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chr5:153,439,041-155,044,238

Best TWAS P=2.14e-21 · Best GWAS P=1.47e-24 conditioned to 0.351

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
20	ROSMAP	Brain Pre-frontal Cortex	CNOT8	0.13	0.05	lasso	2	0.07	6.4e-09	-7.6	9.5	2.1e-21	-0.84	0.03	0.97	TRUE
8	GTEx	Artery Aorta	CNOT8	0.15	0.10	lasso	2	0.07	7.6e-05	-7.6	7.5	9.5e-14	-0.62	0.85	0.05	TRUE
4	GTEx	Adipose Subcutaneous	CNOT8	0.21	0.22	lasso	3	0.22	3.0e-18	-7.8	8.4	3.2e-17	-0.63	1.00	0.00	FALSE
9	GTEx	Artery Tibial	CNOT8	0.27	0.20	lasso	3	0.20	7.2e-16	-7.8	8.4	3.9e-17	-0.63	1.00	0.00	FALSE
22	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CNOT8	0.07	0.00	enet	20	0.03	2.4e-03	4.0	8.4	6.1e-17	-0.57	0.02	0.62	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CNOT8	0.06	0.04	lasso	5	0.05	1.5e-06	-8.0	8.2	1.7e-16	-0.74	0.01	0.99	FALSE
17	GTEx	Testis	CNOT8	0.15	0.09	lasso	7	0.12	6.5e-06	-7.5	8.2	2.6e-16	-0.67	0.58	0.24	FALSE
3	GTEx	Adipose Subcutaneous	GEMIN5	0.11	0.11	lasso	4	0.11	5.3e-09	-7.5	8.1	7.8e-16	-0.63	1.00	0.00	FALSE
10	GTEx	Artery Tibial	FAXDC2	0.17	0.09	lasso	5	0.08	9.2e-07	-7.8	8.0	9.3e-16	-0.62	0.95	0.03	FALSE
19	NTR	Blood	LARP1	0.03	0.00	bslmm	501	0.00	1.2e-02	-7.2	-8.0	9.7e-16	0.49	0.04	0.77	FALSE
18	GTEx	Thyroid	CNOT8	0.22	0.18	lasso	6	0.18	1.3e-13	-7.5	8.0	1.1e-15	-0.67	0.99	0.01	FALSE
11	GTEx	Breast Mammary Tissue	CNOT8	0.23	0.06	lasso	7	0.08	4.0e-05	-7.5	8.0	1.8e-15	-0.60	0.78	0.05	FALSE
12	GTEx	Esophagus Muscularis	CNOT8	0.17	0.07	lasso	2	0.04	1.0e-03	-7.8	7.8	8.8e-15	-0.63	0.74	0.05	FALSE
5	GTEx	Adipose Subcutaneous	FAXDC2	0.11	0.12	lasso	2	0.12	6.0e-10	-7.5	7.6	2.1e-14	-0.63	1.00	0.00	FALSE
16	GTEx	Skin Sun Exposed Lower leg	CNOT8	0.18	0.17	lasso	3	0.16	1.3e-13	-7.8	7.6	2.1e-14	-0.63	1.00	0.00	FALSE
15	GTEx	Nerve Tibial	CNOT8	0.20	0.20	lasso	5	0.20	6.5e-14	-7.8	7.6	2.2e-14	-0.62	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	CNOT8	0.17	0.15	lasso	6	0.12	1.3e-06	-7.8	7.6	3.2e-14	-0.62	0.94	0.03	FALSE
13	GTEx	Lung	CNOT8	0.30	0.23	lasso	7	0.22	1.1e-16	-7.6	7.6	3.6e-14	-0.62	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	GEMIN5	0.13	0.10	lasso	2	0.08	7.7e-05	-7.5	7.2	5.1e-13	-0.61	0.29	0.09	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CNOT8	0.04	0.03	lasso	1	0.02	2.7e-03	-6.8	6.8	1.3e-11	-0.59	0.01	0.91	FALSE
14	GTEx	Muscle Skeletal	CNOT8	0.10	0.02	enet	8	0.05	7.5e-06	-7.8	6.7	2.2e-11	-0.54	0.05	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	MRPL22	0.07	0.04	lasso	8	0.02	4.1e-03	6.4	6.5	7.0e-11	-0.52	0.47	0.02	FALSE