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chr1:37,222,762-39,167,106

Best TWAS P=7.62e-11 · Best GWAS P=7.52e-10 conditioned to 0.144

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Tibial	MEAF6	0.25	0.13	lasso	7	0.17	2.4e-13	-5.8	-5.3	1.4e-07	-0.10	0.02	0.98	FALSE
2	GTEx	Breast Mammary Tissue	RP11-109P14.9	0.19	0.00	lasso	4	0.01	1.4e-01	-6.0	-6.0	2.5e-09	-0.32	0.04	0.23	FALSE
3	GTEx	Breast Mammary Tissue (Male)	RP11-422J8.1	0.09	0.04	lasso	3	0.06	1.7e-02	-4.8	5.5	2.9e-08	0.24	0.05	0.14	FALSE
4	GTEx	Cells EBV-transformed lymphocytes	GNL2	0.25	0.10	lasso	4	0.07	2.3e-03	-5.8	-6.5	7.6e-11	-0.08	0.02	0.96	TRUE
5	GTEx	Cells EBV-transformed lymphocytes	MEAF6	0.36	0.10	lasso	5	0.23	5.6e-08	-5.8	-6.0	2.6e-09	-0.09	0.02	0.97	FALSE
6	GTEx	Cells Transformed fibroblasts	GNL2	0.24	0.19	lasso	6	0.18	7.6e-14	-5.7	-5.7	1.6e-08	-0.11	0.02	0.98	FALSE
7	GTEx	Esophagus Mucosa	MEAF6	0.12	0.10	enet	7	0.09	2.1e-06	-5.8	-5.5	3.6e-08	-0.09	0.02	0.98	FALSE
8	GTEx	Esophagus Muscularis	MEAF6	0.13	0.02	lasso	5	0.01	4.6e-02	-6.0	-5.8	8.9e-09	-0.06	0.02	0.94	FALSE
9	GTEx	Lung	MEAF6	0.11	0.10	lasso	3	0.10	2.9e-08	-5.8	-5.8	6.0e-09	-0.10	0.02	0.98	FALSE
10	GTEx	Skin Not Sun Exposed Suprapubic	MEAF6	0.13	0.11	lasso	2	0.09	7.9e-06	-5.8	-5.8	8.5e-09	-0.11	0.02	0.96	FALSE
11	GTEx	Spleen	MEAF6	0.24	0.18	lasso	3	0.14	2.2e-04	-6.0	-5.5	3.4e-08	-0.07	0.02	0.91	FALSE
12	GTEx	Stomach	MEAF6	0.17	0.09	lasso	7	0.11	6.5e-06	2.9	-5.5	3.5e-08	-0.06	0.07	0.89	FALSE
13	GTEx	Whole Blood	FHL3	0.24	0.20	enet	20	0.23	3.1e-21	6.2	5.3	1.2e-07	0.90	0.00	1.00	FALSE
14	GTEx	Whole Blood	SF3A3	0.16	0.08	lasso	4	0.09	2.3e-08	6.2	5.5	4.7e-08	0.92	0.00	1.00	FALSE
15	NTR	Blood	MEAF6	0.05	0.02	lasso	3	0.03	3.9e-11	3.2	-5.2	2.5e-07	-0.05	0.90	0.09	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	EPHA10	0.10	0.06	enet	34	0.07	1.2e-09	-2.5	5.2	1.8e-07	0.44	0.97	0.02	FALSE
17	YFS	Blood	FHL3	0.69	0.49	enet	33	0.57	8.2e-237	6.2	5.5	3.4e-08	0.90	0.00	1.00	TRUE
18	YFS	Blood	GNL2	0.06	0.06	lasso	12	0.06	2.0e-20	-5.7	-5.3	8.6e-08	-0.05	0.03	0.97	FALSE
19	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	GNL2	0.03	0.01	enet	4	0.03	1.2e-03	-5.7	-5.4	8.1e-08	-0.07	0.01	0.92	FALSE
20	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MEAF6	0.10	0.02	blup	45	0.07	1.6e-06	3.0	-6.4	1.9e-10	-0.04	0.01	0.93	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GNL2	0.08	0.09	lasso	3	0.09	1.0e-10	-5.7	-5.7	1.5e-08	-0.09	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	MEAF6	0.08	0.03	enet	8	0.06	2.0e-07	2.9	-5.7	1.6e-08	-0.04	0.02	0.97	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	GNL2	0.04	0.04	lasso	1	0.03	1.2e-04	-5.7	-5.7	9.5e-09	-0.10	0.00	0.99	FALSE
24	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MEAF6	0.03	0.01	lasso	2	0.01	1.7e-02	3.2	-5.2	1.9e-07	-0.05	0.02	0.66	FALSE
25	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GNL2	0.07	0.00	blup	48	0.01	3.8e-02	-5.7	-5.8	4.8e-09	-0.02	0.01	0.62	FALSE
26	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	MEAF6	0.12	0.06	blup	45	0.08	3.5e-04	-5.8	-5.9	3.7e-09	-0.05	0.01	0.88	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	GNL2	0.07	0.00	enet	15	0.01	1.5e-02	4.1	-5.5	3.4e-08	-0.02	0.01	0.31	FALSE
28	The Cancer Genome Atlas	Thyroid Carcinoma	MEAF6	0.22	0.09	enet	9	0.15	8.8e-15	3.2	-5.1	2.9e-07	0.02	0.99	0.00	FALSE