Best TWAS P=2.14e-21 · Best GWAS P=1.47e-24 conditioned to 0.351
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CNOT8 | 0.06 | 0.04 | lasso | 5 | 0.05 | 1.5e-06 | -8.0 | 8.2 | 1.7e-16 | -0.74 | 0.01 | 0.99 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | MRPL22 | 0.07 | 0.04 | lasso | 8 | 0.02 | 4.1e-03 | 6.4 | 6.5 | 7.0e-11 | -0.52 | 0.47 | 0.02 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | GEMIN5 | 0.11 | 0.11 | lasso | 4 | 0.11 | 5.3e-09 | -7.5 | 8.1 | 7.8e-16 | -0.63 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | CNOT8 | 0.21 | 0.22 | lasso | 3 | 0.22 | 3.0e-18 | -7.8 | 8.4 | 3.2e-17 | -0.63 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | FAXDC2 | 0.11 | 0.12 | lasso | 2 | 0.12 | 6.0e-10 | -7.5 | 7.6 | 2.1e-14 | -0.63 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Adipose Visceral Omentum | GEMIN5 | 0.13 | 0.10 | lasso | 2 | 0.08 | 7.7e-05 | -7.5 | 7.2 | 5.1e-13 | -0.61 | 0.29 | 0.09 | FALSE |
| 7 | GTEx | Adipose Visceral Omentum | CNOT8 | 0.17 | 0.15 | lasso | 6 | 0.12 | 1.3e-06 | -7.8 | 7.6 | 3.2e-14 | -0.62 | 0.94 | 0.03 | FALSE |
| 8 | GTEx | Artery Aorta | CNOT8 | 0.15 | 0.10 | lasso | 2 | 0.07 | 7.6e-05 | -7.6 | 7.5 | 9.5e-14 | -0.62 | 0.85 | 0.05 | TRUE |
| 9 | GTEx | Artery Tibial | CNOT8 | 0.27 | 0.20 | lasso | 3 | 0.20 | 7.2e-16 | -7.8 | 8.4 | 3.9e-17 | -0.63 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Artery Tibial | FAXDC2 | 0.17 | 0.09 | lasso | 5 | 0.08 | 9.2e-07 | -7.8 | 8.0 | 9.3e-16 | -0.62 | 0.95 | 0.03 | FALSE |
| 11 | GTEx | Breast Mammary Tissue | CNOT8 | 0.23 | 0.06 | lasso | 7 | 0.08 | 4.0e-05 | -7.5 | 8.0 | 1.8e-15 | -0.60 | 0.78 | 0.05 | FALSE |
| 12 | GTEx | Esophagus Muscularis | CNOT8 | 0.17 | 0.07 | lasso | 2 | 0.04 | 1.0e-03 | -7.8 | 7.8 | 8.8e-15 | -0.63 | 0.74 | 0.05 | FALSE |
| 13 | GTEx | Lung | CNOT8 | 0.30 | 0.23 | lasso | 7 | 0.22 | 1.1e-16 | -7.6 | 7.6 | 3.6e-14 | -0.62 | 1.00 | 0.00 | FALSE |
| 14 | GTEx | Muscle Skeletal | CNOT8 | 0.10 | 0.02 | enet | 8 | 0.05 | 7.5e-06 | -7.8 | 6.7 | 2.2e-11 | -0.54 | 0.05 | 0.92 | FALSE |
| 15 | GTEx | Nerve Tibial | CNOT8 | 0.20 | 0.20 | lasso | 5 | 0.20 | 6.5e-14 | -7.8 | 7.6 | 2.2e-14 | -0.62 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | CNOT8 | 0.18 | 0.17 | lasso | 3 | 0.16 | 1.3e-13 | -7.8 | 7.6 | 2.1e-14 | -0.63 | 1.00 | 0.00 | FALSE |
| 17 | GTEx | Testis | CNOT8 | 0.15 | 0.09 | lasso | 7 | 0.12 | 6.5e-06 | -7.5 | 8.2 | 2.6e-16 | -0.67 | 0.58 | 0.24 | FALSE |
| 18 | GTEx | Thyroid | CNOT8 | 0.22 | 0.18 | lasso | 6 | 0.18 | 1.3e-13 | -7.5 | 8.0 | 1.1e-15 | -0.67 | 0.99 | 0.01 | FALSE |
| 19 | NTR | Blood | LARP1 | 0.03 | 0.00 | bslmm | 501 | 0.00 | 1.2e-02 | -7.2 | -8.0 | 9.7e-16 | 0.49 | 0.04 | 0.77 | FALSE |
| 20 | ROSMAP | Brain Pre-frontal Cortex | CNOT8 | 0.13 | 0.05 | lasso | 2 | 0.07 | 6.4e-09 | -7.6 | 9.5 | 2.1e-21 | -0.84 | 0.03 | 0.97 | TRUE |
| 21 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CNOT8 | 0.04 | 0.03 | lasso | 1 | 0.02 | 2.7e-03 | -6.8 | 6.8 | 1.3e-11 | -0.59 | 0.01 | 0.91 | FALSE |
| 22 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | CNOT8 | 0.07 | 0.00 | enet | 20 | 0.03 | 2.4e-03 | 4.0 | 8.4 | 6.1e-17 | -0.57 | 0.02 | 0.62 | FALSE |