Best TWAS P=9.72e-11 · Best GWAS P=2.1e-11 conditioned to 0.000263
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PHC2 | 0.12 | 0.09 | bslmm | 500 | 0.12 | 4.7e-14 | -6.5 | -6.4 | 1.9e-10 | -0.66 | 0.03 | 0.97 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RN7SKP16 | 0.09 | 0.02 | lasso | 3 | 0.01 | 5.9e-02 | -6.3 | 6.2 | 5.6e-10 | 0.54 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | AL513327.1 | 0.09 | 0.03 | enet | 22 | 0.07 | 2.0e-04 | -4.5 | 5.6 | 2.0e-08 | 0.60 | 0.10 | 0.72 | FALSE |
| 4 | GTEx | Muscle Skeletal | TRIM62 | 0.05 | 0.01 | lasso | 5 | 0.01 | 8.3e-02 | -4.4 | -5.5 | 2.9e-08 | -0.56 | 0.24 | 0.66 | FALSE |
| 5 | GTEx | Muscle Skeletal | ZNF362 | 0.04 | 0.01 | enet | 7 | 0.02 | 4.9e-03 | -5.1 | 5.6 | 2.4e-08 | 0.70 | 0.09 | 0.74 | FALSE |
| 6 | YFS | Blood | ZNF362 | 0.11 | 0.11 | enet | 37 | 0.12 | 1.3e-36 | -6.0 | 5.7 | 1.2e-08 | 0.46 | 0.38 | 0.62 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PHC2 | 0.04 | 0.04 | enet | 9 | 0.04 | 1.8e-04 | -6.3 | 6.5 | 9.7e-11 | 0.57 | 0.03 | 0.96 | TRUE |