCST2 HAUS6 NOL10 NUCKS1
Leg predicted mass (left) 1.32 5 2 4.4 -0.45 0.373 ASCL2 DCST2 GGCX NUCKS1 WDPCP
Trunk fat mass 0.97 3 0 0.0 0.40 0.499 EHBP1 GGCX WDPCP
Waist circumference 1.23 2 1 2.2 0.07 0.934 EHBP1 WDPCP
Past tobacco smoking 1.44 1 1 2.2 0.00 1.000 TRIM8
Nervous feelings 1.09 2 0 0.0 0.00 1.000 BHLHA15 LMTK2
Hearing difficulty/problems with background noise 1.39 2 1 2.2 0.00 1.000 NUCKS1 TRIM8
Forced vital capacity (FVC) 1.02 4 1 2.2 -0.40 0.596 LIME1 MDM4 STMN3 TRIM8
Heel bone mineral density (BMD) T-score, automated (right) 1.07 1 0 0.0 0.00 1.000 TAX1BP1
Heart attack 1.43 1 0 0.0 0.00 1.000 AC007098.1
Allergy 2.78 7 2 4.4 -0.38 0.347 C11orf30 CRTC2 EEFSEC LIME1 STMN3 TRIM8 WDPCP
Hayfever/allergic rhinitis (self-reported) 1.73 1 0 0.0 0.00 1.000 C11orf30
Fluid intelligence score 0.97 1 0 0.0 0.00 1.000 CRTC2
Neuroticism score 1.01 1 0 0.0 0.00 1.000 NUCKS1
Weight 1.30 7 2 4.4 0.38 0.347 AC007098.1 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP
Impedance of arm (right) 1.25 6 2 4.4 0.58 0.174 ASCL2 DCST2 EEFSEC NUCKS1 TAX1BP1 WDPCP
Arm fat percentage (right) 0.90 1 0 0.0 0.00 1.000 TAX1BP1
Trunk fat-free mass 1.29 6 3 6.7 -0.52 0.234 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Hip circumference 1.27 4 2 4.4 -0.46 0.440 DCST2 EHBP1 GGCX WDPCP
Worrier / anxious feelings 1.30 1 0 0.0 0.00 1.000 TRIM8
Forced expiratory volume in 1-second (FEV1) 1.07 2 0 0.0 0.00 1.000 LIME1 MDM4
Noisy workplace 1.22 1 0 0.0 0.00 1.000 CRTC2
Asthma 1.52 1 0 0.0 0.00 1.000 EEFSEC
Lung cancer (father) 1.63 1 0 0.0 0.00 1.000 MDM4
Forced expiratory volume in 1-second (FEV1), Best measure 1.00 1 0 0.0 0.00 1.000 MDM4
Impedance of arm (left) 1.19 4 2 4.4 0.70 0.300 ASCL2 DCST2 EEFSEC TAX1BP1
Arm fat mass (right) 1.08 3 0 0.0 0.50 0.504 DCST2 EHBP1 WDPCP
Trunk predicted mass 1.29 6 3 6.7 -0.50 0.251 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Standing height 0.80 4 3 6.7 0.12 0.876 DCST2 GGCX NUCKS1 TRIM8
Tense / 'highly strung' 1.27 1 0 0.0 0.00 1.000 NUCKS1
Hair/balding pattern: Pattern 4 1.00 2 2 4.4 0.00 1.000 CRTC2 GRHL3
Peak expiratory flow (PEF) 1.39 2 1 2.2 0.00 1.000 MDM4 NUCKS1
Gout (self-reported) 1.25 1 0 0.0 0.00 1.000 DCST2
Birth weight 1.78 3 1 2.2 0.00 1.000 ASCL2 DCST2 NUCKS1
Forced vital capacity (FVC), Best measure 0.93 3 1 2.2 0.00 1.000 MDM4 STMN3 TRIM8
Body fat percentage 0.86 1 0 0.0 0.00 1.000 EHBP1
Arm fat-free mass (right) 1.43 7 3 6.7 -0.44 0.273 ASCL2 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP
Comparative body size at age 10 0.99 1 1 2.2 0.00 1.000 NUCKS1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.93 1 0 0.0 0.00 1.000 NUCKS1
Angina (self-reported) 1.17 1 0 0.0 0.00 1.000 GGCX
Medication: Allopurinol 1.20 1 0 0.0 0.00 1.000 DCST2
Mean time to correctly identify matches 1.12 2 0 0.0 0.00 1.000 NUCKS1 RP11-554A11.9
Whole body fat mass 1.06 2 0 0.0 0.00 1.000 EHBP1 WDPCP
Leg fat mass (right) 1.03 2 0 0.0 0.00 1.000 EHBP1 WDPCP
Arm predicted mass (right) 1.47 7 2 4.4 -0.44 0.279 ASCL2 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP
Pulse rate, automated reading 1.20 4 0 0.0 -0.45 0.549 C11orf30 CTSK PDLIM5 PPP1R14A
Comparative height size at age 10 1.06 5 2 4.4 0.44 0.453 DCST2 GGCX HAUS6 NUCKS1 TRIM8
Hypertension (Self-reported) 1.33 2 0 0.0 0.00 1.000 MDM4 SKAP2
Illnesses of father: Heart disease 1.66 2 0 0.0 0.00 1.000 AC007098.1 GGCX
Forced expiratory volume in 1-second (FEV1), predicted 1.03 1 1 2.2 0.00 1.000 TRIM8
Whole body fat-free mass 1.33 6 3 6.7 -0.39 0.393 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Leg fat-free mass (right) 1.34 7 2 4.4 0.43 0.336 AGAP6 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Mood swings 0.87 1 0 0.0 0.00 1.000 NUCKS1
Diabetes diagnosed by doctor 1.56 1 0 0.0 0.00 1.000 HNF1B
Asthma (self-reported) 1.56 1 0 0.0 0.00 1.000 EEFSEC
Illnesses of father: None of the above (group 1) 1.53 1 0 0.0 0.00 1.000 NUCKS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.32 1 0 0.0 0.00 1.000 STMN3
Whole body water mass 1.34 6 3 6.7 -0.40 0.371 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Leg predicted mass (right) 1.33 7 2 4.4 0.43 0.334 AGAP6 ASCL2 DCST2 GGCX NUCKS1 TRIM8 WDPCP
Arm fat mass (left) 1.12 3 0 0.0 -0.38 0.616 DCST2 EHBP1 WDPCP
Medication: Blood pressure 1.54 1 0 0.0 0.00 1.000 CTSK
High cholesterol (Self-reported) 1.29 1 0 0.0 0.00 1.000 AC007098.1
Illnesses of father: High blood pressure 1.11 1 0 0.0 0.00 1.000 MDM4
Ever smoked 1.40 1 0 0.0 0.00 1.000 TRIM8
Basal metabolic rate 1.36 7 3 6.7 -0.47 0.244 ASCL2 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP
Arm fat-free mass (left) 1.42 7 2 4.4 -0.43 0.289 ASCL2 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP
Diastolic blood pressure, automated reading 1.31 5 0 0.0 0.71 0.175 C11orf30 LIME1 MDM4 SKAP2 STMN3
Vascular/heart problems diagnosed by doctor 1.36 4 0 0.0 -0.57 0.432 CRTC2 CTSK MDM4 SKAP2
Medication: Omeprazole (e.g. Zanprol) 0.84 1 0 0.0 0.00 1.000 C2orf43
Heart disease (siblings) 1.65 1 0 0.0 0.00 1.000 AC007098.1
Impedance of whole body 1.33 7 1 2.2 0.44 0.327 ASCL2 DCST2 EEFSEC HNF1B NOL10 NUCKS1 TAX1BP1
Leg fat mass (left) 1.06 2 0 0.0 0.00 1.000 EHBP1 WDPCP
Arm predicted mass (left) 1.43 6 3 6.7 -0.34 0.457 DCST2 EHBP1 GGCX NUCKS1 TRIM8 WDPCP

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.288 1.7
GTEx Adipose Visceral Omentum 6 0.325 1.6
GTEx Adrenal Gland 2 0.154 1.5
GTEx Artery Aorta 5 0.188 1.5
GTEx Artery Coronary 2 0.187 1.5
GTEx Artery Tibial 8 0.240 1.6
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 4 0.301 1.7
GTEx Brain Cerebellum 6 0.334 1.6
GTEx Brain Cortex 3 0.319 1.6
GTEx Brain Frontal Cortex BA9 3 0.358 1.7
GTEx Brain Hippocampus 0 0.000 1.6
GTEx Brain Hypothalamus 1 0.185 1.6
GTEx Brain Nucleus accumbens basal ganglia 2 0.254 1.7
GTEx Brain Putamen basal ganglia 1 0.178 1.7
GTEx Breast Mammary Tissue 7 0.393 1.7
GTEx Breast Mammary Tissue (Male) 4 0.372 1.7
GTEx Breast Mammary Tissue (Female) 6 0.405 1.7
GTEx Cells EBV-transformed lymphocytes 4 0.316 1.6
GTEx Cells Transformed fibroblasts 10 0.269 1.6
GTEx Colon Sigmoid 5 0.381 1.6
GTEx Colon Transverse 7 0.378 1.7
GTEx Esophagus Gastroesophageal Junction 2 0.153 1.5
GTEx Esophagus Mucosa 10 0.337 1.7
GTEx Esophagus Muscularis 9 0.314 1.7
GTEx Heart Atrial Appendage 2 0.141 1.6
GTEx Heart Left Ventricle 4 0.292 1.6
GTEx Liver 1 0.156 1.6
GTEx Lung 5 0.195 1.6
GTEx Muscle Skeletal 6 0.233 1.5
GTEx Nerve Tibial 14 0.362 1.7
GTEx Ovary 1 0.121 1.5
GTEx Pancreas 2 0.137 1.6
GTEx Pituitary 0 0.000 1.6
GTEx Prostate 4 0.529 2.0
GTEx Skin Not Sun Exposed Suprapubic 7 0.318 1.6
GTEx Skin Sun Exposed Lower leg 11 0.338 1.6
GTEx Small Intestine Terminal Ileum 1 0.245 1.6
GTEx Spleen 3 0.235 1.7
GTEx Stomach 3 0.231 1.6
GTEx Testis 9 0.320 1.6
GTEx Thyroid 10 0.281 1.6
GTEx Uterus 1 0.195 1.5
GTEx Vagina 2 0.345 1.6
GTEx Whole Blood 4 0.225 1.6
METSIM Adipose 6 0.149 1.5
NTR Blood 8 0.380 1.7
ROSMAP Brain Pre-frontal Cortex 6 0.150 1.5
YFS Blood 12 0.297 1.7
CommonMind Brain Pre-frontal Cortex 11 0.232 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 4 0.279 1.6
The Cancer Genome Atlas Breast Invasive Carcinoma 12 0.308 1.6
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Esophageal Carcinoma 1 0.169 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.219 1.6
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.084 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.083 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.167 1.7
The Cancer Genome Atlas Brain Lower Grade Glioma 6 0.158 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 2 0.207 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 8 0.309 1.6
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.046 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.145 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 17 0.418 1.8
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.213 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.069 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.089 1.5
The Cancer Genome Atlas Thyroid Carcinoma 12 0.263 1.6
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4